Skin Research and Technology最新文献_第2页

Cosmetic Interventions for Skin Microbiome Modulation: Current Strategies and Future Directions. 皮肤微生物组调节的美容干预：当前策略和未来方向。

IF 3.2 4区医学

Skin Research and Technology Pub Date : 2026-04-01 DOI: 10.1111/srt.70352

Raquel Taléns-Visconti, Octavio Diez-Sales, Amparo Nácher

{"title":"Cosmetic Interventions for Skin Microbiome Modulation: Current Strategies and Future Directions.","authors":"Raquel Taléns-Visconti, Octavio Diez-Sales, Amparo Nácher","doi":"10.1111/srt.70352","DOIUrl":"10.1111/srt.70352","url":null,"abstract":"Background: Human skin harbors a highly diverse and dynamic microbiome that maintains barrier function and homeostasis, while endogenous/exogenous factors and cosmetic products modulate microbial balance. Dysbiosis contributes to inflammatory diseases like atopic dermatitis and acne; however, evidence for microbiome-targeted cosmetics remains preliminary. This article critically examines the impact of cosmetic products on the skin microbiota, distinguishing between potentially harmful formulations and those specifically developed to preserve microbial balance, collectively termed \"microbiome-friendly\" cosmetics.Materials and methods: This narrative review synthesizes clinical, microbiological, and mechanistic studies on the skin microbiome's composition, endogenous/exogenous determinants, dysbiosis in skin diseases, and the impact of conventional and microbiome‑targeted cosmetics. Databases were searched up to January 2026 for peer‑reviewed studies, with emphasis on human clinical trials and systematic analyses.Results: Most conventional cosmetics do not induce major dysbiosis in healthy skin when properly formulated. For advanced formulations, including ingredients such as probiotics, prebiotics, postbiotics, and paraprobiotics, early clinical and microbiological studies report promising benefits without compromising microbial diversity. However, evidence is limited by heterogeneous designs, small sample sizes, and the lack of standardized criteria for \"microbiome‑friendly\" claims.Conclusions: The evidence indicates that informed cosmetic selection and use of skincare products support microbiome balance as a complementary skin health strategy as may be key for both preventative and therapeutic strategies in managing skin disorders, just as allowing a dynamic understanding of the skin microbiome to improve human health.","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"32 4","pages":"e70352"},"PeriodicalIF":3.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13084527/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147692088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dermoscopic Features of Plantar and Palmar Melanocytic Nevi in Children: Dermoscopy of Children's Plantar and Palmar Melanocytic Nevi. 儿童足底及掌黑素细胞痣的皮肤镜特征：儿童足底及掌黑素细胞痣的皮肤镜检查。

IF 3.2 4区医学

Skin Research and Technology Pub Date : 2026-04-01 DOI: 10.1111/srt.70350

Zixing Cui, Jianping Wu, Ling Fang, Chuanli Ren

{"title":"Dermoscopic Features of Plantar and Palmar Melanocytic Nevi in Children: Dermoscopy of Children's Plantar and Palmar Melanocytic Nevi.","authors":"Zixing Cui, Jianping Wu, Ling Fang, Chuanli Ren","doi":"10.1111/srt.70350","DOIUrl":"10.1111/srt.70350","url":null,"abstract":"Introduction: Plantar and palmar melanocytic nevi constitute a distinct subtype of nevi, characterized by unique dermoscopic patterns. Currently, limited research has focused on the dermoscopic features of plantar and palmar melanocytic nevi in children.Objective: To characterize the dermoscopic features of congenital and acquired plantar and palmar melanocytic nevus in children and to evaluate the diagnostic contribution of dermoscopy.Methods: A retrospective analysis was conducted on 180 pediatric patients initially clinically diagnosed with plantar and palmar nevi. Dermoscopic evaluation was performed using Dermo-II system, followed by histopathological confirmation.Results: Histopathology confirmed 172 plantar and palmar nevi and 8 cases of black heel. The most prevalent dermoscopic patterns were the parallel furrow pattern (54.65%), fibrillar pattern (22.09%), and reticular pattern (10.47%). No significant differences were observed between congenital and acquired nevi. Dermoscopy achieved 100% concordance with histopathology, significantly higher than clinical diagnosis alone (95.56%; p = 0.0075).Conclusion: Dermoscopy is a reliable, non-invasive adjunct for diagnosing pediatric plantar and palmar nevi, potentially reducing unnecessary excisions.","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"32 4","pages":"e70350"},"PeriodicalIF":3.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13084522/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147692124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Establishment of a BALB/c Mouse Model for Photoaged Skin: Insights into UV-Induced Dermatological Changes. BALB/c小鼠光老化皮肤模型的建立：对紫外线引起的皮肤变化的见解。

