Skin Research and Technology最新文献

{"title":"Choosing the Right Tewl Device: A Comparison of Inter- and Intra-Device Reliability of the Vapometer and Dermalab across Measurement Ranges.","authors":"Tanja Klotz, Suzanne Edwards, Guy Maddern, Marcus Wagstaff","doi":"10.1111/srt.70358","DOIUrl":"https://doi.org/10.1111/srt.70358","url":null,"abstract":"<p><strong>Background: </strong>Measurement of transepidermal water loss (TEWL) is widely used to evaluate skin barrier function.</p><p><strong>Materials and methods: </strong>This study compared two devices-the DermaLab (DL) TEWL probe and the VapoMeter (VM) - from data collected across three studies to measure TEWL in scarred and normal skin. Each site was measured three times per device, alternating devices to allow vapor clearance. Inter-device reliability was assessed from 1,617 paired locations, each averaged from the three readings. Intra-observer reliability was able to be determined from a dataset of 1,628 DL and 1,635 VM measurements.</p><p><strong>Results: </strong>Data were stratified into low, medium, and high TEWL ranges based on measurement distribution and observations. Overall inter-device reliability was 'good' but varied by range: 'poor' in low, 'excellent' in medium, and 'moderate' in high TEWL ranges. In the medium range, the VM reported nearly twice the TEWL values compared to the DL, while in the high range, it read approximately 34% higher.</p><p><strong>Conclusions: </strong>Both devices showed excellent intra-observer reliability overall. However, in the low TEWL range, the DL exhibited 'moderate' reliability, whereas the VM showed slightly better, 'good' reliability. Differences in chamber architecture-semiopen for the DermaLab and closed for the VM-appear to drive the observed variability in measurement reliability across TEWL ranges. Analysis of this large dataset indicates that the VM likely approaches saturation at the categorized 'high' TEWL values, constraining its accuracy, whereas the DermaLab exhibits reduced measurement stability at low TEWL levels, limiting its applicability under those conditions. Targeted methodological work is needed to refine DL performance in the lowTEWL regime and to more precisely define the upper operational limit of the VM.</p>","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"32 5","pages":"e70358"},"PeriodicalIF":3.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13140847/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147842424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: The Effects of 1064 nm Laser on Red Telangiectasias Using Pulse Shape Modulation.","authors":"","doi":"10.1111/srt.70348","DOIUrl":"10.1111/srt.70348","url":null,"abstract":"","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"32 4","pages":"e70348"},"PeriodicalIF":3.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13052103/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147609793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Using the AOPT-LTL Technique for the Treatment of Melasma: A Clinical Study.","authors":"Qingmei Jin, Richeng Dong, Jiahui Zhi, Meilan Nan, Longquan Pi, Zhehu Jin, Chenglong Jin","doi":"10.1111/srt.70347","DOIUrl":"10.1111/srt.70347","url":null,"abstract":"<p><strong>Background: </strong>Melasma is a common acquired pigmentation disorder, with a high incidence rate in women. Owing to the complex pathogenesis of melasma, there is currently no unified treatment. Advanced optimal pulse technology with low energy, three pulses, and long pulse width (AOPT-LTL) is a treatment technique based on the photomodulatory effect of optimal pulse technology (OPT), which has been used in the treatment of sensitive skin and rosacea.</p><p><strong>Aims: </strong>To evaluate the efficacy and safety of AOPT-LTL for the treatment of melasma.</p><p><strong>Methods: </strong>Twenty-five Chinese females with melasma were enrolled. AOPT-LTL treatments were delivered at 2-week intervals. The melasma area and severity index (MASI) score, clinician erythema assessment (CEA) score, clinical efficacy, incidence of adverse reactions, and patient satisfaction were compared between baseline and post-treatment.