Shima Behzad, Liesl Eibschutz, Max Yang Lu, Ali Gholamrezanezhad
{"title":"Optimizing the power of AI for fracture detection: from blind spots to breakthroughs.","authors":"Shima Behzad, Liesl Eibschutz, Max Yang Lu, Ali Gholamrezanezhad","doi":"10.1007/s00256-025-04951-0","DOIUrl":"https://doi.org/10.1007/s00256-025-04951-0","url":null,"abstract":"<p><p>Artificial Intelligence (AI) is increasingly being integrated into the field of musculoskeletal (MSK) radiology, from research methods to routine clinical practice. Within the field of fracture detection, AI is allowing for precision and speed previously unimaginable. Yet, AI's decision-making processes are sometimes wrought with deficiencies, undermining trust, hindering accountability, and compromising diagnostic precision. To make AI a trusted ally for radiologists, we recommend incorporating clinical history, rationalizing AI decisions by explainable AI (XAI) techniques, increasing the variety and scale of training data to approach the complexity of a clinical situation, and active interactions between clinicians and developers. By bridging these gaps, the true potential of AI can be unlocked, enhancing patient outcomes and fundamentally transforming radiology through a harmonious integration of human expertise and intelligent technology. In this article, we aim to examine the factors contributing to AI inaccuracies and offer recommendations to address these challenges-benefiting both radiologists and developers striving to improve future algorithms.</p>","PeriodicalId":21783,"journal":{"name":"Skeletal Radiology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparison of anterior inferior iliac spine morphology between femoroacetabular impingement and developmental dysplasia of the hip: A cohort study in symptomatic patients.","authors":"Hirotaka Nakashima, Osamu Miyamoto, Takatoshi Aoki, Midori Ueno, Yoichi Murata, Patrick Quinn, Shinichiro Takada, Keisuke Nakayama, Akinori Sakai, Soshi Uchida","doi":"10.1007/s00256-025-04953-y","DOIUrl":"https://doi.org/10.1007/s00256-025-04953-y","url":null,"abstract":"<p><strong>Objective: </strong>To compare Anterior Inferior Iliac Spine (AIIS) morphology between femoroacetabular impingement (FAI) and developmental dysplasia (DDH) and investigate the correlation between AIIS and hip morphology.</p><p><strong>Materials and methods: </strong>374 patients (423 hips) who underwent primary hip arthroscopic surgery were retrospectively reviewed. The inclusion criteria were patients with labral tears and either FAI or DDH. Preoperative demographics and imaging variables were compared. Patient demographics, including age, sex, and body mass index, were assessed. For imaging evaluation, the lateral center edge (LCE), sharp, vertical center anterior (VCA), alpha, and Tönnis angles and AIIS morphology according to Hetsroni's classification were assessed.</p><p><strong>Results: </strong>310 patients (359 hips) were included in this study. The FAI cases involved 241 hips (148 males, 93 females), and the DDH cases involved 118 hips (34 males, 84 females). AIIS type 3 included 10 hips (4.1%) in the FAI group and 21 hips (17.8%) in the DDH group. The proportion of AIIS type 3 in the DDH group was significantly higher than that in the FAI group (chi-squared test, p < 0.001). In the FAI group, there were no significant correlations between AIIS and radiographic parameters. In the DDH group, there were significant correlations between AIIS and the LCE (R = -0.279, p = 0.002), VCA (R = -0.194, p = 0.037), and Tönnis (R = 0.241, p = 0.009) angles.</p><p><strong>Conclusion: </strong>AIIS type 3 was more prevalent in DDH than in FAI patients. In DDH patients, there was a significant correlation between AIIS protrusion and the severity of dysplasia.</p>","PeriodicalId":21783,"journal":{"name":"Skeletal Radiology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Lumbosacral transitional vertebra on whole-spine CT: prevalence and association with rib abnormalities.","authors":"Shuji Nagata, Chihiro Yamada, Miyuki Sawano, Yuki Shouji, Gaku Shioyama, Shinobu Nakamura, Yusuke Uchiyama, Hiroshi Nishimura, Shuichi Tanoue","doi":"10.1007/s00256-025-04952-z","DOIUrl":"https://doi.org/10.1007/s00256-025-04952-z","url":null,"abstract":"<p><strong>Objective: </strong>To determine the prevalence of lumbosacral transitional vertebrae (LSTV) and rib abnormalities and investigate the association between LSTV subtypes and rib abnormalities using whole-spine CT.