IF 3.2 4区医学

Skin Research and Technology Pub Date : 2026-04-01 DOI: 10.1111/srt.70353

Cuc Bach Huynh, Ngoc Bich Vu, Trung The Van, Phuc Van Pham

{"title":"Establishment of a BALB/c Mouse Model for Photoaged Skin: Insights into UV-Induced Dermatological Changes.","authors":"Cuc Bach Huynh, Ngoc Bich Vu, Trung The Van, Phuc Van Pham","doi":"10.1111/srt.70353","DOIUrl":"https://doi.org/10.1111/srt.70353","url":null,"abstract":"Background: Photoaging, primarily induced by prolonged ultraviolet (UV) radiation exposure, significantly alters skin structure and function, necessitating models for deeper understanding and intervention development. This study aims to establish a BALB/c mouse model for investigating photoaging, leveraging their haired skin and genetic consistency.Materials and methods: Six-week-old female BALB/c mice were subjected to repeated exposure to Ultraviolet A (315-400 nm) (UVA) and Ultraviolet B (280-315 nm) (UVB) radiation at doses corresponding to one and two minimal erythemal doses (MEDs), four times weekly for 12 weeks. Skin aging was evaluated through clinical observations of wrinkles, thickness, hydration, and elasticity, as well as histopathological analyses of epidermal and dermal thickness and collagen degradation. Additionally, gene expression was conducted for collagen Types I and III, and matrix metalloproteinases (MMPs) 1, 2, and 3.Results: UV-exposed mice exhibited significant increases in skin thickness and wrinkle formation, with concurrent decreases in hydration and elasticity compared to controls. Aging signs were more pronounced in the two MED-group than in the one MED-group. Histological assessment showed epidermal hyperplasia, dermal thickening, and collagen degradation. Furthermore, UV irradiation upregulated MMP-1, MMP-2, and MMP-3 expression while downregulating Collagen 1 and 3, indicating molecular pathways of skin aging.Conclusions: The BALB/c mouse model effectively mimics human photoaging under chronic UV exposure using a two-MED protocol, which corresponds to a total dose of 51.8 J/cm2 UVA and 5.53 J/cm2 UVB. This practical model, which exhibits skin features comparable to those of humans, provides a closer approximation of human skin responses for comprehensive studies on the mechanisms and interventions of photoaging.","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"32 4","pages":"e70353"},"PeriodicalIF":3.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13103728/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147779979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RETRACTION: Correlation Between Acanthosis Nigricans Scoring Chart (ANSC) and Narrowband Reflectance Spectrophotometer in Assessing Severity of Acanthosis Nigricans. 结论：黑棘皮评分表（ANSC）与窄带反射分光光度计评价黑棘皮严重程度的相关性。

IF 3.2 4区医学

Skin Research and Technology Pub Date : 2026-03-01 DOI: 10.1111/srt.70341

引用次数: 0

Near-Infrared Spectroscopy Combined With Skin Impedance for Detection of Skin Cancer in Primary Care. 近红外光谱联合皮肤阻抗在初级保健中检测皮肤癌。

