探索合并失眠和睡眠呼吸暂停(COMISA)与勃起功能障碍之间的联系:对男性性健康的影响。

IF 3.6 2区 医学 Q1 UROLOGY & NEPHROLOGY
Monica Levy Andersen, David Gozal, Sergio Tufik
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引用次数: 0

摘要

导言:这篇综述探讨了合并失眠和睡眠呼吸暂停(COMISA)与勃起功能障碍(ED)这两种严重影响男性健康的疾病之间的相互作用。COMISA是一种最近才被发现的疾病,其特点是失眠和阻塞性睡眠呼吸暂停同时存在,已被证明会扰乱睡眠结构并导致间歇性缺氧。这些干扰越来越多地与男性普遍存在的性功能障碍(ED)的恶化联系在一起。了解 COMISA 与 ED 之间的联系对于制定同时解决睡眠和性健康问题的综合治疗方法至关重要:我们旨在探索 COMISA 和 ED 在流行病学、生理学和潜在治疗方面的交叉点。这篇综述旨在更好地理解这些疾病之间的关系,并强调需要一种综合的诊断和治疗方法来同时解决睡眠和性健康问题:方法:通过全面分析,包括对现有研究的详细审查,我们探讨了激素失衡和神经通路的改变共同导致 ED 的复杂病理生理学,以及这些因素如何特别易受同时存在的 COMISA 的影响:我们的分析表明,与COMISA相关的睡眠结构紊乱和间歇性缺氧会加重ED。荷尔蒙失调、内皮功能障碍、自律神经失衡以及炎症和氧化应激增加是 COMISA 影响 ED 的主要机制。这些因素共同损害了血管健康,降低了睾酮水平,破坏了勃起的神经控制,加剧了 ED 的严重程度:本综述强调,有必要采用综合方法进行诊断和治疗,同时考虑睡眠和性健康,以改善整体疗效。这些见解应有助于加深对COMISA和ED之间关系的理解,鼓励在这一领域开展进一步研究,并有可能开发出创新的治疗策略来管理这些密切相关的健康问题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Exploring the link between comorbid insomnia and sleep apnea (COMISA) and erectile dysfunction: implications for male sexual health.

Introduction: This review explores the interplay between comorbid insomnia and sleep apnea (COMISA) and erectile dysfunction (ED), 2 conditions that significantly impact men's health. COMISA, a recently recognized condition characterized by the coexistence of insomnia and obstructive sleep apnea, has been shown to disrupt sleep architecture and cause intermittent hypoxia. These disturbances are increasingly linked to the exacerbation of ED, a prevalent issue among men. Understanding the connection between COMISA and ED is crucial for developing integrated treatment approaches that address both sleep and sexual health.

Objectives: We aim to explore the epidemiological, physiological, and potential therapeutic intersections of COMISA and ED. This review sets out to develop a better understanding of the relationship between these conditions and to emphasize the need for an integrated diagnostic and therapeutic approach that addresses both sleep and sexual health.

Methods: Through a comprehensive analysis, including a detailed examination of extant studies, we address the hormonal imbalances and alterations in neural pathways that collectively contribute to the complex pathophysiology of ED and how these are particularly susceptible to the concurrent presence of COMISA.

Results: Our analysis indicates that disruptions in sleep architecture and intermittent hypoxia associated with COMISA can exacerbate ED. Hormonal imbalances, endothelial dysfunction, autonomic imbalance, and increased inflammation and oxidative stress are key mechanisms through which COMISA influences ED. These factors collectively impair vascular health, reduce testosterone levels, disrupt neural control of erections, and contribute to the severity of ED.

Conclusions: This review underscores the necessity for an integrated approach to diagnosis and therapy that considers both sleep and sexual health to improve overall outcomes. These insights should foster a deeper understanding of the relationship between COMISA and ED, encourage further research in this area, and potentially lead to the development of innovative treatment strategies to manage these closely intertwined health concerns.

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来源期刊
Sexual medicine reviews
Sexual medicine reviews UROLOGY & NEPHROLOGY-
CiteScore
7.60
自引率
8.30%
发文量
5
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