Skin Research and Technology最新文献

{"title":"The Effect of Polynucleotide-Hyaluronic Acid Hydrogel in the Recovery After Mechanical Skin Barrier Disruption.","authors":"Ye Jin Ha, Ka Hee Tak, Jin-Min Jung, Jong Lyul Lee, Chan Wook Kim, Young-Chang Ah, Seok-Soon Kim, Ik Jun Moon, Yong Sik Yoon","doi":"10.1111/srt.70068","DOIUrl":"https://doi.org/10.1111/srt.70068","url":null,"abstract":"<p><strong>Background: </strong>The epidermal barrier acts as a defense against external agents as well as helps to maintain body homeostasis. Polynucleotides (PN), exogenous DNA fragments, promote wound repair through their stimulatory and anti-inflammatory effects. Recent findings indicate a synergistic effect of PN and hyaluronic acid (HA) combinations in regulating inflammation and promoting cell proliferation. This study aims to elucidate the effects of PN and HA on repairing the epidermal barrier following its disruption by tape stripping (TS) in a mouse model.</p><p><strong>Materials and methods: </strong>After disrupting the epidermal barrier using TS, a formulation containing PN (14 mg/mL) and HA (6 mg/mL) was applied. Trans-epidermal water loss (TEWL) was measured at 0, 3, 6, 24, 48, and 72 h. Mice were euthanized after the final application at 72 h, and tissue samples were analyzed for epidermal/dermal thickness, neutrophil infiltration, and filaggrin expression.</p><p><strong>Results: </strong>We observed a significant reduction in TEWL in the PN+HA group compared to that in the control group (20.8 ± 0.5 vs. 43.7 ± 0.5 g/m²h at 72 h, p < 0.05), indicating an improvement in barrier function. Histological evaluation showed decreased epidermal and dermal thickening in the PN+HA group compared to that in the control group (epidermal: 29.4 ± 2.2 vs. 57.9 ± 3.5 μm; dermal: 464.8 ± 25.9 vs. 825.9 ± 44.8 μm, both p < 0.05). Additionally, neutrophil infiltration in the dermis was significantly reduced, and filaggrin protein levels were significantly higher in the PN+HA group compared to those in the control group (4.8 ± 0.4 vs. 21.1 ± 3.3 for neutrophils; 0.84 ± 0.04 vs. 0.42 ± 0.03 for filaggrin, both p < 0.05).</p><p><strong>Conclusion: </strong>These results suggest that PN+HA may be an effective therapeutic strategy for repairing skin barrier damage.</p>","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"30 9","pages":"e70068"},"PeriodicalIF":2.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11413333/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142294946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of current practices and perceived effectiveness of injectable polynucleotide for enlarged facial pores among cosmetic physicians: A survey-based evaluation.","authors":"Dagyeong Lee, Hosung Choi, Kyounghun Yoo, Young Jin Park, Hyun Jun Park, Seung Min Oh, Gun Hyon Ji, Gong Chan Rah, Dong Wook Shin","doi":"10.1111/srt.13738","DOIUrl":"10.1111/srt.13738","url":null,"abstract":"<p><strong>Background: </strong>Polynucleotides stimulate collagen formation and are used clinically to enhance elasticity. In this study, we investigated current practices and perceived effectiveness of polynucleotide injection treatment for enlarged facial pores among cosmetic physicians.</p><p><strong>Materials and methods: </strong>A survey was developed to investigate clinicians' use and effectiveness of polynucleotides in the treatment of enlarged facial pores. This survey was distributed to clinicians at the Korean Aesthetic Surgery & Laser Society Autumn Symposium.</p><p><strong>Results: </strong>A total of 407 physicians who used polynucleotides for enlarged facial pores were enrolled in the survey. Polynucleotides were used by 75.7%, 87.7%, and 72.2% of physicians for enlarged facial pores caused by excessive sebum production, reduced elasticity, and acne, respectively. Among those users, 81.4%, 83.8%, and 76.8% in those same categories, respectively, responded that polynucleotides were \"very effective\" or \"effective.\" Furthermore, most clinicians combined polynucleotides with microneedle radiofrequency as energy-based devices and with botulinum toxin as injection therapy.</p><p><strong>Conclusion: </strong>This study highlights the widespread use and perceived efficacy of polynucleotide injection among cosmetic physicians in the Republic of Korea for enlarged facial pores due to excessive sebum production, reduced elasticity, and acne. Positive feedback from practitioners supports the benefits of using polynucleotides in enlarged facial pore treatment.</p>","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"30 9","pages":"e13738"},"PeriodicalIF":2.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11375025/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142133670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LncRNA SLNCR1 facilitates angiogenesis and tumor growth in melanoma via DNMT1-mediated epigenetically silencing SPRY2.","authors":"Ke Li, Lijun Wu, Jingting Jiang","doi":"10.1111/srt.13910","DOIUrl":"10.1111/srt.13910","url":null,"abstract":"<p><strong>Background: </strong>The malignancy of melanoma is attributed to its pronounced invasiveness, extensive vascularization, and rapid tumor cell growth and metastasis. LncRNA SLNCR1 is closely associated with a variety of aggressive tumors. However, our understanding of SLNCR1 influences on malignant melanoma growth metastasis mechanism especially proangiogenic mechanism remains unclear.