</p><p><strong>Materials and methods: </strong>The vertebral levels were counted caudally from the cervical vertebra, based on the eighth being the first thoracic vertebra, the twentieth as the first lumbar vertebra, and the twenty-fifth being the first sacral vertebra using sagittal reconstructed CT. Sacralization is when 23 vertebrae are found, whereas lumbarization is the presence of 25 vertebrae.</p><p><strong>Results: </strong>This retrospective study included 551 patients (407 females and 144 males). There is no evidence of a difference in age and sex that was observed between the LSTV and no LSTV groups (95% CIs; - 0.34, 3.08; p = 0.12 and p = 0.24, respectively). LSTV were reported in 16.3% of participants, consisting of 12.3% of sacralization and 4.0% of lumbarization. The incidence rate of lumbarization was significantly high in male participants (p = 0.031). Rib abnormalities were reported in 14.0% of participants, consisting of 12.6% of twelfth hypoplastic rib and 1.5% of lumbar rib. In patients with LSTV, all twelfth hypoplastic ribs were found in the sacralization group and all lumbar ribs were found in the lumbarization group (p < 0.001). The types based on the Castellvi classification demonstrated a significant difference between the sacralization and lumbarization groups (p = 0.007).</p><p><strong>Conclusion: </strong>The findings of our study suggest that patients with sacralization and lumbarization are predisposed to having twelfth hypoplastic ribs and lumbar ribs, respectively.</p>","PeriodicalId":21783,"journal":{"name":"Skeletal Radiology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Review of pulmonary manifestations of rheumatoid arthritis.","authors":"Stella Chen, Susannah Kay","doi":"10.1007/s00256-025-04930-5","DOIUrl":"https://doi.org/10.1007/s00256-025-04930-5","url":null,"abstract":"<p><p>Rheumatoid arthritis (RA) is a systemic autoinflammatory disorder that primarily affects joints. However, RA can involve extra-articular structures as well, including the lungs, affecting significant morbidity and mortality, though the precise mechanisms of extra-articular RA are still under investigation. Accurate diagnosis of these conditions can be challenging and requires a multidisciplinary approach. This review aims to describe proposed mechanisms of pulmonary RA and characterize common, clinically relevant pulmonary manifestations of RA, including parenchymal disease (interstitial lung disease and multiple pulmonary nodules), small and large airway involvement, and pleural effusions. In particular, CT imaging may reveal developing pulmonary disease before clinical symptoms present, revealing the importance of maintaining a high degree of suspicion for RA-related pulmonary disease.</p>","PeriodicalId":21783,"journal":{"name":"Skeletal Radiology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Imaging clues for the diagnosis of various pathogenic causes of infectious spondylitis.","authors":"Pornrujee Hirunpat, Theeraphol Panyaping, Wannisa Wongpipathpong, Siriporn Hirunpat","doi":"10.1007/s00256-025-04943-0","DOIUrl":"https://doi.org/10.1007/s00256-025-04943-0","url":null,"abstract":"<p><p>Infectious spondylitis is not a common disease; however, its incidence has increased recently due to the increasing number of older patients with chronic diseases and immunocompromised status globally. The clinical presentation of infectious spondylitis may be non-specific, causing delays in diagnosis and treatment, and leading to significant sequelae. Imaging usually plays a crucial role in characterizing the presence and extent of the disease, leading to proper management, reduced mortality, and long-term neurological morbidity. Many studies have proposed imaging features to distinguish between the common causes of infectious spondylitis, pyogenic or tuberculous infections, while the less common infections, including those caused by fungi or other bacterial organisms such as brucellosis, melioidosis, and actinomycosis, are believed to lack specific imaging characteristics. In this review, we highlight the characteristic imaging findings of both common and uncommon pathogens, which can serve as key clues for accurately diagnosing various pathogenic causes of infectious spondylitis.</p>","PeriodicalId":21783,"journal":{"name":"Skeletal Radiology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hana Farzaneh, Meghan Jardon, Soterios Gyftopoulos, Mohammad Samim
