Sexual medicine reviews最新文献

筛选
英文 中文
Newer formulations of oral testosterone undecanoate: development and liver side effects. 较新的十一酸睾酮口服制剂:开发和肝脏副作用。
IF 3.6 2区 医学
Sexual medicine reviews Pub Date : 2024-09-18 DOI: 10.1093/sxmrev/qeae062
Irwin Goldstein, Nachiappan Chidambaram, Adrian Dobs, Shelby King, Martin Miner, Ranjith Ramasamy, Faysal A Khera, Mohit Khera
{"title":"Newer formulations of oral testosterone undecanoate: development and liver side effects.","authors":"Irwin Goldstein, Nachiappan Chidambaram, Adrian Dobs, Shelby King, Martin Miner, Ranjith Ramasamy, Faysal A Khera, Mohit Khera","doi":"10.1093/sxmrev/qeae062","DOIUrl":"https://doi.org/10.1093/sxmrev/qeae062","url":null,"abstract":"<p><strong>Introduction: </strong>Testosterone deficiency is a clinical disorder due to either failure of the testes to produce testosterone or failure of the hypothalamus or pituitary to produce sufficient gonadotropins. Previous formulations of oral testosterone therapy, particularly methyltestosterone, have been associated with adverse liver effects. Many different routes of testosterone delivery have been developed, each with their own administrative benefits and challenges. Newer formulations of oral testosterone undecanoate (TU) provide a convenient administration option, although their use has been limited by hepatotoxicity concerns based on older methyltestosterone data, and prescribing physicians may still be concerned about adverse liver effects.</p><p><strong>Objectives: </strong>In this review, we discuss the history of oral testosterone development, clarify the mechanism of action of oral TU, and describe the relevant liver safety findings.</p><p><strong>Methods: </strong>Relevant literature was allocated to present a review on the history of oral TU development and the mechanism of action of oral TU. We pooled data from individual studies of oral TU products to present a safety summary.</p><p><strong>Results: </strong>Overall, safety results from studies of the newer formulations of oral TU showed that increased liver function test values are not generally associated with oral TU formulations and that no clinically significant liver toxicities were noted in clinical trials of oral TU.</p><p><strong>Conclusion: </strong>Continued research into the safety of oral TU will contribute to a better understanding of the potential risks in patients receiving this therapy, an outcome that highlights the importance of providing patient education and reassurance regarding oral TU safety.</p>","PeriodicalId":21813,"journal":{"name":"Sexual medicine reviews","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142295935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hyaluronic acid and urology: a systematic review and meta-analysis. 透明质酸与泌尿科:系统回顾与荟萃分析。
IF 3.6 2区 医学
Sexual medicine reviews Pub Date : 2024-09-06 DOI: 10.1093/sxmrev/qeae060
Bradley J Roth, Muhammed A M Hammad, Mark I Sultan, Elia Abou Chawareb, Jasmin Banton, Sean Sung Hun Park, Paul E Perito, Faysal A Yafi, Omer Raheem
{"title":"Hyaluronic acid and urology: a systematic review and meta-analysis.","authors":"Bradley J Roth, Muhammed A M Hammad, Mark I Sultan, Elia Abou Chawareb, Jasmin Banton, Sean Sung Hun Park, Paul E Perito, Faysal A Yafi, Omer Raheem","doi":"10.1093/sxmrev/qeae060","DOIUrl":"10.1093/sxmrev/qeae060","url":null,"abstract":"<p><strong>Introduction: </strong>The use of hyaluronic acid as a nonsurgical treatment for various conditions within urology has been of great interest in recent literature.</p><p><strong>Objectives: </strong>In this study, we aimed to provide an updated review and analysis of the current state of hyaluronic acid use in urology, characterize its adverse effects, and briefly discuss future directions of research for hyaluronic acid in urology.</p><p><strong>Methods: </strong>PubMed searches were run utilizing multiple terms, including \"hyaluronic acid,\" \"penile,\" \"augmentation,\" \"Peyronie disease,\" \"premature ejaculation,\" and \"cosmetic urology,\" among other related iterations. Relevant data extracted included International Index of Erectile Function score, intravaginal ejaculatory latency, glans circumference, penile girth, and plaque size. We also included studies which reported on complications of hyaluronic acid injections. Aggregated analysis was performed on studies with complete pre and post injection data at time closest to 6 months postinjection.