Sexual medicine reviews最新文献

{"title":"Korean red ginseng and male sexual function: reality or myth?","authors":"Wajid Zaman, Mozaniel Santana de Oliveira, Adnan Amin","doi":"10.1093/sxmrev/qeag043","DOIUrl":"https://doi.org/10.1093/sxmrev/qeag043","url":null,"abstract":"","PeriodicalId":21813,"journal":{"name":"Sexual medicine reviews","volume":"14 3","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148424070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The NLRP3 inflammasome in the pathogenesis of erectile dysfunction: mechanistic insights and therapeutic potential.","authors":"Feng Yin, Hongming Chen, Hongtai Tu, Hao Zhong, Yunqi Mo, Tianxiang Xie, Zhubinyun Lai, Junrong Zou, Rihai Xiao","doi":"10.1093/sxmrev/qeag054","DOIUrl":"https://doi.org/10.1093/sxmrev/qeag054","url":null,"abstract":"<p><strong>Introduction: </strong>The NLRP3 inflammasome is a critical innate immune sensor that drives inflammatory responses and has been implicated in various chronic diseases. However, its specific role in erectile dysfunction (ED) remains incompletely understood, and the evidence supporting its clinical relevance has not been systematically evaluated.</p><p><strong>Methods: </strong>This narrative review followed a structured literature search in PubMed, Web of Science, and Scopus from inception to 2026, using predefined keyword combinations covering NLRP3 inflammasome, pyroptosis, oxidative stress, endothelial dysfunction, neuroinflammation, endocrine dysregulation, and targeted inhibitors. Inclusion criteria comprised original studies, systematic reviews, and meta-analyses reporting NLRP3-related mechanisms or interventions in ED, without restriction to animal or human studies. The retrieved evidence was critically appraised, and the level of evidence was graded according to the Oxford Centre for Evidence-Based Medicine (OCEBM 2011) classification.</p><p><strong>Results: </strong>Preclinical studies, predominantly in rodent models of diabetic, hypertensive, and hyperuricaemic ED, consistently show NLRP3 upregulation/activation in penile tissues and improvement of erectile function after NLRP3-targeting interventions. Mechanistically, NLRP3 contributes to ED through three interrelated pathways: (1) endothelial dysfunction via pyroptosis and reduced nitric oxide bioavailability; (2) neuroinflammation affecting both peripheral autonomic nerves and central regulatory circuits; and (3) endocrine dysregulation, particularly impairment of Leydig cell steroidogenesis and testosterone production. Pharmacological inhibitors (MCC950, CY-09), IL-1 receptor antagonists, caspase-1 inhibitors, and natural products (curcumin, resveratrol) have shown efficacy in animal models; however, human data are limited to biomarker analyses, and no clinical trials have been reported for ED.</p><p><strong>Conclusions: </strong>Current evidence supports a functional association and causal plausibility of NLRP3 inflammasome in ED pathogenesis, but direct causality in humans remains unconfirmed. Future research should prioritize rigorous causal validation, on-target specificity verification, and clinically aligned endpoints to facilitate translation of NLRP3-targeted strategies into ED therapeutics.</p>","PeriodicalId":21813,"journal":{"name":"Sexual medicine reviews","volume":"14 3","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148685792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A call for the universal implementation of a person-centered gynecological examination.","authors":"Mijal Luria","doi":"10.1093/sxmrev/qeag053","DOIUrl":"https://doi.org/10.1093/sxmrev/qeag053","url":null,"abstract":"","PeriodicalId":21813,"journal":{"name":"Sexual medicine reviews","volume":"14 3","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148621540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The scientific study of masturbation: a bibliometric analysis.","authors":"Gracia M Sánchez-Pérez, Juan Carlos Sierra, Pablo Mangas","doi":"10.1093/sxmrev/qeag052","DOIUrl":"10.1093/sxmrev/qeag052","url":null,"abstract":"<p><strong>Introduction: </strong>Given the contradictory positions regarding masturbation-from its promotion as a healthy practice to its association with negative experiences, which highlight the complexity of this behavior-a bibliometric approach is necessary to help structure this debate. This study aims to map scientific articles indexed in Scopus to identify research production on masturbation, including trends in production growth, sources, authors, countries, affiliations, relevant terms, and collaboration networks.