</p><p><strong>Results: </strong>All patients were treated and followed up. After 1 month of treatment, skin inflammation decreased, and pigmentation started to fade. With continued treatment, the inflammation progressively reduced, the affected area became smaller, and pigmentation lightened further. After the first course of treatment, 19 patients had a declined rate of MASI (MDR) >20%, and the effective rate was 76%. At the end of treatment, the MASI score and CEA score of all patients decreased significantly. Moreover, the MDR of all patients was >20%, and the effective rate of treatment was 100%. During treatment, all patients had no obvious adverse reactions, no recurrence after follow-up for 3 months, and patient satisfaction was high.</p><p><strong>Conclusions: </strong>AOPT-LTL is effective and safe for treating melasma.</p>","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"32 4","pages":"e70347"},"PeriodicalIF":3.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13055887/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147634238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical Excision of Plantar Wart.","authors":"María José Chiva Miralles","doi":"10.1111/srt.70327","DOIUrl":"10.1111/srt.70327","url":null,"abstract":"<p><p>B&G: Plantar warts are common reasons for consultation and present multiple treatments as well as varying results.</p><p><strong>Methods: </strong>This clinical case demonstrates the step-by-step process for surgical removal of plantar warts.</p><p><strong>Results: </strong>Healing times are shorter than with conventional treatments.</p><p><strong>Conclusion: </strong>Surgical removal of plantar warts is a first-line treatment.</p>","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"32 4","pages":"e70327"},"PeriodicalIF":3.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13084331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147691438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revealing Hidden Clues: The \"Rubbing Technique\" to Enhance Detection of Nodular Basal Cell Carcinoma.","authors":"Zyber Hasa, Roberta Vezzoni, Filippo Chersi, Erika Giulioni, Iris Zalaudek","doi":"10.1111/srt.70302","DOIUrl":"https://doi.org/10.1111/srt.70302","url":null,"abstract":"<p><p>Nodular basal cell carcinoma (nBCC) of the face can be challenging to diagnose in its early stages. We report our observation of a simple and rapid clinical maneuver that enhances the visualization of arborizing vessels, erosions, and bleeding, thereby facilitating the identification of nBCC. This preliminary observation suggests that the technique may reduce unnecessary biopsies, preserve cosmetic outcomes, and support timelier patient management.</p>","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"32 4","pages":"e70302"},"PeriodicalIF":3.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13111756/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147780121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: \"Effect of Interleukin‑12 Gene Expression on Insulin Resistance in Patients With Acne Vulgaris\".","authors":"","doi":"10.1111/srt.70355","DOIUrl":"https://doi.org/10.1111/srt.70355","url":null,"abstract":"","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"32 4","pages":"e70355"},"PeriodicalIF":3.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13107163/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147780021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Aromatherapy Oil Applications on Strıae Gravidarum: A Systematic Review.","authors":"Tuba Güner Emül, Emine Kaplan Serin","doi":"10.1111/srt.70354","DOIUrl":"10.1111/srt.70354","url":null,"abstract":"<p><strong>Background: </strong>Striae gravidarum is a skin change that occurs during pregnancy, which does not pose a physiological threat to health but can cause psychological distress for individuals. Women may use moisturizers or aromatherapeutic oils in attempts to prevent the formation of striae.</p><p><strong>Aim: </strong>The purpose of this study is to review the literature on randomized controlled trials evaluating the effectiveness of aromatherapy oils in preventing striae gravidarum.</p><p><strong>Methods: </strong>The protocol for this systematic review and the writing of the article were based on the PRISMA-P (Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols) criteria. The systematic review was conducted using the Google Scholar, PubMed, Web of Science, Scopus, and Cochrane Library databases between December 2024 and January 2025. Studies were selected by defining inclusion and exclusion criteria according to the PICOS method.