</p><p><strong>Results: </strong>A total of 33 studies met our inclusion criteria. Studies had marked heterogeneity in design, but most reported positive results. A total of 16 studies were included in our analysis. Intravaginal ejaculatory latency, penile girth, glans circumference, and International Index of Erectile Function were all increased on a fixed-effects model. Reduction in plaque size was not significant (P = .069). Complications were rare.</p><p><strong>Conclusion: </strong>Literature on hyaluronic acid for urologic issues demonstrates promising results; however, the quality of studies was variable. Our analysis of these studies largely corroborates these findings; however, the results are limited by the data available. Hyaluronic acid may be promising, but we highly implore standardization of study regimens in randomized controlled trials.</p>","PeriodicalId":21813,"journal":{"name":"Sexual medicine reviews","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142141155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the relationship between temporomandibular disorders and sexual function. 探索颞下颌关节紊乱与性功能之间的关系。
IF 3.6 2区 医学
Sexual medicine reviews Pub Date : 2024-09-05 DOI: 10.1093/sxmrev/qeae063
Kalichman Leonid
{"title":"Exploring the relationship between temporomandibular disorders and sexual function.","authors":"Kalichman Leonid","doi":"10.1093/sxmrev/qeae063","DOIUrl":"https://doi.org/10.1093/sxmrev/qeae063","url":null,"abstract":"<p><strong>Introduction: </strong>Temporomandibular disorders (TMDs) encompass various conditions affecting the temporomandibular joint and surrounding structures, often presenting with pain, limited movement, and functional impairments. TMDs may affect kissing and oral sex, in addition to influencing sexual function, as any other chronic pain condition.</p><p><strong>Objective: </strong>The study sought to examine the connection between TMDs and sexual function.</p><p><strong>Methods: </strong>A literature review was conducted, synthesizing evidence from various disciplines, including dentistry, physical therapy, psychology, and sexual medicine. Relevant studies were analyzed to elucidate the multifaceted nature of TMDs and their potential impact on sexual health.</p><p><strong>Results: </strong>Emerging evidence suggests a complex relationship between TMDs and sexual function, with chronic pain, psychological distress, and physiological factors potentially contributing to sexual dysfunction.</p><p><strong>Conclusion: </strong>Understanding the interconnectedness of TMDs and sexual function is essential for providing comprehensive care. Further research is needed to assess the association between TMDs and sexual dysfunction, elucidate the underlying mechanisms, and develop targeted interventions that address both TMD symptoms and sexual health concerns.</p>","PeriodicalId":21813,"journal":{"name":"Sexual medicine reviews","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142141154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigating iontophoresis as a therapeutic approach for Peyronie's disease: a systematic review. 将离子透入疗法作为佩罗尼氏病治疗方法的研究:系统综述。
IF 3.6 2区 医学
Sexual medicine reviews Pub Date : 2024-08-26 DOI: 10.1093/sxmrev/qeae058
Sahand Eslami, Fateme Tahmasbi, Alireza Rahimi-Mamaghani, Sarvin Sanaie, Carlo Bettocchi, Omid Sedigh, Farzin Soleimanzadeh
{"title":"Investigating iontophoresis as a therapeutic approach for Peyronie's disease: a systematic review.","authors":"Sahand Eslami, Fateme Tahmasbi, Alireza Rahimi-Mamaghani, Sarvin Sanaie, Carlo Bettocchi, Omid Sedigh, Farzin Soleimanzadeh","doi":"10.1093/sxmrev/qeae058","DOIUrl":"https://doi.org/10.1093/sxmrev/qeae058","url":null,"abstract":"<p><strong>Introduction: </strong>Iontophoresis therapy (IPT) is a noninvasive technique that uses electrical impulses to deliver charged molecules into the skin for controlled and targeted drug delivery. IPT has been explored as a noninvasive treatment option for Peyronie's disease (PD), but the current literature in this regard is still scarce.</p><p><strong>Objective: </strong>We aimed to systematically review the current literature on the application of IPT in the management of PD to provide a comprehensive evaluation and holistic outlook on the subject.</p><p><strong>Method: </strong>A comprehensive search strategy was implemented in the following databases to retrieve research articles: PubMed (MEDLINE), Scopus, and Web of Science. Google Scholar was also manually searched. The search results were imported into Rayyan reference management for assessment based on the predefined inclusion criteria. The quality of the articles was evaluated by the proper JBI checklist (ie, per the study design), and the JBI grades of recommendation were used for grading the evidence.