Seminars in Ophthalmology最新文献_第2页

Lacrimal History - Part 20: Doyens of Dacryology Series - Antoine Maítre-Jan (1650-1725) and His 1707 Monograph, 'Traité des Maladies de L'oeil'. 泪史-第20部分：泪学系列的几十年-安托万Maítre-Jan（1650-1725）和他的1707专著，‘ trait<s:1> des Maladies de L’oeil'。

IF 1.9 4区医学

Seminars in Ophthalmology Pub Date : 2025-05-13 DOI: 10.1080/08820538.2025.2505340

Mohammad Javed Ali

引用次数: 0

Onset and Resolution of Ocular Motor Cranial Nerve Palsies Following the Use of Intra-Arterial Chemotherapy for Retinoblastoma. 视网膜母细胞瘤动脉化疗后眼运动脑神经麻痹的发病和消退。

IF 1.9 4区医学

Seminars in Ophthalmology Pub Date : 2025-05-07 DOI: 10.1080/08820538.2025.2501796

Ali Al-Gilgawi, Zishan Naeem, Catriona Duncan, Fergus Robertson, Mandeep S Sagoo, M Ashwin Reddy

{"title":"Onset and Resolution of Ocular Motor Cranial Nerve Palsies Following the Use of Intra-Arterial Chemotherapy for Retinoblastoma.","authors":"Ali Al-Gilgawi, Zishan Naeem, Catriona Duncan, Fergus Robertson, Mandeep S Sagoo, M Ashwin Reddy","doi":"10.1080/08820538.2025.2501796","DOIUrl":"https://doi.org/10.1080/08820538.2025.2501796","url":null,"abstract":"Introduction: Intra-arterial chemotherapy (IAC) has revolutionised the treatment of retinoblastoma with respect to eye salvage. We present a case series assessing the onset and resolution of cranial nerve palsies following IAC in the treatment of retinoblastoma.Materials and methods: A retrospective case series examining children treated with IAC between 2014 and 2020 for refractory retinoblastoma. The initial approach to catheterisation was the same in all cases. All patients were assessed by an orthoptist and those with nerve palsies were followed up for resolution.Results: There were 41 patients treated with IAC in this time period with a median age of 15 months (5-125). Of these, 7 (17%) developed cranial nerve palsies (NP). These were either 3rd (3 of 7), 6th (1 of 7) or mixed 3rd and 6th (3 of 7) palsies. Onset was at a median of 5 days after the injection. Five resolved and resolution was at a median of 3 months (0.75-26) from onset. Two children still had extra-ocular muscle involvement due to NPs that did not resolve and the cumulative doses of Melphalan were 47.5 mg and 37.5 mg. All children who had cranial nerve palsies that resolved had a cumulative dose of less than 20 mg of Melphalan.Conclusion: Cranial nerve palsy is an infrequent occurrence after IAC but families need to be aware of this as a complication. It is reassuring that the majority resolve. In our experience, a high cumulative dose of melphalan due to the refractory nature of the tumour increases the risk of this complication long term.","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"1-6"},"PeriodicalIF":1.9,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144013454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lacrimal History - Part 15: Doyens of Dacryology Series - Jean-Louis Petit (1674-1750) and His Lacrimal Work in 'Oeuvres Completes'. 泪的历史-第15部分：泪的系列-让-路易佩蒂（1674年至1750年）和他的泪的工作在‘欧弗尔斯完成’。

IF 1.9 4区医学

Seminars in Ophthalmology Pub Date : 2025-05-06 DOI: 10.1080/08820538.2025.2500269

Hafsa Javed Ali, Mohammad Javed Ali

引用次数: 0

Lacrimal History - Part 29: Doyens of Dacryology Series - Mikhail Krasnov (1929-2006) and Vladimir Beloglazov (1930-2012). 泪史-第29部分：泪学系列-米哈伊尔·克拉斯诺夫（1929-2006）和弗拉基米尔·别洛格拉佐夫（1930-2012）。

IF 1.9 4区医学

Seminars in Ophthalmology Pub Date : 2025-05-01 Epub Date: 2024-12-03 DOI: 10.1080/08820538.2024.2436301

Vasily Yartsev, Mohammad Javed Ali

引用次数: 0

Ocular Immune-Related Adverse Events Associated with PD-1 Inhibitors: From Molecular Mechanisms to Clinical Management. 与 PD-1 抑制剂相关的眼部免疫相关不良事件：从分子机制到临床管理。

IF 1.9 4区医学

Seminars in Ophthalmology Pub Date : 2025-05-01 Epub Date: 2024-11-28 DOI: 10.1080/08820538.2024.2433636

