Small Structures最新文献_第4页

Metabolic Mechanism of Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cell Regulated by Magnetoelectric Microenvironment 磁电微环境调控骨髓间充质干细胞成骨分化的代谢机制

Small Structures Pub Date : 2024-12-11 DOI: 10.1002/sstr.202400466

Han Zhao, Fangyu Zhu, Yusi Guo, Xuliang Deng, Wenwen Liu

{"title":"Metabolic Mechanism of Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cell Regulated by Magnetoelectric Microenvironment","authors":"Han Zhao, Fangyu Zhu, Yusi Guo, Xuliang Deng, Wenwen Liu","doi":"10.1002/sstr.202400466","DOIUrl":"https://doi.org/10.1002/sstr.202400466","url":null,"abstract":"Conventional methods to stimulate the metabolism of bone marrow mesenchymal stem cells (BMSCs) for osteogenic differentiation typically involve systemic mobilization, which faces challenges including limited in vivo half‐life, lack of selectivity, and potential side‐effects. Therefore, localized modulation of BMSCs represents a more efficient and safer alternative. However, few studies have explored the regulation of a localized stimuli‐responsive microenvironment to activate osteogenic differentiation via mitochondrial pathways and clarified its underlying mechanisms. Herein, a novel strategy to accelerate the metabolic switch of BMSCs in tissue defects through targeted modulation using built‐in magnetoelectric biomaterials is proposed. BMSCs cultured in the magnetoelectric microenvironment exhibited an increased mitochondrial membrane potential, the highest oxygen consumption rate and enhanced adenosine triphosphate production. Furthermore, BMSCs in the magnetoelectric microenvironment demonstrated a successful metabolic switch of energy resource from glycolysis to oxidative phosphorylation, indicating a strong tendency toward osteogenic differentiation. The highest multiclass metabolite profile, indicating the most active metabolic state, was shown in rats cranial defect model treated with magnetoelectric microenvironment. This research introduces a novel approach to accelerate bone defect repair by targeted modulation of BMSC mitochondria with magnetoelectric microenvironment and provides a promising direction for exploring the intrinsic mechanisms through which the magnetoelectric microenvironment promotes bone regeneration.","PeriodicalId":21841,"journal":{"name":"Small Structures","volume":"6 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/sstr.202400466","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147332879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Highly Stretchable, Transparent Hydrogel for Electromagnetic Interference Shielding 用于电磁干扰屏蔽的高度可拉伸透明水凝胶

Small Structures Pub Date : 2024-12-11 DOI: 10.1002/sstr.202400486

Yanghang Lian, Huagao Wang, Lulu Liu, Li Guan, Mengmeng Lin, Quanlin Li, Xiaoqin Guo, Zhen Liu, Peng Chen, Biao Zhao, Rui Zhang

{"title":"Highly Stretchable, Transparent Hydrogel for Electromagnetic Interference Shielding","authors":"Yanghang Lian, Huagao Wang, Lulu Liu, Li Guan, Mengmeng Lin, Quanlin Li, Xiaoqin Guo, Zhen Liu, Peng Chen, Biao Zhao, Rui Zhang","doi":"10.1002/sstr.202400486","DOIUrl":"https://doi.org/10.1002/sstr.202400486","url":null,"abstract":"The demand for transparent electromagnetic interference (EMI) shielding materials has intensified, driven by the shortcomings of conventional transparent shielding materials, which exhibit limited light transmittance properties and struggle to perform effectively in complex environments. Herein, a conductive, stretchable, and adaptable P(AM ‐co ‐AA) hydrogel is developed by cross‐linking acrylamide (AM) with acrylic acid (AA). The hydrophilic groups contained in AA and AM endow the hydrogels a light transmission of over 80%. The introduction of carboxyl group and acyl amino group provides a good hydrogen bonding environment, and the rich polymer network structure formed by appropriate monomer ratio is more conducive to the mechanical properties and EMI shielding properties of hydrogels. The P(AM ‐co ‐AA) hydrogel demonstrates favorable mechanical properties, boasting a maximum strain at break of 1322%. Additionally, the EMI shielding performance of the hydrogel is as high as 37 dB. Even when subjected to external forces, the hydrogel maintains a total shielding effectiveness of 20 dB at a strain level of 150%. In this work, ideas are provided to prepare stretchable and transparent hydrogel with excellent EMI performance for complex application environment.","PeriodicalId":21841,"journal":{"name":"Small Structures","volume":"6 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/sstr.202400486","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147898094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Porous‐Skeleton‐Encapsulated Electronic Yarn: High‐Precision Pressure Sensing, Moisture Monitoring, and Personal Protection for Exercise Rehabilitation 多孔-骨架-封装电子纱：高精度压力传感、湿度监测和运动康复的个人保护

