Skin Research and Technology最新文献

{"title":"Preliminary Evaluation of the Value of a Small-Molecule Probe Targeting DNMT1 in Detecting the Methylation of PAX1 in Cervical Cancer.","authors":"Baohua Yang, Qunxian Cheng, Xiaoqian Hong, Xiuxiang Zhu, Ziyin Xia, Wei Chen, Ling Xu","doi":"10.1111/srt.70074","DOIUrl":"https://doi.org/10.1111/srt.70074","url":null,"abstract":"<p><strong>Background: </strong>To investigate the screening value of a small-molecule probe to assess the methylation of PAX1 in cervical cancer.</p><p><strong>Materials and methods: </strong>The diagnostic threshold of the grayscale values for cervical lesions was assessed by plotting the Receiver Operating Characteristic (ROC) curve of subjects. Grayscale values were significantly different among the four groups (p < 0.05). Compared with the LSIL and cervicitis groups, a considerably higher grayscale value was found in the CA and high-grade squamous intraepithelial lesion (HSIL) groups (both p < 0.05).</p><p><strong>Results: </strong>The differential ROC curves of the grayscale values showed that the diagnostic Area Under Curve of the probe for cervicitis and low-grade squamous intraepithelial lesion (LSIL) was 0.8724 (95% CI = 0.7762-0.9685, p < 0.0001), for cervicitis and CA was 1.0000 (p < 0.0001), for the LSIL and HSIL was 0.5484 (95% CI = 0.3826-0.7142, p = 0.5755), and for the LSIL and CA was 0.7724 (95% CI = 0.6016-0.9432, p = 0.0138).</p><p><strong>Conclusion: </strong>The small molecular probe has certain application value in differentiating the type of cervical lesions and has better efficacy in distinguishing cervical inflammatory and precancerous lesions from carcinogenesis, but less efficacy in determining the type of precancerous lesions.</p>","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"30 10","pages":"e70074"},"PeriodicalIF":2.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11430213/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142353369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of ceramides on skin absorption by Raman spectroscopy.","authors":"Song Hee Kim, Jeonghoon Yun, Woncheol Kim, Eunsu Seon, Chanhwi Lee, Jaejoon Jeon, Mid Eum Yun, Keun Hyung Park","doi":"10.1111/srt.70046","DOIUrl":"https://doi.org/10.1111/srt.70046","url":null,"abstract":"<p><strong>Introduction: </strong>Ceramides are essential epidermal constituents that play a critical role in skin moisturization treatment as a raw material in cosmetics formulation. Recently, ceramides have been known to be frequently applied in various cosmetic formulations. Despite ceramide's beneficial characteristics, academic research regarding ceramides and their skin absorption remains insufficient. Therefore, our study conducted clinical research employing Raman spectroscopy to investigate the effects of ceramides on skin absorption to enhance the understanding of ceramides' dermatological functionality and their topical application in cosmetics science.</p><p><strong>Materials and methods: </strong>Twenty healthy individuals with dry skin have participated in this clinical trial. In this double-arm designed trial, the test group received an investigational product with ceramides (5000 ppm) and a control group received an investigational product without the ceramides while all other components remained identical. The subjects visited the clinical research center and acclimatized for 30 min in constant humidity and temperature for equilibrium, subsequently conducting a measurement. Before the trial, the research subject's target site (lower arm area) was kept clean, devoid of any cosmetic administering 24 h before the trial when investigational product was topically applied.</p><p><strong>Results: </strong>Our findings with Raman spectroscopy statistically demonstrate that skin absorption amount, speed and depth for both groups improved overall (p < 0.05) after administration of the investigational product. Notably, the test group received an investigational product with ceramides (5000 ppm) indicating superior effectiveness across all parameters compared to a control group from comparison analysis of each parameter (p < 0.05).</p><p><strong>Conclusion: </strong>This study concludes that ceramide-containing cosmetics provide a beneficial effect on skin absorption via visual and statistical results of Raman spectroscopy analysis.</p>","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"30 10","pages":"e70046"},"PeriodicalIF":2.