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Relationship Between Cytokines and Face Skin Symptoms in Newborns in Two Japanese Cities. 日本两个城市新生儿细胞因子与面部皮肤症状的关系
IF 2 4区 医学
Skin Research and Technology Pub Date : 2024-10-01 DOI: 10.1111/srt.70098
Kaori Yonezawa, Sachi Higuchi, Satsuki Shimizu, Takeo Minematsu, Megumi Haruna
{"title":"Relationship Between Cytokines and Face Skin Symptoms in Newborns in Two Japanese Cities.","authors":"Kaori Yonezawa, Sachi Higuchi, Satsuki Shimizu, Takeo Minematsu, Megumi Haruna","doi":"10.1111/srt.70098","DOIUrl":"10.1111/srt.70098","url":null,"abstract":"<p><strong>Aim: </strong>Several skin disorder symptoms may appear in infants, each resulting from a different inflammatory response. In this study, we investigated the relationship between skin cytokine levels and skin symptoms in newborns.</p><p><strong>Methods: </strong>This cross-sectional study was conducted in Tokyo and Oita, two Japanese cities. The participants were healthy, 1-month-old infants and their parents. Symptoms including erythema, papules, dryness, and exudate/yellow scaling on infant faces were evaluated as outcomes. Cytokine levels (interleukin [IL]-4, IL-6, IL-8, and IL-17) were measured by skin blotting. A multilevel analysis using a mixed-effects model was conducted to account for regional differences.</p><p><strong>Results: </strong>A total of 231 infants (119 from Tokyo and 112 from Oita) participated in this study. Erythema, papules, dryness, and exudate/yellow scaling were present in 59 (25.5%), 133 (57.6%), 37 (16.0%), and 16 (6.9%) of the infants, respectively. In terms of the associations between symptoms and cytokines, there was a significant association between papules and IL-8 positivity (adjusted odds ratio [AOR]: 1.94, 95% confidence interval [CI] 1.09-3.47) even after adjustment for differences in barrier function, area, and skin care.</p><p><strong>Conclusions: </strong>This study demonstrated that cytokines were linked to skin conditions, even after accounting for regional differences and genetic factors. This suggests that different symptoms point to the involvement of various cytokines in skin conditions in neonates, with mechanisms varying based on the symptoms. These findings could aid in developing specific preventive strategies in the future.</p>","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"30 10","pages":"e70098"},"PeriodicalIF":2.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11457040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reflectance Confocal Microscopy Features of Ectopic Mongolian Spot and Blue Nevus. 异位蒙古斑和蓝色痣的反射共聚焦显微镜特征
IF 2 4区 医学
Skin Research and Technology Pub Date : 2024-10-01 DOI: 10.1111/srt.70084
Yuantao Song, Tiantian Bi, Meixiang Rong, Xinxin Liu, Yangyang Lin, Qinfeng Li
{"title":"Reflectance Confocal Microscopy Features of Ectopic Mongolian Spot and Blue Nevus.","authors":"Yuantao Song, Tiantian Bi, Meixiang Rong, Xinxin Liu, Yangyang Lin, Qinfeng Li","doi":"10.1111/srt.70084","DOIUrl":"10.1111/srt.70084","url":null,"abstract":"","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"30 10","pages":"e70084"},"PeriodicalIF":2.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11452924/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142378235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Occupational Exposures and Skin Cancer: A Brief Report. 职业暴露与皮肤癌:简要报告。
IF 2 4区 医学
Skin Research and Technology Pub Date : 2024-10-01 DOI: 10.1111/srt.70107
Aarushi K Parikh, Isabella J Tan, Bernard A Cohen
{"title":"Occupational Exposures and Skin Cancer: A Brief Report.","authors":"Aarushi K Parikh, Isabella J Tan, Bernard A Cohen","doi":"10.1111/srt.70107","DOIUrl":"10.1111/srt.70107","url":null,"abstract":"","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"30 10","pages":"e70107"},"PeriodicalIF":2.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11466288/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142401203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development and Validation of a Total Body Photo-Numeric Freckling Density Scale. 开发并验证全身照片数字雀斑密度表。
IF 2 4区 医学
Skin Research and Technology Pub Date : 2024-10-01 DOI: 10.1111/srt.70081
Mirko Susinna, Adam Mothershaw, Nima Ghahari, Sam Kahler, Clare Primiero, Harpal Dillon, Catherine Fischer, Monika Janda, H Peter Soyer, Brigid Betz-Stablein
