Seminars in Ophthalmology最新文献

{"title":"Lacrimal History - Part 40: Doyens of Dacryology Series - Reynaldo Manansala Javate (1954-) and Mohsen Bahmani Kashkouli (1967-).","authors":"Mohammad Javed Ali","doi":"10.1080/08820538.2025.2485595","DOIUrl":"https://doi.org/10.1080/08820538.2025.2485595","url":null,"abstract":"","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"1-3"},"PeriodicalIF":1.9,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143731519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraocular Tumor Biopsy.","authors":"Khushboo Chauhan, Arun Singh, Vishal Raval","doi":"10.1080/08820538.2025.2484228","DOIUrl":"https://doi.org/10.1080/08820538.2025.2484228","url":null,"abstract":"<p><strong>Background: </strong>Intraocular biopsy is a diagnostic procedure used to obtain tissue samples to identify intraocular lesions, including tumors, infections, and inflammatory conditions. Inconclusive clinical and imaging findings necessitate intraocular biopsy.</p><p><strong>Methods: </strong>This retrospective review reviewed the relevant literature, including relevant reviews, original articles, case reports, and case series published up to July 2024.</p><p><strong>Results: </strong>Depending on the location and suspected nature of the lesion, intraocular biopsy is performed using various techniques, such as fine-needle aspiration biopsy (FNAB), vitreous biopsy, and chorioretinal biopsy. Despite its challenges, such as small sample size and potential complications like retinal detachment and hemorrhage, intraocular biopsy plays a vital role in guiding management decisions, including treatment planning. Recent advancements in molecular pathology and imaging-guided biopsy techniques have enhanced tissue yield and safety, making biopsy an invaluable diagnostic tool. In ocular oncology, prognostic biopsy for uveal melanoma has become the standard of care.</p><p><strong>Conclusion: </strong>Intraocular biopsy remains a crucial diagnostic tool for treatment decision-making and improving patient outcomes. Technological advancements continue to refine its efficacy and safety, reinforcing its role in modern ophthalmic practice.</p>","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"1-8"},"PeriodicalIF":1.9,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Small Choroidal Melanoma: Diagnosis, Treatment Outcomes, and Unending Controversy.","authors":"Kapil Mishra, Prithvi Mruthyunjaya","doi":"10.1080/08820538.2025.2480188","DOIUrl":"https://doi.org/10.1080/08820538.2025.2480188","url":null,"abstract":"<p><strong>Purpose: </strong>Small choroidal melanoma (SCM) remains a diagnostic challenge due to its clinical overlap with choroidal nevus. This overlap encompasses a wide clinical phenotype of lesions termed indeterminate choroidal lesions. Treating an indeterminate lesion is weighed against significant visual morbidity from local treatment versus increased metastatic risk with tumor size.</p><p><strong>Methods: </strong>This comprehensive review includes diagnosis, controversies, management, and future therapy options for small choroidal melanoma.</p><p><strong>Results: </strong>For diagnostically challenging cases, indeterminate choroidal lesions can be closely monitored for growth utilizing multimodal imaging. Tumor biopsies can be performed for either diagnostic purposes in indeterminate choroidal lesions or for metastatic risk prognostication in small choroidal melanomas. Several new treatment options exist to reduce the risk of radiation complications.</p><p><strong>Conclusion: </strong>Despite significant advances in diagnostic imaging, molecular analysis, and treatment techniques for SCM, these tumors may still pose a challenge on appropriate timing and management options.</p>","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"1-10"},"PeriodicalIF":1.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Episcleral Plaque Brachytherapy.","authors":"Vishal Raval, Rohan Kapoor, Arun Singh","doi":"10.1080/08820538.2025.2480189","DOIUrl":"https://doi.org/10.1080/08820538.2025.2480189","url":null,"abstract":"<p><strong>Background: </strong>Episcleral plaque brachytherapy is a treatment method for ocular tumors that involves placing radionuclide sources directly on or around the tumor using an episcleral plaque. This technique offers the advantage of a highly focused radiation dose, minimizing exposure to critical eye structures. Various radionuclides such as I-125, Ru-106, and Pd-103 are used in ocular brachytherapy. The choice of radionuclides depends on several factors, such as tumor size, location, and desired dose rate.