</p><p><strong>Results: </strong>A systematic search yielded 451 publications, 11 of which met the criteria to be included in this systematic review. The results demonstrated that IPT, usually with verapamil and dexamethasone, has shown promising results in treating PD. These methods can reduce pain, plaque size, and penile curvature while improving sexual function and quality of life with no serious adverse events. However, most studies had moderate to low quality, indicating a weak recommendation for a certain health management strategy.</p><p><strong>Conclusion: </strong>Based on the extant literature, there is currently insufficient evidence to support the use of IPT for the management of PD. Placing it in the forefront of research can facilitate the management choices for PD even further, given its therapeutic potential.</p>","PeriodicalId":21813,"journal":{"name":"Sexual medicine reviews","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142073899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Androgens and erectile dysfunction: from androgen deficiency to treatment. 雄激素与勃起功能障碍:从雄激素缺乏到治疗。
IF 3.6 2区 医学
Sexual medicine reviews Pub Date : 2024-06-26 DOI: 10.1093/sxmrev/qeae030
Yuan Wang, Rui Jiang
{"title":"Androgens and erectile dysfunction: from androgen deficiency to treatment.","authors":"Yuan Wang, Rui Jiang","doi":"10.1093/sxmrev/qeae030","DOIUrl":"10.1093/sxmrev/qeae030","url":null,"abstract":"<p><strong>Introduction: </strong>Androgens play important roles in regulating the growth and development of the male reproductive system and maintaining libido and erectile function. The specific mechanisms by which androgen deficiency leads to erectile dysfunction (ED) are not yet fully understood.</p><p><strong>Objectives: </strong>To understand the mechanisms and treatment of androgen deficiency-related ED.</p><p><strong>Methods: </strong>A literature search in the past 10 years was conducted in PubMed and Google Scholar to determine the effects of androgen deficiency on erectile function and the treatment of androgen deficiency.</p><p><strong>Results: </strong>Androgen deficiency can be caused by hypothalamic-pituitary lesions and injuries, testicular-related diseases and injuries, endocrine and metabolic disorders, the side effects of medication, and age. Androgen deficiency can lead to ED by inhibiting the NOS/NO/cGMP pathway (nitric oxide synthase/nitric oxide/cyclic guanosine monophosphate) and altering the expression of ion channel proteins, as well as by inducing oxidative stress, death, and fibrosis in penile corpus cavernosum cells. Testosterone replacement therapy is effective at improving the serum testosterone levels and erectile function in patients with androgen deficiency. For patients who need to maintain a low androgenic state, erectile function can be improved by lifestyle changes, treatment with phosphodiesterase type 5 inhibitors, low-intensity extracorporeal shock wave therapy, and stem cell therapy.</p><p><strong>Conclusions: </strong>Androgen deficiency can affect the structure and function of the penile corpus cavernosum, leading to ED. Areas of further study include how androgen replacement therapy can improve erectile function and how to improve the maintenance of erectile function in patients with hypoandrogenic status.</p>","PeriodicalId":21813,"journal":{"name":"Sexual medicine reviews","volume":" ","pages":"458-468"},"PeriodicalIF":3.6,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140892173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Addressing the unspoken: sexual dysfunction in men with systemic lupus erythematosus, a call to action for rheumatologists. 解决不为人知的问题:系统性红斑狼疮男性患者的性功能障碍,呼吁风湿病学家行动起来。
IF 3.6 2区 医学
Sexual medicine reviews Pub Date : 2024-06-26 DOI: 10.1093/sxmrev/qeae033
Abril Carrillo, Daniela Marengo-Rodríguez, Monserrat Ibarra-Velasco-Siles, María José Chávez-Barajas, Ana Barrera-Vargas, Luis Fernando Pérez-García, Javier Merayo-Chalico