</p><p><strong>Methods: </strong>The expression of SLNCR1 was evaluated in melanoma tissues, adjacent tissues, melanoma cell lines. The abilities of SLNCR1 on proliferation, migration, and angiogenesis of HUVECs were detected by CCK-8, flow cytometry, and Western blot assays. The association between SLNCR1, DNMT1, and SPRY2 was assessed by ChIP, RIP, and Western blot assays. The effect of SLNCR1 on tumor growth was determined using a xenograft model in nude mice.</p><p><strong>Results: </strong>SLNCR1 was confirmed to be highly expressed in melanoma tissues and cells. CM from melanoma cells transfected with sh-SLNCR1 attenuated proliferation, migration, and angiogenesis of HUVECs. Moreover, loss of SLNCR1 hindered tumor growth and metastasis, as evidenced by reduced tumor size and weight, as well as angiogenesis. Mechanistic studies revealed that SLNCR1 silenced SPRY2 expression, likely through enhancing DNMT1-mediated DNA methylation of SPRY2 promoter.</p><p><strong>Conclusion: </strong>SLNCR1 is an oncogene that interacts with DNMT1 to mediate SPRY2 methylation, thereby suppressing SPRY2 expression and promoting the angiogenesis and tumor growth in melanoma. SLNCR1 may serve as a potential target for melanoma treatment.</p>","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"30 9","pages":"e13910"},"PeriodicalIF":2.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11411697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142294944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Melanoma Diagnosis: Integration of Zero-Shot and Few-Shot Learning With Large Language Models.","authors":"Takashi Nagaoka","doi":"10.1111/srt.70060","DOIUrl":"10.1111/srt.70060","url":null,"abstract":"","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"30 9","pages":"e70060"},"PeriodicalIF":2.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11418626/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142294940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypericum sampsonii ameliorates radiodermatitis by inhibiting NLRP3 inflammasome activation.","authors":"Jiayu Liao, Zhihong Liu, Sumei Wu","doi":"10.1111/srt.70047","DOIUrl":"10.1111/srt.70047","url":null,"abstract":"<p><strong>Background: </strong>Radiodermatitis (RD) is an inflammatory lesion of skin mucosa caused by radiation, which causes itching and pain in patients' skin. Hypericum sampsonii has an anti-inflammatory effect. This study aims to explore the potential effect and mechanism of H. sampsonii on RD.</p><p><strong>Materials and methods: </strong>The RD model was established using X-ray irradiation of mice and the pain response of mice under different treatment methods. Serum levels of IL-1β, IL-6, and TNF-α were measured by ELSA. The RD cell model was constructed by RAW264.7 cell, H. sampsonii intervention was conducted, and the changes of the NLRP3 inflammasome in the cells were detected by qRT-PCR. The cells were stimulated with LPS and the protein changes of TLR4/NF-κB were investigated by Western Blotting.</p><p><strong>Results: </strong>H. sampsonii can better improve the skin status of RD mice, relieve pain, and reduce the secretion of serum inflammatory factors IL-1β, IL-6, and TNF-α. H. sampsonii significantly down-regulated the expression of NLRP3, Caspase-1, pro IL-1β, and IL-1β. Lps-induced activation of the TLR4/NF-κB pathway promotes the expression of NLRP3 and pro-IL-1β, and H. sampsonii can inhibit this promotion.</p><p><strong>Conclusion: </strong>H. sampsonii may inhibit NLRP3 inflammatory vesicle activation via interfering with TLR4/NF-κB signaling to reduce the inflammatory response in macrophages and thus play a role in the treatment of RD.</p>","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"30 9","pages":"e70047"},"PeriodicalIF":2.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11418631/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142294943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the causative connection between urticaria, inflammatory cytokines, and mental disorders: Perspectives from genetic evidence.","authors":"ZhiRong Liu, YuanYing Wang, ShiHao Wang, JiaXin Wu, Cui Jia, Xuan Tan, XinLian Liu, XinWei Huang, LuShun Zhang","doi":"10.1111/srt.13906","DOIUrl":"10.1111/srt.13906","url":null,"abstract":"<p><strong>Background: </strong>The genetic association between urticaria and mental disorders and whether inflammatory cytokines mediate this process remains unclear.</p><p><strong>Materials and methods: </strong>A Mendelian randomization (MR) approaches to elucidate the causal relationship between urticaria and mental disorders and to validate the mediation of inflammatory cytokines. Genome-wide association study (GWAS) databases used were obtained from Psychiatric Genomics Cooperation (PGC), GWAS Catalog, and FinnGen Consortium. Our study was conducted using inverse variance weighted (IVW) and Bayesian weighted MR (BWMR) methods for joint analysis.