Small Structures Pub Date : 2024-12-05 DOI: 10.1002/sstr.202400423

Xinyi Wang, Chunyu Zhao, Congcong Lou, Lin Mei, Liang Lü, Jianpeng Wu, Yunqi Xu, Zimu Li, Shuai Liu, Xinglong Gong, Tianzhi Luo, Honghao Ma, Shouhu Xuan

{"title":"Porous‐Skeleton‐Encapsulated Electronic Yarn: High‐Precision Pressure Sensing, Moisture Monitoring, and Personal Protection for Exercise Rehabilitation","authors":"Xinyi Wang, Chunyu Zhao, Congcong Lou, Lin Mei, Liang Lü, Jianpeng Wu, Yunqi Xu, Zimu Li, Shuai Liu, Xinglong Gong, Tianzhi Luo, Honghao Ma, Shouhu Xuan","doi":"10.1002/sstr.202400423","DOIUrl":"https://doi.org/10.1002/sstr.202400423","url":null,"abstract":"The potential applications of smart electronic textiles (E‐textiles) in exercise rehabilitation are promising. However, there is still a high challenge in achieving multimodal signal output, high fidelity, and low detection limit measurements. This study describes a structure‐dependent dual‐mode moisture‐pressure sensing yarn (MACHy) that features a porous skeleton encapsulating the electrode core yarn through a chemical and physical crosslinking‐induced gelation process. The porous skeleton absorbs water and alters MACHy's resistance, endowing the excellent moisture detection performance. Meanwhile, the single MACHy is pressure‐insensitive. When the MACHy yarns interweave, a piezoresistive pressure sensor unit with a low detection limit (0.01 N), high fidelity, and wide detection range (50 N) is fabricated due to the elastic porous shell and the twisted electrode core yarn, which enlarges the deformation space. The scalable MACHy is further woven into an intelligent wristband, demonstrating both Bluetooth music control and wound exudate alarm. Finally, an intelligent knee pad combining machine learning to accurately identify knee poses is prepared. Moreover, the MACHy fabric exhibits controllable joint heating (25–85 °C), cefazolin sodium salt release (150 μg with 50 min), and electromagnetic interference shielding (30 dB) performance, which provides new insights into the design and application of multimodal sensing textiles.","PeriodicalId":21841,"journal":{"name":"Small Structures","volume":"6 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/sstr.202400423","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147909602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Nature Knows Best: Extracellular Matrix‐Gelatin Hydrogel Masking Bioauthentic Bone Scaffold Locking Blood Clot to Induce M2 Macrophage‐Mediated Bone Regeneration via Activating an Endocytosis‐Macroautophagy‐Inflammation Axis 自然最了解：细胞外基质-明胶水凝胶掩盖生物真实骨支架锁定血凝块，通过激活内吞-大自噬-炎症轴诱导M2巨噬细胞介导的骨再生

Small Structures Pub Date : 2024-11-21 DOI: 10.1002/sstr.202400499

Jieyun Xu, Xiaoran Yu, Hongcheng Chen, Junlong Xue, Zhuohong Gong, Zhengjie Shan, Shi‐Jie Chen, Yuanlong Guo, Xiaomeng Gao, Linjun Zhang, Yin Xiao, Feilong Deng, Zetao Chen

{"title":"Nature Knows Best: Extracellular Matrix‐Gelatin Hydrogel Masking Bioauthentic Bone Scaffold Locking Blood Clot to Induce M2 Macrophage‐Mediated Bone Regeneration via Activating an Endocytosis‐Macroautophagy‐Inflammation Axis","authors":"Jieyun Xu, Xiaoran Yu, Hongcheng Chen, Junlong Xue, Zhuohong Gong, Zhengjie Shan, Shi‐Jie Chen, Yuanlong Guo, Xiaomeng Gao, Linjun Zhang, Yin Xiao, Feilong Deng, Zetao Chen","doi":"10.1002/sstr.202400499","DOIUrl":"https://doi.org/10.1002/sstr.202400499","url":null,"abstract":"Individualized biological hydroxyapatite (BHA) scaffolds are essential for repairing critical craniomaxillofacial bone defects. Additive manufacturing relies on synthetic hydroxyapatite and biomimetic structures, making the resulting scaffolds inferior to natural bone. A subtractive manufacturing solution is proposed to cut natural bone blocks and then sinter them into BHA scaffolds. However, BHA scaffolds with fragile mechanical performance, fail to maintain scaffold integrity, due to microcracks generated by loss of organics from extracellular matrix (ECM). To preserve natural structure and enhance mechanical properties, ECM‐gelatin hydrogel (ECM‐Gel) is utilized as a micron‐level coating to smooth surface microcracks like a facial mask. ECM‐Gel shows potential in regulating blood clot fibrin network which may induce a favorable macrophage‐mediated bone regeneration. Therefore, a gelatin hydrogel‐masked BHA (G‐BHA) scaffold system is developed using crosslinker genipin (2 and 8 mM). ECM‐Gel formed a “hybrid layer”, smoothing the micron‐level microcracks and enhancing mechanical properties of BHA; it activated platelets to lock blood clot with dense fibrin network, inducing M2 macrophage via a potential endocytosis‐macroautophagy‐inflammation axis for bone regeneration. In vivo experiments confirmed G‐BHA scaffolds promoted ectopic and in situ bone regeneration. Therefore, ECM‐gel‐masking demonstrates great potential in developing individualized bioauthentic bone scaffolds with favorable blood clot and macrophage‐mediated bone regeneration.","PeriodicalId":21841,"journal":{"name":"Small Structures","volume":"6 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/sstr.202400499","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147921484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Hollow Structured‐Controllable Polyimide Nanofibers with Extreme Conditions Tolerance for Efficient Thermal Insulation 中空结构可控聚酰亚胺纳米纤维，具有极端条件耐受性，高效隔热

