Skin Research and Technology最新文献

{"title":"RETRACTION: Clinical Analysis of 10 cases With Subcutaneous Panniculitis-like T-cell Lymphoma and Tissue AURKA Expression.","authors":"","doi":"10.1111/srt.70230","DOIUrl":"10.1111/srt.70230","url":null,"abstract":"","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"31 9","pages":"e70230"},"PeriodicalIF":3.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Assessment of Cellular Atypia Utilizing Line-Field Confocal Optical Coherence Tomography (LC-OCT).","authors":"Shazli Razi, Priya Agarwal, Gaurav N Pathak, Babar K Rao","doi":"10.1111/srt.70227","DOIUrl":"10.1111/srt.70227","url":null,"abstract":"","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"31 9","pages":"e70227"},"PeriodicalIF":3.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12431589/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145055571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: Causal Relationships Between Dietary Antioxidant Vitamin Intake and Atopic Dermatitis: A Two-Sample Mendelian Randomization Study.","authors":"","doi":"10.1111/srt.70229","DOIUrl":"10.1111/srt.70229","url":null,"abstract":"","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"31 9","pages":"e70229"},"PeriodicalIF":3.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444423/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced Skin Permeation and Pigmentation Reduction Effects of a Novel Tranexamic Acid-Mandelic Acid Ion-Pairing Complex.","authors":"Hyungjoon Jeon, Nojin Park, Jong Gu Won, Yong Won Shin, Jiwon Choi, Kyoungin Min, Eunjung Choi, Chang Kyu Kim, Sang-Wook Park, Nam Seo Son","doi":"10.1111/srt.70222","DOIUrl":"10.1111/srt.70222","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigated the enhanced skin permeation and pigmentation reduction effects of an ion-pair complex formed between tranexamic acid (TXA) and mandelic acid (MA). The TXA-MA complex demonstrated superior skin permeability and greater inhibition of cytokine expression compared to TXA alone, ultimately proving more effective in reducing skin pigmentation.</p><p><strong>Methods: </strong>After spectroscopic analysis of the TXA-MA ion-pairing complex (TXA-MA complex) structure, an in vitro skin permeation study was conducted using a Franz cell system with porcine skin. Additionally, the effect of the TXA-MA complex on UVB (ultraviolet B)-induced expression changes of inflammation-related genes (IL-1α, IL-6, IL-8, COX2) was evaluated using a human epidermal keratinocyte cell lines (HaCaT) cell model. Finally, an in vivo human study was performed to analyze the efficacy of TXA-MA in reducing actual skin pigmentation.</p><p><strong>Results: </strong>The formation of the TXA-MA complex was confirmed through zeta-potential measurements, ¹H NMR study, and Fourier-transform infrared spectroscopy (FT-IR) spectroscopy. Skin permeation studies using porcine skin showed enhanced permeability of the TXA-MA complex compared to TXA at equivalent concentrations. In the HaCaT cell model, the TXA-MA complex exhibited greater inhibition of inflammatory markers IL-1α, IL-6, IL-8, and COX-2 expression than TXA alone. Finally, a 4-week human clinical study using ANTERA 3D imaging demonstrated that the TXA-MA complex was significantly more effective than TXA alone in reducing skin pigmentation.</p><p><strong>Conclusion: </strong>This study successfully formed a TXA-MA complex. Compared to TXA, the TXA-MA complex showed superior effects in skin permeability, inhibition of inflammatory marker expression, and actual skin pigmentation reduction. These results suggest that the TXA-MA complex holds greater potential as an effective cosmetic ingredient for pigmentation improvement than TXA alone.</p>","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"31 9","pages":"e70222"},"PeriodicalIF":3.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12426310/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discovery of a Novel Cyclopeptide as Tyrosinase Inhibitor for Skin Lightening.","authors":"Huailong Chang, Kan Tao, Hu Huang, Jinping Jia, Shah Nawaz Khan, Jiahua Cui","doi":"10.1111/srt.70207","DOIUrl":"10.1111/srt.70207","url":null,"abstract":"<p><strong>Background: </strong>Melanin synthesis plays a crucial role in skin pigmentation, and inhibiting tyrosinase, the key enzyme in melanin production, is a primary strategy for developing skin-lightening agents. This study investigates the tyrosinase inhibitory potential of CHP-9, a novel cyclopeptide, and evaluates its cytotoxicity and efficacy as a cosmetic depigmenting agent.</p><p><strong>Methods: </strong>CHP-9 was synthesized via a solid-phase peptide synthesis strategy. The tyrosinase inhibitory activity was assessed using an enzymatic assay, while its effects on melanin content were evaluated in cultured human melanocytes. The MTT assay was performed to assess cytotoxicity across a range of CHP-9 concentrations (0.0781-10 mg/mL). Molecular docking simulations were conducted to elucidate the interaction between CHP-9 and human tyrosinase (PDB ID: 5M8M). Statistical analysis was performed using GraphPad Prism Software, and significance was determined via one-way ANOVA.