Skin Research and Technology最新文献

{"title":"Demographic Reporting and the Absence of Hispanic/Latino Representation in Dermatology Artificial Intelligence: A Scoping Review.","authors":"Sofía Pérez-Lalinde, Francisco Flores","doi":"10.1111/srt.70385","DOIUrl":"10.1111/srt.70385","url":null,"abstract":"<p><strong>Background: </strong>Artificial intelligence (AI) is increasingly integrated into dermatology, particularly through image-based diagnostic tools. However, concerns persist regarding unequal performance across skin tones and limited demographic transparency in model development. Evidence suggests that AI systems trained predominantly on lighter skin types may perform less accurately in darker phototypes, yet reporting of skin tone, race, and ethnicity remains inconsistent across studies.</p><p><strong>Objective: </strong>To map how dermatology AI studies report skin tone, race and ethnicity, Hispanic/Latino identity, and subgroup diagnostic performance.</p><p><strong>Methods: </strong>PubMed, Embase, and Scopus were searched for articles published between January 2020 and November 2025 that applied AI or deep learning to human dermatologic conditions and reported at least one diagnostic performance metric. Two reviewers independently screened studies and extracted data on demographic reporting, dataset composition, and performance across subgroups.</p><p><strong>Results: </strong>Sixteen studies met inclusion criteria. Most datasets were composed predominantly of lighter skin types (Fitzpatrick I-III), with limited inclusion of Fitzpatrick V-VI. Although thirteen studies reported some form of skin-tone information, reporting approaches varied substantially. Race and ethnicity were inconsistently documented, often using broad categories, and no study explicitly identified Hispanic or Latino participants. Only a minority of studies stratified diagnostic performance by skin tone or demographic subgroups; Among those that performed subgroup analyses, consistent performance disparities were observed, including reduced specificity, increased false-positive rates, and lower overall diagnostic accuracy in darker skin tones.</p><p><strong>Conclusions: </strong>Current dermatology AI literature frequently lacks the demographic transparency necessary to assess algorithmic fairness and generalizability. The underrepresentation of darker skin tones and the absence of Hispanic/Latino identity reporting limit the equitable clinical applicability of existing AI systems. Standardized demographic reporting, intentional dataset diversification, and routine subgroup performance analyses are essential for the development of fair and inclusive dermatology AI tools.</p>","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"32 9","pages":"e70385"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13570332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148956637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined Effect of Silybin and Sodium Acetylated Hyaluronate on UV-Induced Photoaging.","authors":"Sen Hou, Hanliang Song, Jianying Zhang, Anzhang Li","doi":"10.1111/srt.70382","DOIUrl":"10.1111/srt.70382","url":null,"abstract":"<p><strong>Background: </strong>Exposure to solar ultraviolet (UV) radiation is a major cause of skin photoaging, which is characterized by decreased collagen levels in the dermis. Both silybin and sodium acetylated hyaluronate (HA) are potential anti-aging compounds. However, when used alone, both agents show limited anti-aging efficacy. This study aimed to examine the combined effects of silybin and HA on UV-induced skin photoaging and elucidate the underlying mechanisms.</p><p><strong>Methods: </strong>In this study, cytotoxicities of silybin and HA were assessed across a range of concentrations, both with and without UV exposure. We quantified mRNA levels of matrix metalloproteinase-1 (MMP-1), collagen type I (Col I), and collagen type III (Col III) after silybin and HA treatment to study their collagen synthesis promotion and degradation inhibition effects. Reducibility and reactive oxygen species (ROS) scavenging activity were also characterized for each compound. Collagen protein content was then measured after individual and combined treatments.</p><p><strong>Results: </strong>Silybin showed obvious cytotoxicity when its concentration reached 0.01%, while HA remained largely non-toxic even at concentrations of 1%. UV irradiation slightly increased the cytotoxicity of both silybin and HA. Notably, silybin effectively inhibited collagen degradation by downregulating MMP-1 mRNA expression, although it failed to upregulate Col I and III mRNA levels. In contrast, HA did not inhibit, and at higher concentrations slightly elevated, MMP-1 mRNA expression, while it was efficient in promoting Col I and III mRNA expression. Therefore, combined treatment with silybin and HA led to the downregulation of MMP-1 mRNA levels and upregulation of Col I and III mRNA levels. Silybin also showed high reducibility and therefore provided strong ROS scavenging capacity. As MMP-1 synthesis is primarily induced by ROS, silybin exhibited strong MMP-1 inhibition. Meanwhile, HA showed weak ROS scavenging capacity owing to its low reducibility. Nevertheless, the combination of silybin and HA inhibited collagen degradation (primarily via silybin) and promoted Col I and III mRNA expression and protein synthesis (primarily via HA), thereby increasing overall collagen protein levels.