Sensors International最新文献_第2页

A smart glove to evaluate Parkinson's disease by flexible piezoelectric and inertial sensors 一种用柔性压电和惯性传感器评估帕金森病的智能手套

Sensors International Pub Date : 2025-01-01 DOI: 10.1016/j.sintl.2024.100324

R. De Fazio , C. Del-Valle-Soto , V.M. Mastronardi , M. De Vittorio , P. Visconti

{"title":"A smart glove to evaluate Parkinson's disease by flexible piezoelectric and inertial sensors","authors":"R. De Fazio , C. Del-Valle-Soto , V.M. Mastronardi , M. De Vittorio , P. Visconti","doi":"10.1016/j.sintl.2024.100324","DOIUrl":"10.1016/j.sintl.2024.100324","url":null,"abstract":"<div><div>Parkinson's disease (PD), to date, is widespread. It is a neurodegenerative disease that impairs the quality of life of the affected, as it is a slowly but progressively evolving disease. This paper presents a smart glove for evaluating PD patients by monitoring hand tremors and evaluating specific exercises involved by the MDS-UPDRS (Movement Disorder Society - Unified Parkinson Disease Rating Scale), enabling disease evolution assessment. The smart glove consists of a TPU flexible support, integrating two flexible MEMS piezoelectric sensors based on Aluminum Nitride and an inertial sensor to detect finger and arm movements. The smart glove integrates an electronic conditioning section for piezoelectric signals to make them suitable for the following acquisition by a microcontroller section based on nRF52840 SoC, which jointly processes the piezoelectric and inertial signals related to standard patient's hand and arm exercises (i.e., finger tapping, fist opening/closing of the hand, resting hand tremor), assigning them scores according to the MDS-UPDRS. Three embedded Machine Learning (ML) algorithms based on Neural Networks (NN) were deployed to classify piezoelectric and inertial signals. Seven individuals, six of them with diagnosed PD, were involved in developing ML models. Datasets were gathered to train and test the ML algorithms, constituted by signal samples related to three tests involved in the UPDRS scale according to PD severity. The tests demonstrated the proper operation of the proposed smart glove in tracking the movement changes induced by PD; also, the developed embedded ML algorithms showed performance in classifying hand/arm movements, reaching 95.12 %, 98.39 %, and 96.62 % for finger-tapping, hand-fist closure, and resting tremor, respectively.</div></div>","PeriodicalId":21733,"journal":{"name":"Sensors International","volume":"6 ","pages":"Article 100324"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143099030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel method utilizing a portable digital image-based colorimeter detector and a glutathione-functionalized gold nanoparticles (GSH-AuNPs) sensor for the highly selective and sensitive detection of creatinine in urine sample 一种利用便携式数字图像比色仪检测器和谷胱甘肽功能化金纳米颗粒（GSH-AuNPs）传感器的高选择性和高灵敏度检测尿样中肌酐的新方法

Sensors International Pub Date : 2025-01-01 DOI: 10.1016/j.sintl.2025.100327

Eduwin Saputra , Zora Rispa Kase , Idham Ananta Timur , Aufaclav Zatu Kusuma Frisky , Naufal Dhaffa Akbar Wicaksono , Wisnu Aryo Jatmiko , Zulfa Munawwaroh , Alimin , Fajar Inggit Pambudi , Sri Juari Santosa