IF 3.2 4区医学

Skin Research and Technology Pub Date : 2026-03-01 DOI: 10.1111/srt.70344

Maria Fragkou Dragka, Tommy Löfstedt, Magnus Falk

{"title":"Near-Infrared Spectroscopy Combined With Skin Impedance for Detection of Skin Cancer in Primary Care.","authors":"Maria Fragkou Dragka, Tommy Löfstedt, Magnus Falk","doi":"10.1111/srt.70344","DOIUrl":"10.1111/srt.70344","url":null,"abstract":"Background: The established method in primary care to distinguish skin cancer from benign lesions is clinical examination, with or without dermoscopy. The experience among primary care physicians in assessing skin tumours varies, as does the accessibility to teledermoscopy. To enhance diagnostic performance, improved methods for skin tumour assessment are warranted. The aim of this study was to investigate the diagnostic performance of a non-invasive method that combines near-infrared spectroscopy with skin impedance measurement (NIRIMP) to detect skin cancer in primary care.Material and methods: NIRIMP measurements were collected prospectively from patients seeking primary care for skin lesion examination. The measurements were compared to the true lesion diagnosis using several machine learning methods, to determine the best machine learning methods to use and to determine the diagnostic performance of NIRIMP in distinguishing skin cancer from benign lesions.Results: Eighty participants with 109 lesions were included. Among these, 50 skin cancers or in situ cancers were detected: eight melanomas/in situ melanomas, four in situ squamous cell carcinomas, and 38 basal cell carcinomas. The ability of NIRIMP to distinguish any skin cancer/in situ cancer, as illustrated by the area under the receiver operating characteristics curve (AUC), was 0.776 and for melanomas/in situ melanomas alone the AUC was 0.911. When detecting any skin cancer, the AUC was slightly higher for NIR alone (0.826) compared to NIRIMP (0.776), whereas for IMP alone it was slightly lower (0.693).Conclusions: Near infrared spectroscopy appears to be a promising bioengineering technique to detect skin cancer in primary care settings, of potential benefit for future skin lesion assessment. However, there was no compelling evidence supporting the benefit of adding skin impedance to improve diagnostic performance.","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"32 3","pages":"e70344"},"PeriodicalIF":3.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13097356/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147435273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to "Efficacy of Dual-frequency Noninvasive Monopolar Radiofrequency in Skin Tightening: Histological Evidence". 修正“双频无创单极射频在皮肤紧致中的疗效：组织学证据”。

IF 3.2 4区医学

Skin Research and Technology Pub Date : 2026-03-01 DOI: 10.1111/srt.70335

引用次数: 0

Skin Colour Does Not Define Ethnicity: Quantifying Variation and Overlap Across Diverse Populations. 肤色不能定义种族：量化不同人群的变异和重叠。

IF 3.2 4区医学

Skin Research and Technology Pub Date : 2026-03-01 DOI: 10.1111/srt.70343

Yan Lu, Kaida Xiao, Changjun Li, Michael Pointer

{"title":"Skin Colour Does Not Define Ethnicity: Quantifying Variation and Overlap Across Diverse Populations.","authors":"Yan Lu, Kaida Xiao, Changjun Li, Michael Pointer","doi":"10.1111/srt.70343","DOIUrl":"10.1111/srt.70343","url":null,"abstract":"Background: Skin colour is a prominent human trait historically used to define ethnicity, yet its validity as a classification tool remains questionable.Materials and methods: We quantitatively analyse over 14 000 skin reflectance measurements from eight ethnically diverse groups in the International Skin Spectra Archive (ISSA), using a standard colour space designed to model human visual perception. We assess intragroup variation and intergroup overlap through two complementary approaches: individual-level perceptual differences and group-level shared gamut volumes.Results: Results show that within-group variability in chromaticity and lightness frequently exceeds between-group differences. At the individual level, 89.4% (95% CI: 81.5%-91.9%) of samples have perceptually indistinguishable counterparts across ethnicities. At the group level, the median shared gamut overlap is 60.5% (95% CI: 54.5%-63.6%), indicating substantial overlap in skin colour distributions. The two methods correlate strongly (r = 0.83, p < 0.001), confirming robust intergroup overlap.Conclusion: Skin colour exhibits high within-group dispersion and extensive between-group overlap. These findings challenge the use of skin colour as a reliable indicator of ethnicity and underscore the need for objective, data-driven classification frameworks. They also highlight the complex, continuous nature of human skin variation, beyond simplistic ethnic categories.","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"32 3","pages":"e70343"},"PeriodicalIF":3.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13097458/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147444874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced Whitening Effect of the Formulations via Inhibition of Tyrosinase Activity by Combination of 4-n-Butylresorcinol, Licochalcone A and Glabridin at an Optimal Ratio. 4-正丁基间苯二酚、甘草查尔酮A、光甘草定以最佳配比组合抑制酪氨酸酶活性，增强美白效果。

