Skin Research and Technology最新文献

{"title":"Discovery of a Novel Cyclopeptide as Tyrosinase Inhibitor for Skin Lightening.","authors":"Huailong Chang, Kan Tao, Hu Huang, Jinping Jia, Shah Nawaz Khan, Jiahua Cui","doi":"10.1111/srt.70207","DOIUrl":"10.1111/srt.70207","url":null,"abstract":"<p><strong>Background: </strong>Melanin synthesis plays a crucial role in skin pigmentation, and inhibiting tyrosinase, the key enzyme in melanin production, is a primary strategy for developing skin-lightening agents. This study investigates the tyrosinase inhibitory potential of CHP-9, a novel cyclopeptide, and evaluates its cytotoxicity and efficacy as a cosmetic depigmenting agent.</p><p><strong>Methods: </strong>CHP-9 was synthesized via a solid-phase peptide synthesis strategy. The tyrosinase inhibitory activity was assessed using an enzymatic assay, while its effects on melanin content were evaluated in cultured human melanocytes. The MTT assay was performed to assess cytotoxicity across a range of CHP-9 concentrations (0.0781-10 mg/mL). Molecular docking simulations were conducted to elucidate the interaction between CHP-9 and human tyrosinase (PDB ID: 5M8M). Statistical analysis was performed using GraphPad Prism Software, and significance was determined via one-way ANOVA.</p><p><strong>Results: </strong>CHP-9 exhibited significant tyrosinase inhibition (28.57% at 1% concentration) and reduced melanin content in treated melanocytes from 30.90 ± 1.13 to 23.51 ± 1.14 µg/mL. Cytotoxicity assays confirmed CHP-9's high biocompatibility, with cell viability exceeding 90% at concentrations up to 2.5 mg/mL. Docking studies revealed strong binding affinity between CHP-9 and key tyrosinase residues via hydrogen bonding, supporting its inhibitory mechanism.</p><p><strong>Conclusions: </strong>CHP-9 exhibited significant tyrosinase inhibition (28.57% at 1% concentration) and reduced melanin content in melanocytes, while maintaining over 90% cell viability at effective doses. These findings suggest that CHP-9 is a safe and effective candidate for cosmetic skin-lightening applications. Further research is needed to enhance formulation stability and evaluate long-term efficacy in vivo.</p>","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"31 9","pages":"e70207"},"PeriodicalIF":3.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12430830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145055720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: Sonographic Comparison of Subcutaneous Fat Layer Thickness in the Scalp Area in Patients With Androgenetic Alopecia Compared to Healthy Individuals: Cross-Sectional.","authors":"","doi":"10.1111/srt.70224","DOIUrl":"10.1111/srt.70224","url":null,"abstract":"","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"31 9","pages":"e70224"},"PeriodicalIF":3.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12434169/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145065552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: Comparative Outcomes of Autologous Cultured Melanocytes Transplantation and Non-Cultured Epidermal Cell Suspension Transplantation in Piebaldism Patients: A Retrospective Study.","authors":"","doi":"10.1111/srt.70226","DOIUrl":"10.1111/srt.70226","url":null,"abstract":"","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"31 9","pages":"e70226"},"PeriodicalIF":3.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444424/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-Time, Noninvasive Diagnosis of Bullous Pemphigoid: Diagnostic Performance of Line-Field Confocal Optical Coherence Tomography.","authors":"Frank Friedrich Gellrich, Samal Rakhmetova, Claudia Günther, Stefan Beissert, Sarah Hobelsberger","doi":"10.1111/srt.70235","DOIUrl":"10.1111/srt.70235","url":null,"abstract":"<p><strong>Background: </strong>Bullous pemphigoid (BP) is a common autoimmune blistering dermatosis often difficult to distinguish from other inflammatory conditions. Timely diagnosis is crucial for appropriate management. Line-field confocal optical coherence tomography (LC-OCT), a noninvasive imaging technique that uses an 800nm laser to generate high-resolution vertical and horizontal cross-sectional images of the skin, is evaluated as a diagnostic tool for BP.</p><p><strong>Materials and methods: </strong>A prospective, single-center study was conducted on 26 patients with suspected BP. LC-OCT imaging, histopathology, and direct immunofluorescence (DIF) were performed. LC-OCT images were assessed for the presence of key diagnostic features, including subepidermal cleavage and eczema criteria.</p><p><strong>Results: </strong>Based on histopathology, DIF, indirect immunofluorescence (IIF), and ELISA, the final diagnoses were 15 BP cases and 11 non-BP cases. LC-OCT correctly identified 12 of 15 BP cases and all 11 non-BP cases, demonstrating a sensitivity of 0.8 and a specificity of 1.0. The presence of subepidermal cleavage was a key diagnostic criterion for BP (p = 0.000). The absence of alternating hypo- and hyper-reflective layers (p = 0.000), thickened and disrupted stratum corneum (p = 0.014), spongiosis (p = 0.036), and thickened epidermis (p = 0.043), which occurred significantly less frequently in BP cases, further supported the diagnosis.