{"title":"A novel method utilizing a portable digital image-based colorimeter detector and a glutathione-functionalized gold nanoparticles (GSH-AuNPs) sensor for the highly selective and sensitive detection of creatinine in urine sample","authors":"Eduwin Saputra , Zora Rispa Kase , Idham Ananta Timur , Aufaclav Zatu Kusuma Frisky , Naufal Dhaffa Akbar Wicaksono , Wisnu Aryo Jatmiko , Zulfa Munawwaroh , Alimin , Fajar Inggit Pambudi , Sri Juari Santosa","doi":"10.1016/j.sintl.2025.100327","DOIUrl":"10.1016/j.sintl.2025.100327","url":null,"abstract":"<div><div>Various methods can be employed to detect creatinine in urine, but the colorimetric method stands out for its speed, simplicity, and cost-effectiveness. In this study, glutathione-functionalized gold nanoparticles (GSH-AuNPs) were synthesized and used as a sensor to detect creatinine, utilizing a portable digital image-based colorimeter developed in our laboratory. The synthesized GSH-AuNPs exhibit a distinctive wine-red colour and have a uniform spherical shape with an average size of 56.7 nm, showing a maximum absorbance peak at a wavelength of 522 nm. The optimum conditions for detecting creatinine were a pH of 6 and a reaction time of 20 min. FTIR data confirm that the detection mechanism involves hydrogen bond between the -NH<sub>2</sub> group of creatinine and the -COO<sup>-</sup> group on the surface of the GSH-AuNPs. This is evidenced by a shift in the stretching vibration of the -COO<sup>-</sup>, leading to the aggregation of the GSH-AuNPs, resulting in an average size of 191.5 nm. The developed portable colorimeter, used as a detector for the GSH-AuNPs sensor in creatinine detection, achieved a limit of detection (LoD) of 0.016 mM. In comparison, the UV–Vis spectrophotometer as the detector has a LoD of 0.029 mM, and the Jaffe method has a LoD of 0.038 mM, making the proposed colorimetric method the most sensitive. The proposed colorimetric method demonstrates good selectivity for creatinine and has been successfully applied to detect creatinine in artificial urine with a recovery value of 99–103 %.</div></div>","PeriodicalId":21733,"journal":{"name":"Sensors International","volume":"6 ","pages":"Article 100327"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143550855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Buckypaper for high sensitivity strain and temperature sensing 高灵敏度应变和温度传感用巴克纸

Sensors International Pub Date : 2025-01-01 DOI: 10.1016/j.sintl.2025.100342

Rufaydah Hassan, Amal M.K. Esawi, Mustafa Arafa

{"title":"Buckypaper for high sensitivity strain and temperature sensing","authors":"Rufaydah Hassan, Amal M.K. Esawi, Mustafa Arafa","doi":"10.1016/j.sintl.2025.100342","DOIUrl":"10.1016/j.sintl.2025.100342","url":null,"abstract":"<div><div>This study investigates the use of Carbon Nanotube (CNT) Buckypapers (BP) as strain and temperature sensors. To further improve the sensor sensitivity, the produced BP was subjected to a combination of post-treatments; namely, annealing, exposure to a boiling solvent, and compaction. The effect of these post-treatments on the sensor's gauge factor was evaluated to determine the best post-treatments (or combinations thereof) that give the highest gauge factor. Loading/unloading as well as heating/cooling experiments were carried out to examine the piezoresistivity behavior and temperature sensitivity of the produced sensors. The morphology of the best-performing sensor and its fracture morphology were evaluated using scanning electron microscopy (SEM) and compared to as-fabricated sensors that have not been subjected to any post-treatments. In addition, in-situ tensile testing of the BP sensor was carried out to elucidate the mechanisms which influence the response of the BP sensor under strain.</div><div>The study revealed that by employing a combination of annealing and compaction, it was possible to attain a remarkable sensitivity, with gauge factors exceeding 170 and a Temperature Coefficient of Resistance value of −0.0064 %/°C. It was observed that the sensor's electrical resistance increases with strain and decreases with temperature. The increase with strain was related to the effect of strain on the morphology of the dense entangled network of the CNTs that make up the BPs. The CNTs were observed to straighten and move away from each other thus reducing the CNT-CNT junctions responsible for electrical conductance. On the other hand, the decrease in electrical resistance as temperature increases is attributed to the increased inter-tube hopping of electrons which is facilitated by temperature. The CNT-based sensor with its high sensitivity, flexibility, and lightweight is suitable for a wide range of applications such as structural health monitoring, human motion sensing, wearable electronics, and biomedical applications.</div></div>","PeriodicalId":21733,"journal":{"name":"Sensors International","volume":"6 ","pages":"Article 100342"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144279472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GaN Nanopowder synthesis via nitridation: Fabrication and characterization of GaN thin Films for UV detection applications 氮化法合成氮化镓纳米粉末：用于紫外检测的氮化镓薄膜的制备和表征

Sensors International Pub Date : 2025-01-01 DOI: 10.1016/j.sintl.2025.100329

Mahdi Hajimazdarani , Peyman Yaghoubizadeh , Ali Jafari , Ali Kenarsari Moghadam , Mojtaba Hajimazdarani , Mohammad Javad Eshraghi