{"title":"Addressing the unspoken: sexual dysfunction in men with systemic lupus erythematosus, a call to action for rheumatologists.","authors":"Abril Carrillo, Daniela Marengo-Rodríguez, Monserrat Ibarra-Velasco-Siles, María José Chávez-Barajas, Ana Barrera-Vargas, Luis Fernando Pérez-García, Javier Merayo-Chalico","doi":"10.1093/sxmrev/qeae033","DOIUrl":"10.1093/sxmrev/qeae033","url":null,"abstract":"<p><strong>Introduction: </strong>Sexual dysfunction (SD) is highly prevalent and multifactorial; nevertheless, recent research has shed light on a notable phenomenon: male patients with systemic lupus erythematosus (SLE) exhibit an elevated prevalence of sexual function disorders compared with the general population. Despite this recognition, the precise nature and extent of this association remain incompletely understood.</p><p><strong>Objectives: </strong>This comprehensive review aims to clarify the link by providing an overview of the fundamental components of normal male sexual function, delving into the pathogenesis of male SD and exploring the primary factors predisposing male SLE patients to SD. Additionally, the review offers insights into potential screening, diagnostic, and treatment strategies based on the current body of literature.</p><p><strong>Methods: </strong>A meticulous search of relevant literature was conducted using the PubMed and Google Scholar databases.</p><p><strong>Results: </strong>Studies exploring the correlation between SLE and SD in both genders have revealed a nearly 2-fold increased risk of SD among individuals with SLE compared with healthy counterparts. Moreover, these studies suggest that male SLE patients may have a higher susceptibility to SD, with reported prevalence ranging from 12% to 68%, compared with 0% to 22% in healthy individuals. Male patients with SLE are influenced by a spectrum of pathological factors, including pharmacological, psychological, and disease-related determinants, which, through their intricate interplay, elevate the likelihood of developing SD.</p><p><strong>Conclusion: </strong>Healthcare professionals must remain vigilant in understanding the intricacies of human sexuality and its dysfunction, particularly in males with SLE. The objective is to establish effective and potentially standardized methods for promptly diagnosing and optimally managing SD, recognizing its significant impact on the quality of life for males living with SLE. The pivotal role of rheumatologists in initiating discussions about sexual health, diagnosing SD, investigating causes, and implementing tailored strategies is underscored as crucial in addressing this multifaceted issue.</p>","PeriodicalId":21813,"journal":{"name":"Sexual medicine reviews","volume":" ","pages":"434-441"},"PeriodicalIF":3.6,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141155356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sexual dysfunction in women with primary Sjögren's syndrome: a systematic review and meta-analysis. 原发性斯约格伦综合征女性患者的性功能障碍:系统综述和荟萃分析。
IF 3.6 2区 医学
Sexual medicine reviews Pub Date : 2024-06-26 DOI: 10.1093/sxmrev/qeae009
Chia-Wen Hsu, Jian Tao Lee, Malcolm Koo
{"title":"Sexual dysfunction in women with primary Sjögren's syndrome: a systematic review and meta-analysis.","authors":"Chia-Wen Hsu, Jian Tao Lee, Malcolm Koo","doi":"10.1093/sxmrev/qeae009","DOIUrl":"10.1093/sxmrev/qeae009","url":null,"abstract":"<p><strong>Introduction: </strong>Primary Sjögren's syndrome (pSS) is an inflammatory autoimmune condition affecting the exocrine glands, which can adversely affect the sexual activities of women with pSS.</p><p><strong>Objectives: </strong>The study sought to evaluate the performance of the Female Sexual Function Index (FSFI) score in women with pSS regarding desire, arousal, orgasm, lubrication, satisfaction, and pain compared with those of healthy individuals.</p><p><strong>Methods: </strong>A systematic review was conducted by examining studies published up to May 2023 using Embase, Web of Science, Scopus, and PubMed with the search terms \"sexual\" and \"Sjögren's syndrome.\"</p><p><strong>Results: </strong>Out of the 228 articles retrieved, 9 met the criteria for inclusion in this systematic review. Six of these studies were cross-sectional, involving 229 women with pSS and 303 control subjects. Results from the meta-analysis showed that women with pSS had significantly lower scores in all 6 FSFI subdomains and the total FSFI score compared with healthy individuals. Lubrication showed the largest decrease, followed by pain. In addition, women with pSS exhibited significantly higher standardized mean differences in depression and in anxiety, as assessed by the Hospital Anxiety and Depression Scale, when compared with control subjects.</p><p><strong>Conclusion: </strong>This updated meta-analysis underscores the importance of assessing genitourinary atrophy, disease-related psychological changes, and dyspareunia in women with pSS. It also emphasizes the need for customized therapeutic approaches to address these sexual dysfunctions effectively.</p>","PeriodicalId":21813,"journal":{"name":"Sexual medicine reviews","volume":" ","pages":"299-306"},"PeriodicalIF":3.6,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140120657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Top 50 most cited articles about female sexual dysfunction: a bibliometric analysis. 关于女性性功能障碍被引用最多的 50 篇文章:文献计量分析。