</p><p><strong>Methods: </strong>A retrospective review of the literature from PubMed (1998-2024).</p><p><strong>Results: </strong>Special emphasis is placed on indications for ocular brachytherapy and variations in treatment approaches for choroidal and retinal tumors. This article provides a comprehensive overview of ocular brachytherapy, focusing on its history, indications, technique, and complications. It also provides insight into new innovations in ocular brachytherapy.</p><p><strong>Conclusion: </strong>This article highlights the indications for ocular brachytherapy in choroidal and retinal tumors and describes its complications. This review of the literature on synthesized variations in treatment approaches was conducted to identify the most commonly used management strategies.</p>","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"1-8"},"PeriodicalIF":1.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adjuvant Brachytherapy Using Iodine-125 Plaques for Conjunctival Melanoma with Scleral Invasion.","authors":"Alyssa C Bonnell, Laura D Selby, Minh T Nguyen, Jonathan Chen, Alexei V Chvetsov, Andrew W Stacey","doi":"10.1080/08820538.2025.2479781","DOIUrl":"https://doi.org/10.1080/08820538.2025.2479781","url":null,"abstract":"<p><strong>Purpose: </strong>To report a series of patients with unresectable conjunctival melanoma treated with surgical excision followed by adjuvant iodine-125 plaque brachytherapy.</p><p><strong>Methods: </strong>A retrospective review of a consecutive series of patients at one institution who were found to have scleral-invasive conjunctival melanoma and who were treated with adjuvant plaque brachytherapy. Pre-operative, radiation, and post-operative data were collected for each patient. Patients were evaluated for intraocular pressure, visual acuity (VA), radiation complications, local recurrence, and presence of metastatic disease.</p><p><strong>Results: </strong>A total of 9 patients met inclusion criteria. After surgical excision, all 9 patients were treated with iodine-125 plaque brachytherapy with a dose of 85 Gy to a depth of 3 mm from the plaque face for a prescribed dwell time of 2-3 days. Patients were followed for a median of 45 months (range: 3-66). There have been no local recurrences to this point. Following surgery, 4 of the 9 patients maintained a VA of 20/50 or better. Overall mean visual acuity declined from Snellen 20/59 preoperatively to 20/209 postoperatively. Limbal stem cell deficiency occurred in 3 patients (33%) but may be explained by additional treatments provided in each of these patients (mitomycin C eyedrops in two and proton beam radiation in one). One patient with a second, high-risk forniceal conjunctival melanoma developed metastatic disease.</p><p><strong>Conclusions: </strong>Plaque brachytherapy with iodine-125, delivering a dose of 85 Gy to a depth of 3 mm over a short period of time (3 days) provides safe and promising results for vision and tumor control in patients with scleral-invasive conjunctival melanoma.</p>","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"1-5"},"PeriodicalIF":1.9,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential Risks of Ocular Molecular and Cellular Changes in Spaceflight.","authors":"Ryung Lee, Joshua Ong, Ethan Waisberg, Thomas Mader, John Berdahl, Alex Suh, Nicholas Panzo, Hamza Memon, Ritu Sampige, Blake Katsev, Cihan Mehmet Kadipasaoglu, Christopher E Mason, Afshin Beheshti, Sara R Zwart, Scott M Smith, Andrew G Lee","doi":"10.1080/08820538.2025.2471443","DOIUrl":"https://doi.org/10.1080/08820538.2025.2471443","url":null,"abstract":"<p><strong>Purpose: </strong>Many fundamental cellular and molecular changes are known to occur in biological systems during spaceflight, including oxidative stress, DNA damage, mitochondrial damage, epigenetic factors, telomere lengthening, and microbial shifts. We can apply the consequences of these molecular changes in ocular cells, such as the retinal ganglion cells and corneal epithelium, to identify ophthalmologic risks during spaceflight. This review aims to discuss the potential molecular changes in greater detail and apply the principles to ocular cells and ophthalmic disease risk in astronauts.</p><p><strong>Methods: </strong>A targeted, relevant search of the literature on the topic and related topics of ocular surface and spaceflight was conducted with scholarly databases PubMed, Web of Science, and Embase from inception to July2024 with search terms \"oxidative stress\"; \"DNA damage\"; \"Mitochondrial Dysfunction\"; \"Epigenetics\"; \"Telomeres\"; \"Microbiome\"; \"ocular cells\"; \"spaceflight\"; \"microgravity\"; \"radiation.