Sleep Science最新文献

{"title":"Insomnia Improved by Intravenous Mesenchymal Stem Cell Transplant: A Case Report.","authors":"Takahiro Honda Pazili","doi":"10.1055/s-0045-1809993","DOIUrl":"10.1055/s-0045-1809993","url":null,"abstract":"<p><p>While several therapeutic options for insomnia are currently available, they often require long-term use and come with certain disadvantages. Given insomnia's significant impact on health overall, more effective treatments are warranted. Here, we report two patients with moderate to severe insomnia whose symptoms significantly improved following the intravenous administration of <i>ex vivo</i> -expanded bone marrow-derived mesenchymal stem cells (MSC). The cases were 50-year-old and 38-year-old men with mild diabetes. They both developed insomnia several years ago and suffered from it despite taking some medications. We cultured their bone-marrow-derived MSCs and intravenously administered 1,5 × 10 ⁸ cells to each patient. After the treatment, the insomnia of both patients was drastically improved, while diabetes itself showed only mild improvement. Notably, their improvements were associated with an increase in plasma interleukin-4 levels. This is the first case report demonstrating the therapeutic effects of MSCs on insomnia.</p>","PeriodicalId":21848,"journal":{"name":"Sleep Science","volume":"18 3","pages":"e365-e368"},"PeriodicalIF":1.8,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12440579/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autonomic Cardiovascular Assessment in Obstructive Sleep Apnea Using Beat-to-Beat Blood Pressure: A Pilot Study.","authors":"Renata Carvalho Cremaschi, Natalia Buitrago-Ricaute, Peter Novak, Fernando Morgadinho Santos Coelho, Vanderci Borges","doi":"10.1055/s-0045-1811200","DOIUrl":"10.1055/s-0045-1811200","url":null,"abstract":"<p><strong>Objective: </strong>To perform autonomic cardiovascular tests on patients with suspected OSA.</p><p><strong>Materials and methods: </strong>In 2020, patients aged ≥18 years without difficult-to-control hypertension, cardiopathy, or pulmonary disease executed 6Hz deep breathing, 15-second Valsalva maneuver (40mmHg), and 5-minute active standing after the type 1 polysomnography at the Neurology (Federal University of São Paulo). The tests recorded blood pressure using beat-to-beat plethysmography, an electrocardiogram, and respiratory effort.</p><p><strong>Results: </strong>Among the seventeen patients, ten had moderate OSA, and twelve were male. The mean age and disease duration were 52 and 14 years. Hypertension and obesity were frequent. They had mild autonomic symptom burden, mainly adrenergic sympathetic overactivity, and at least one-third of them had cardiovagal abnormalities.</p><p><strong>Conclusion: </strong>A small sample of patients with untreated moderate-to-severe OSA had autonomic abnormalities in tests using beat-to-beat blood pressure. Sympathetic overdrive in long-term daytime was manifested as orthostatic hypertension. Emerging technologies contributed to diagnosing the OSA-related autonomic dysfunction beyond the polysomnographic approach.</p>","PeriodicalId":21848,"journal":{"name":"Sleep Science","volume":"18 4","pages":"e430-e435"},"PeriodicalIF":1.8,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12755936/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145889894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dream Recall, Nightmares, and Aggression-Related Dream Content in Patients with REM Sleep Behavior Disorder (RBD).","authors":"Ruben Jigalin, Michael Schredl","doi":"10.1055/s-0045-1809924","DOIUrl":"10.1055/s-0045-1809924","url":null,"abstract":"<p><p>Patients with REM sleep behavior disorder (RBD) enact their dreams, leading to enhanced dream recall. They report more negative emotions in their dreams, recall retrospective nightmares more frequently, and often experience more aggressive dreams. This study aims to understand dream characteristics in REM sleep behavior disorder using both retrospective and prospective measures in a controlled sleep laboratory setting to address possible recall biases in retrospective dream recall frequency. The sample comprises 102 iRBD-diagnosed patients (21 women, 81 men; M = 64.08, SD = 11.27) and 208 healthy controls (136 women, 72 men; M = 30.08, SD = 12.03), all undergoing identical procedures of two consecutive nights in the sleep laboratory, enabling a robust comparative examination of dream patterns. Retrospective assessments revealed a higher frequency of dream recall in patients with iRBD, while no significant difference was observed in prospective assessments. Nightmares were also reported more frequently in retrospective assessments in iRBD patients compared to healthy controls. Aggressive dream content was more frequent in patients with iRBD compared to controls, a future prospective diary study might clarify whether this heightened aggression in dreams is related to waking-life traits.