</p><p><strong>Conclusions: </strong>This study reveals the complementary mechanisms through which silybin and HA collectively increase dermal collagen levels-silybin by protecting existing collagen from degradation and HA by promoting collagen synthesis-guiding their combined use in cosmetics to protect the skin from UV-induced photoaging.</p>","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"32 9","pages":"e70382"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13570327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148956618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MIR31HG Modulates IL-4 Secretion by Keratinocytes and M2-Like Macrophage Polarization to Promote Local Immunosuppression in Condyloma Acuminata.","authors":"Xiaohang Xie, Lian Liu, Huayu Huang, Yuchun Cao, Zhichao Gu","doi":"10.1111/srt.70384","DOIUrl":"10.1111/srt.70384","url":null,"abstract":"<p><strong>Background: </strong>Condyloma acuminata (CA) is clinically associated with localized immunosuppression, yet the mechanisms underlying HPV-mediated immune evasion remain poorly understood. Although the long non-coding RNA MIR31HG has been implicated in inflammatory regulation, its role in the immunosuppressive microenvironment of CA has not been explored.</p><p><strong>Methods: </strong>We analyzed MIR31HG expression in CA and normal skin tissues. HaCaT cells infected with CA-derived HPV6/11 (HPV6/11-HaCaT) and controls treated with skin-derived supernatant were established to explore the association between HPV6/11 and MIR31HG. The HPV6/11-HaCaT model was further used to investigate the effects of MIR31HG on cytokine secretion and macrophage polarization. Bioinformatic prediction, dual-luciferase reporter assays and rescue experiments targeting PI3K/AKT and IL-4 signaling were performed to investigate the underlying molecular mechanisms.</p><p><strong>Results: </strong>MIR31HG was significantly upregulated in CA keratinocytes compared with normal skin. In vitro, HPV6/11 induced the expression of MIR31HG. Functional studies demonstrated that MIR31HG induced a cytokine shift in HPV6/11-HaCaT cells, characterized by elevated anti-inflammatory IL-4 and reduced pro-inflammatory mediators, including TNF-α, IFN-β, IL-6 and IL-8. This IL-4 surge promoted M2-like macrophage polarization, a hallmark of immunosuppression, thereby contributing to an immunosuppressive microenvironment in CA. Mechanistically, MIR31HG functioned as a ceRNA for miR-214-3p in HPV6/11-HaCaT cells, leading to enhanced PTEN expression and subsequent suppression of the PI3K/AKT pathway, thereby contributing to an immunosuppressive cytokine profile and M2-like macrophage polarization.</p><p><strong>Conclusion: </strong>Our findings highlight the immunomodulatory role of keratinocytes in CA and highlight the MIR31HG/IL-4 axis as a novel therapeutic target for CA, bridging mechanistic insight with translational potential.</p>","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"32 9","pages":"e70384"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13579096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148977913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence Based Skin Analysis Models for Predicting Visual Grades and Device Measured Physiological Values From Facial Images.","authors":"Eunyoung Lee, Jeongho Lee, Nahee Kim, Junchae Na, Byungcheol Park, Sang-Il Choi","doi":"10.1111/srt.70375","DOIUrl":"10.1111/srt.70375","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to develop and validate an artificial intelligence (AI)-based skin assessment framework capable of predicting both dermatologist-assigned visual grades and device-derived physiological measurements from facial images. In addition, we evaluated the impact of image-acquisition modality (DSLR, tablet, or smartphone) on model performance.</p><p><strong>Methods: </strong>A total of 1,099 Korean participants aged 14-69 years were enrolled. High-resolution facial images were obtained from seven standardized angles using a DSLR camera, and a subset of additional images was collected using a tablet and participant-owned smartphones. Five board-certified dermatologists graded eight facial signs, and physiological parameters were measured using non-invasive skin assessment devices. CoAtNet-4 served as the backbone architecture for both classification (visual grading) and regression (physiological prediction). Model performance was assessed using mean absolute error and correlation analyses.