Skin Research and Technology最新文献

{"title":"Comparative Evaluation of Topical Stabilized Retinaldehyde 0.1% vs. 0.05% on Skin Biophysical and Biomechanical Parameters.","authors":"Anna Deda, Wiktoria Odrzywołek, Agata Lebiedowska, Anna Banyś, Małgorzata Bożek, Dagmara Kuca, Nina Wiśniewska, Dominika Wcisło-Dziadecka, Sławomir Wilczyński","doi":"10.1111/srt.70326","DOIUrl":"10.1111/srt.70326","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to evaluate the biophysical and biomechanical effects of topical stabilized retinaldehyde (RAL) treatments on skin, using different concentrations of retinal (0.05% and 0.1%).</p><p><strong>Materials and methods: </strong>Employing a split-face design and noninvasive methods such as high-frequency ultrasonography, the Antera 3D camera, and the Cutometer, the effectiveness of these preparations was assessed among 56 women aged 30-58 years.</p><p><strong>Results: </strong>The application of topical stabilized RAL resulted in statistically significant improvements in skin parameters. High-frequency ultrasonography revealed increased dermal density across all facial regions after 24 weeks, while Cutometer measurements showed enhanced skin elasticity and viscoelasticity. Antera 3D imaging demonstrated significant reductions in wrinkle parameters, particularly with the higher concentration (0.1%) of RAL. The treatments were generally well-tolerated, with minimal adverse effects reported, highlighting their suitability for sensitive skin.</p><p><strong>Conclusion: </strong>Results indicated significant improvements in skin texture and firmness, particularly with the higher 0.1% concentration of RAL over 24-week period, making it a promising option for long-term skin rejuvenation therapy.</p>","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"32 2","pages":"e70326"},"PeriodicalIF":2.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12928007/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147271863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: Comment on ChatGPT and Psoriasis Patient Concerns.","authors":"","doi":"10.1111/srt.70339","DOIUrl":"10.1111/srt.70339","url":null,"abstract":"","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"32 2","pages":"e70339"},"PeriodicalIF":3.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12895129/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146166652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementing GPT-4 Learning Models in Dermatology: An Assessment of Medical Quality and Utility.","authors":"Aryan Naik, Peter Vien, Thanh-Nga Tran","doi":"10.1111/srt.70331","DOIUrl":"10.1111/srt.70331","url":null,"abstract":"<p><strong>Background: </strong>Artificial intelligence, including large language models (LLMs) such as GPT-4, can generate responses to clinical queries using predictive algorithms trained on large online datasets. Current literature lacks a comprehensive assessment of the medical quality and accuracy of dermatologic GPT-4-generated outputs.</p><p><strong>Methods: </strong>A standardized query was used to ask GPT-4 models (Copilot and ChatGPT-4) to generate summaries and treatment recommendations for 33 dermatologic conditions, which were then compared to corresponding sections of UpToDate (UTD) excerpts. DISCERN scores were calculated for each source by two authors (AN and PV). Concordance between GPT-4-generated treatments and UTD was evaluated by a certified dermatologist. Word count and Flesch Kincaid reading score were generated in R. Paired t-tests and one-way and weighted ANOVA were conducted in R.</p><p><strong>Results: </strong>The DISCERN instrument classified UTD content as being of \"fair\" medical quality (mean [SD], 3.08 [0.34]), while both ChatGPT-4 and Copilot produced content of \"poor\" medical quality (mean [SD], 2.28 [0.22] and mean [SD], 2.31 [0.35], respectively). ChatGPT-4's treatment recommendations demonstrated 33.5% greater average concordance with UTD treatment recommendations (mean [SD], 64.89% [29.29]), in comparison to Copilot (mean [SD], 31.38% [31.08%]); (95% CI, 22.3%-44.7%, p < 0.001).</p><p><strong>Conclusions: </strong>Overall, GPT-4 models produced dermatological content with few harmful recommendations. However, GPT-4-generated content performed poorly on the DISCERN instrument, and validation of LLM-generated responses remains challenging. Results suggest LLM parameters and query structures may be optimizable for dermatologic applications. If implemented alongside the professional judgement of certified dermatologists, future LLMs may serve as time-saving dermatologic tools, enhancing patient care.</p>","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"32 2","pages":"e70331"},"PeriodicalIF":2.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12914478/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146214108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: Artificial Dermatitis Versus Artificial Intelligence: Detecting Etiology With Google Lens.","authors":"","doi":"10.1111/srt.70340","DOIUrl":"10.1111/srt.70340","url":null,"abstract":"","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"32 2","pages":"e70340"},"PeriodicalIF":3.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12895131/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146166592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: Laser-Assisted Blepharoplasty: An Innovative Safe and Effective Technique.","authors":"","doi":"10.1111/srt.70319","DOIUrl":"10.1111/srt.70319","url":null,"abstract":"","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"32 1","pages":"e70319"},"PeriodicalIF":3.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12790470/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145949154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: Use of a Microwave Device for the Treatment of Cellulite and Localized Fat Adiposity: A 1-Year Follow-Up Study.","authors":"","doi":"10.1111/srt.70317","DOIUrl":"10.1111/srt.70317","url":null,"abstract":"","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"32 1","pages":"e70317"},"PeriodicalIF":3.