</p>","PeriodicalId":21848,"journal":{"name":"Sleep Science","volume":"18 4","pages":"e379-e386"},"PeriodicalIF":1.8,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12755932/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145889926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When You Don't Have Chronotype Data: Sleep Questionnaires as a Circadian Window.","authors":"Matteo Carpi","doi":"10.1055/s-0045-1809926","DOIUrl":"10.1055/s-0045-1809926","url":null,"abstract":"","PeriodicalId":21848,"journal":{"name":"Sleep Science","volume":"18 4","pages":"e453-e454"},"PeriodicalIF":1.8,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12755930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145889931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial - A New Chapter for <i>Sleep Science</i>.","authors":"Claudia Roberta de Castro Moreno","doi":"10.1055/s-0045-1809667","DOIUrl":"https://doi.org/10.1055/s-0045-1809667","url":null,"abstract":"","PeriodicalId":21848,"journal":{"name":"Sleep Science","volume":"18 2","pages":"e119"},"PeriodicalIF":1.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12263198/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144650523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abnormal Sexual Behavior During Sleep in an Adolescent: Sexsomnia and Defecation.","authors":"Oya Güleşen Kapan, Zeynep Ihtiyar Aydilek, Mustafa Kapan, Mehmet Baştemur, Güray Koç, Şahin Bodur, Sinan Yetkin, Mehmet Ayhan Cöngöloğlu","doi":"10.1055/s-0045-1809927","DOIUrl":"10.1055/s-0045-1809927","url":null,"abstract":"<p><p>Sexsomnia is characterized by sexual behaviors ranging from masturbation, sexual sounds, and verbalizations, to touching and full sexual intercourse during NREM sleep, with subsequent amnesia. Autonomic activation occurs with sexual arousal. Sexsomnia has been described mostly in adult males and is still an underrecognized condition. Treatment is often effective but without current consensus. In a case now reported of an adolescent male with sexsomnia, which is rarely reported in the literature, a novel feature that is now first reported is defecation accompanying sexsomnia as a co-occurring autonomic disturbance during sleep.</p>","PeriodicalId":21848,"journal":{"name":"Sleep Science","volume":"18 4","pages":"e444-e446"},"PeriodicalIF":1.8,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12755937/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145889855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep Architecture, Muscle Function, and Daily Life Activities in Patients with Sarcopenia.","authors":"Eduardo López-Ramírez, Gabriela Millán-Rosas, Rafael Santana-Miranda, Daniel Santana-Vargas, Adrián Poblano, Romel Gutiérrez-Escobar","doi":"10.1055/s-0045-1809061","DOIUrl":"10.1055/s-0045-1809061","url":null,"abstract":"<p><strong>Objective: </strong>To examine associations between polysomnography, muscle mass and strength, and daily life activity index (DLAI) in patients with sarcopenia.</p><p><strong>Materials and methods: </strong>We measured polysomnography, muscle mass and strength, and DLAI in 16 patients with sarcopenia and 26 controls > 60 years old and then compared variables and correlations in the patients with sarcopenia.</p><p><strong>Results: </strong>We found no differences in polysomnography between patients with sarcopenia and controls. Among patients with sarcopenia, latency to rapid eye-movement (REM) sleep was positively correlated with weight, REM %, and total sleep time was positively correlated with grip strength. Latency of REM sleep was negatively correlated with body mass index, NREM sleep, and apnea index was negatively correlated with grip strength. Daily life activity index correlated positively with grip strength.</p><p><strong>Conclusion: </strong>Patients with sarcopenia showed significant correlations between polysomnography and weight, body mass index, and grip strength, suggesting a complex relationship involving sleep architecture, muscle function, and DLAI that deserves more research.</p>","PeriodicalId":21848,"journal":{"name":"Sleep Science","volume":"18 3","pages":"e317-e322"},"PeriodicalIF":1.8,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12460013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145150663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep Quality in Patients with Tinnitus.","authors":"Adriana Laybauer Silveira Unchalo, Cauê Denardi Santos, Laura Weber Weingaertner, Fábio André Selaimen, Nicole Cislaghi Sartor, Adriane Ribeiro Teixeira","doi":"10.1055/s-0045-1809666","DOIUrl":"10.1055/s-0045-1809666","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the association between sleep quality and chronic tinnitus.</p><p><strong>Materials and methods: </strong>The present is a prospective observational cross-sectional study in which convenience sampling ( <i>n</i>  = 51) was used to assess individuals with chronic tinnitus at a specialized outpatient clinic in a tertiary referral hospital. The data collection tools included a demographics questionnaire, a sleep quality questionnaire (the Mini Sleep Questionnaire), a questionnaire to assess the impact of tinnitus (Tinnitus Handicap Inventory), and pure-tone audiometry. The data was analyzed using the student's <i>t</i> -test or analysis of variance (ANOVA), the Mann-Whitney or Kruskal-Wallis's test, and the Pearson's Chi-squared or Fisher's exact test.</p><p><strong>Results: </strong>There was a predominance of women and middle-aged adults with bilateral tinnitus and hearing loss. The scores on the Tinnitus Handicap Inventory revealed that the tinnitus had a moderate to catastrophic impact on quality of life. Most participants classified themselves as having severe sleep difficulties on the Mini Sleep Questionnaire. Furthermore, patients with higher scores on the Tinnitus Handicap Inventory tended to show poor quality sleep patterns on the Mini Sleep Questionnaire. Regarding the association between sex and the scores on the Tinnitus Handicap Inventory, more men were severely handicapped, whereas more women were catastrophically handicapped. There was also a significant association between age group and hearing loss.