IF 3.2 4区医学

Skin Research and Technology Pub Date : 2026-03-01 DOI: 10.1111/srt.70334

Tao Zhang, Yiyu Wang, Ying Xu, Yue Liu, Baoxia Zhuang, Xinyuan Zhang, Chungan Liao, Wei Liu, Yanyun Ma

{"title":"Enhanced Whitening Effect of the Formulations via Inhibition of Tyrosinase Activity by Combination of 4-n-Butylresorcinol, Licochalcone A and Glabridin at an Optimal Ratio.","authors":"Tao Zhang, Yiyu Wang, Ying Xu, Yue Liu, Baoxia Zhuang, Xinyuan Zhang, Chungan Liao, Wei Liu, Yanyun Ma","doi":"10.1111/srt.70334","DOIUrl":"10.1111/srt.70334","url":null,"abstract":"Background: Companies launch tons of skin-whitening products to cater to the consumer market. Though skin-whitening cosmeceuticals are continuously developing, most cosmeceuticals are used alone, there is very little academic research conducting investigations into the effect of skin-whitening cosmeceutical combinations.Objective: In this study, we aimed to screen out skin whitening agents and determine their optimal ratio to develop a formula with this combination. Further, to verify the skin whitening efficacy of blue light-induced in in vivo models with or without UV and clinical tests were performed.Materials and methods: Molecular docking simulations were used to screen out the best combination of skin whitening agents when combined in different ratios. In vitro tyrosinase activity and melanin content experiments helped to verify the best ratio combination. Clinical trials were also conducted to confirm the skin whitening efficacy on human skin.Results: 4-n-butylresorcinol, licochalcone A, and glabridin exhibited stronger binding affinities to tyrosinase, and the best combination molar ratio is 5:1:1, which could inhibit both tyrosinase activity and melanin content in vitro. Further, the formulation containing this combination showed good skin whitening efficacy and could even prevent UVA and blue light-induced pigmentation.Conclusion: The 5:1:1 molar ratio of 4-n-butylresorcinol, licochalcone A, and glabridin was the best ratio that could inhibit both tyrosinase activity and melanin content. The formulation containing this ratio combination can enhance the skin whitening efficacy and also can prevent the UV and blue light induced skin pigmentation.","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"32 3","pages":"e70334"},"PeriodicalIF":3.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13098250/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147481295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to "Pthirus pubis infestation of the scalp in a 4-month-old infant:A case report". 纠正“1例4月龄婴儿头皮耻毛感染1例”。

IF 3.2 4区医学

Skin Research and Technology Pub Date : 2026-02-01 DOI: 10.1111/srt.70337

引用次数: 0

Correction to "Dermoscopy and reflectance confocal microscopy-augmented characterization of pigmented micro-basal cell carcinoma (less than 2 mm diameter)." 修正了“皮肤镜和反射共聚焦显微镜-增强特征的色素微基底细胞癌（小于2毫米直径）。”

IF 3.2 4区医学

Skin Research and Technology Pub Date : 2026-02-01 DOI: 10.1111/srt.70306

引用次数: 0