Small Structures Pub Date : 2024-11-19 DOI: 10.1002/sstr.202400439

Renhao Li, Yan Bao, Ruyue Guo, Lu Gao, Wenbo Zhang, Chao Liu, Haihang Zhao

{"title":"Hollow Structured‐Controllable Polyimide Nanofibers with Extreme Conditions Tolerance for Efficient Thermal Insulation","authors":"Renhao Li, Yan Bao, Ruyue Guo, Lu Gao, Wenbo Zhang, Chao Liu, Haihang Zhao","doi":"10.1002/sstr.202400439","DOIUrl":"https://doi.org/10.1002/sstr.202400439","url":null,"abstract":"The rational use of efficient thermal insulation materials is one of the effective strategies for energy management. However, existing thermal insulation materials often exhibit poor stability, suboptimal thermal insulation performance, and weak mechanical properties in some extreme environments. Herein, this work develops an easy and scalable strategy for creating hollow polyimide (PI) nanofibers through coaxial electrospinning and high‐temperature template removal technology, in which the internal hollow structure is precisely controlled. A large amount of air is filled in the hollow structure within the nanofibers and the voids between the nanofibers, giving PI nanofibers low density (23.3 mg cm −3 ) and high porosity (98.2%). This characteristic also effectively suppresses the heat transfer of PI nanofibers, resulting in an ultralow thermal conductivity (20.6 mW m −1 K −1 ). Meanwhile, PI nanofibers also exhibit excellent mechanical properties with a stress and strain of 5.52 MPa and 62.7%, respectively. In addition, compared to other commercial thermal insulation materials, PI nanofibers demonstrate superior extreme temperature tolerance (from −196 to 350 °C) and flame retardancy (limit oxygen index of 30.8%). Given these advantages, this work provides inspiration for the structural design of nanofiber materials with efficient thermal insulation.","PeriodicalId":21841,"journal":{"name":"Small Structures","volume":"6 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/sstr.202400439","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147918910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

A Covalent Organic Polymer Containing Dative Nitrogen→Boron Bonds: Preparation, Single‐Crystal Structure, and Photoresponse/Photocatalytic Performance 含氮→硼键的共价有机聚合物：制备、单晶结构和光响应/光催化性能

Small Structures Pub Date : 2024-11-11 DOI: 10.1002/sstr.202400492

Lizhong He, Lei Zhang, Jinglun Yang, Fangyuan Kang, Xiang Wang, Qianfeng Gu, Dong‐Sheng Li, Lang Jiang, Qichun Zhang

引用次数: 6

Multifunctional Carbon Dots Derived from Human Hair for Fast Healing Wounds Together with Oleogels 从人类头发中提取的多功能碳点与油凝胶一起用于快速愈合伤口

Small Structures Pub Date : 2024-10-20 DOI: 10.1002/sstr.202400435

Xiaofeng Shi, Qianli Ma, Xinlin Jia, Zhao‐Fan Wu, Chaohong Yu, Tian Gao, Wei Xu, Zhaonan Sun, Jingwei Zhang, Huan‐Ming Xiong, Yuanqing Mao

引用次数: 12

Chiral Mesostructure‐Induced Ferroelectricity and Photoelectric Chiral Anisotropy of MnWO₄ MnWO4的手性介面结构诱导铁电性和光电手性各向异性