</p><p><strong>Conclusion: </strong>The data analysis revealed a significant association between sleep quality and tinnitus in the sample.</p>","PeriodicalId":21848,"journal":{"name":"Sleep Science","volume":"18 4","pages":"e372-e378"},"PeriodicalIF":1.8,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12755928/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145889924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Continuous Positive Airway Pressure on the Degree of Sleepiness, Functional Quality of Sleep, and Electrophysiological Hearing Responses in Individuals with Obstructive Sleep Apnea.","authors":"Marisa Mizrahi Farber, Liliane Aparecida Fagundes Silva, Geraldo Lorenzi-Filho, Carla Gentile Matas","doi":"10.1055/s-0045-1809060","DOIUrl":"10.1055/s-0045-1809060","url":null,"abstract":"<p><strong>Introduction: </strong>Obstructive sleep apnea (OSA) affects nerve impulse transmission in the auditory pathway due to oxygen supply. Continuous positive airway pressure (CPAP) therapy improves oxygen levels, potentially alleviating sleepiness and enhancing central auditory pathway function.</p><p><strong>Objective: </strong>To longitudinally evaluate the effect of CPAP on the degree of sleepiness, functional quality of sleep, and electrophysiological hearing responses of the central auditory pathways of patients with moderate to severe OSA.</p><p><strong>Materials and methods: </strong>There were 31 adults (21 men and 10 women), aged 20 to 70 years, of which 18 were from the group with and 13 from the one without CPAP. All patients underwent three assessments: the first one performed immediately after CPAP prescription; the second, 3 months later; and the third, 6 months after the initial assessment. The Epworth Sleepiness Scale (ESS), the Functional Outcomes of Sleep Questionnaire-10 (FOSQ-10), auditory brainstem response (ABR), and long-latency auditory evoked potentials (LLAEP) were used for these assessments.</p><p><strong>Results: </strong>The ESS did not detect any changes in excessive daytime sleepiness levels and the FOSQ-10 showed no improvement in either group. Analysis from ABR revealed a high proportion of altered results in both groups at the three assessment times. During the LLAEP, it was observed that the CPAP group exhibited reduced P2 latencies compared with the non-CPAP group in the second assessment. However, this improvement was not sustained in the subsequent assessment, possibly attributed to OSA-induced damage.</p><p><strong>Conclusion: </strong>Treatment with CPAP for 6 months did not improve the degree of sleepiness, functional quality of sleep, or electrophysiological response of hearing, demonstrating that OSA can irreversibly harm the individual.</p>","PeriodicalId":21848,"journal":{"name":"Sleep Science","volume":"18 3","pages":"e281-e291"},"PeriodicalIF":1.8,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12440591/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effective Factors Related to Sleep Disorder in Infants Under 12 Months Old.","authors":"Khatereh Khamenehpour, Isa Mohammadi Zeidi, Saeed Shahsavari, Alireza Razzaghi","doi":"10.1055/s-0044-1793927","DOIUrl":"10.1055/s-0044-1793927","url":null,"abstract":"<p><p><b>Objective</b>  Infant sleep problems are ranked as one of the leading sources of stress for many families. The present study was conducted to determine the effective factors related to sleep disorders in infants under 12 months old. <b>Materials and Methods</b>  In this cross-sectional study, 410 infants who were referred to the sleep department were evaluated. The Brief Infant Sleep Questionnaire (BISQ) was used to assess the infants' sleep patterns. Statistical tests such as analysis of variance (ANOVA), Chi-squared, and linear regression analysis were used to compare the mean and percentage across the infant age groups and to determine the risk factors related to infant sleep disorders. <b>Results</b>  Out of 410 infants, 289 (70.5%) had at least 1 of the symptoms of sleep disorder. The highest and lowest percentages for sleep disorders were related to \"waking for more than 1 hour at night\" and \"sleeping less than 540 minutes in 24 hours\" with 50% and 23.7%, respectively. The results of the linear regression analysis showed that the factors of age (β = -1.04; 95% CI; -1.55-0.53) and parent perception (β = -0.31; 95% CI; 0.24-0.37) had significant effects on infant sleep disorders. <b>Conclusion</b>  The percentage of infant sleep disorder was rather high among the samples studied, and the age and parent perception variables were recognized as effective factors related to sleep disorder. Health providers and medical staff need to pay more attention to providing the necessary interventions considering infants' age and parents' perception.</p>","PeriodicalId":21848,"journal":{"name":"Sleep Science","volume":"18 2","pages":"e190-e196"},"PeriodicalIF":1.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12263203/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144650524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}