{"title":"GaN Nanopowder synthesis via nitridation: Fabrication and characterization of GaN thin Films for UV detection applications","authors":"Mahdi Hajimazdarani , Peyman Yaghoubizadeh , Ali Jafari , Ali Kenarsari Moghadam , Mojtaba Hajimazdarani , Mohammad Javad Eshraghi","doi":"10.1016/j.sintl.2025.100329","DOIUrl":"10.1016/j.sintl.2025.100329","url":null,"abstract":"<div><div>This study presents a novel method for synthesizing gallium nitride nanoparticles via nitridation and their subsequent deposition onto silicon substrates using electron beam evaporation for UV detection applications. The structural and optical properties of the resulting gallium nitride thin films were thoroughly characterized. X-ray diffraction confirmed that the synthesized powder has a wurtzite crystal structure, while the deposited thin film has an amorphous structure. Field emission scanning electron microscopy revealed a uniform layer with an approximate thickness of 150 nm. Energy dispersive spectroscopy confirmed that the stoichiometric ratio of gallium to nitrogen was maintained throughout the coating process. Additionally, ultraviolet diffuse reflectance spectroscopy measurements revealed a bandgap of 3.37 eV for the deposited thin film. Additionally, gold electrodes were deposited on the gallium nitride thin film, and the optical sensor's detection properties were evaluated, demonstrating a sensitivity of 133.6 along with rise and fall times of 18 ms and 15 ms, respectively. These findings underscore the potential of gallium nitride-based materials for advanced optical sensor applications in various fields.</div></div>","PeriodicalId":21733,"journal":{"name":"Sensors International","volume":"6 ","pages":"Article 100329"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143099033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A composite of platinum nanoparticles and multiwalled carbon nanotubes modified electrode for sensitive and simultaneous detection of hydroquinone and methylparaben in cosmetic products 铂纳米粒子与多壁碳纳米管修饰电极的复合材料用于化妆品中对苯二酚和对羟基苯甲酸甲酯的灵敏同时检测

Sensors International Pub Date : 2025-01-01 DOI: 10.1016/j.sintl.2025.100335

Adilla Chairunisa , Wulan Tri Wahyuni , Irmanida BatuBara , Budi Riza Putra

{"title":"A composite of platinum nanoparticles and multiwalled carbon nanotubes modified electrode for sensitive and simultaneous detection of hydroquinone and methylparaben in cosmetic products","authors":"Adilla Chairunisa , Wulan Tri Wahyuni , Irmanida BatuBara , Budi Riza Putra","doi":"10.1016/j.sintl.2025.100335","DOIUrl":"10.1016/j.sintl.2025.100335","url":null,"abstract":"<div><div>In this study, a glassy carbon electrode (GCE) was modified with a composite of platinum nanoparticles (PtNPs) and multiwalled carbon nanotubes (MWCNTs) to serve as a sensing platform for the simultaneous detection of hydroquinone (HQ) and methylparaben (MP). The GCE surface was modified using a simple drop-casting technique with a PtNPs/MWCNT composite, and the composite was subsequently characterized by UV–Vis and FTIR spectroscopy, XRD, FESEM-EDS, and TEM techniques. The highest sensitivity of the developed sensor was achieved when the optimum composition of PtNPs and MWCNT was 4:6 on the surface of the GCE. This phenomenon may be attributed to the synergistic interaction between PtNPs and MWCNTs, which enhances the conductivity of the modified electrodes. The synergistic effect in relation to the catalytic activity of PtNPs and the large electroactive surface area of MWCNT results in an enhanced electrocatalytic signal for sensing purposes. Concurrently, the analytical performance of PtNPs/MWCNT/GCE was investigated using the differential pulse voltammetry (DPV) technique, which showed a linear response for HQ and MP in the ranges of 5–200 μM and 50–500 μM, respectively. Moreover, this proposed sensor demonstrated a low limit of detection and good sensitivity for the simultaneous detection of HQ (0.4 μM and 1.8136 μA μM<sup>−1</sup> cm<sup>−2</sup>) and MP (0.8 μM and 0.7076 μA μM<sup>−1</sup> cm<sup>−2</sup>). Furthermore, the proposed sensor exhibited excellent stability, reproducibility, and good selectivity, with recovery values ranging from 97.9 % to 101.6 % for HQ and from 98.8 % to 103.3 % for MP. Thus, this proposed sensor has been applied for the simultaneous detection of HQ and MP in cosmetic products, showing good recovery values that emphasize its potential as a promising sensing platform for detecting contaminant compounds in cosmetic products.</div></div>","PeriodicalId":21733,"journal":{"name":"Sensors International","volume":"6 ","pages":"Article 100335"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143854481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design of a high accuracy wideband current sensing system by tunneling magnetoresistive device with digital parametric equalizer 带数字参数均衡器的隧道磁阻式高精度宽带电流传感系统的设计