</p><p><strong>Methods: </strong>A bibliometric analysis was conducted on 3239 articles published in scientific journals. The selected studies included terms related to masturbation in the title, abstract, and keywords. Articles published between 1840 and 2025 were analyzed, examining their temporal evolution, the most productive authors, countries, and institutions, as well as relevant terms, trending topics, co-occurrence, and collaborations using the R-bibliometrix package.</p><p><strong>Results: </strong>A progressive growth in scientific production was observed, particularly from the 1970s onward. The most productive journals were Archives of Sexual Behavior, The Journal of Sexual Medicine, and The Journal of Sex Research. Scientific output was concentrated mainly in North America and Europe. Trending terms such as \"NoFap\" and \"manosphere\" were identified, and limited collaboration networks were observed.</p><p><strong>Conclusion: </strong>The findings highlight the sustained growth and increasing multidisciplinary nature of masturbation research, while emphasizing the need for broader geographical representation and continued development of this field.</p>","PeriodicalId":21813,"journal":{"name":"Sexual medicine reviews","volume":"14 3","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148607668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-orgasmic illness syndrome: possible role of mast cells, immunoglobulins, and multi-organ system inflammatory response.","authors":"James G Pfaus, Alyssa Yee","doi":"10.1093/sxmrev/qeag067","DOIUrl":"https://doi.org/10.1093/sxmrev/qeag067","url":null,"abstract":"<p><strong>Introduction: </strong>Post-orgasmic Illness Syndrome (POIS) is an incapacitating reaction that erupts following ejaculation/orgasm. The reaction occurs in different clusters, with general fatigue or flu-like symptoms, headache, brain fog, itchy rash, irritated eyes, congested nose, sore throat, and/or muscle tension. Symptoms typically last several hours to days. Although sensitized immune and autoimmune responses are implicated, it is not yet known how the symptoms are initiated or progress into fully-blown POIS. The objective of this narrative review is to assess the potential role played by mast cells, immunoglobulins, and sensitized systemic histamine responses in the etiology of symptoms related to POIS.</p><p><strong>Methods: </strong>A narrative review of current literature on mast cell and histamine physiology, pathophysiology, studies suggesting that POIS is due to a potential sensitization of mast cells to proteins in semen or other mast cell triggers, stress and conditioned immune responses, and the role of immunoglobulin Es and other immune targets gleaned from successful treatments. Searches for current literature were conducted in PubMed, Web of Science, SCOPUS, and EBSCOhost.</p><p><strong>Results: </strong>The symptoms of POIS resemble those of a systemic cytokine storm and multi-system inflammatory responses to the orgasm trigger more than a simple acute histamine intolerance. Longer duration of symptoms and the mood and neuropsychiatric symptoms are particular to POIS. In some cases of POIS, this may begin with a sensitized immune reaction to constituents in semen in mail POIS patients, while in other cases ejaculation/orgasm may activate mast cells and overwhelm several systems of the body with inflammatory mediators. Many sufferers have a history of allergies, atopic disorders, or known mast cell associated conditions.</p><p><strong>Discussion: </strong>More basic and clinical research is needed to determine both basal and provoked immune and related endocrine and physiological responses at ejaculation/orgasm in individuals with POIS relative to matched controls that do not have POIS.</p>","PeriodicalId":21813,"journal":{"name":"Sexual medicine reviews","volume":"14 3","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148892336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The interplay between the obsessive-compulsive disorder and sexual function: a systematic review.","authors":"Davide Doroldi, Lorenzo Cialini, Giulia Origlia, Tessa Giannini, Barbara Blasutto, Antonio Del Casale, Grazia Spitoni, Tommaso Boldrini, Giacomo Ciocca","doi":"10.1093/sxmrev/qeag044","DOIUrl":"https://doi.org/10.1093/sxmrev/qeag044","url":null,"abstract":"<p><strong>Introduction: </strong>This review explores the relationship between obsessive-compulsive disorder (OCD) and sexual functioning.