</p><p><strong>Results: </strong>CHP-9 exhibited significant tyrosinase inhibition (28.57% at 1% concentration) and reduced melanin content in treated melanocytes from 30.90 ± 1.13 to 23.51 ± 1.14 µg/mL. Cytotoxicity assays confirmed CHP-9's high biocompatibility, with cell viability exceeding 90% at concentrations up to 2.5 mg/mL. Docking studies revealed strong binding affinity between CHP-9 and key tyrosinase residues via hydrogen bonding, supporting its inhibitory mechanism.</p><p><strong>Conclusions: </strong>CHP-9 exhibited significant tyrosinase inhibition (28.57% at 1% concentration) and reduced melanin content in melanocytes, while maintaining over 90% cell viability at effective doses. These findings suggest that CHP-9 is a safe and effective candidate for cosmetic skin-lightening applications. Further research is needed to enhance formulation stability and evaluate long-term efficacy in vivo.</p>","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"31 9","pages":"e70207"},"PeriodicalIF":3.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12430830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145055720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: Sonographic Comparison of Subcutaneous Fat Layer Thickness in the Scalp Area in Patients With Androgenetic Alopecia Compared to Healthy Individuals: Cross-Sectional.","authors":"","doi":"10.1111/srt.70224","DOIUrl":"10.1111/srt.70224","url":null,"abstract":"","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"31 9","pages":"e70224"},"PeriodicalIF":3.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12434169/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145065552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: Comparative Outcomes of Autologous Cultured Melanocytes Transplantation and Non-Cultured Epidermal Cell Suspension Transplantation in Piebaldism Patients: A Retrospective Study.","authors":"","doi":"10.1111/srt.70226","DOIUrl":"10.1111/srt.70226","url":null,"abstract":"","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"31 9","pages":"e70226"},"PeriodicalIF":3.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444424/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-Time, Noninvasive Diagnosis of Bullous Pemphigoid: Diagnostic Performance of Line-Field Confocal Optical Coherence Tomography.","authors":"Frank Friedrich Gellrich, Samal Rakhmetova, Claudia Günther, Stefan Beissert, Sarah Hobelsberger","doi":"10.1111/srt.70235","DOIUrl":"10.1111/srt.70235","url":null,"abstract":"<p><strong>Background: </strong>Bullous pemphigoid (BP) is a common autoimmune blistering dermatosis often difficult to distinguish from other inflammatory conditions. Timely diagnosis is crucial for appropriate management. Line-field confocal optical coherence tomography (LC-OCT), a noninvasive imaging technique that uses an 800nm laser to generate high-resolution vertical and horizontal cross-sectional images of the skin, is evaluated as a diagnostic tool for BP.</p><p><strong>Materials and methods: </strong>A prospective, single-center study was conducted on 26 patients with suspected BP. LC-OCT imaging, histopathology, and direct immunofluorescence (DIF) were performed. LC-OCT images were assessed for the presence of key diagnostic features, including subepidermal cleavage and eczema criteria.</p><p><strong>Results: </strong>Based on histopathology, DIF, indirect immunofluorescence (IIF), and ELISA, the final diagnoses were 15 BP cases and 11 non-BP cases. LC-OCT correctly identified 12 of 15 BP cases and all 11 non-BP cases, demonstrating a sensitivity of 0.8 and a specificity of 1.0. The presence of subepidermal cleavage was a key diagnostic criterion for BP (p = 0.000). The absence of alternating hypo- and hyper-reflective layers (p = 0.000), thickened and disrupted stratum corneum (p = 0.014), spongiosis (p = 0.036), and thickened epidermis (p = 0.043), which occurred significantly less frequently in BP cases, further supported the diagnosis.</p><p><strong>Conclusion: </strong>LC-OCT demonstrates high sensitivity and specificity in diagnosing BP, offering a rapid, point-of-care diagnostic approach. LC-OCT can be used to evaluate unclear inflammatory skin conditions and guide further investigations. However, LC-OCT has limitations in diagnosing non-bullous stages of BP; thus, histology and DIF remain the gold standard for definitive diagnosis.</p>","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"31 9","pages":"e70235"},"PeriodicalIF":3.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12457975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145131931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: Use of Biologics in Patients With Psoriasis-A Retrospective Analysis Based on Real-World Data.","authors":"","doi":"10.1111/srt.70233","DOIUrl":"10.1111/srt.70233","url":null,"abstract":"","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"31 9","pages":"e70233"},"PeriodicalIF":3.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: The Causal Relationship Between Psoriasis and Artificial Joint Re-Operation After Arthroplasty: A Two-Sample Mendelian Randomization Study.","authors":"","doi":"10.1111/srt.70232","DOIUrl":"10.1111/srt.70232","url":null,"abstract":"","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"31 9","pages":"e70232"},"PeriodicalIF":3.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12445188/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}