Skin Research and Technology最新文献

{"title":"Non-invasive Imaging Modalities for Breslow Thickness Estimation in Melanoma: A Scoping Review.","authors":"Biagio Scotti, Martina Lambertini, Leonardo Veneziano, Federico Venturi, Elisabetta Magnaterra, Carlotta Baraldi, Emi Dika","doi":"10.1111/srt.70392","DOIUrl":"10.1111/srt.70392","url":null,"abstract":"<p><strong>Background: </strong>Breslow thickness (BT) is the most important prognostic biomarker in cutaneous melanoma and directly influences surgical management, sentinel lymph node biopsy decisions and survival outcomes. Several non-invasive imaging modalities have been investigated for preoperative BT estimation; however, their relative performance and clinical applicability remain unclear.</p><p><strong>Objective: </strong>To evaluate the agreement between non-invasive imaging-derived and histopathologically measured BT and to compare the technical characteristics, diagnostic performance, and clinical utility of currently available imaging modalities for preoperative melanoma staging.</p><p><strong>Methods: </strong>A scoping review was conducted according to Joanna Briggs Institute methodology and reported following PRISMA-ScR guidelines. MEDLINE, Scopus, and Web of Science were searched from inception to December 1, 2025. Original studies evaluating non-invasive imaging techniques for BT estimation in cutaneous melanoma were included. Imaging modalities assessed comprised dermoscopy, reflectance confocal microscopy (RCM), optical coherence tomography (OCT), ultrasound (US), multispectral imaging (MSI), photoacoustic techniques, magnetic resonance imaging (MRI), single-photon emission computed tomography (SPECT), and artificial intelligence (AI)-based approaches.</p><p><strong>Results: </strong>Ninety-two studies met the inclusion criteria. Dermoscopy provided indirect assessment of invasiveness, while RCM and OCT offered complementary microstructural information but limited direct thickness estimation. US, particularly high-frequency (≥20 MHz) and ultra-high-frequency (≥50 MHz) systems, showed the strongest and most consistent evidence for direct BT assessment, with correlation coefficients often exceeding 0.90 and high performance across clinically relevant thresholds. Nevertheless, performance varied across devices, probe frequencies, acquisition protocols, and operators, with frequent overestimation and reduced accuracy in selected subgroups (in situ and thin melanomas). MSI showed moderate-to-good classification performance, while photoacoustic techniques yielded promising results but limited to small cohorts. Evidence for MRI and SPECT was scarce. AI-based approaches achieved moderate-to-good predictive performance but did not consistently outperform experienced clinicians, with generalizability limited by dataset and methodological heterogeneity.</p><p><strong>Conclusions: </strong>US currently represents the most extensively validated and clinically applicable non-invasive modality for preoperative BT estimation. A hierarchical imaging approach appears most appropriate, with dermoscopy as the first-line diagnostic tool, RCM and OCT providing additional lesion characterization, and HFUS enabling complementary depth assessment in lesions strongly suspicious for melanoma. Emerging photoacoustic and AI-based approaches require further ","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"32 10","pages":"e70392"},"PeriodicalIF":2.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13662740/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149184255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of 1.5- and 3.0-mm High-Intensity Focused Ultrasound for Eyebrow Lifting in Korean Adults: A Prospective Randomized Split-Face Study.","authors":"Kwang Ho Yoo, Hyewon Song, Yuhwa Choi","doi":"10.1111/srt.70393","DOIUrl":"https://doi.org/10.1111/srt.70393","url":null,"abstract":"<p><strong>Background: </strong>High-intensity focused ultrasound (HIFU) is widely used for noninvasive eyebrow lifting, but within-subject comparisons of cartridge focal depths are scarce.</p><p><strong>Objective: </strong>To evaluate the efficacy and safety of 1.5- and 3.0-mm cartridges for eyebrow lifting in Korean adults, with an exploratory between-depth comparison.</p><p><strong>Methods: </strong>In this randomized split-face study, 20 Korean adults were treated once with the 1.5-mm cartridge on one side and the 3.0-mm contralaterally (225 J/side). Average and maximum eyebrow heights (AEH, primary; MEH, secondary) were measured from standardized photographs at baseline, post-treatment, and weeks 1, 4, and 12. Satisfaction, pain, and adverse events were recorded.