IF 3.6 2区 医学
Sexual medicine reviews Pub Date : 2024-06-26 DOI: 10.1093/sxmrev/qeae013
Susan Gong, Samuel Yim, Abdo Kabarriti
{"title":"Top 50 most cited articles about female sexual dysfunction: a bibliometric analysis.","authors":"Susan Gong, Samuel Yim, Abdo Kabarriti","doi":"10.1093/sxmrev/qeae013","DOIUrl":"10.1093/sxmrev/qeae013","url":null,"abstract":"<p><strong>Introduction: </strong>Female sexual dysfunction (FSD) consists of low libido, sexual arousal problems, anorgasmia, and dyspareunia. Sexual function is an important aspect of life for many women and is closely correlated with overall well-being. FSD is often underrepresented in the academic space when compared with male sexual disorders, such as erectile dysfunction. As FSD spans many fields (eg, urology, gynecology, psychology), bibliometric analyses are an important resource to highlight landmark articles.</p><p><strong>Objectives: </strong>To identify key articles about FSD by citation number and bibliometric analysis to facilitate future scholarly efforts into more FSD research.</p><p><strong>Methods: </strong>We searched for articles in the Web of Science Core Collection between 1900 and 2023 using terms specific to FSD. We identified relevant FSD articles and selected the top 50 most cited. A bibliometric analysis was performed to collect and analyze data about title, authorship, publication year, citation number, journal and impact factor, country and institution, study type, citation index, specialty, and conflict of interest.</p><p><strong>Results: </strong>An overall 6858 results were identified. The top 50 most cited articles were published between 1997 and 2014 in 12 countries, across 32 institutions, and in 20 journals. The United States produced the most articles. The Journal of Sexual Medicine published the most articles. The mean number of citations per article was 351.64. Observational studies were most common. More than half were sponsored. Of all the specialties, most articles were categorized as urology and nephrology. Research about FSD has been much less impactful than research about male sexual dysfunction, possibly owing to stigma and decreased clinical training.</p><p><strong>Conclusion: </strong>As FSD covers many fields, bibliometric analyses are invaluable to understand the vast body of knowledge. We hope that this research emphasizes the lack of attention that FSD has had and that it provides health care professionals with a valuable tool to understand the trajectory of FSD to guide future education efforts.</p>","PeriodicalId":21813,"journal":{"name":"Sexual medicine reviews","volume":" ","pages":"270-278"},"PeriodicalIF":3.6,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140140846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Current treatment options for erectile dysfunction in kidney transplant recipients. 肾移植受者勃起功能障碍的现有治疗方案。
IF 3.6 2区 医学
Sexual medicine reviews Pub Date : 2024-06-26 DOI: 10.1093/sxmrev/qeae028
Lucio Dell'Atti
{"title":"Current treatment options for erectile dysfunction in kidney transplant recipients.","authors":"Lucio Dell'Atti","doi":"10.1093/sxmrev/qeae028","DOIUrl":"10.1093/sxmrev/qeae028","url":null,"abstract":"<p><strong>Introduction: </strong>Erectile dysfunction (ED) and kidney dysfunction share common risk factors linked to conditions involving endothelial impairment, such as coronary artery disease, dyslipidemia, diabetes mellitus, hypertension, smoking, and obesity. Men with chronic kidney disease experience a high incidence and prevalence of ED. While a functional renal graft can alleviate the issue for some patients, a significant portion of recipients still experience ED (20%-50%).</p><p><strong>Objectives: </strong>This narrative review describes the variety of current treatments modalities on ED in kidney transplant recipients (KTRs) and their clinical outcomes.</p><p><strong>Methods: </strong>MEDLINE, Web of Science, PubMed, and Google Scholar were used to find eligible articles pertaining to the treatment options of ED in KTRs. A total of 64 articles were evaluated.