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12790474/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145949167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: Identification of VLDL as a Biomarker for Prewarning of Androgenic Alopecia.","authors":"","doi":"10.1111/srt.70330","DOIUrl":"10.1111/srt.70330","url":null,"abstract":"","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"32 1","pages":"e70330"},"PeriodicalIF":3.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12814612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145998991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Split Face Study Comparing the Effect of a PDLLA Based Product and PLLA on the Nasolabial Fold (NLF).","authors":"Je-Young Park, Dong Jin Im, Hee Dae Jeon, Hyun Jo Kim, Do Young Rhee, BonCheol Leo Goo, Kwang Ho Han, Zhongfan Chang, Hei Sung Kim","doi":"10.1111/srt.70324","DOIUrl":"10.1111/srt.70324","url":null,"abstract":"<p><strong>Background: </strong>Injectable Poly-L-lactic acid (PLLA) is effective in restoring mid-face volume and is widely used treating the nasolabial fold (NLF). This study aimed to compare the safety and efficacy of a novel PDLLA based product (PDLLA + non-cross-linked HA; Poly-D, L-lactic acid + hyaluronic acid) with that of a commonly used PLLA for NLF correction.</p><p><strong>Methods: </strong>In this multi-center, randomized, split-face, evaluator-blinded study, 33 subjects received injections of the PDLLA based product on one NLF and PLLA injection on the other (three injections total, administered at 4-week intervals). Wrinkle severity was assessed using standardized photographs taken at baseline (week 0); before the second and third injections (weeks 4 and 8); 4 weeks after the third injection (week 12); and 3 months after the final injection (week 24) using the Wrinkle Severity Rating Scale (WSRS). Safety data were collected through subject interviews and case report forms.</p><p><strong>Results: </strong>Both the PDLLA based product and PLLA significantly improved NLF wrinkle severity at all time points compared to baseline (p < 0.001). The degree of improvement was comparable between the two products throughout the observation period.</p><p><strong>Conclusion: </strong>The PDLLA based product demonstrated non-inferiority to PLLA for NLF correction. Further studies are needed to assess long-term safety.</p>","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"32 1","pages":"e70324"},"PeriodicalIF":2.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12802405/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145966929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"Non-Invasive Diagnosis of Pink Basal Cell Carcinoma: How Much Can We Rely on Dermoscopy and Reflectance Confocal Microscopy?\"","authors":"","doi":"10.1111/srt.70308","DOIUrl":"10.1111/srt.70308","url":null,"abstract":"","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"32 1","pages":"e70308"},"PeriodicalIF":3.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12831055/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146041572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Wound Healing with a Novel Alginate/Eggshell Membrane-Based Hydrogel Enriched with Red Ginseng Roots and Centella Asiatica.","authors":"Samaneh Esmaeili, Majid Rahmati, Majid Salehi, Badrul Hisham Yahaya, Sepehr Zamani","doi":"10.1111/srt.70325","DOIUrl":"10.1111/srt.70325","url":null,"abstract":"<p><strong>Background: </strong>Bridging ancient herbal wisdom with modern biomaterial innovation, this study pioneers a smart hydrogel infused with Red Ginseng (RG) (angiogenesis-boosting ginsenosides) and Centella asiatica (collagen-stimulating asiaticoside), synergized with alginate and upcycled eggshell membrane for unrivaled wound adhesion and eco-conscious design. Unlike conventional hydrogels, this bioactive synergy accelerates tissue regeneration while fighting antibiotic-resistant infections, thus opening up a new era of wound care inspired by nature.</p><p><strong>Methods & materials: </strong>Initially, seven distinct hydrogel formulations were generated by blending sodium alginate and eggshell membrane with RG roots and centella asiatica at optimal concentrations. Subsequently, the hydrogels' structural characteristics were assessed using scanning electron microscope (SEM) and Fourier Transforms Infrared Spectroscopy (FTIR) techniques. Following structural validation, the study comprehensively evaluated the physical attributes of the hydrogels, encompassing swelling behavior, stability, weight loss, porosity, and antibacterial properties. Biocompatibility of the prepared hydrogels was assessed through hemolytic activity and cell viability analyses. Moreover, the therapeutic efficacy of the hydrogels was examined using a rat model, encompassing RNA expression and histological assessments to elucidate their potential wound-healing attributes.</p><p><strong>Results: </strong>The developed hydrogel exhibited a porous architecture with interconnected cavities conducive to facilitating cell migration. Additionally, the hydrogels demonstrated antibacterial properties, as confirmed by antibacterial assays. MTT analysis revealed a positive impact on cell proliferation, with no observed cellular toxicity. Furthermore, in vivo experiments demonstrated that the hydrogels outperformed the control group, treated with gauze, in accelerating wound closure. Notably, the alginate/eggshell membrane/RG roots/Centella asiatica group exhibited the highest percentages of wound closure, re-epithelialization, and gene expression.</p><p><strong>Conclusion: </strong>This hydrogel transcends conventional wound care, harnessing RG's angiogenic magic and centella's collagen-boosting power within a sustainable alginate-eggshell matrix to forge a bioactive bridge between lab bench and bedside. Its triple potential (rapid closure, infection defense, and scar suppression) makes it a promising dressing.</p>","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"32 1","pages":"e70325"},"PeriodicalIF":2.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12828342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146030724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}