</p><p><strong>Results: </strong>This systematic review included four randomized controlled trials with a total of participants. Two of the studies were published in 2024, one in 2022, and the other in 2020. This systematic review included four randomized controlled trials with a total of 671 pregnant participants. The essential oils used in the studies included coconut oil, rose oil, sesame oil, sweet almond oil, and olive oil. The studies found that coconut oil was effective in preventing striae gravidarum, while rose, sesame, and sweet almond oils were not effective.</p><p><strong>Conclusion: </strong>There is some evidence for the effect of aromatherapy in preventing striae gravidarum. However, larger sample sizes, higher-quality studies, and randomized controlled trials with blinding methods are needed to evaluate the effectiveness of aromatherapy oils and determine their beneficial effects on pregnant women.</p>","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"32 4","pages":"e70354"},"PeriodicalIF":3.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13084530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147692080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biometric Evaluation of Baumann Skin Typing.","authors":"Shohreh Delavar, Aireza Firooz, Mansour Nassiri Kashani, Saman Ahmad Nasrollahi, Fatemeh Amiri, Taraneh Yazdanparast","doi":"10.1111/srt.70338","DOIUrl":"10.1111/srt.70338","url":null,"abstract":"<p><strong>Introduction: </strong>With the increasing demand for personalized skincare, accurate identification of individual skin types has become essential. The Baumann skin type (BST) classification system is widely used in clinical and commercial settings, yet lacks sufficient biometric validation. This study aims to evaluate the correlation between BST categories and objective skin biophysical parameters.</p><p><strong>Materials & methods: </strong>Seventy-one healthy volunteers participated in the study. Skin parameters including stratum corneum hydration, transepidermal water loss (TEWL), melanin index, sebum levels, elasticity, and pH were measured using the MPA 580 system. Skin thickness and echodensity of the epidermis and dermis were assessed via high-frequency ultrasound (HFU), while depth, area, and volume of the nasolabial folds were analyzed using VisioFace CSI software. Each participant completed the BST questionnaire, and correlations between BST scores and measured skin parameters were assessed using Pearson's correlation coefficient.</p><p><strong>Results: </strong>The oily vs. dry score was correlated with hydration (r = 0.08, p = 0.507), TEWL (r = -0.065, p = 0.591), and sebum (r = 0.299, p = 0.011). The sensitive vs.resistant score correlated with TEWL (r = 0.388, p = 0.001) and pH (r =  0.445, p < 0.001). The pigmented vs. non-pigmented score correlated with melanin index (r =  0.280, p = 0.018). The wrinkle vs. tight score was correlated with skin firmness (R0; r = 0.495, p< 0.001), total skin elasticity (R2; r = -0.318, p = 0.007), dermal thickness (r = -0.242, p = 0.042), dermal density (r = -0.189, p = 0.115), epidermal thickness (r = -0.128, p = 0.288), nasolabial fold volume (r = 0.138, p = 0.250), surface (r = 0.150, p = 0.213), and depth (r = 0.048, p = 0.690).</p><p><strong>Conclusion: </strong>The oily vs. dry (O/D) score showed a poor but significant correlation with sebum, while hydration and TEWL were not significant. The pigmented vs. non-pigmented (P/NP) score demonstrated a poor but significant correlation with the melanin index. The sensitive vs. resistant (S/R) score showed fair and significant correlations with TEWL and pH. The wrinkle-tight (W/T) score showed fair and statistically significant correlations with elasticity parameters (R0 and R2), while correlations with nasolabial fold parameters, dermal density, and epidermal thickness were not significant; dermal thickness showed a poor but statistically significant correlation.</p>","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"32 4","pages":"e70338"},"PeriodicalIF":3.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13074428/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147676212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Efficacy and Safety of Fractional CO₂ Laser and Gold Microneedling Radiofrequency for Atrophic Acne Scars: A Systematic Review.","authors":"Xiaoyan Xiang, Weilong Shuai, Yunzhu Mu","doi":"10.1111/srt.70345","DOIUrl":"10.1111/srt.70345","url":null,"abstract":"<p><strong>Background: </strong>Acne is a prevalent dermatological disorder that profoundly affects patients' quality of life, frequently resulting in both physical discomfort and psychological distress. Conventional treatments, including topical agents, oral medications, and chemical peels, are primarily designed to alleviate symptoms but may be insufficient in effectively addressing persistent acne scars. Recent innovations in therapeutic technologies, such as microneedling radiofrequency (RF) and fractional carbon dioxide (CO₂) laser, have demonstrated significant potential in enhancing skin regeneration and improving the aesthetic appearance of acne scars.