</p><p><strong>Results: </strong>The MR results showed that urticaria increased the risk of attention deficit hyperactivity disorder (ADHD) (odds ratio [OR] <math><semantics><mo>=</mo> <annotation>$ = $</annotation></semantics> </math> 1.088, 95% confidence interval [CI]: 1.026-1.154, p <math><semantics><mo>=</mo> <annotation>$ = $</annotation></semantics> </math> 0.0051); cholinergic urticaria increased the risk of bipolar disorder (BD) (OR <math><semantics><mo>=</mo> <annotation>$ = $</annotation></semantics> </math> 1.012, 95% CI: 1.001-1.022, p <math><semantics><mo>=</mo> <annotation>$ = $</annotation></semantics> </math> 0.0274); dermatographic urticaria increased the risk of ADHD (OR <math><semantics><mo>=</mo> <annotation>$ = $</annotation></semantics> </math> 1.057, 95% CI: 1.005-1.112, p <math><semantics><mo>=</mo> <annotation>$ = $</annotation></semantics> </math> 0.0323); idiopathic urticaria increased the risk of schizophrenia (SCZ) (OR <math><semantics><mo>=</mo> <annotation>$ = $</annotation></semantics> </math> 1.057, 95% CI: 1.005-1.112, p <math><semantics><mo>=</mo> <annotation>$ = $</annotation></semantics> </math> 0.0323); other unspecified urticaria increased the risk of ADHD (OR <math><semantics><mo>=</mo> <annotation>$ = $</annotation></semantics> </math> 1.085, 95% CI: 1.023-1.151, p <math><semantics><mo>=</mo> <annotation>$ = $</annotation></semantics> </math> 0.0063). We found that eight inflammatory cytokines were negatively associated with mental disorders and seven inflammatory cytokines were positively associated with mental disorders. Finally, our results suggested that inflammatory cytokines do not act as mediators between urticaria and mental disorders.</p><p><strong>Conclusions: </strong>Our study reveals a causal relationship between urticaria and the increased risk of mental disorders. We suggest that the treatment of urticaria could incorporate psychiatric interventions and mental health assessment of patients.</p>","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"30 9","pages":"e13906"},"PeriodicalIF":2.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11413335/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142294948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-powered 675-nm laser: Safety and efficacy in clinical evaluation and in vitro evidence for different skin disorders.","authors":"Massimo D F Vitale, Francesca Madeddu, Irene Fusco, Laura Pieri, Paolo Bonan, Tiziano Zingoni, Giada Magni, Francesca Rossi","doi":"10.1111/srt.70019","DOIUrl":"https://doi.org/10.1111/srt.70019","url":null,"abstract":"<p><strong>Background: </strong>Laser technology is a viable therapeutic option for treating a number of skin pathologic conditions, including pigmented lesions, vascular lesions and acne scars.</p><p><strong>Aim: </strong>In this work, through in vitro and clinical investigations we test the efficacy, the safety and the speed of treatment of high-powered laser system emitting a 675-nm in the management of various skin condition.</p><p><strong>Materials and methods: </strong>In vitro experiments were performed irradiating adult human dermal fibroblasts cells (HDFa) with 675-nm laser for 24, 48 and 72 h with different fluences and Ki-67⁺ cells were counted. The confocal microscopy images of control and treated samples were acquired. Clinical skin rejuvenation/diseases treatments with 675 nm laser device were performed with different laser parameters in 11 patients with pigmented lesions, 5 patients with acne scars and 23 patients for skin rejuvenation. Data were evaluated with the validated global score using 5-point scales (GAIS) and patient's satisfaction scale.</p><p><strong>Results: </strong>The application of the high-power 675 nm laser has proven effective in stimulating cell proliferation in in vitro experiments and it led to good results for all skin pathologies. GAIS showed values between 3 and 4 points for all treated pathologies, all scores between '75%-good improvements' and '100%-excellent improvements'. The treatment time was reduced by 50% compared to the old parameters setting, resulting in a faster and good patient's satisfying technique. No serious adverse effects were recorded.</p><p><strong>Conclusion: </strong>the preclinical and clinical data confirm the efficacy and safety of this high-powered 675 nm laser for several skin condition.</p>","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"30 9","pages":"e70019"},"PeriodicalIF":2.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11359081/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142111903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeted precision cryotherapy for acne vulgaris.","authors":"Ji Yeon Hong, Ka Ram Kim, Hyun Jung Kim, Joon Seok, Kui Young Park","doi":"10.1111/srt.70045","DOIUrl":"10.1111/srt.70045","url":null,"abstract":"<p><strong>Background: </strong>Acne vulgaris poses a significant dermatological challenge, necessitating alternative treatments due to limitations and side effects associated with current therapies. This pilot clinical trial investigated the feasibility and efficacy of precision cryotherapy for acne vulgaris.