Skin Research and Technology最新文献

{"title":"Surface Characterization of Skin Substitute Materials.","authors":"Alexander Jaekel, Michaela Wirtz","doi":"10.1111/srt.70187","DOIUrl":"10.1111/srt.70187","url":null,"abstract":"<p><strong>Background: </strong>Transdermal therapeutic systems use substance transport through the skin to provide an active pharmaceutical ingredient. To ensure a reliable supply, adhesion to skin must be guaranteed. In practice in vivo studies as well as in vitro studies on steel (ISO-standard for self-adhesive tapes) are used. As in vitro-in vivo correlation is poor, extensive in vivo studies are applied during industrial product performance tests. Hence, a specialized skin substitute material for in vitro adhesion testing is needed.</p><p><strong>Materials and methods: </strong>Synthetic leather (polyurethane), silicone (Dragon Skin), gelatines, and VitroSkin are used as skin substitute materials. For topographical analysis, reflected light microscopy and confocal light microscopy are applied. Infrared spectroscopy is performed for analysis of functional groups. Dermatological skin probe systems are used to analyze friction, surface pH, and elasticity. To bundle all data with regards to skin similarity, mid-level data fusion is applied.</p><p><strong>Results: </strong>For all substitute materials, common topographic characteristics compared to human skin can be observed. However, all materials show limitations regarding their topography. Gelatine and VitroSkin feature comparable surface functionality compared to human skin. All materials show significant deficits in their mechanical properties. All characteristics can be summarized as the Skin Similarity Index to give a comprehensive overview regarding substitutes similarity to skin.</p><p><strong>Conclusions: </strong>A comprehensive evaluation of topography, chemical functionality, and mechanical properties regarding a skin substitutes similarity to human skin was performed. This data should be considered as a baseline for further research in the field of adhesion to skin. By adding further characteristics and materials, it is a versatile approach that can be implemented in a variety of areas.</p>","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"31 7","pages":"e70187"},"PeriodicalIF":2.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12206586/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144529517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: Clinical Application of 675 Nm Laser Therapy for Dorsal Hand Skin Hyperpigmentation.","authors":"","doi":"10.1111/srt.70214","DOIUrl":"10.1111/srt.70214","url":null,"abstract":"","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"31 7","pages":"e70214"},"PeriodicalIF":2.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12280396/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144683031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seborrheic Keratosis-Like Melanoma: Novel Insights Into Clinical, Dermoscopic, and Reflectance Confocal Microscopy Diagnosis of an Atypical Melanoma Variant.","authors":"Federico Venturi, Stephano Cedirian, Giulia Veronesi, Biagio Scotti, Carlotta Baraldi, Emi Dika","doi":"10.1111/srt.70206","DOIUrl":"10.1111/srt.70206","url":null,"abstract":"<p><strong>Background: </strong>Studies have found that few lesions clinically diagnosed as seborrheic keratosis (SK) revealed Cutaneous melanoma (CM) on histopathology. When CM mimics SK, they are defined as seborrheic keratosis-like melanoma (SKLM), and a delayed diagnosis and treatment can occur.</p><p><strong>Methods: </strong>We conducted a retrospective descriptive, monocentric study of the epidemiological, clinical, videodermoscopy (VDS), and reflectance confocal microscopy (RCM) characteristics of histopathologically proven SKLM diagnosed between 2018 and 2024.</p><p><strong>Results: </strong>The study population consisted of 60 patients: 44 males (73.3%) and 16 females (26.7%) with lesions located in 73.3% of cases on the trunk. Concerning histological type, superficial spreading melanoma was the more frequent (86.7%). More than 50% of tumors had a Breslow thickness <0.8 mm. The findings from the VDS examination using the revised Argenziano Seven Point Checklist revealed that 100% of cases presented at least one dermoscopic melanoma-specific criterion and, for this reason, had an indication for surgical excision. Typical RCM patterns associated with melanoma diagnosis were observed, including irregular honeycomb/cobblestone pattern (82.1%), irregular DEJ nests (78.6%), dermal inflammation (53.6%), irregular dermal nests (53.6%), dendritic cells in sheets/tangled lines (50%), and atypical round cells (39.3%).