Sensors International Pub Date : 2025-01-01 DOI: 10.1016/j.sintl.2024.100311

Sen Qian , Hui Huang , Fuchao Li , Qiang Shi , Xiaohui Yan , Jinghong Guo

{"title":"Design of a high accuracy wideband current sensing system by tunneling magnetoresistive device with digital parametric equalizer","authors":"Sen Qian , Hui Huang , Fuchao Li , Qiang Shi , Xiaohui Yan , Jinghong Guo","doi":"10.1016/j.sintl.2024.100311","DOIUrl":"10.1016/j.sintl.2024.100311","url":null,"abstract":"<div><div>Wideband current sensors play a crucial role in the future power grid, especially with the increasing integration of renewable energy and nonlinear loads. This research developed a sensor configuration using tunneling magnetoresistive (TMR) devices for wideband current measurement. A parametric equalizer was also introduced to compensate for minor fluctuations in the TMR sensor's frequency response, thereby reducing wideband measurement errors. A calibration setup was created to test the frequency-dependent accuracy of the compensated TMR sensor. Results showed that relative errors in wideband measurements were reduced to 2 % after compensation, compared to 6 % of the uncompensated results, with power frequency measurement errors falling below 1 %. Furthermore, the designed TMR sensors were deployed in a 0.4 kV household district, demonstrating their practical application in diagnosing the spectral content of the load current. The analysis revealed a range of wideband components, including low-frequency components below 50 Hz, intermediate harmonics, and supraharmonics.</div></div>","PeriodicalId":21733,"journal":{"name":"Sensors International","volume":"6 ","pages":"Article 100311"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143099028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lighting the way forward: The bright future of photonic integrated circuits 照亮前进的道路：光子集成电路的美好未来

Sensors International Pub Date : 2025-01-01 DOI: 10.1016/j.sintl.2025.100326

M.A. Butt, B. Janaszek, R. Piramidowicz

引用次数: 0

Advancing point-of-care testing with nanomaterials-based screen-printing electrodes 推进基于纳米材料的丝网印刷电极的即时检测

Sensors International Pub Date : 2025-01-01 DOI: 10.1016/j.sintl.2025.100328

Sophia Nazir

{"title":"Advancing point-of-care testing with nanomaterials-based screen-printing electrodes","authors":"Sophia Nazir","doi":"10.1016/j.sintl.2025.100328","DOIUrl":"10.1016/j.sintl.2025.100328","url":null,"abstract":"<div><div>Although numerous studies have been conducted on multiple screen-printing electrodes (SPEs), little emphasis has been placed on systematically assessing scholarly work on nanomaterial-equipped SPEs in bioanalytical research. The fabrication of state-of-the-art portable screen-printing measuring devices represents significant disease monitoring and diagnosis advancements. This review classifies screen-printing electrodes based on the nanomaterials used. It discusses cost, regulatory approvals for portable screen-printing electrodes in point-of-care diagnostics, sensitivity, specificity, size reductions, and proposed solutions. It looks into the significance of new nanomaterials and substrates in fabricating point-of-care diagnostic devices and miniaturisation techniques. The review primarily focuses on the recent downsizing advances that have resulted in a growing number of portable screen-printing electrodes for quick point-of-care diagnostics. Special attention is given to identifying different bioanalytics associated with distinct medical problems. Screen-printing biosensors potentially transform healthcare by allowing for rapid, accurate, and individualised diagnosis. These biosensors improve disease management, medical outcomes, and global diagnostic accessibility as technology advances.</div></div>","PeriodicalId":21733,"journal":{"name":"Sensors International","volume":"6 ","pages":"Article 100328"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143099037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A dual sensing probe for Cd2+ and Zn2+ detection in water based on tautomerization of acetamidoquinoline containing dipicolylamine and its application in water samples and cell imaging 基于二聚胺乙酰氨基喹啉互变异构的水中Cd2+和Zn2+双传感探针及其在水样和细胞成像中的应用

Sensors International Pub Date : 2025-01-01 DOI: 10.1016/j.sintl.2025.100336

Waroton Paisuwan , Takuya Kodama , Tanapat Palaga , Thitiporn Pattarakankul , Mongkol Sukwattanasinitt , Nantanat Chailanggar , Mamoru Tobisu , Anawat Ajavakom