</p><p><strong>Materials and methods: </strong>Microneedling RF operates by generating mechanical microinjuries in conjunction with RF energy, thereby stimulating dermal remodeling and collagen synthesis. In contrast, fractional CO₂ laser creates precisely controlled microthermal zones that facilitate wound healing and promote the regeneration of new tissue. This review critically examines the clinical efficacy of these two modalities, exploring their individual mechanisms and comparing treatment outcomes. Additionally, the potential synergistic effects of combining these technologies are discussed.</p><p><strong>Results: </strong>Both microneedling RF and fractional CO₂ laser have demonstrated clinical efficacy in treating acne scars. The treatment outcomes, however, may vary depending on patient-specific factors and treatment parameters. The combined use of these modalities is currently under investigation for its potential to enhance therapeutic effects.</p><p><strong>Conclusion: </strong>Microneedling RF and fractional CO₂ laser have proven to be effective in improving acne scars, with promising results in skin regeneration and scar appearance. Future research should focus on refining treatment protocols and exploring the synergistic effects of combining these approaches to optimize clinical outcomes.</p>","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"32 4","pages":"e70345"},"PeriodicalIF":3.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13052295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147609786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shake-Induced Temporary Ion-Pairing Between Lecithin and Glycolic Acid for Enhanced Exfoliation in a Novel Biphasic Serum: Comparative Ex Vivo and in Vivo Randomised Studies.","authors":"Koo Chul Kwon, Mi Jung Kim","doi":"10.1111/srt.70349","DOIUrl":"10.1111/srt.70349","url":null,"abstract":"<p><strong>Background: </strong>Chemical exfoliation efficacy is significantly limited by pH-dependent permeability reduction above the pKa of glycolic acid (3.83), constraining consumer product development.</p><p><strong>Objective: </strong>To develop and evaluate a biphasic serum utilizing temporary lecithin-glycolate ion-pairing to enhance stratum corneum permeation while maintaining safety at pH 3.9.</p><p><strong>Methods: </strong>A biphasic formulation containing 10 wt% (weight percent) glycolic acid and 0.1 wt% lecithin was developed. Temporary ion-pairing was characterized by FT-IR spectroscopy. Ex vivo permeation and exfoliation were evaluated using porcine skin models. A 2-week double-blind, split-face clinical study (n = 37) assessed efficacy using instrumental probes (Visioscan, Corneofix, VISIA-CR, and ANTERA 3D) for exfoliation-related parameters and sensitive skin compatibility.</p><p><strong>Results: </strong>FT-IR analysis confirmed lecithin-glycolate bonding via red-shifted C = O peaks, with spectral comparisons before and after shaking demonstrating the reversible nature of the change. The biphasic serum achieved 4.19-fold higher epidermal glycolic acid delivery compared to conventional formulations with minimal deep penetration. Clinical evaluation demonstrated superior exfoliation (45.52% improvement, p < 0.001), enhanced skin brightness, texture, and hydration. Redness and transepidermal water loss, assessed for sensitive skin suitability, showed significant improvements.</p><p><strong>Conclusion: </strong>The biphasic system successfully overcomes pH-dependent limitations of glycolic acid through temporary ion-pairing, providing enhanced exfoliation efficacy with a superior safety profile for consumer applications.</p>","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"32 4","pages":"e70349"},"PeriodicalIF":3.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13083595/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147692091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}