</p><p><strong>Results: </strong>When evaluated using DSLR images, the model achieved a mean exact-grade accuracy of 51.4%, with an average of 93.3% of predictions falling within ± 1 grade across facial signs. High correlations were observed for wrinkles, pigmentation, pores, and sagging, whereas lip dryness demonstrated comparatively lower correlations. For physiological metrics, strong correlations were observed for pigmentation spot count, cheek pore visibility, and wrinkle severity, whereas hydration and elasticity showed moderate correlations. Performance on mobile-device images remained high and showed strong agreement with DSLR-based predictions, although a noticeable decline in pigmentation-related accuracy was observed.</p><p><strong>Conclusion: </strong>The proposed AI framework reliably approximates dermatologist visual grading and multiple device-based physiological measurements, offering a comprehensive, image-driven approach to skin aging assessment. However, model performance varies across facial attributes and remains sensitive to image quality, emphasizing the need for domain adaptation and image enhancement strategies to ensure robust application in consumer environments.</p>","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"32 9","pages":"e70375"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13530381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148866636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing Biopsy Decisions in Benign Longitudinal Melanonychia: A Dermoscopic-Pathologic Study of Nail Matrix Nevus vs. Melanocytic Activation.","authors":"Qilin Sun, Zijing Du, Zhengyu Shen, Jun Chen, Xue Wang, Hui Xu, Qingqing Cen, Ke Liu","doi":"10.1111/srt.70378","DOIUrl":"10.1111/srt.70378","url":null,"abstract":"<p><strong>Background: </strong>Longitudinal melanonychia (LM) is a common clinical manifestation of nail melanocytic lesions and poses diagnostic challenges in distinguishing benign melanocytic activation (MA) from melanocytic hyperplasia such as nail matrix nevus(NMN).</p><p><strong>Objectives: </strong>This study aimed to identify clinical, dermoscopic, and histopathologic features that distinguish NMN from MA in LM and facilitate biopsy decision-making.</p><p><strong>Methods: </strong>We retrospectively reviewed 33 patients with LM (21 MA and 12 NMN) who underwent nail biopsy at our institution between 2019 and 2021. All cases underwent preoperative clinical photography and histopathological examination. Among them, 23 cases underwent dermoscopy, and 16 cases underwent immunohistochemical examination.</p><p><strong>Results: </strong>No significant differences in age or sex distribution were observed between groups (MA: 39.7 yrs, M:F = 1:2.5; NMN: 35.3 yrs, M:F = 1.4:1). Dermoscopy revealed distinct background colors (MA: gray, NMN: brown; P < 0.05) and higher Hutchinson sign frequency in NMN (45% vs. 8%; P < 0.05). Stripe width differences were non-significant (MA: 3.2 mm, NMN: 2.9 mm; P > 0.05). Histopathologic examination of MA revealed scattered melanin granule deposition in the nail bed or nail matrix, with no obvious nevus cell nests, while NMN showed nevus cell nests. In immunohistochemistry, S100 positivity was detected only in NMN (60% vs. 0%, p = 0.018) CONCLUSIONS: Dermoscopic features of LM (background color, Hutchinson sign), combined with other clinical characteristics such as predilection sites and progressive changes, can provide valuable clues for differentiating MA from melanocytic proliferative LM represented by NMN, thereby reducing unnecessary biopsies.</p>","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"32 8","pages":"e70378"},"PeriodicalIF":2.8,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13501103/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148809097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Limitations of ITA for Skin Type Estimation Under Uncontrolled Imaging Conditions.","authors":"Neda Alipour, Ted Burke, Jane Courtney","doi":"10.1111/srt.70374","DOIUrl":"10.1111/srt.70374","url":null,"abstract":"<p><strong>Background: </strong>Accurately assessing skin color diversity is essential for evaluating whether image datasets without explicit skin type labels are sufficiently diverse for training deep learning models. Traditional methods, such as the Fitzpatrick scale, categorize skin types into six discrete classes but may not fully capture the complexity of skin color and its interaction with light under varying conditions. Continuous and quantitative approaches have been proposed to better represent skin color variation, but their reliability under uncontrolled imaging conditions remains unclear.</p><p><strong>Materials and methods: </strong>This study evaluated individual typology angle (ITA), an image-derived color or lightness metric commonly mapped to Fitzpatrick skin type (FST) categories. A dermatologist-labeled dataset (PAD-UFES-20) was used to analyze the performance of ITA. A skin patch image dataset was derived from PAD-UFES-20, and skin color features were extracted for evaluation.