</p><p><strong>Results: </strong>Both measures increased significantly at all time points (unadjusted p < 0.05). At week 12, AEH increased by 1.76 ± 1.19 mm (1.5-mm) and 1.23 ± 1.33 mm (3.0-mm); 98.75% one-sided CI lower bounds (1.10 and 0.51 mm) met the corrected primary efficacy criterion. MEH met the separately corrected criterion with the 1.5-mm (0.57 mm) but not the 3.0-mm cartridge (-0.08 mm). The exploratory week-12 AEH difference was nonsignificant (p = 0.116). No treatment-related adverse events occurred over 12 weeks, supporting short-term tolerability in this cohort rather than definitive safety.</p><p><strong>Conclusions: </strong>Each cartridge was associated with significant within-subject increases in photographic eyebrow-height measures through 12 weeks and high satisfaction, although the corrected MEH criterion was not met with the 3.0-mm cartridge. Without a sham control, findings indicate within-subject improvement, not causal efficacy; the between-cartridge comparison is inconclusive, not evidence of equivalence. Larger, sham-controlled studies are needed.</p>","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"32 10","pages":"e70393"},"PeriodicalIF":2.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13659797/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149184268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic Effects of Solar Exposure and Skin Sensitivity on Skin Aging: A Clinical Study Using Multimodal Noninvasive Measurements.","authors":"Du Shan, Lin Guihua, Zhong Xinqing, Shi Jiajia, YunHa Lee, Xiong Zhi","doi":"10.1111/srt.70389","DOIUrl":"https://doi.org/10.1111/srt.70389","url":null,"abstract":"<p><strong>Background: </strong>Solar exposure is the primary extrinsic factor contributing to skin aging. Sensitive skin, characterized by impaired barrier function and heightened reactivity, may be more vulnerable to solar-induced damage. However, the potential interaction between skin sensitivity and solar exposure in accelerating skin aging has not been systematically quantified using objective clinical measurements.</p><p><strong>Objectives: </strong>To investigate the interactive effects of skin sensitivity and solar exposure on multiple aging-related skin parameters using multimodal noninvasive measurement techniques.</p><p><strong>Methods: </strong>This single-center observational study enrolled 124 healthy Chinese female volunteers aged 25-34 years. Participants were categorized according to skin sensitivity (sensitive vs. nonsensitive) and occupational solar exposure (indoor vs. outdoor), forming four groups (n = 31 per group): indoor sensitive (IS), outdoor sensitive (OS), indoor nonsensitive (INS), and outdoor nonsensitive (ONS). Skin barrier function, surface morphology, elasticity, dermal structure, and sebum secretion were evaluated using a series of noninvasive instruments. Two-way analysis of variance (ANOVA) was used to assess the main effects and interaction effects of skin sensitivity and solar exposure.</p><p><strong>Results: </strong>Significant interaction effects between skin sensitivity and solar exposure were observed for seven aging-related parameters, including transepidermal water loss (TEWL), stratum corneum thickness (SCT), second harmonic generation (SHG), autofluorescence (AF), skin roughness, nasolabial fold length, and sebum secretion (p < 0.05). The outdoor sensitive group exhibited the most pronounced aging phenotype, characterized by increased TEWL, reduced stratum corneum thickness, decreased SHG and AF signals, greater skin roughness, and longer nasolabial folds.</p><p><strong>Conclusion: </strong>Skin sensitivity and solar exposure exhibit a significant synergistic effect in the skin aging process. Individuals with sensitive skin under chronic solar exposure demonstrate more severe barrier dysfunction, dermal matrix degradation, and wrinkle formation. These findings suggest that sensitive skin represents a high-risk phenotype for photoaging and highlight the importance of combined barrier repair and effective photoprotection strategies for this population.</p>","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"32 10","pages":"e70389"},"PeriodicalIF":2.