Small Structures Pub Date : 2024-09-28 DOI: 10.1002/sstr.202400243

Jianwei Zuo, Quanzheng Deng, Lu Han, Shunai Che, Yingying Duan

引用次数: 1

Thermal Methanol Synthesis from CO2 Using Cu/ZnO Catalysts: Insights from First-Principles Calculations 使用 Cu/ZnO 催化剂从 CO2 热合成甲醇：第一原理计算的启示

Small Structures Pub Date : 2024-09-19 DOI: 10.1002/sstr.202400345

Cong Xi, Yixin Nie, Hongjuan Wang, Cunku Dong, Jiuhui Han, Xi-Wen Du

{"title":"Thermal Methanol Synthesis from CO2 Using Cu/ZnO Catalysts: Insights from First-Principles Calculations","authors":"Cong Xi, Yixin Nie, Hongjuan Wang, Cunku Dong, Jiuhui Han, Xi-Wen Du","doi":"10.1002/sstr.202400345","DOIUrl":"https://doi.org/10.1002/sstr.202400345","url":null,"abstract":"Catalytic hydrogenation of carbon dioxide to methanol offers a promising avenue for recycling CO2, enhancing environmental sustainability. Cu/ZnO has long been identified as one of the most effective heterogeneous catalysts for this reaction, yet the detailed understanding of its reaction mechanism and active sites remains incomplete. Recent advances have highlighted the critical role of defects, such as ZnCu steps and stacking faults on Cu surfaces, in enhancing catalyst performance. Here this concept is explored through first-principles surface simulations of six models, featuring diverse Cu–Zn combinations and specific coordination environments under realistic conditions. It is revealed that Cu/ZnO catalysts with kink defects, rather than surface ZnCu alloys, exhibit optimal activity for methanol synthesis. Specifically, the findings demonstrate how intermediate configurations and rate-determining steps vary with changes in surface structure and reveal the role of the kink in promoting CO2 reduction to methanol through electronic structure calculation. Moreover, it is found that the predominant synthetic pathway for CH3OH from CO2 involves the reverse water gas shift and CO hydrogenation, rather than the formate route, on Cu/ZnO surfaces with kinks.","PeriodicalId":21841,"journal":{"name":"Small Structures","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142260162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Monodispersed Iron Selenide Nanoparticles United with Carbon Nanotubes for Highly Reversible Zinc–Air Batteries 单分散硒化铁纳米粒子与碳纳米管结合用于高可逆锌-空气电池

Small Structures Pub Date : 2024-09-19 DOI: 10.1002/sstr.202400181

Hua Zhang, Tong Zeng, Jiale Ma, Yue Jiang, Yang Huang, Yuxin Cheng, Haifeng Ye, Cuiyun Zeng, Chenghui Zeng, Minshen Zhu, Shuiliang Chen

{"title":"Monodispersed Iron Selenide Nanoparticles United with Carbon Nanotubes for Highly Reversible Zinc–Air Batteries","authors":"Hua Zhang, Tong Zeng, Jiale Ma, Yue Jiang, Yang Huang, Yuxin Cheng, Haifeng Ye, Cuiyun Zeng, Chenghui Zeng, Minshen Zhu, Shuiliang Chen","doi":"10.1002/sstr.202400181","DOIUrl":"https://doi.org/10.1002/sstr.202400181","url":null,"abstract":"Developing electrocatalysts that exhibit exceptional activity without relying on noble metals, all while ensuring high efficiency and durability for the oxygen reduction and evolution reactions, poses a challenging yet highly desired task. Monodispersed nanoparticles on a conductive framework through strong metal–support interactions are known to show excellent catalytic performance. Herein, monodispersed iron selenide embedded in a carbon nanotube network is synthesized. Graphitic carbon shells enclosing monodispersed iron selenide address the primary challenge of nanoparticle catalysts—aggregation and corrosion of nanoparticles over repeated oxygen redox reactions. By amplifying the interaction of Fe with carbon nanotubes, the heterogeneous catalyst forms highly active centers for oxygen redox reaction from the coordinated iron atoms, along with conductive iron–nitrogen–carbon nanotube pathways for rapid charge transfer. As a result, the heterogeneous catalyst exhibits superior activity for both oxygen reduction (E1/2 = 0.88 V) and oxygen evolution (η = 360 mV@10 mA cm−2) and excellent stability of negligible degradation over 5000 cycles. The overall catalytic performance surpasses the noble metals. Therefore, rechargeable zinc–air batteries using the heterogeneous catalyst exhibit a high power density of 130.9 mW cm−2, excellent round-trip efficiency of ≈70%, and cycling stability for over 1100 h at 10 mA cm−2.","PeriodicalId":21841,"journal":{"name":"Small Structures","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142260164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0