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11430771/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142353370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Annular Elastic Fibrolytic Giant Cell Granuloma: A Dermoscopic Diagnosis.","authors":"Ting Zhang, Ling-Long Cai","doi":"10.1111/srt.70067","DOIUrl":"10.1111/srt.70067","url":null,"abstract":"","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"30 10","pages":"e70067"},"PeriodicalIF":2.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11452252/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142375913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skin Tone Analysis Through Skin Tone Map Generation With Optical Approach and Deep Learning.","authors":"Geunho Jung, Semin Kim, Sangwook Yoo","doi":"10.1111/srt.70088","DOIUrl":"10.1111/srt.70088","url":null,"abstract":"<p><strong>Background: </strong>Skin tone assessment is critical in both cosmetic and medical fields, yet traditional methods like the individual typology angle (ITA) have limitations, such as sensitivity to illuminants and insensitivity to skin redness.</p><p><strong>Methods: </strong>This study introduces an automated image-based method for skin tone mapping by applying optical approaches and deep learning. The method generates skin tone maps by leveraging the illuminant spectrum, segments the skin region from face images, and identifies the corresponding skin tone on the map. The method was evaluated by generating skin tone maps under three standard illuminants (D45, D65, and D85) and comparing the results with those obtained using ITA on skin tone simulation images.</p><p><strong>Results: </strong>The results showed that skin tone maps generated under the same lighting conditions as the image acquisition (D65) provided the highest accuracy, with a color difference of around 6, which is more than twice as small as those observed under other illuminants. The mapping positions also demonstrated a clear correlation with pigment levels. Compared to ITA, the proposed approach was particularly effective in distinguishing skin tones related to redness.</p><p><strong>Conclusion: </strong>Despite the need to measure the illuminant spectrum and for further physiological validation, the proposed approach shows potential for enhancing skin tone assessment. Its ability to mitigate the effects of illuminants and distinguish between the two dominant pigments offers promising applications in both cosmetic and medical diagnostics.</p>","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"30 10","pages":"e70088"},"PeriodicalIF":2.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11452249/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142375923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overexpression of SEZ6L2 and Immune Infiltration in Cancer Based on Gene Image Diagnosis.","authors":"Liangfu Ding, Jilin Zeng, Junyong Zhao","doi":"10.1111/srt.70096","DOIUrl":"10.1111/srt.70096","url":null,"abstract":"<p><strong>Background: </strong>With the rapid advancement of optical image diagnostic technology, researchers are delving into the potential applications in the field of cancer diagnosis and treatment. The exact link between the SEZ6L2 gene and cancer immune infiltration remains elusive.</p><p><strong>Materials and methods: </strong>This study aims to investigate the relationship between SEZ6L2 gene overexpression and cancer immune infiltration using optical image diagnostic technology, thereby presenting novel insights for enhancing cancer diagnosis and treatment strategies. Tissue samples obtained from cancer patients were meticulously analyzed to quantitatively assess the expression of the SEZ6L2 gene through light image diagnostic technology. Additionally, immunohistochemical techniques were employed to assess the nature and quantity of immune infiltrating cells within the cancerous tissues.</p><p><strong>Results: </strong>The enrichment pathways were found to include complement activation, circulating immunoglobulin mediated humoral immune response, protein activation cascade, immunoglobulin complex, and immunoglobulin. In addition, the expression of SEZ6L2 is closely related to the infiltration level of tumor infiltrating immune cells (TIICs), and there is a potential relationship between the expression of SEZ6L2 and different marker genes of TIIC.</p><p><strong>Conclusion: </strong>Increased SEZ6L2 mRNA expression in breast invasive carcinoma was significantly associated with negative prognosis and immune invasion. SEZ6L2 may be a novel prognostic biomarker and a potential immunotherapeutic target in BRCA.</p>","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"30 10","pages":"e70096"},"PeriodicalIF":2.