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13628154/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149115056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Site-Specific Characterization and Quantification of Facial Corticosteroid Addiction Dermatitis: A Multimodal Nomogram Integrating High-Frequency Ultrasonography and Transepidermal Water Loss.","authors":"Jun Wang, Ji Tao Gui, Rong Yu, Hai Rui Wang, Yang Hu, Ting Li","doi":"10.1111/srt.70388","DOIUrl":"10.1111/srt.70388","url":null,"abstract":"<p><strong>Background: </strong>The evaluation of facial corticosteroid addiction dermatitis (FCAD) lacks objective criteria, and existing clinical evaluation methods largely ignore regional facial heterogeneity. This study aimed to develop a site-adjusted multimodal nomogram integrating 22-MHz high-frequency ultrasonography (HFUS) and transepidermal water loss (TEWL) to serve as an adjunctive quantitative assessment tool to quantify the FCAD pathological state objectively.</p><p><strong>Materials and methods: </strong>In this prospective case-control study, 279 facial sites (119 lesional, 160 healthy) from 40 patients with FCAD and 40 healthy controls (HCs) were evaluated. Generalized estimating equations (GEE) were employed to adjust for the intra-subject clustering effect of multisite data.</p><p><strong>Results: </strong>Multivariable GEE identified four independent predictors for FCAD: marked blood flow on power Doppler imaging (PDI) (adjusted odds ratio [aOR] = 19.46, p < 0.001), subepidermal low-echogenic band (SLEB) thickness (aOR = 1.76 per 0.01 mm increase, p = 0.005), TEWL (aOR = 1.11, p = 0.002), and the chin site (vs. forehead, aOR = 0.35, p = 0.009). The resulting nomogram achieved an area under the curve (AUC) of 0.905, significantly outperforming a single-parameter vascular model (AUC = 0.821, p < 0.05). At the optimal probability cutoff, sensitivity was 85.7% and specificity was 86.9%.</p><p><strong>Conclusion: </strong>Integrating vascular, structural, and functional dimensions with anatomical site adjustments establishes a robust baseline for characterizing FCAD. This multimodal nomogram is intended for use as an adjunctive tool for quantitative assessment and disease monitoring, facilitating a critical shift from subjective clinical evaluation to precise, quantitative imaging.</p>","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"32 10","pages":"e70388"},"PeriodicalIF":2.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13656343/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149169024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation Study of Subjective Clinical Evaluation and Skin Biophysical Properties in Facial Skin among Young Korean Women; Pilot Study.","authors":"Jin Ho Kim, Min Joo Kim, Won Seok Choi","doi":"10.1111/srt.70391","DOIUrl":"https://doi.org/10.1111/srt.70391","url":null,"abstract":"<p><strong>Background: </strong>Although standardized, evidence-based diagnostic tools are essential for the assessment of the efficacy of facial skin rejuvenation, aesthetic medicine has largely relied on subjective evaluations, especially in primary clinics. Recent studies have demonstrated the potential of skin biophysical properties for objective assessment; however, they are not widely applied in clinical practice.</p><p><strong>Aims: </strong>To investigate the correlation of physicians' clinical evaluations of skin hydration, skin firmness, melanin, and erythema with skin biophysical properties.</p><p><strong>Patients/methods: </strong>Twenty Korean women with healthy skin were clinically and quantitatively evaluated. The former comprised questionnaires with 7-point scales regarding the grade of skin hydration, firmness, melanin, and erythema, completed by a dermatologist; the latter comprised measurements of conductance, trans-epidermal water loss (TEWL), gross elasticity (R2), dermal thickness, and melanin and erythema by another physician independently to subjective assessment.</p><p><strong>Results: </strong>Conductance and TEWL were significantly correlated with subjective hydration scores (Spearman's 𝜌 = 0.456 and 𝜌 = -0.604, respectively). Moreover, the objectively measured melanin index demonstrated a significant positive correlation with the clinically assessed melanin severity score (𝜌 = 0.612, p < 0.01). Clinical evaluation of erythema was significantly correlated with Young's modulus (𝜌 = -0.614) and inversely correlated with dermal thickness (𝜌 = 0.781, both p < 0.01).