</p><p><strong>Conclusion: </strong>LC-OCT demonstrates high sensitivity and specificity in diagnosing BP, offering a rapid, point-of-care diagnostic approach. LC-OCT can be used to evaluate unclear inflammatory skin conditions and guide further investigations. However, LC-OCT has limitations in diagnosing non-bullous stages of BP; thus, histology and DIF remain the gold standard for definitive diagnosis.</p>","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"31 9","pages":"e70235"},"PeriodicalIF":3.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12457975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145131931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: Use of Biologics in Patients With Psoriasis-A Retrospective Analysis Based on Real-World Data.","authors":"","doi":"10.1111/srt.70233","DOIUrl":"10.1111/srt.70233","url":null,"abstract":"","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"31 9","pages":"e70233"},"PeriodicalIF":3.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: The Causal Relationship Between Psoriasis and Artificial Joint Re-Operation After Arthroplasty: A Two-Sample Mendelian Randomization Study.","authors":"","doi":"10.1111/srt.70232","DOIUrl":"10.1111/srt.70232","url":null,"abstract":"","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"31 9","pages":"e70232"},"PeriodicalIF":3.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12445188/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: Evaluation and Comparison of the Efficacy and Safety of the Combination of Topical Phenytoin and Microneedling With Microneedling Alone in the Treatment of Atrophic Acne Scars: A Controlled Blinded Randomized Clinical Trial.","authors":"","doi":"10.1111/srt.70225","DOIUrl":"10.1111/srt.70225","url":null,"abstract":"","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"31 9","pages":"e70225"},"PeriodicalIF":3.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12434309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145065485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: Dermoscopy and Reflectance Confocal Microscopy Finding of Different Anatomic Sites of Langerhans Cell Histiocytosis.","authors":"","doi":"10.1111/srt.70231","DOIUrl":"10.1111/srt.70231","url":null,"abstract":"","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"31 9","pages":"e70231"},"PeriodicalIF":3.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12445283/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: A Study of the Effect of Natural Brown Cotton Gauze on the Healing of Infected Wounds.","authors":"","doi":"10.1111/srt.70220","DOIUrl":"https://doi.org/10.1111/srt.70220","url":null,"abstract":"","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"31 8","pages":"e70220"},"PeriodicalIF":3.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12376313/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144967742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skin Elasticity of the Face: Demographic and Lifestyle Intricacies.","authors":"Gitanjali Petkar, Adaam Domun, Nusayha Sokeechand, Muzzammil Hosenally","doi":"10.1111/srt.70209","DOIUrl":"10.1111/srt.70209","url":null,"abstract":"<p><strong>Background: </strong>The assessment of improvements in facial skin features using instrumental measurements is often challenging. This is also true for the assessment of signs of ageing within various populations. For the purpose of clinical studies, there is a need to document the values that could be generated using such instrumental measurement. This paper, thus, investigates the effect of demographic profile and lifestyle on facial elasticity using an elasticity meter on a diverse and multiethnic population.</p><p><strong>Materials and methods: </strong>This one-day clinical study involved the participation of 300 participants for demographic profiling and self-reported lifestyle (after consenting). Skin elasticity measurements were taken using an elasticity meter in controlled conditions. Generated data included both absolute and relative parameters. These were tabulated using simple descriptive statistics, by demographic profile and lifestyle. Inferential statistical analyses were applied to assess for significant differences among groups.</p><p><strong>Results: </strong>Benchmark instrumental values are reported in the form of central tendencies and dispersions. Gender, age, phototype, ethnicity, occupation and transportation methods revealed salient differences in terms of skin elasticity. On the other hand, only non-significant trends were noted for other demographic characteristics and lifestyle behaviours investigated.</p><p><strong>Conclusion: </strong>The findings propose some benchmark values that could be used to inform the design of future clinical trials. This includes sample size calculations, taking into consideration the panels being studied. There is a need to take into consideration the demographic and lifestyle background of the proposed panel when designing a study aimed at improving facial skin ageing features. These factors may have an influence on the response, thus confounding the study results and conclusions. Future longitudinal studies looking at long-term behavioural influences are required to better understand the dynamics of skin elasticity.</p>","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"31 8","pages":"e70209"},"PeriodicalIF":3.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12322738/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144785197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}