{"title":"Musculoskeletal abscopal effect: a review of the important imaging findings and their clinical relevance.","authors":"Hana Farzaneh, Meghan Jardon, Soterios Gyftopoulos, Mohammad Samim","doi":"10.1007/s00256-025-04944-z","DOIUrl":"https://doi.org/10.1007/s00256-025-04944-z","url":null,"abstract":"<p><p>The abscopal effect is a rare but important phenomenon in which targeted therapy of the primary tumor, mainly radiation therapy, leads to the regression of malignant cells at distant sites from the primary tumor and outside the field of treatment. Radioembolization is a developing area of interventional oncology, typically involving microscopic radioactive spheres loaded with yttrium-90. The abscopal effect on distant bone metastases has been previously reported in patients following palliative radiotherapy; however, it has also been observed with more targeted radiation treatments, such as yttrium-90, primarily outside the musculoskeletal system. Musculoskeletal radiologists should be familiar with the abscopal effect, as the indications for radiation therapy are on the rise, and recent advancements in immune therapy have resulted in the induction of the abscopal effect. Herein, we present a case of the abscopal effect in musculoskeletal metastatic disease following targeted radioembolization. We also review the literature on the abscopal effect involving metastatic bone lesions resulting from different types of cancer therapy. Finally, we present recent advancements in cancer treatment with the aim of utilizing this effect.</p>","PeriodicalId":21783,"journal":{"name":"Skeletal Radiology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jessica R Smith, Balvinder K Bharath, Martine A Mallinson, Kim Mason, Beverly Snaith
{"title":"Cone beam CT in the imaging of musculoskeletal trauma: a scoping review.","authors":"Jessica R Smith, Balvinder K Bharath, Martine A Mallinson, Kim Mason, Beverly Snaith","doi":"10.1007/s00256-025-04947-w","DOIUrl":"https://doi.org/10.1007/s00256-025-04947-w","url":null,"abstract":"<p><strong>Introduction: </strong>Cone beam computed tomography (CBCT) is an emerging technology in musculoskeletal (MSK) imaging. The objective of this scoping review was to provide an overview of the research surrounding CBCT utility in bony injury assessment as an alternative to other imaging modalities and investigate any gaps in the current evidence base.</p><p><strong>Methods: </strong>MEDLINE, CINAHL, and PubMed were searched up to January 2025 for articles including CBCT studies on human participants following trauma. An online literature review tool was used to manage and streamline the review process.</p><p><strong>Results: </strong>The search yielded 23 studies. The image quality and diagnostic accuracy of CBCT were high overall, and a number of studies confirmed the radiation dose to be lower than multislice CT. Studies examined CBCT for extremity trauma, with half the studies focused solely on the wrist. The utility appears greatest in the identification of radiographically occult fractures. Limited cost-effectiveness analysis has been undertaken.</p><p><strong>Conclusions: </strong>Overall, the literature suggests CBCT can be an effective tool in the diagnosis of bony injuries with greater sensitivity than radiography at a lower radiation dose than multi-slice computed tomography. However, evaluation of wider patient and economic impacts of adopting CBCT in MSK trauma pathways is recommended.</p>","PeriodicalId":21783,"journal":{"name":"Skeletal Radiology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Georg Wilhelm Kajdi, Thomas Marth, Jung-Ah Choi, Mazda Farshad, Reto Sutter