</p><p><strong>Conclusions: </strong>Unlike skin hydration, melanin, and erythema, skin firmness did not significantly correlate with biophysical properties. Thus, clinical evaluation is insufficient to establish treatment strategies for skin tightening in young women. Quantitative data may be an effective adjunctive diagnostic tool for patients who require subclinical interventions. This study was pilot study to explore the potential of objective measurements as adjunctive diagnostic tool in clinical setting, while some limitations include a small sample size, narrow range of age, and sex bias.</p>","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"32 10","pages":"e70391"},"PeriodicalIF":2.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13635474/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149115011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Dermal Fibroblast-Conditioned Media on Human Dermal Fibroblasts Treated With Electromagnetic Transduction Therapy.","authors":"Jeongah Ko, Sang Bum Suh, Yeong Ju Oh, Ji Youn Suh, Sung Bin Cho","doi":"10.1111/srt.70394","DOIUrl":"10.1111/srt.70394","url":null,"abstract":"<p><strong>Background: </strong>Electromagnetic transduction therapy (EMTT) is a high-intensity pulsed electromagnetic field therapy used in musculoskeletal medicine. However, its therapeutic effects on human dermal fibroblasts (HDFs) remain unclear. Secretomes from human dermal fibroblast-conditioned medium (HDFCM) can enhance wound repair and tissue regeneration.</p><p><strong>Methods: </strong>Young and aged HDFs were treated with EMTT (40 or 80 mT) following HDFCM pretreatment (0, 30, or 60%). Proliferation and migration were assessed using cell proliferation and wound healing assays. Senescence-associated β-galactosidase (SA-β-Gal) staining and enzyme-linked immunosorbent assay (ELISA) were performed to evaluate the effects of EMTT and HDFCM on senescence and pro- and anti-inflammatory cytokine secretion.</p><p><strong>Results: </strong>HDFCM significantly enhanced the proliferation of young and aged HDFs, particularly aged cells, in a dose-dependent manner. EMTT at 40 mT further enhanced these effects, with 40 mT EMTT plus 30% HDFCM yielding the greatest increase in the number of aged HDF. SA-β-Gal activity, minimal in young cells, was elevated in aged HDFs, but was reduced by 40 mT EMTT with or without HDFCM. Contrastingly, 80 mT EMTT increased SA-β-Gal activity unless counteracted by 60% HDFCM. Moreover, interleukin-6 was upregulated and transforming growth factor-β was downregulated by HDFCM and EMTT treatments.</p><p><strong>Conclusion: </strong>EMTT at low magnetic field strength, particularly if combined with HDFCM, promotes proliferation and migration while reducing senescence in aged HDFs. This approach may offer a promising therapeutic strategy for skin regeneration and antiaging applications, especially for aging or damaged dermal tissues.</p>","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"32 10","pages":"e70394"},"PeriodicalIF":2.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13656786/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149167353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness and Safety of a Moisturizer Containing Centella Asiatica Extract, Ceramide NP, and Panthenol for Erythema and Skin Barrier in Erythematotelangiectatic Rosacea: A Randomized Controlled Trial Study.","authors":"Xia Jiang, Haoyun Luo, Xiao He, Chenmin Hu, Kena Dan, Yongchao Dang, Tian Qian, Daojun Zhang, Fei Hao","doi":"10.1111/srt.70396","DOIUrl":"10.1111/srt.70396","url":null,"abstract":"<p><strong>Background: </strong>Erythematotelangiectatic rosacea is a chronic recurrent inflammatory disease that often impose a significant psychological burden on patients. Given that effective moisturization is integral to its management, the choice of a proper moisturizer is a critical clinical consideration. Our study aims to assess the effectiveness and safety of a moisturizer containing Centella asiatica extract, ceramide NP, and panthenol for erythema and skin barrier in Chinese patients with erythematotelangiectatic rosacea.</p><p><strong>Methods: </strong>All enrolled patients were prescribed oral minocycline 50 mg once daily and applied moisturizer twice daily. Facial images of facial redness, stratum corneum hydration (SCH), transepidermal water loss (TEWL), and Clinician's Erythema Assessment (CEA) were collected at baseline, day 7 (D7), day 14 (D14), and day 28 (D28). Time to a 1-point reduction in the Patient's Self-Assessment (PSA) scale and Rosacea-specific Quality-of-life instrument (RosQol) were also recorded by patients.