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11447639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142366456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-Frequency Ultrasound Findings of Nerve Sheath Myxoma in the Instep Skin.","authors":"Guiwu Chen, Xiaoling Leng, Haibo Luo, Su Yu, Jiaxin Meng, Xiaomin Liao","doi":"10.1111/srt.70078","DOIUrl":"10.1111/srt.70078","url":null,"abstract":"","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"30 10","pages":"e70078"},"PeriodicalIF":2.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11452925/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142378234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical Leukoderma Induced by Pesticides.","authors":"Qianya Zhao, Lisheng Nan, Caiqin Mao, Yan Wu, Xianwei Wu","doi":"10.1111/srt.70083","DOIUrl":"10.1111/srt.70083","url":null,"abstract":"","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"30 10","pages":"e70083"},"PeriodicalIF":2.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11452256/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142375915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple Eruptive Sebaceous Hyperplasia Secondary to Muir-Torre Syndrome Treated With Fractional Carbon Dioxide Laser Resurfacing Technique: A Case Report.","authors":"Miriam Leuzzi, Corrado Zengarini, Michelangelo La Placa, Martina Mussi, Antonio Russo, Davide Melandri, Alessandro Pileri, Bianca Maria Piraccini, Iria Neri","doi":"10.1111/srt.70100","DOIUrl":"10.1111/srt.70100","url":null,"abstract":"","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"30 10","pages":"e70100"},"PeriodicalIF":2.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11452254/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142375921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship Between Cytokines and Face Skin Symptoms in Newborns in Two Japanese Cities.","authors":"Kaori Yonezawa, Sachi Higuchi, Satsuki Shimizu, Takeo Minematsu, Megumi Haruna","doi":"10.1111/srt.70098","DOIUrl":"10.1111/srt.70098","url":null,"abstract":"<p><strong>Aim: </strong>Several skin disorder symptoms may appear in infants, each resulting from a different inflammatory response. In this study, we investigated the relationship between skin cytokine levels and skin symptoms in newborns.</p><p><strong>Methods: </strong>This cross-sectional study was conducted in Tokyo and Oita, two Japanese cities. The participants were healthy, 1-month-old infants and their parents. Symptoms including erythema, papules, dryness, and exudate/yellow scaling on infant faces were evaluated as outcomes. Cytokine levels (interleukin [IL]-4, IL-6, IL-8, and IL-17) were measured by skin blotting. A multilevel analysis using a mixed-effects model was conducted to account for regional differences.</p><p><strong>Results: </strong>A total of 231 infants (119 from Tokyo and 112 from Oita) participated in this study. Erythema, papules, dryness, and exudate/yellow scaling were present in 59 (25.5%), 133 (57.6%), 37 (16.0%), and 16 (6.9%) of the infants, respectively. In terms of the associations between symptoms and cytokines, there was a significant association between papules and IL-8 positivity (adjusted odds ratio [AOR]: 1.94, 95% confidence interval [CI] 1.09-3.47) even after adjustment for differences in barrier function, area, and skin care.</p><p><strong>Conclusions: </strong>This study demonstrated that cytokines were linked to skin conditions, even after accounting for regional differences and genetic factors. This suggests that different symptoms point to the involvement of various cytokines in skin conditions in neonates, with mechanisms varying based on the symptoms. These findings could aid in developing specific preventive strategies in the future.</p>","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"30 10","pages":"e70098"},"PeriodicalIF":2.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11457040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reflectance Confocal Microscopy Features of Ectopic Mongolian Spot and Blue Nevus.","authors":"Yuantao Song, Tiantian Bi, Meixiang Rong, Xinxin Liu, Yangyang Lin, Qinfeng Li","doi":"10.1111/srt.70084","DOIUrl":"10.1111/srt.70084","url":null,"abstract":"","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"30 10","pages":"e70084"},"PeriodicalIF":2.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11452924/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142378235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}