{"title":"Diagnostic value of a coronal STIR sequence in conjoined lumbar nerve root detection: an MRI accuracy study.","authors":"Georg Wilhelm Kajdi, Thomas Marth, Jung-Ah Choi, Mazda Farshad, Reto Sutter","doi":"10.1007/s00256-025-04945-y","DOIUrl":"https://doi.org/10.1007/s00256-025-04945-y","url":null,"abstract":"<p><strong>Objectives: </strong>To assess diagnostic accuracy for conjoined lumbosacral nerve root (CLNR) detection on MRI when adding a coronal STIR sequence to the standard lumbar spine protocol.</p><p><strong>Materials and methods: </strong>In this retrospective study, two radiologists assessed the presence of CLNR and lumbosacral transitional vertebrae (LSTV), using a standard lumbar MRI protocol and an expanded protocol with an additional coronal STIR sequence. Prior radiologist consensus using the expanded protocol served as a reference standard for diagnosis.</p><p><strong>Results: </strong>In 751 patients (mean age 61.2 ± 15.7 years, 435 females), CLNR was found in 38 patients (5.1%) in consensus. Without coronal STIR, 13 CLNR patients were correctly identified, CLNR was missed in 25 patients, and 3 patients were falsely detected as having one (sensitivity of 34.2%, specificity of 99.6%, positive predictive value (PPV) of 81.3%, negative predictive value (NPV) of 96.6%, and accuracy of 96.3%). With coronal STIR, 31 CLNR patients were correctly identified, CLNR were missed in 7 patients, and one patient was falsely detected as having one (sensitivity of 81.6%, specificity of 99.9%, PPV of 96.9%, NPV of 99.0%, and accuracy of 98.9%). Inter-reader agreement improved from moderate without coronal STIR (κ = 0.592; 95% CI 0.38, 0.80) to almost perfect with coronal STIR (κ = 0.915; 95% CI 0.84, 0.99). LSTV had a prevalence of 13.3% among patients without and 26.3% among patients with CLNR (p = 0.025).</p><p><strong>Conclusion: </strong>Coronal STIR greatly improved sensitivity and inter-reader agreement for CLNR detection on MRI while slightly improving the specificity and accuracy. A significant association of CLNR and LSTV was found.</p>","PeriodicalId":21783,"journal":{"name":"Skeletal Radiology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yenpo Lin, Marcio Bottene Villa Albers, Jake Fiore, Anna Bryn Williams, Audrey Wimberly, Samuel A Taylor, Lawrence V Gulotta, Ek T Tan, Darryl B Sneag
{"title":"MR neurography findings of brachial plexopathy following total shoulder arthroplasty.","authors":"Yenpo Lin, Marcio Bottene Villa Albers, Jake Fiore, Anna Bryn Williams, Audrey Wimberly, Samuel A Taylor, Lawrence V Gulotta, Ek T Tan, Darryl B Sneag","doi":"10.1007/s00256-025-04946-x","DOIUrl":"10.1007/s00256-025-04946-x","url":null,"abstract":"<p><strong>Objectives: </strong>To characterize nerve injury patterns following total shoulder arthroplasty (TSA).</p><p><strong>Methods: </strong>This retrospective study reviewed brachial plexus MR neurography (MRN) in patients with brachial plexopathy within 180 days post TSA from 2016 to 2023. Patients with pre-existing neurologic symptoms or without available electrodiagnostic testing (EDX) data were excluded. MRN findings were extracted from the original report and independently reviewed by a second, musculoskeletal fellowship trained radiologist.</p><p><strong>Results: </strong>A total of 27 patients (15F/12 M, mean age 67) were included. MRN and EDX-confirmed nerve injury localization matched in 13 patients, with nerve hyperintensity and/or enlargement identified in 7 cases at the plexus proper and 6 cases at the branch nerve level (suprascapular, axillary, radial, median). Nerve impingement by screw (n = 3) or extruded cement (n = 1) and mass effects including soft tissue edema (n = 1), hematoma (n = 2), or joint effusion (n = 2) were identified. MRN detected muscle denervation in 8 of 19 patients with EMG abnormalities, with a median TSA-to-MRN interval of 62.5 days (range, 19-95) versus 3 days (range, 2-155) in those without denervation on MRN (p = 0.003). Inter-rater reliability demonstrated substantial to almost perfect agreement for MRN assessments, except for cord hyperintensity. All patients were clinically followed up: 3 had complete symptomatic resolution and 21/27 reported partial improvement at a mean follow-up time of 25.5 months.</p><p><strong>Conclusions: </strong>MRN findings closely correlated with EDX-confirmed clinical diagnoses in cases with MRN abnormalities. Additionally, MRN identified secondary findings, such as local mass effect on nerve segments, that can guide management.</p>","PeriodicalId":21783,"journal":{"name":"Skeletal Radiology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}