</p><p><strong>Results: </strong>A total of 75 patients with rosacea were enrolled, 39 patients were randomized to the experimental group and 36 to the control group. Our study showed that the variations of a* value, facial red area, SCH and RosQol from baseline to D28 were rapidly and significantly greater in the experimental group, and the mean rank of CEA was significantly higher in the control group at D28. All AEs were mild and self-limiting.</p><p><strong>Conclusions: </strong>This study found that the moisturizer containing Centella asiatica extract, ceramide NP, and panthenol delivers rapid, effective adjunctive benefits in rosacea treatment and represents a reliable daily skincare option for patients.</p>","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"32 10","pages":"e70396"},"PeriodicalIF":2.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13670011/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149184132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design of a Gelatin/Carboxymethyl Cellulose Hydrogel Containing Myrtus Communis Extract with Anti-inflammatory Capabilities for Accelerated Wound Healing; in Vitro and in Vivo Study.","authors":"Sepehr Zamani, Mahdi Naeiji, Hasan Maghsoodifar, Seyed Amir Hossein Sadeghi Douki, Nariman Rezaie Kolarijani, Morteza Alizadeh, Zohreh Arabpour, Zahra Kourdi, Ali R Djalilian, Majid Salehi","doi":"10.1111/srt.70383","DOIUrl":"10.1111/srt.70383","url":null,"abstract":"<p><strong>Background: </strong>Achieving optimal skin integrity after an injury requires using a wound dressing with desirable hydrogel properties. This study aims to develop a hydrogel primarily made from gelatin and carboxymethyl cellulose (GEL/CMC).</p><p><strong>Methods & materials: </strong>We incorporated Myrtus communis extract into the hydrogel to evaluate its healing effect on full-thickness wounds. The plant extract acts as a regulator of inflammation, promoting proliferation and pro-angiogenic factors, while the natural polymers support these processes. The characterization of Myrtus communis and the hydrogel involved various methods, including assessments of mechanical properties, morphology, hemocompatibility, cytotoxicity, and animal testing.</p><p><strong>Results: </strong>The hydrogels exhibited porous designs with interconnected pores, with a mean size of 119.73 ± 13.67. They also showed a swelling capability of up to 90% of their starting weight within 48 h. The hydrogels also demonstrated both biocompatibility and hemocompatibility characteristics. In the final phase, the assessment of wound healing in the animal model revealed that using the synthesized hydrogels greatly enhanced the healing process (closure of the wound area: 88.73 ± 3.95%).</p><p><strong>Conclusion: </strong>In summary, this scaffold has shown promise in promoting tissue re-epithelialization and regeneration, which makes it a highly favorable option for improving the healing of skin wounds.</p>","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"32 9","pages":"e70383"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13598798/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149025894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Knowledge, Attitudes, Practices and Perceptions Regarding the Use of Sunscreen Among Pharmacists in Jordan.","authors":"Alaa Alghananim, Roua Aldala'een, Abdallah Y Naser, Alaa Ahmed Alsharif, Sarah Khamis","doi":"10.1111/srt.70379","DOIUrl":"10.1111/srt.70379","url":null,"abstract":"<p><strong>Background: </strong>Sunscreens are agents to protect the skin from the destructive effects of ultraviolet (UV) radiation. Pharmacists are expert healthcare providers who guide consumers regarding the usage of sunscreen. This study aims to evaluate pharmacists' knowledge, attitudes, practices and perceptions regarding sunscreen use in Jordan.</p><p><strong>Method: </strong>A cross-sectional study was conducted among pharmacists in Jordan using a self-administered questionnaire created using Google Forms and distributed online social media platforms. The questionnaire contained five sections to assess demographics (9 items), knowledge (11 items), attitudes (8 items), practices (12 items) and perceptions (2 items). The data was analyzed using descriptive and inferential statistics.