\"</p><p><strong>Results: </strong>A total of 115 articles were included following screening and eligibility assessment. Key findings include molecular changes and their contributions to ophthalmic diseases like cataracts, spaceflight-associated neuro-ocular syndrome, and dry eye syndrome.</p><p><strong>Conclusion: </strong>This review provides a comprehensive overview of risks to vision associated with long-duration spaceflight missions beyond low Earth orbit (LEO). Further investigation into targeted countermeasures is imperative to mitigate vision-threatening sequelae in astronauts undertaking deep-space exploration.</p>","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"1-11"},"PeriodicalIF":1.9,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treat-And-Extend Versus Pro Re Nata Regimen of Intravitreal Conbercept Injection for Neovascular Age-Related Macular Degeneration: Results from COCOA, a Prospective, Open-Label, Multicenter, Randomized Phase IV Clinical Trial.","authors":"Yaoyao Sun, Wenfang Zhang, Bojie Hu, Bin Sun, Tonghe Zhang, Suqin Yu, Gongqiang Yuan, Rongping Dai, Ke Fan, Lifei Wang, Pei Cheng, Gang An, Liangbao An, Fang Wang, Weiqi Chen, Jie Zhang, Xiyuan Zhou, Feng Wang, Jian Ye, Xionggao Huang, Xiaoyan Peng, Jun Li, Miaoqin Wu, Guangming Wan, Jingxiang Zhong, Shaoping Ha, Xiao Ke, Jianhong Liang, Huijun Qi, Hong Yin, Tong Qian, Jinfeng Qu, Xuan Shi, Jing Hou, Heng Miao, Yuou Yao, Enzhong Jin, Xun Deng, Jian Zhang, Xiaoqing Shi, Jun Liu, Jie Ma, Jia Liu, Ye Tao, Bin Liu, Xiaoxin Li, Mingwei Zhao","doi":"10.1080/08820538.2025.2467853","DOIUrl":"https://doi.org/10.1080/08820538.2025.2467853","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate and contrast the effectiveness and safety of two conbercept treatment protocols-a three-dose treat-and-extend (3+T&E) regimen and a three-dose pro re nata (3+PRN) regimen-in Chinese patients diagnosed with neovascular age-related macular degeneration (nAMD).</p><p><strong>Methods: </strong>Eligible patients, who had not undergone anti-VEGF intraocular injections within 3 months prior to enrollment, were randomly assigned to either the 3+T&E or 3+PRN regimen. The 3+T&E group received at least three monthly injections, with subsequent visit intervals extended based on disease activity assessment. The primary endpoint was the mean change in best-corrected visual acuity (BCVA) from baseline to week 48, using a predefined noninferiority threshold.</p><p><strong>Results: </strong>Among 501 participants (249 in 3+T&E, 252 in 3+PRN), approximately half had prior anti-VEGF treatment. At 48 weeks, both regimens showed significant BCVA improvements (+9.9 for 3+PRN, +8.6 for 3+T&E; <i>p</i> = .208), with comparable rates of ≥15-letter gains (32.12% for 3+PRN, 30.77% for 3+T&E; <i>p</i> = .827). The 3+PRN group received fewer injections (mean 6.4 vs. 6.9 in 3+T&E; <i>p</i> = .028) but had shorter intervals between injections (6.93 weeks vs. 7.46 weeks in 3+T&E; <i>p</i> = .010). Drug-related adverse events occurred in 5% of patients, with ocular events evenly distributed and minimal cardiovascular events reported.</p><p><strong>Conclusion: </strong>Both 3+T&E and 3+PRN conbercept regimens effectively improved visual and anatomical outcomes in Chinese nAMD patients. The 3+T&E regimen was noninferior to 3+PRN in improving BCVA from baseline to week 48. The 3+T&E regimen enabled longer injection intervals while 3+PRN regimen with less injections is more cost-effective while maintaining a comparable safety profile. Treatment plan tailored to an individual patient's situation appears necessary.</p>","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"1-7"},"PeriodicalIF":1.9,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lacrimal History - Part 39: Doyens of Dacryology Series - Jeffrey Jay Hurwitz (1944-2022).","authors":"Ahsen Hussain, Mohammad Javed Ali","doi":"10.1080/08820538.2025.2474341","DOIUrl":"https://doi.org/10.1080/08820538.2025.2474341","url":null,"abstract":"","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"1-3"},"PeriodicalIF":1.9,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Telemedicine in Retinoblastoma: A Review.","authors":"Mattan Arazi, Ido Didi Fabian","doi":"10.1080/08820538.2025.2471989","DOIUrl":"https://doi.org/10.1080/08820538.2025.2471989","url":null,"abstract":"<p><strong>Purpose: </strong>To perform a scoping review of the literature investigating the use of telemedicine in retinoblastoma (RB) care, as well as its integration into broader health-care systems worldwide.