</p><p><strong>Results: </strong>In KTRs, ED stems from a multifaceted etiology: anxiety, drug side effects, interference with penile vascularity, or the response of cavernosal muscle to neurotransmitters, along with changes in the endocrine milieu. A diverse range of treatments to restore erectile function has proven to be safe and effective for KTRs. Options include drug therapy, surgical interventions, intracavernosal injection therapies, vacuum erection devices, and extracorporeal shockwave therapy.</p><p><strong>Conclusion: </strong>The initial treatment approach may involve the use of a phosphodiesterase type 5 inhibitors at a low dosage, especially if testosterone-circulating levels align with the diagnosis of hypogonadism. The consideration of a combination therapy involving testosterone and phosphodiesterase type 5 inhibitors should be contemplated due to the associated beneficial effects. Extracorporeal shockwave therapy has shown positive short-term clinical and physiological effects on erectile function in patients who did not respond to first-line treatments, resulting in spontaneous erections sufficient for sexual penetration in 50% of cases. Penile implants should be considered as third-line options based on specific patient needs and compliance with clinical conditions.</p>","PeriodicalId":21813,"journal":{"name":"Sexual medicine reviews","volume":" ","pages":"442-448"},"PeriodicalIF":3.6,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140899715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Iatrogenic injuries to reservoirs of inflatable penile prosthesis during urologic surgery: a scoping review and case report. 泌尿外科手术中充气式阴茎假体储液器的先天性损伤:范围综述和病例报告。
IF 3.6 2区 医学
Sexual medicine reviews Pub Date : 2024-06-26 DOI: 10.1093/sxmrev/qeae026
Priyanka Achalu, Michael Okene, Hossein Mirheydar
{"title":"Iatrogenic injuries to reservoirs of inflatable penile prosthesis during urologic surgery: a scoping review and case report.","authors":"Priyanka Achalu, Michael Okene, Hossein Mirheydar","doi":"10.1093/sxmrev/qeae026","DOIUrl":"10.1093/sxmrev/qeae026","url":null,"abstract":"<p><strong>Introduction: </strong>First-line treatment options for patients with erectile dysfunction whose medical management has failed include the inflatable penile prosthesis (IPP). Many patients with an IPP require subsequent urologic surgery, during which the reservoir of the IPP can be injured.</p><p><strong>Objectives: </strong>This review aims to present a summary of current literature related to iatrogenic injuries to the IPP sustained during urologic surgery.</p><p><strong>Methods: </strong>Two reviewers independently performed a systematic search on PubMed using standardized search terms to identify pertinent articles. After preliminary review, relevant studies were analyzed to identify the presence of perioperative complications resulting in IPP reservoir injury. Results were categorized by surgical procedures.</p><p><strong>Results: </strong>Among 13 articles included, all were based on urologic surgery. Four studies identified IPP reservoir injury as a result of surgical injury. Of these, injuries occurred during radical prostatectomy (n = 3) and prostatic urethral lift surgery (UroLift, n = 1). Most radical prostatectomy studies without IPP reservoir injuries also described intentional surgical techniques that were employed to prevent reservoir damage, including modulation of reservoir inflation-deflation (n = 3), temporary reservoir repositioning (n = 1), or reservoir capsule dissection to improve visualization (n = 1). Findings from an additional novel case report on IPP injury during a UroLift procedure are presented in this review.</p><p><strong>Conclusion: </strong>Approximately one-third of studies identified intraoperative IPP reservoir injury as a significant complication of urologic surgery, particularly during radical prostatectomy. Novel case report findings also contribute the only other case of IPP reservoir damage sustained from delivery of UroLift implants. Findings are used to create a standardized surgical checklist that guides perioperative planning measures prior to pursuing surgery in adjacent spaces.</p>","PeriodicalId":21813,"journal":{"name":"Sexual medicine reviews","volume":" ","pages":"513-518"},"PeriodicalIF":3.6,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140871710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信