</p><p><strong>Objectives: </strong>The aim is to highlight the clinical relevance of sexual health in OCD and encourage more comprehensive assessment and intervention strategies.</p><p><strong>Methods: </strong>This study explores the association between OCD symptoms and genital pain or sexual functioning, using the Desire, Excitement, Plateau, Orgasm, Resolution model as a conceptual framework. We conducted a Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020-compliant systematic review, searching PsycINFO, MEDLINE, Scopus, and Web of Science for studies published until February 26, 2026, including adult participants assessed for OCD symptoms and at least one phase of the sexual response cycle or genital pain. Data extracted included study design, participant characteristics, assessment tools, and the sexual functioning domains evaluated. Quality assessment was performed using the QUIPS Tool.</p><p><strong>Results: </strong>We included 13 articles. OCD symptoms are associated with sexual desire, arousal, and female orgasm dysfunctions, likely due to the cognitive, emotional, and behavioral rigidity associated with the disorder. These interferences can impact both individual well-being and relationship satisfaction. No consistent evidence emerged regarding the association between OCD symptoms and male orgasmic function or genital pain; therefore, the currently available findings do not allow firm conclusions to be drawn about these relationships. Given the limited number of specific studies on this topic, further research is needed to improve clinical understanding and inform tailored treatment approaches that address both psychopathology and sexual health.</p><p><strong>Conclusion: </strong>The results of this study emphasize the association of sexual dysfunctions and OCD symptoms and the importance of evaluating sexual functioning in these patients, with a focus on enhancing their quality of life.</p>","PeriodicalId":21813,"journal":{"name":"Sexual medicine reviews","volume":"14 3","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148376954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Internet-based cognitive behavioral therapy, web-based counseling, and online/digital psychoeducation for male sexual dysfunction: a systematic review.","authors":"","doi":"10.1093/sxmrev/qeag063","DOIUrl":"10.1093/sxmrev/qeag063","url":null,"abstract":"","PeriodicalId":21813,"journal":{"name":"Sexual medicine reviews","volume":"14 3","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148727258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of non-pharmacological treatments for sexual difficulties in adults with multiple sclerosis: a systematic review and meta-analysis.","authors":"Emily White, Abimbola Adanijo, Pearla Papiernik-Berkhauer, Sam Norton, Rona Moss-Morris, Ashley Brown","doi":"10.1093/sxmrev/qeag032","DOIUrl":"10.1093/sxmrev/qeag032","url":null,"abstract":"<p><strong>Introduction: </strong>Sexual difficulties affect 50%-80% of people with multiple sclerosis (PwMS) and arise from neurogenic, symptom-mediated, and psychosocial mechanisms. Despite their prevalence, sexual dysfunction remains under-recognized in multiple sclerosis (MS) care and underrepresented in clinical guidelines. Non-pharmacological interventions-such as psychosexual counseling, educational programs, and physiotherapy-may provide accessible and scalable management options. However, their effectiveness and quality remain uncertain.</p><p><strong>Objectives: </strong>This review aimed to systematically evaluate and meta-analyze controlled clinical trials of non-pharmacological interventions for sexual difficulties in adults with MS.</p><p><strong>Methods: </strong>Eight databases were searched from inception to May 2023, May 2025, and March 2026. Eligible studies were randomized or quasi-randomized trials assessing non-pharmacological interventions targeting sexual function or related outcomes using validated measures. Primary outcomes were sexual function or difficulty; secondary outcomes included sexual distress, satisfaction, and quality of life. Risk of bias was assessed using Version 2 of the Cochrane Risk of Bias tool for randomized trials or Risk of Bias in Non-randomized Studies of Interventions and Grading of Recommendations Assessment, Development, and Evaluation determined the certainty of evidence. Random-effects models were used for meta-analysis. The review followed Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines and was registered with the international prospective register of systematic reviews (PROSPERO; CRD42023399271).