Seminars in Ophthalmology最新文献

{"title":"Comparison of Dry Eye Treatment Outcomes in Patients with or without Autoimmune Disease.","authors":"Heya Lee, Seko Li, Gina Zhu, Aishah Ahmed, Tiffany S Liu","doi":"10.1080/08820538.2025.2574618","DOIUrl":"https://doi.org/10.1080/08820538.2025.2574618","url":null,"abstract":"<p><strong>Purpose: </strong>Assess and compare the efficacy of cyclosporine and lifitegrast in patients with dry eye disease (DED) and with or without autoimmune disease.</p><p><strong>Methods: </strong>430 DED patients from 2018 to 2023 in Wilmer Institute who did or did not receive cyclosporine and/or lifitegrast were selected. Demographics, cataract surgery status, autoimmune comorbidities, visual acuity (VA), and punctate epithelial erosions (PEE) were assessed between treatment groups. VA was assessed using Snellen measurements converted logMAR (logarithm of the minimum angle of resolution) scores. PEE was measured using the integer PEE grade scale, with 0 defined as no PEE. Chi-square and Fisher's Exact test were used to compare categorical variables across groups. Kendall correlation was used to assess the overall trend of VA and PEE grades over time and to determine the number of eyes with significant improvement. Multiple regression was used to analyze the effect of various variables on VA and PEE changes.</p><p><strong>Results: </strong>One hundred and sixty patients received cyclosporine, 45 received lifitegrast, 59 received both, and 166 were controls. The differences in race, age at visit, and sex were not found to be significantly different between treatment groups, as well as the number of autoimmune disease patients. Kendall correlation of logMAR scores revealed that out of 575 eyes with three or more best-corrected VA measurements, only 31 eyes saw significant vision improvement. The number of eyes with improved VA between treatment groups was not significantly different. Using similar statistical methods, the number of eyes with lowered PEE grades was not significantly different between groups. When analyzing changes in logMAR, multiple regression suggested that treatment with cyclosporine and both cyclosporine and lifitegrast is associated with improved visual acuity only if patients also had an autoimmune disease (cyclosporine β = 0.076, <i>p</i> = 3E-6; Both, β = 0.083, <i>p</i> = 5E-5; cyclosporine:autoimmune β = -0.072, <i>p</i> = .010; Both:autoimmune β = -0.181, <i>p</i> = 2E-6). Regression of change in PEE grades revealed that cyclosporine is similarly associated with lower grades in autoimmune patients (cyclosporine:autoimmune β = -0.520, <i>p</i> = 8E-12).</p><p><strong>Conclusions: </strong>Cyclosporine and lifitegrast treatment does not seem to significantly improve visual acuity and PEE compared to control. However, the presence of autoimmune disease significantly modulates the efficacy of DED treatment.</p>","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"1-8"},"PeriodicalIF":2.3,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145308974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lacrimal History - Part 71: Doyens of Dacryology Series - William Spencer Watson (1836-1906) and His Detailed Lacrimal Treatise of 1892.","authors":"Mohammad Javed Ali","doi":"10.1080/08820538.2025.2576422","DOIUrl":"https://doi.org/10.1080/08820538.2025.2576422","url":null,"abstract":"","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"1-8"},"PeriodicalIF":2.3,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145309032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lacrimal History - Part 69: Doyens of Dacryology Series - George Milbry Gould (1848-1922), Erastus Eugene Holt (1849-1931), Functions of the Punctum, and Lacrimal Epidemiology.","authors":"Mohammad Javed Ali","doi":"10.1080/08820538.2025.2574191","DOIUrl":"https://doi.org/10.1080/08820538.2025.2574191","url":null,"abstract":"","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"1-6"},"PeriodicalIF":2.3,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145281131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lacrimal History - Part 63: Doyens of Dacryology Series - Jacob Parsons Schaeffer (1878-1970) and the Embryology of the Lacrimal Drainage System.","authors":"Mohammad Javed Ali","doi":"10.1080/08820538.2025.2574190","DOIUrl":"https://doi.org/10.1080/08820538.2025.2574190","url":null,"abstract":"","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"1-6"},"PeriodicalIF":2.3,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lacrimal History - Part 68: Lacrimal Drainage System and Faith: The 1731 Case of Marie Carteri.","authors":"Mohammad Javed Ali","doi":"10.1080/08820538.2025.2572245","DOIUrl":"https://doi.org/10.1080/08820538.2025.2572245","url":null,"abstract":"","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"1-2"},"PeriodicalIF":2.3,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145252576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lacrimal History - Part 66: Doyens of Dacryology Series - The Lacrimal Anatomical Concepts of Albrecht von Haller (1708-1777), Karl Friedrich Theodor Krause (1797-1868), Joseph Hyrtl (1810-1894), and Paul-Jules Tillaux (1834-1904).","authors":"Mohammad Javed Ali","doi":"10.1080/08820538.2025.2572242","DOIUrl":"https://doi.org/10.1080/08820538.2025.2572242","url":null,"abstract":"","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"1-13"},"PeriodicalIF":2.3,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145245072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lacrimal History - Part 65: Doyens of Dacryology Series - Peter Julian Dolman (1960-).","authors":"Mohammad Javed Ali, Bhupendra C K Patel","doi":"10.1080/08820538.2025.2569997","DOIUrl":"https://doi.org/10.1080/08820538.2025.2569997","url":null,"abstract":"","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"1-3"},"PeriodicalIF":2.3,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145233526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lacrimal History - Part 62: Doyens of Dacryology Series - Jean Charles Eugéne Foltz (1822-1876) and His Concepts of the Tear Flow and the Valve of Foltz.","authors":"Mohammad Javed Ali","doi":"10.1080/08820538.2025.2569202","DOIUrl":"https://doi.org/10.1080/08820538.2025.2569202","url":null,"abstract":"","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"1-4"},"PeriodicalIF":2.3,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ocular Surface Squamous Neoplasia with Coexistent Pterygia: A Study of 14 Cases and Review of Literature.","authors":"Vijitha S Vempuluru, Aniruddh Heroor, Prapti Praful Chheda, Gaurav Patil, Bhargavi Vatte, Swathi Kaliki","doi":"10.1080/08820538.2024.2346748","DOIUrl":"10.1080/08820538.2024.2346748","url":null,"abstract":"<p><strong>Purpose: </strong>To report the clinical presentation, anterior segment optical coherence tomography features, treatment, and outcomes of ocular surface squamous neoplasia (OSSN) associated with pterygium.</p><p><strong>Methods: </strong>Retrospective interventional series of 14 cases in a 28-month study period.</p><p><strong>Results: </strong>OSSN was coexistent with pterygium (<i>n</i> = 14) in < 1% of all pterygia (<i>n</i> = 7384). The mean age at the presentation of OSSN with pterygium was 49 years (median, 49 years; range, 36 to 71 years). Referral diagnosis included pterygium sans OSSN (<i>n</i> = 7, 50%), granuloma (<i>n</i> = 1, 7%), actinic keratosis (<i>n</i> = 1, 7%), and conjunctivitis (<i>n</i> = 1, 7%). All OSSNs were unilateral, and six patients (43%) had bilateral pterygia. Tumors arose from the nasal (<i>n</i> = 8, 57%), or temporal (<i>n</i> = 6, 43%) quadrants. The mean tumor diameter was 4 mm (median, 4 mm; range, 2 to 6 mm), and the mean thickness was 2 mm (median, 1 mm; range, 1 to 3 mm). The delineation between OSSN and pterygium could be identified on anterior segment optical coherence tomography (AS-OCT) in all (100%) cases. All patients received 1% topical 5-fluorouracil (5-FU), and complete tumor regression was achieved in 13 (93%) cases with a mean number of 2 cycles (median, two cycles; range, 1 to 4 cycles). There were no significant adverse effects. No tumor recurrence was noted over a mean follow-up period of 11 months (median 12 months; range, 1 to 4 months).</p><p><strong>Conclusion: </strong>AS-OCT allows accurate detection and mapping of tumor extent in OSSN with coexistent pterygium, and topical 5-FU yields excellent tumor control.</p>","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"659-667"},"PeriodicalIF":2.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140851255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Small Choroidal Melanoma: Diagnosis, Treatment Outcomes, and Unending Controversy.","authors":"Kapil Mishra, Prithvi Mruthyunjaya","doi":"10.1080/08820538.2025.2480188","DOIUrl":"10.1080/08820538.2025.2480188","url":null,"abstract":"<p><strong>Purpose: </strong>Small choroidal melanoma (SCM) remains a diagnostic challenge due to its clinical overlap with choroidal nevus. This overlap encompasses a wide clinical phenotype of lesions termed indeterminate choroidal lesions. Treating an indeterminate lesion is weighed against significant visual morbidity from local treatment versus increased metastatic risk with tumor size.</p><p><strong>Methods: </strong>This comprehensive review includes diagnosis, controversies, management, and future therapy options for small choroidal melanoma.</p><p><strong>Results: </strong>For diagnostically challenging cases, indeterminate choroidal lesions can be closely monitored for growth utilizing multimodal imaging. Tumor biopsies can be performed for either diagnostic purposes in indeterminate choroidal lesions or for metastatic risk prognostication in small choroidal melanomas. Several new treatment options exist to reduce the risk of radiation complications.</p><p><strong>Conclusion: </strong>Despite significant advances in diagnostic imaging, molecular analysis, and treatment techniques for SCM, these tumors may still pose a challenge on appropriate timing and management options.</p>","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"624-633"},"PeriodicalIF":2.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12228555/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}