</p><p><strong>Conclusion: </strong>Our study provides valuable insights into the dermoscopic, RCM, and histological features of SKLM based on the largest monocentric cohort. The distinctive dermoscopic patterns, along with the confocal features, aid in the differentiation from other pigmented lesions.</p>","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"31 7","pages":"e70206"},"PeriodicalIF":2.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12254041/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144620349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: Dermoscopic and Reflectance Confocal Microscopic Features of Children Scabies.","authors":"","doi":"10.1111/srt.70211","DOIUrl":"10.1111/srt.70211","url":null,"abstract":"","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"31 7","pages":"e70211"},"PeriodicalIF":2.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12280394/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144683033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: Evaluating the Results of Eyebrow Lift by Combining Methods of Subcutaneous Flap and Thread Support in Patients with Droopy Eyebrows.","authors":"","doi":"10.1111/srt.70210","DOIUrl":"10.1111/srt.70210","url":null,"abstract":"","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"31 7","pages":"e70210"},"PeriodicalIF":2.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12280228/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144683034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Menopause, Menstrual Cycle, and Skin Barrier Function.","authors":"Đurđa Cvjetković Nikoletić, David Ivanov, Olivera Levakov, Jelena Bulajić, Sonja Lukač, Vedrana Karan Rakić, Milana Ivkov-Simić","doi":"10.1111/srt.70203","DOIUrl":"10.1111/srt.70203","url":null,"abstract":"<p><strong>Background: </strong>There are a limited number of studies describing the impact of the menstrual cycle and postmenopause on the skin barrier function, and existing research data are conflicting. The aim of our research was to investigate the impact of the menstrual cycle and postmenopause on the epidermal barrier function and its main biophysical parameters-transepidermal water loss (TEWL) and skin hydration (SH).</p><p><strong>Materials and methods: </strong>Eighty-one female participants were included in the study, aged 18-65 years, of which 36 in the reproductive period (average age 27.06 ± 5.60 years) and 45 in postmenopause (average age 56.56 ± 4.37 years). TEWL and SH were measured during the ovulatory and mid-luteal phases in participants in the reproductive period, and on two occasions, 7 days apart, in posmenopausal participants.</p><p><strong>Results: </strong>The mean TEWL value was significantly higher in the mid-luteal phase (TEWL 2; 9.92 ± 1.37) compared to the ovulatory phase (TEWL 1; 8.87 ± 1.59). However, no significant difference in TEWL was observed between the two groups of participants. The mean SH value was significantly higher in the ovulatory phase (SH 1; 40.55 ± 7.80) compared to the mid-luteal phase (SH 2; 36.27 ± 7.42). Moreover, SH in the ovulatory phase was significantly higher in comparison to the postmenopausal group (40.55:36.27; p = 0.009).</p><p><strong>Conclusion: </strong>Our study indicates a more functional epidermal barrier during the ovulatory phase, as evidenced by higher TEWL values and lower SH values compared to the mid-luteal phase. However, the differences between the two participant groups remain intriguing, as no significant difference in TEWL was observed between them, despite significantly higher SH values in the ovulatory phase compared to the postmenopausal group.</p>","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"31 7","pages":"e70203"},"PeriodicalIF":2.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12206585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144529516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: Cosentyx Alleviates Psoriasis-Induced Podocyte Injury by Inhibiting the TLR/NF-κB Signaling Pathway.","authors":"","doi":"10.1111/srt.70213","DOIUrl":"10.1111/srt.70213","url":null,"abstract":"","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"31 7","pages":"e70213"},"PeriodicalIF":2.