</p><p><strong>Results: </strong>The results showed substantial overlap between ITA distributions across FST categories and poor agreement with dermatologist-assigned labels. Fixed-threshold ITA classification achieved 22.9% accuracy, below the majority-class baseline accuracy of 51.3%, and failed to correctly classify the darkest skin type (FST VI). Lighting variation, threshold misalignment, overlapping ITA distributions, and dataset imbalance contributed to unstable ITA behavior across skin types.</p><p><strong>Conclusion: </strong>Under uncontrolled imaging conditions, fixed-threshold ITA did not provide reliable Fitzpatrick skin type classification and should not be interpreted as a validated skin type measurement method. These findings demonstrate that ITA is highly sensitive to lighting variation and does not reliably correspond to dermatologist-assigned FST labels. The results highlight the limitations of using ITA as a proxy for skin type assessment in image datasets.</p>","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"32 8","pages":"e70374"},"PeriodicalIF":2.8,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13459198/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148707431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physiological Characteristics of Scalp Skin With High Sebum Production and the Impacts of Shampoo Cleansing.","authors":"Kuangyu Chen, Hiufung Lau, Sheldon Xu, Amy Yu, Steven Wang, Susan Biehle, Christina Gemmer, Charles Zhang, Rui Li","doi":"10.1111/srt.70376","DOIUrl":"10.1111/srt.70376","url":null,"abstract":"<p><strong>Background: </strong>The scalp has a higher sebum content than other body areas, leading to issues such as itchiness, dandruff and discomfort. In individuals with scalp seborrhoea, the relationships between sebum levels, hydration, barrier function and self-perceived scalp condition remain poorly understood.</p><p><strong>Aims: </strong>This study aimed to explore scalp sebum accumulation and associated physiological properties, as well as to evaluate the impact of a single shampoo cleansing efficacy on sebum levels.</p><p><strong>Methods: </strong>This study involved an Asian population with self-reported scalp oiliness and dandruff. Participants with elevated scalp sebum levels (>75 µg/cm²) completed a health questionnaire and underwent assessments of sebum, hydration, barrier function and lipid oxidative stress biomarkers. To compare physiological differences, measurements were also taken at the frontal hairline and nape. Furthermore, the effects of a single shampoo application on scalp sebum levels were evaluated.</p><p><strong>Results: </strong>At baseline, the scalp exhibited higher sebum levels, lower hydration and weaker barrier function compared to the frontal hairline and nape. Scalp hydration negatively correlated with sebum levels measured in scalp pores. Hydroxyoctadecadienoic acid (HODE), an oxidative stress biomarker, positively correlated with scalp sebum. Interestingly, HODE levels also showed a positive correlation with participants' self-reported dandruff and itchiness. After single wash with a shampoo containing 0.5% piroctone olamine (PO), surface and pore sebum levels were significantly reduced, as well as HODE levels.</p><p><strong>Conclusion: </strong>This study underscores the significance of sebum levels and composition in scalp health among Chinese individuals, emphasizing the need for shampoos that remove excess sebum while preserving the scalp barrier.</p>","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"32 8","pages":"e70376"},"PeriodicalIF":2.8,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13464430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148713605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Call for Ethical Guidelines in Cosmetic Dermatology for Adolescents.","authors":"Isabella J Tan, Julia L DiOrio, Bernard A Cohen","doi":"10.1111/srt.70373","DOIUrl":"https://doi.org/10.1111/srt.70373","url":null,"abstract":"<p><strong>Background: </strong>The prevalence of appearance-enhancing dermatology procedures among adolescents has increased markedly, raising ethical concerns regarding body image, developmental suitability, and psychosocial risk. Individuals 19 and under experienced a 75% increase in neuromodulator injections and a 71% increase in hyaluronic acid fillers between 2019 and 2022. Social and commercial forces-including social media and targeted marketing-promote cosmetic intervention as routine self-optimization, despite adolescents' ongoing cognitive, emotional, and identity development.</p><p><strong>Materials and methods: </strong>We focus on elective, nonmedically necessary procedures such as neuromodulators and fillers in individuals aged 13-19. We review ethical principles (autonomy, beneficence, non-maleficence, justice), psychosocial vulnerabilities (including body dysmorphic disorder [BDD]), social media influence, commercial pressures, and longitudinal mental health outcomes. Current regulatory guidance and professional society recommendations are assessed for gaps.