</p><p><strong>Methods: </strong>A total of 20 volunteers underwent targeted precision cryotherapy using a carbon dioxide-based device. Treatment outcomes were assessed using various parameters, including Investigator Global Assessment (IGA) score, acne lesion count, erythema index (EI), global evaluation score, and participant satisfaction. Safety monitoring included adverse event reporting and physical examination.</p><p><strong>Results: </strong>Precision cryotherapy demonstrated a significant reduction (90.25%) in the acne lesion count by week 4, with clinical improvement indicated by IGA score reduction (p < 0.001). The EI showed notable improvements at weeks 1, 2, and 4. The global evaluation score demonstrated a 75%-100% clinical improvement at Visit 4. Participants reported high satisfaction (6.75 ± 0.79) with the procedure. No adverse event or discomfort was reported.</p><p><strong>Conclusion: </strong>Precision cryotherapy effectively improved acne lesions, which was safe and satisfactory for participants. These findings suggest its potential as an alternative therapeutic modality, especially for populations with limited treatment options. Further research is needed to validate the results and explore underlying mechanisms.</p>","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"30 9","pages":"e70045"},"PeriodicalIF":2.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11367662/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142111917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The causal relationship between immune cells and atopic dermatitis: A bidirectional Mendelian randomization study.","authors":"Xu Zhu, Wenzhong Wu","doi":"10.1111/srt.13858","DOIUrl":"10.1111/srt.13858","url":null,"abstract":"<p><strong>Background: </strong>Atopic dermatitis (AD) is a chronic inflammatory skin condition whose origins remain unclear. Existing epidemiological evidence suggests that inflammation and immune factors play pivotal roles in the onset and progression of AD. However, previous research on the connection between immune inflammation and AD has yielded inconclusive results.</p><p><strong>Methods: </strong>To evaluate the causal relationship between immunological characteristics and AD, this study employed a bidirectional, two-sample Mendelian randomization (MR) approach. We utilized large-scale, publicly available genome-wide association studies to investigate the causal associations between 731 immunological feature cells and the risk of AD.</p><p><strong>Results: </strong>Significant associations were identified between six immune phenotypes and AD risk: increased Basophil %CD33dim HLA DR-CD66b-, CD25 on IgD+ CD24+, CD40 on monocytes, HLA DR on CD14+ CD16-monocytes, HLA DR on CD14+monocytes correlated with higher AD risk, while elevated CD3 on CD4 Treg was linked to lower risk. Reverse MR analysis revealed AD as a risk factor for IgD+ CD38br AC and IgD+ CD38br %B cell, but a protective factor against CD20 on IgD+ CD38- naive and CD8 on NKT.</p><p><strong>Conclusion: </strong>Our findings elucidate the intricate interplay between immune cells and AD, informing future research into AD pathophysiology and therapeutics.</p>","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"30 9","pages":"e13858"},"PeriodicalIF":2.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11351690/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142081463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanism of Zuogui pill enhancing ovarian function and skin elastic repair in premature aging rats based on artificial intelligence medical image analysis.","authors":"Xinpei Zhang, Fuju Wang, Xiaodan Zhu, Lan Xu, Ling Qin, Wenjuan Xu, Bozhen Fan","doi":"10.1111/srt.70050","DOIUrl":"10.1111/srt.70050","url":null,"abstract":"<p><strong>Background: </strong>AI medical image analysis shows potential applications in research on premature aging and skin. The purpose of this study was to explore the mechanism of the Zuogui pill based on artificial intelligence medical image analysis on ovarian function enhancement and skin elasticity repair in rats with premature aging.</p><p><strong>Materials and methods: </strong>The premature aging rat model was established by using an experimental animal model. Then Zuogui pills were injected into the rats with premature aging, and the images were detected by an optical microscope. Then, through the analysis of artificial intelligence medical images, the image data is analyzed to evaluate the indicators of ovarian function.</p><p><strong>Results: </strong>Through optical microscope image detection, we observed that the Zuogui pill played an active role in repairing ovarian tissue structure and increasing the number of follicles in mice, and Zuogui pill also significantly increased the level of progesterone in the blood of mice.</p><p><strong>Conclusion: </strong>Most of the ZGP-induced outcomes are significantly dose-dependent.</p>","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"30 9","pages":"e70050"},"PeriodicalIF":2.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11381913/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142154884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}