</p><p><strong>Methods: </strong>A comprehensive search of academic databases, Medline and Embase, as well as public, web-based sources, was performed. Article references were also screened for inclusion within the review. Only English-language sources that presented evidence of dedicated frameworks incorporating telemedicine-based RB care were included.</p><p><strong>Results: </strong>The review identified 57 peer-reviewed studies, of which 19 were found potentially eligible for inclusion. Following exclusion criteria and a web-based search, 11 sources referencing 10 telemedicine frameworks, comprising four peer-reviewed articles, and seven publicly available initiatives, were included. Major themes leveraging telemedicine in RB care included knowledge exchange and capacity building, the establishment of direct partnerships incorporating teleconsultation, and the development of care coordination networks. Many telehealth platforms were effectively integrated into health-care systems; however, challenges included the absence of RB specific initiatives, the need for publicly available, measurable peer-reviewed outcomes and the complexities of multidimensional RB care.</p><p><strong>Conclusion: </strong>Tele-efforts have the potential to enhance delivery of RB care to remote, resource-limited communities. Future research should explore improved integration of policy-driven telemedicine within health-care systems, assess the economic feasibility of providing such care, and facilitate empirical evaluations, ultimately leading to increased sustainability, funding and investment of these models.</p>","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"1-6"},"PeriodicalIF":1.9,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global Research Trends in Endoscopic and External Dacryocystorhinostomy: A Bibliometric Analysis.","authors":"Ahmet Ufuk Kılıçtaş, Furkan Ozer","doi":"10.1080/08820538.2025.2474032","DOIUrl":"https://doi.org/10.1080/08820538.2025.2474032","url":null,"abstract":"<p><strong>Aim: </strong>To carry out an exhaustive bibliometric analysis of the existing literature on endoscopic dacryocystorhinostomy (DCR), with a view to comparing this with the trend in external DCR.</p><p><strong>Methods: </strong>A total of 1,230 publications on endoscopic DCR and 1,036 on external DCR were retrieved from the Web of Science databases and analyzed. Data on publication types, indexing categories, journal and publisher contributions, temporal trends, authorship networks, frequently used keywords, and country-level contributions were evaluated. Co-authorship and keyword co-occurrence networks were visualized to identify collaboration patterns and thematic focuses. Citation metrics, including the top 100 most-cited publications, were also assessed.</p><p><strong>Results: </strong>Original articles accounted for over 85% of the publications in both endoscopic and external DCR literature. The research is predominantly concentrated in ophthalmology (44.4%) and otorhinolaryngology (32.1%) for endoscopic DCR, with most publications indexed in the Science Citation Index Expanded (77.3%). The number of endoscopic DCR publications peaked in 2020, while external DCR peaked in 2015. Ali Mohammad Javed emerged as the most prolific author with 78 publications, and the co-authorship network revealed strong interdisciplinary collaborations. India led the publication output for both endoscopic (16.9%) and external (15.7%) DCR, followed by the United States and Turkey. Frequently used keywords such as \"dacryocystorhinostomy\" and \"epiphora\" highlighted the primary clinical focus.</p><p><strong>Conclusion: </strong>The bibliometric analysis highlights the increasing trend in publications over the last decade, indicating an escalating interest in minimally invasive methods, with endoscopic DCR being a prominent approach for the management of nasolacrimal duct obstruction. Key contributors, impactful journals, and strong collaborations drive innovation in the field. However, research gaps remain in patient-reported metrics, and contributions from underrepresented regions. Addressing these areas through international and multidisciplinary efforts will advance the field further.</p>","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"1-13"},"PeriodicalIF":1.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}