{"title":"Development and Validation of a Total Body Photo-Numeric Freckling Density Scale.","authors":"Mirko Susinna, Adam Mothershaw, Nima Ghahari, Sam Kahler, Clare Primiero, Harpal Dillon, Catherine Fischer, Monika Janda, H Peter Soyer, Brigid Betz-Stablein","doi":"10.1111/srt.70081","DOIUrl":"10.1111/srt.70081","url":null,"abstract":"","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"30 10","pages":"e70081"},"PeriodicalIF":2.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11439887/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142353367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Artificial Intelligence Smartphone Application for Detection of Simulated Skin Changes: An In Vivo Pilot Study. 用于检测模拟皮肤变化的人工智能智能手机应用程序:体内试验研究。
IF 2 4区 医学
Skin Research and Technology Pub Date : 2024-10-01 DOI: 10.1111/srt.70056
Gabriela Lladó Grove, Gorm Reedtz, Brian Vangsgaard, Hassan Eskandarani, Merete Haedersdal, Flemming Andersen, Peter Bjerring
{"title":"Artificial Intelligence Smartphone Application for Detection of Simulated Skin Changes: An In Vivo Pilot Study.","authors":"Gabriela Lladó Grove, Gorm Reedtz, Brian Vangsgaard, Hassan Eskandarani, Merete Haedersdal, Flemming Andersen, Peter Bjerring","doi":"10.1111/srt.70056","DOIUrl":"10.1111/srt.70056","url":null,"abstract":"<p><strong>Background: </strong>The development of artificial intelligence (AI) is rapidly expanding, showing promise in the dermatological field. Skin checks are a resource-heavy challenge that could potentially benefit from AI-tool assistance, particularly if provided in widely available AI solutions. A novel smartphone application(app)-based AI system, \"SCAI,\" was developed and trained to recognize spots in paired images of skin, pursuing identification of new skin lesions. This pilot study aimed to investigate the feasibility of the SCAI-app to identify simulated skin changes in vivo.</p><p><strong>Materials and methods: </strong>The study was conducted in a controlled setting with healthy volunteers and standardized, simulated skin changes (test spots), consisting of customized 3-mm adhesive spots in three colors (black, brown, and red). Each volunteer had a total of eight test spots adhered to four areas on back and legs. The SCAI-app collected smartphone- and template-guided standardized images before and after test spot application, using its backend AI algorithms to identify changes between the paired images.</p><p><strong>Results: </strong>Twenty-four volunteers were included, amounting to a total of 192 test spots. Overall, the detection algorithms identified test spots with a sensitivity of 92.0% (CI: 88.1-95.9) and a specificity of 95.5% (CI: 95.0-96.0). The SCAI-app's positive predictive value was 38.0% (CI: 31.0-44.9), while the negative predictive value was 99.7% (CI: 99.0-100).</p><p><strong>Conclusion: </strong>This pilot study showed that SCAI-app could detect simulated skin changes in a controlled in vivo setting. The app's feasibility in a clinical setting with real-life skin lesions remains to be investigated, where the challenge with false positives in particular needs to be addressed.</p>","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"30 10","pages":"e70056"},"PeriodicalIF":2.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11452258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142375914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thyroid Dysfunction and Alopecia Areata: A Genetic Prediction Causality Analysis Study. 甲状腺功能障碍与脱发:遗传预测因果关系分析研究
IF 2 4区 医学
Skin Research and Technology Pub Date : 2024-10-01 DOI: 10.1111/srt.70063
Yue Zhao, Furong Guo, Mengyue Guo
{"title":"Thyroid Dysfunction and Alopecia Areata: A Genetic Prediction Causality Analysis Study.","authors":"Yue Zhao, Furong Guo, Mengyue Guo","doi":"10.1111/srt.70063","DOIUrl":"https://doi.org/10.1111/srt.70063","url":null,"abstract":"<p><strong>Background: </strong>Observational studies have suggested a correlation between alopecia areata (AA) and thyroid dysfunction (TD). However, the causal relationship between AA and TD remains uncertain. The purpose of this study is to investigate the causal relationship between these two conditions. Understanding the potential causal relationship between AA and TD is valuable for elucidating the pathogenesis of AA and for designing innovative methods to prevent and treat AA and its related complications.</p><p><strong>Methods: </strong>All data for this two-sample Mendelian randomization (MR) study were sourced from public databases. This study selected hypothyroidism, Hashimoto's thyroiditis, hyperthyroidism, subacute thyroiditis, and Graves' disease as exposure factors, with AA as the outcome variable. Data for hypothyroidism, Hashimoto's thyroiditis, hyperthyroidism, subacute thyroiditis, Graves' disease, and AA were obtained from related genome-wide association studies (GWAS). Various MR analysis methods such as inverse variance weighted (IVW), MR-Egger, and weighted median were utilized. Additionally, Cochrane's Q test was used to detect heterogeneity in MR results, and the MR-Egger intercept test and MR pleiotropy residual sum and outlier (MR-PRESSO) test were used to detect horizontal pleiotropy. A leave-one-out analysis was conducted to investigate the sensitivity of this association.