{"title":"A dual sensing probe for Cd2+ and Zn2+ detection in water based on tautomerization of acetamidoquinoline containing dipicolylamine and its application in water samples and cell imaging","authors":"Waroton Paisuwan , Takuya Kodama , Tanapat Palaga , Thitiporn Pattarakankul , Mongkol Sukwattanasinitt , Nantanat Chailanggar , Mamoru Tobisu , Anawat Ajavakom","doi":"10.1016/j.sintl.2025.100336","DOIUrl":"10.1016/j.sintl.2025.100336","url":null,"abstract":"<div><div>Two novel fluorescent probes (<strong>2QAD</strong> and <strong>6QAD</strong>) for metal ion detection were designed and synthesized based on acetamidoquinoline derivatives containing dipicolylamine unit. <strong>2QAD</strong> distinctively exhibits fluorescence enhancement with Cd<sup>2+</sup> and Zn<sup>2+</sup> in aqueous media at different emission wavelengths of 350 and 380 nm, respectively. The fluorescence enhancement of <strong>2QAD</strong> involves inhibiting the PET process from the dipicolylamine group to the quinoline ring by the corresponding 1:1 complexation with each metal ion. The reversibility of complexes when adding EDTA indicates the static fluorescence-enhancing mechanism. The distinguished fluorescence responses result from amide-imidic tautomerization of <strong>2QAD</strong> induced by the complexation with different metal ions, confirmed by <sup>1</sup>H NMR. From the results of fluorescence titration, the LOD values for Cd<sup>2+</sup> and Zn<sup>2+</sup> were calculated to be 17 and 8.5 ppb, respectively, with a good linear range. Furthermore, the <strong>2QAD</strong> probe can be employed to determine the amount of Cd<sup>2+</sup> and Zn<sup>2+</sup> in real water samples and can also be applied to macrophage cell RAW264.7.</div></div>","PeriodicalId":21733,"journal":{"name":"Sensors International","volume":"6 ","pages":"Article 100336"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143881714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of a sugar-derived silver nanoparticle-based electrochemical immunosensor for sensitive D-dimer detection 基于糖源银纳米粒子的d -二聚体灵敏检测电化学免疫传感器的研制

Sensors International Pub Date : 2025-01-01 DOI: 10.1016/j.sintl.2025.100332

Fatma Ozturk Kirbay , İdris Yazgan , Dilek Odaci

{"title":"Development of a sugar-derived silver nanoparticle-based electrochemical immunosensor for sensitive D-dimer detection","authors":"Fatma Ozturk Kirbay , İdris Yazgan , Dilek Odaci","doi":"10.1016/j.sintl.2025.100332","DOIUrl":"10.1016/j.sintl.2025.100332","url":null,"abstract":"<div><div>D-dimer (DD) is a key marker of coagulation and fibrinolysis activation. Clinicians can make important decisions with the aid of quick analysis and quantification, ideally at the patient's bedside. Electrochemical immunosensors are effective point-of-care technologies to address these issues. Here, we describe the development of a simple electrochemical immunosensor to detect DD. The immunosensor is constructed by electrodeposition of lactose methoxide aniline silver nanoparticles (LMA-AgNPs) on a screen-printed carbon electrode (SPCE). The LMA-AgNP and SPCE/LMA-AgNP were characterized by Fourier transform infrared (FTIR) spectroscopy, high-resolution transmission electron microscopy (HR-TEM), scanning electron microscopy-energy dispersive X-ray spectroscopy (SEM-EDS), and X-ray photoelectron spectroscopy (XPS). The electrochemical behavior of the SPCE/LMA-AgNP was examined using electrochemical impedance spectroscopy (EIS), differential pulse voltammetry (DPV), and cyclic voltammetry (CV). Then, Anti-D-Dimer antibody (Anti-DD) was immobilized on SPCE/LMA-AgNP. Along with the analytical characterization of the SPCE/LMA-AgNP/Anti-DD immunosensor, the linear range for DD, limit of detection (LOD), potential chemical interferences, and real sample applications were also evaluated. The antigen/antibody interaction at various DD concentrations was monitored using DPV. The SPCE/LMA-AgNP/Anti-DD shows a linear response in the DD concentration range of 0.01–1 pg/mL and a LOD of 0.2 fg/mL. In addition, the SPCE/LMA-AgNP/Anti-DD showed excellent specificity and no response to potential interfering substances, for instance urea, insulin, C-reactive protein (CRP), and serum amyloid A (SAA). Eventually, the SPCE/LMA-AgNP/Anti-DD is applied in human serum, which shows good recovery values (97.2 %). The SPCE/LMA-AgNP/Anti-DD can be fabricated cheaply and easily for bedside clinical evaluation.</div></div>","PeriodicalId":21733,"journal":{"name":"Sensors International","volume":"6 ","pages":"Article 100332"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143791293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0