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12280397/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144683032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: Causal Relationship Between Dyslipidemia and Risk of Facial Aging: Insights From Mendelian Randomization in East Asian Populations.","authors":"","doi":"10.1111/srt.70201","DOIUrl":"10.1111/srt.70201","url":null,"abstract":"","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"31 6","pages":"e70201"},"PeriodicalIF":2.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12181390/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: Genetic Causal Relationship between Gut Microbiota and Basal Cell Carcinoma: A Two-Sample Mendelian Randomization Study.","authors":"","doi":"10.1111/srt.70198","DOIUrl":"10.1111/srt.70198","url":null,"abstract":"","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"31 6","pages":"e70198"},"PeriodicalIF":2.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12181641/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Dermatoprotective Properties of Clinopodium nepeta and Thymus vulgaris Essential Oils: Phytochemical Analysis, Anti-Elastase, Anti-Tyrosinase, Photoprotective Activities, and Antimicrobial Potential Against Dermatopathogenic Strains.","authors":"Mohamed Taibi, Amine Elbouzidi, Nour Eddine Bentouhami, Mounir Haddou, Abdellah Baraich, Yousra Hammouti, Yousra Belbachir, Reda Bellaouchi, Ramzi A Mothana, Mohammed F Hawwal, Abdeslam Asehraou, Salwa Karboune, Mohamed Addi, Bouchra El Guerrouj, Khalid Chaabane","doi":"10.1111/srt.70191","DOIUrl":"10.1111/srt.70191","url":null,"abstract":"<p><strong>Background: </strong>The growing demand on natural ingredients in cosmetics has immensely contributed to a renewed interest in cosmetic industry in plant derivatives, especially essential oils. The aim of this study is to examine the dermatoprotective and antifungal properties of Clinopodium nepeta (CNEO) and Thymus vulgaris (TVEO) essential oils.</p><p><strong>Materials and methods: </strong>Gas chromatography-mass spectrometry (GC-MS) analysis was performed to identify the chemical composition of the essential oils. Anti-elastase and anti-tyrosinase activities were evaluated using standard enzymatic inhibition assays, and IC₅₀ values were calculated. Photoprotective properties were determined using in vitro sun protection factor (SPF) calculations. Antifungal and antibacterial activities were assessed using the disc diffusion method and minimum inhibitory concentration (MIC) determination against Candida albicans, Candida glabrata, Micrococcus luteus, and Staphylococcus aureus.</p><p><strong>Results: </strong>GC-MS analysis revealed the presence of 13 compounds in CNEO, mainly oxygenated monoterpenes (91.9%) with pulegone (42.3%) as the main component, and 25 compounds in TVEO, with α-terpineol (19.8%) and carvacrol (13.5%) as the dominant compounds. CNEO showed superior anti-elastase activity (IC₅₀ = 13.55 ± 0.81 µg/mL) compared with TVEO (IC₅₀ = 28.40 ± 2.64 µg/mL). Both oils demonstrated significant anti-tyrosinase effects, with CNEO showing greater efficacy in inhibiting monophenolase (IC₅₀ = 36.71 ± 4.09 µg/mL) and diphenolase (IC₅₀ = 22.77 ± 0.97 µg/mL) than TVEO. SPF calculations revealed notable photoprotective properties for both oils, with CNEO (SPF = 6.472) slightly outperforming TVEO (SPF = 5.640). Antifungal tests against C. albicans and C. glabrata, and antibacterial tests against M. luteus and S. aureus showed that both oils possess strong antifungal and antibacterial activities, with CNEO demonstrating superior efficacy (MIC = 0.50 ± 0.00% v/v for both Candida strains) compared with TVEO (MIC = 0.011 ± 0.00% v/v for both Candida strains).</p><p><strong>Conclusion: </strong>This study provides the first comprehensive assessment of the dermatoprotective, antifungal, and antibacterial activities of CNEO and confirms the potential of TVEO in cosmetic, antifungal, and antibacterial applications. The results suggest that these essential oils could serve as promising natural ingredients in dermatoprotective, antifungal, and antibacterial formulations.</p>","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"31 6","pages":"e70191"},"PeriodicalIF":2.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12165951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144294922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}