</p><p><strong>Results: </strong>We found statistically significant genetic predictions of AA with hypothyroidism, Hashimoto's thyroiditis, and subacute thyroiditis (IVW OR = 1.4009815, 95% confidence interval [CI]: 1.1210399-1.750829; p = 0.003030698, OR = 1.396101, 95% CI: 1.030134-1.89208; p = 0.03144273, OR = 0.732702, 95% CI: 0.604812-0.887634; p = 0.001483368). Furthermore, tests for pleiotropy showed no evidence of pleiotropy, enhancing the credibility of the study results. Finally, the leave-one-out test demonstrated the stability and robustness of this association.</p><p><strong>Conclusion: </strong>This study provides new evidence of a potential genetic link between thyroid issues and AA. By employing the two-sample MR method to eliminate confounding factors and reverse causation, unbiased results were obtained, confirming a causal relationship between hypothyroidism, Hashimoto's thyroiditis, subacute thyroiditis, and AA. This lays the foundation for further mechanistic studies and potential clinical applications. Future research should further explore the specific biological mechanisms between TD and the onset of AA.</p>","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"30 10","pages":"e70063"},"PeriodicalIF":2.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11430218/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142353371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Case of Darier Disease Treated With a Dye Laser. 一例用染料激光治疗的达里尔病例
IF 2 4区 医学
Skin Research and Technology Pub Date : 2024-10-01 DOI: 10.1111/srt.70057
Mario Sannino, Beatrice Marina Pennati, Tiziano Zingoni, Irene Fusco, Giovanni Cannarozzo, Elena Campione, Giuseppe Lodi
{"title":"A Case of Darier Disease Treated With a Dye Laser.","authors":"Mario Sannino, Beatrice Marina Pennati, Tiziano Zingoni, Irene Fusco, Giovanni Cannarozzo, Elena Campione, Giuseppe Lodi","doi":"10.1111/srt.70057","DOIUrl":"10.1111/srt.70057","url":null,"abstract":"","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"30 10","pages":"e70057"},"PeriodicalIF":2.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11452257/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142375911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erysipelas Complicated by COVID-19. 由 COVID-19 并发的红斑狼疮。
IF 2 4区 医学
Skin Research and Technology Pub Date : 2024-10-01 DOI: 10.1111/srt.70062
Jie-Lun Wen, Qi-Ze Wang, Ming-Hui Peng, Lu Liu, Li-Yue Sun
{"title":"Erysipelas Complicated by COVID-19.","authors":"Jie-Lun Wen, Qi-Ze Wang, Ming-Hui Peng, Lu Liu, Li-Yue Sun","doi":"10.1111/srt.70062","DOIUrl":"10.1111/srt.70062","url":null,"abstract":"","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"30 10","pages":"e70062"},"PeriodicalIF":2.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11452250/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142375919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of Ultraviolet Dermoscopy in Detecting Scabies Signs. 紫外线皮肤镜在检测疥疮体征中的作用
IF 2 4区 医学
Skin Research and Technology Pub Date : 2024-10-01 DOI: 10.1111/srt.70080
Alexandre Raphael Meduri, Giulia Ciccarese, Riccardo Viola, Giorgia Sbarra, Gerardo Cazzato, Paolo Romita, Caterina Foti
{"title":"Role of Ultraviolet Dermoscopy in Detecting Scabies Signs.","authors":"Alexandre Raphael Meduri, Giulia Ciccarese, Riccardo Viola, Giorgia Sbarra, Gerardo Cazzato, Paolo Romita, Caterina Foti","doi":"10.1111/srt.70080","DOIUrl":"10.1111/srt.70080","url":null,"abstract":"","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"30 10","pages":"e70080"},"PeriodicalIF":2.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11452253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142375922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dermoscopic Features of Pili Annulati: Features of PA. 环状韧带的皮肤镜特征:PA 的特征
IF 2 4区 医学
Skin Research and Technology Pub Date : 2024-10-01 DOI: 10.1111/srt.70059
Yuantao Song, Meixiang Rong, Xibo Gao, Tiantian Bi, Yangyang Lin, Qinfeng Li
{"title":"Dermoscopic Features of Pili Annulati: Features of PA.","authors":"Yuantao Song, Meixiang Rong, Xibo Gao, Tiantian Bi, Yangyang Lin, Qinfeng Li","doi":"10.1111/srt.70059","DOIUrl":"10.1111/srt.70059","url":null,"abstract":"","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"30 10","pages":"e70059"},"PeriodicalIF":2.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11452261/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142375917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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