</p><p><strong>Results: </strong>Thirty-two studies (N = 1844) met inclusion criteria; 23 contributed to the meta-analysis. Most interventions were psychobehavioral (n = 24), with 4 involving exercise/physiotherapy, 3 combining components and one other non-pharmacological intervention. The pooled effect was large (Hedges g = 2.1, SE = 0.62, P = .001) with high heterogeneity (I2 = 98.88%). Removing 2 outliers reduced the effect to g = 1.27 with high heterogeneity (I2 = 85.15%). Structured counseling models, particularly Permission-Limited Information-Specific Suggestion-Intensive Therapy (PLISSIT)-based interventions for women, showed the largest benefits. However, studies were small, unregistered, and at high risk of bias; most only included heterosexual married women from Iran, limiting generalizability.</p><p><strong>Conclusion: </strong>Structured psychosexual interventions, especially PLISSIT-based models, show promise for improving sexual outcomes in PwMS. Nonetheless, the certainty of evidence and evidence quality are very low, highlighting the need for larger, more diverse, and methodologically rigorous trials.</p>","PeriodicalId":21813,"journal":{"name":"Sexual medicine reviews","volume":"14 3","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148397829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of erectile dysfunction and its associated factors among hypertensive men in Africa: a systematic review and meta-analysis.","authors":"Eshet Gebrie, Elias Chane, Berihun A Mengistie, Getasew Kibralew, Henok Worku, Birhan Mulugeta, Amanuale Zayede","doi":"10.1093/sxmrev/qeag046","DOIUrl":"10.1093/sxmrev/qeag046","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Endothelial dysfunction and arterial stiffness are key underlying mechanisms that contribute to erectile dysfunction (ED), a common and often underdiagnosed condition among men with hypertension. Furthermore, certain classes of antihypertensive medications may adversely affect erectile function, adding to the burden of the disease. While the link between hypertension and ED is well-established globally, the epidemiology of this comorbidity in the African context is less clearly defined. Although several individual studies have investigated the prevalence of ED among hypertensive men within specific African countries, there is currently no continent-wide pooled estimate to inform regional healthcare policy and clinical practice. This review aimed to determine the pooled prevalence of ED and its associated factors among hypertensive men in Africa.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A comprehensive literature search was conducted on PubMed, HINARI/Research4Life, and Google Scholar to find relevant studies. Data extraction and quality assessment were performed independently by two reviewers using a prepared standard Microsoft Excel 19 form and the Joanna Briggs Institute critical appraisal checklist. STATA version 17 was used to conduct the meta-analysis. Heterogeneity was assessed using the I2 and Cochran's Q test. Meta-analysis was conducted using a random-effects model, Publication bias was assessed using the funnel plot and Egger's test statistics. Moreover, subgroup analysis, and sensitivity analysis were also performed.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Eighteen studies involving 3648 male hypertensive patients from three African regions were included. The pooled prevalence of ED was 65.05% (95% CI: 54.23-75.87), with substantial heterogeneity across studies (I2 = 98.39%). The prevalence varied by African region, country, assessment tool, sampling method, and study population, with the highest estimates observed in Central Africa, in studies using the SHIM and those employing convenience sampling. A higher prevalence was also reported among hypertensive men with comorbidity. Older age was significantly associated with ED, with higher odds among men aged 61-80 years (OR = 3.70, 95% CI: 2.04-6.71) and those aged &gt;80 years (OR = 5.34, 95% CI: 3.51-8.13). Additional significant factors included stage II hypertension (OR = 3.81, 95% CI: 2.25-6.44), hypertension duration &gt;10 years (OR = 4.20, 95% CI: 1.83-9.62), antihypertensive polytherapy (OR = 2.87, 95% CI: 1.93-4.26), comorbid conditions (OR = 2.59, 95% CI: 1.16-5.79), and depression (OR = 2.67, 95% CI: 1.72-4.14).