</p><p><strong>Results: </strong>Adolescents' emerging autonomy is developmentally incomplete, and appearance-based motivations are often transient and externally influenced. Longitudinal data link cosmetic procedures with higher depression, anxiety, and lower self-esteem. BDD affects ∼2% of adolescents, who rarely improve after intervention and may worsen. Social media exposure doubles the likelihood of considering cosmetic procedures, and commercial marketing further normalizes aesthetic ideals. Existing professional guidelines rarely mandate validated psychosocial screening, structured counseling, or cooling-off periods, leaving adolescents vulnerable to premature intervention.</p><p><strong>Conclusion: </strong>A standardized, multi-component ethical framework is necessary to guide clinicians caring for adolescents seeking elective aesthetic procedures. Recommendations include medical-necessity assessment, structured counseling, strengthened parental consent, validated BDD screening, and careful documentation with follow-up. Clear, evidence-informed ethical standards are essential to safeguard adolescent well-being and prioritize patient welfare over commercial interest.</p>","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"32 8","pages":"e70373"},"PeriodicalIF":2.8,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13488599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148797880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Augmented Skin Beneficial Effects of Thermus Thermophilus and Bacillus Subtilis Mixed-Culture Ferment Extract by Tripeptide GHK-Cu.","authors":"Jingyi Wang, Kan Tao, Hu Huang, Huailong Chang","doi":"10.1111/srt.70360","DOIUrl":"10.1111/srt.70360","url":null,"abstract":"<p><strong>Background: </strong>Skin aging is a complex process driven by multiplex factors, including chronic inflammation and UV exposure. It has become common practice for cosmetic formulations to counteract skin aging by targeting different pathways simultaneously with a pool of active ingredients. The present study aims to explore the skin protective effects of a novel extract of ferment in combination with copper tripeptide-1 GHK-Cu from an anti-inflammation perspective.</p><p><strong>Materials and methods: </strong>An extract of the Thermus thermophilus and Bacillus subtilis mixed-culture ferment (TBFE) was prepared and the skin protective effects of its combination with the human tripeptide derivative GHK-Cu were explored through in vitro, ex vivo, and clinical tests.</p><p><strong>Results: </strong>The combination outperformed TBFE or GHK-Cu alone in inhibiting secretion of inflammatory cytokines by lipopolysaccharide-stimulated macrophages. In addition, one face cream formulated with the combination as the sole active ingredients protected human skin explants from ultraviolet irradiation induced damage by maintaining skin morphology and decreasing the degradation of extracellular matrix. Finally, results from the clinical study demonstrated that the combination was effective in decreasing wrinkles and improving skin barrier conditions.</p><p><strong>Conclusion: </strong>It is concluded that the combination of TBFE and GHK-Cu exerts anti-aging effects on human skin by targeting inflammation, extracellular matrix, and skin barrier function. Therefore, the combination offers a promising option for anti-aging skincare regimen by addressing multiple mechanisms involved in skin aging.</p>","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"32 8","pages":"e70360"},"PeriodicalIF":2.8,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13455814/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148702144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Trifarotene Treatment of a Typical Kyrle's Disease With Overview of Topical Therapies.","authors":"Wiktor Kruczek, Aleksandra Frątczak, Karina Polak, Paulina Rutecka, Dawid Wolak, Mirosław Śnietura, Bartosz Miziołek, Beata Bergler-Czop","doi":"10.1111/srt.70359","DOIUrl":"10.1111/srt.70359","url":null,"abstract":"<p><p>Kyrle's disease is a rare skin disorder involving transepidermal keratin elimination, usually linked to systemic illness. We report a unique case-a healthy 26-year-old man resistant to standard therapy. Remission was achieved with daily topical trifarotene 0.005% over eight weeks. This is the first reported KD case successfully treated with trifarotene, a selective RAR-γ retinoid targeting keratinocyte differentiation and inflammation. Its efficacy and safety suggest promise for patients unsuitable for systemic therapy. A summary table of all topical treatment methods for Kyrle's disease, included in the article, provides valuable guidance for managing patients with significant comorbidities.</p>","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"32 7","pages":"e70359"},"PeriodicalIF":2.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13387832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148550300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}