</p><p><strong>Results: </strong>A total of 407 pharmacists working in different fields completed the survey, 79.6% were female and 20.4% male. 56.5% of participants were under 30 years old, while 56% of participants had less than 5 years' experience. The results showed that knowledge, attitude and practice scores were significantly associated with age (p = 0.011 and p < 0.001, respectively). In addition, 53.8% of participants were familiar with the Fitzpatrick scale of skin type that categorizes the skin into six types, and 232 participants (57.0%) responded correctly regarding the classification of active ingredients in sunscreen agents. Participants with 5-10 years of experience were less likely (adjusted odds ratio (aOR): 0.59 (95%CI: 0.37-0.94); p-value < 0.05) to have better knowledge of sunscreen compared to others (p < 0.05). Participants aged 30-39 years (aOR: 2.13 (95%CI: 1.34-3.38), p-value < 0.01), those with postgraduate studies (aOR: 2.85 (95%CI: 1.41-5.77), p-value < 0.01), those with 11-15 years of experience (aOR: 2.37 (95%CI: 1.11-5.05), p-value < 0.05), those who work in academia (aOR: 2.65 (95%CI: 1.15-6.10), p-value < 0.05), those who were married (aOR: 1.83 (95%CI: 1.22-2.75), p-value < 0.01), and those who graduated from a public university (aOR: 2.33 (95%CI: 1.55-3.51), p-value < 0.001) were more likely to show positive attitude towards the use of sunscreen.</p><p><strong>Conclusion: </strong>Jordanian pharmacists' knowledge and practice of sunscreen use were generally adequate; however, specific gaps were identified in certain areas. This demonstrated that pharmacists need more specialized courses during their continuing professional development to address these gaps and improve their knowledge and abilities.</p>","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"32 9","pages":"e70379"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13530385/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148866672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced Imaging Techniques for Early in-Vivo Discrimination of Fibrofolliculomas in Birt-Hogg-Dubé Syndrome.","authors":"Maximilian Deußing, Daniela Hartmann, Pontus Mertsch, Charlotte Gust, Michael J Flaig, Marlene Reithmair, Julia Hoefele, Elke C Sattler","doi":"10.1111/srt.70381","DOIUrl":"10.1111/srt.70381","url":null,"abstract":"<p><strong>Background: </strong>Birt-Hogg-Dubé syndrome (BHDS) is a rare genetic tumor syndrome characterized by cutaneous fibrofolliculoma and trichodiscomas, lung bullae with an elevated risk of spontaneous pneumothorax and renal cell cancer.</p><p><strong>Objectives: </strong>Due to rareness of the disease, clinical symptoms and cutaneous manifestations are often misjudged, resulting in delayed medical diagnosis and considerable health risks for patients and their families. Accurate discrimination of fibrofolliculomas from other non-malignant skin tumors can be crucial for early diagnosis and appropriate management of BHDS. In addition, they may clinically overlap with adnexal or follicular papules seen in other rare genodermatoses, including facial angiofibromas in tuberous sclerosis complex, trichilemmomas in Cowden syndrome/PTEN hamartoma tumor syndrome, and trichoepitheliomas in CYLD cutaneous syndrome.</p><p><strong>Methods: </strong>In this study, skin lesions from 15 BHDS patients with genetic confirmed disease-causing variants in FLCN underwent reflectance confocal microscopy (RCM) and Line-Field Confocal Optical Coherence Tomography (LC-OCT) to systematically analyse the morphologic and microstructural features of fibrofolliculomas.</p><p><strong>Results: </strong>In RCM a dilated follicular unit was seen in 12/15 cases (80%), while in LC-OCT this feature was seen in 13/15 (87%). The characteristic round, onion-like shaped hyperreflective structures with a well-demarcated perifollicular halo, corresponding to the histopathological features of branching chords and strands of epithelial cells was seen in all cases (RCM and LC-OCT 100%), aiding clinicians in identifying fibrofolliculomas.</p><p><strong>Conclusion: </strong>Advanced imaging techniques provide a non-invasive approach for early diagnosis of fibrofolliculomas. Therefore, RCM and especially LC-OCT may be promising tools for enhancing the diagnostic precision and sufficient clinical management of Birt-Hogg-Dubé syndrome.</p>","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"32 9","pages":"e70381"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13570421/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148956687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}