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;In Africa, ED is highly prevalent in men with hypertension. Comorbid conditions, depression, antihypertensive polytherapy, advanced age, Stage II hypertension, and hypertension that has been present for more than 10 years are important factors linked to ED. Routine screening and integrated management strategies should be inc","PeriodicalId":21813,"journal":{"name":"Sexual medicine reviews","volume":"14 3","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148449460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of convective water vapor thermal therapy (Rezum) on male sexual function: a systematic review and meta-analysis.","authors":"Ibrahim A Khalil, Mohammad Ghassab Deameh, Abdelrahman Abdelshafi, Hamza Mohamed, Mohamed Ramez, Ahmad R Al-Qudimat Md, Khalid AlRumaihi Md, Kareim Khalafalla Md","doi":"10.1093/sxmrev/qeag050","DOIUrl":"10.1093/sxmrev/qeag050","url":null,"abstract":"<p><strong>Background: </strong>Benign prostatic hyperplasia (BPH) is highly prevalent among aging men, with management often requiring a balance between symptom relief and preservation of sexual function. Convective water vapor thermal therapy (Rezūm) has emerged as a minimally invasive treatment; however, its effects on sexual function remain incompletely defined. This systematic review and meta-analysis evaluated the impact of Rezūm therapy on erectile and ejaculatory function.</p><p><strong>Methods: </strong>A systematic search of PubMed, Web of Science, and Scopus was conducted from inception to October 2025 in accordance with PRISMA guidelines. Studies reporting pre- and postoperative sexual function outcomes using validated instruments were included. To prevent metric mixing, the International Index of Erectile Function (IIEF) data were stratified into 3 distinct instrument frameworks: Group A (True IIEF-5; 0-25 scale), Group B (IIEF-15 Total Score; 0-75 scale), and Group C (IIEF-Erectile Function Domain; 0-30 scale), alongside the Male Sexual Health Questionnaire for Ejaculatory Dysfunction (MSHQ-EjD) score and bother domains. Pooled mean differences (MDs) with 95% confidence intervals (CIs) were calculated using random-effects models, stratified by follow-up duration.</p><p><strong>Results: </strong>Fourteen unique studies comprising 1306 patients were included. Group A (True IIEF-5) scores demonstrated stable erectile function postoperatively, with a significant improvement observed only at 12 months (MD = 1.09; 95% CI, 0.02-2.15; P = .046; I2 = 77.2%); however, this finding did not persist under risk-of-bias-restricted (MD = 0.08; P = .85; I2 = 0%) or r = 0.5 sensitivity analyses (P = .056). Group B (IIEF-15 Total Score) showed no significant change from baseline in the primary pooled analyses at any follow-up interval. However, sensitivity analyses excluding a heterogeneity-driving outlier revealed significant improvements at 3 months (MD = 2.58; 95% CI, 0.01-5.15; P = .049; I2 = 15.7%), 6 months (MD = 5.21; 95% CI, 2.50-7.93; P = .0002; I2 = 0%), and 12 months (MD = 3.09; 95% CI, 0.56-5.61; P = .017; I2 = 0%). Group C (IIEF-Erectile Function domain) scores demonstrated preservation of erectile function through 24 months (all P > .05), despite a transient decline observed in a single cohort at 1 month. Male Sexual Health Questionnaire for Ejaculatory Dysfunction Bother scores demonstrated a significant and sustained reduction in ejaculatory distress from 1 month (MD = -0.35; P = .016) through 12 months (MD = -0.78; P = .0018), while MSHQ-EjD Score outcomes remained largely stable over time.</p><p><strong>Conclusion: </strong>Rezūm therapy demonstrates a favorable sexual safety profile, with preservation of erectile and ejaculatory function. These findings support its role as an effective minimally invasive treatment for BPH, particularly in patients prioritizing sexual function preservation.</p>","PeriodicalId":21813,"journal":{"name":"Sexual medicine reviews","volume":"14 3","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148607696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}