Yuqi Gong, Yushuai Liu, Fagang Jiang, Xinghua Wang

{"title":"Ocular Immune-Related Adverse Events Associated with PD-1 Inhibitors: From Molecular Mechanisms to Clinical Management.","authors":"Yuqi Gong, Yushuai Liu, Fagang Jiang, Xinghua Wang","doi":"10.1080/08820538.2024.2433636","DOIUrl":"10.1080/08820538.2024.2433636","url":null,"abstract":"Purpose: To help ophthalmologists and oncologists better understand the ocular irAEs secondary to PD-1 inhibitors , enabling early detection and management of ocular complications.Methods: We reviewed case reports and related literatures on ocular irAEs secondary to PD-1 inhibitors in PubMed, including a total of 70 case reports, summarizing and analyzing the specific conditions of these patients.Results: The most common malignant tumors were melanoma (n = 41; 58.6%) and lung cancer (n = 13; 18.6%). The main PD-1 inhibitors used were pembrolizumab (n = 38; 54.3%) and nivolumab (n = 28; 40%). They may result in various ocular complications, with the most common being uveitis (n = 35; 50%) and myasthenia gravis (n = 13; 18.57%). Adverse events concerning the cornea and the retina were reported in 8 cases each (11.43%). Neuro-ophthalmic adverse events were reported in 6 cases (8.57%). Most of these toxicities responded to topical and systemic steroids. Severe manifestations, however, may require temporary or permanent cessation of PD-1 inhibitors treatment.Conclusions: With the increasing use of PD-1 inhibitors, ophthalmologists need to remain sensitive to the clinical manifestations of adverse events to ensure timely diagnosis and management. To improve their quality of life and reduce mortality, oncologists and ophthalmologists should maintain close cooperation and implement multi-disciplinary treatment.","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"288-305"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142740428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Asymmetric Intraocular Pressure Changes in Dominant and Contralateral Eyes: The Dark Room Prone Provocative Test. 主侧眼和对侧眼不对称眼压变化：暗室俯卧诱发试验。

IF 1.9 4区医学

Seminars in Ophthalmology Pub Date : 2025-05-01 Epub Date: 2025-01-22 DOI: 10.1080/08820538.2024.2443972

Junwei Wang, Jun Wang, Tsz Kin Ng, Chukai Huang

{"title":"Asymmetric Intraocular Pressure Changes in Dominant and Contralateral Eyes: The Dark Room Prone Provocative Test.","authors":"Junwei Wang, Jun Wang, Tsz Kin Ng, Chukai Huang","doi":"10.1080/08820538.2024.2443972","DOIUrl":"10.1080/08820538.2024.2443972","url":null,"abstract":"Purpose: To evaluate changes in intraocular pressure (IOP) in dominant and contralateral eyes following the dark room prone provocative test (DRPPT) in the study subjects with shallow anterior chamber.Methods: This was a prospective, single-center, non-randomized controlled trial of 43 subjects (86 eyes) with shallow anterior chamber. The dominant eye was identified using the card-hole method. The study subjects underwent the DRPPT for one hour. Pre- and post-DRPPT IOP was measured using an I-Care tonometer, and pupillary parameters, including amplitude of constriction, peak constriction velocity, and peak re-dilation velocity, were also measured using the RAPDx® dynamic pupillometer.Results: Significant increases in IOP were observed in both the dominant and contralateral eyes after DRPPT, compared to their respective pre-DRPPT IOP levels. (p < .01). Moreover, IOP variation before and after DRPPT was significantly greater in the dominant eye than in the contralateral eye (median 3.60 mmHg vs. 2.70 mmHg, p < .05). The dominant eyes exhibited a smaller amplitude of constriction (1.07 ± 0.35 mm vs 1.14 ± 0.34 mm, P < .05) and slower constriction velocity (3.71 ± 1.12 mm/s vs 3.78 ± 1.11 mm/s, P < .05) as compared to the contralateral eyes.Conclusions: This study demonstrated that the dominant eye exhibited greater IOP changes after DRPPT than the contralateral eye. Additionally, it showed smaller pupil constriction and slower contraction, indicating a higher likelihood of pupil blockage in the dominant eye with shallow anterior chambers. This asymmetry partially explains the monocular onset of acute angle-closure attacks.","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"325-331"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143024395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiology of Consumer Product-Related Ocular Injuries in the Incarcerated Population. 监禁人群中消费品相关眼部损伤的流行病学研究。

IF 1.9 4区医学

Seminars in Ophthalmology Pub Date : 2025-05-01 Epub Date: 2025-01-09 DOI: 10.1080/08820538.2025.2450685

David Mothy, Hassaam S Choudhry, Aneesh P Reddy, Mohammad H Dastjerdi

{"title":"Epidemiology of Consumer Product-Related Ocular Injuries in the Incarcerated Population.","authors":"David Mothy, Hassaam S Choudhry, Aneesh P Reddy, Mohammad H Dastjerdi","doi":"10.1080/08820538.2025.2450685","DOIUrl":"10.1080/08820538.2025.2450685","url":null,"abstract":"Purpose: To characterize the epidemiology of consumer product-related ocular injury in the United States (US) incarcerated population, and identify preventable causes.Methods: The National Electronic Injury Surveillance System (NEISS) database was queried for cases of eye injury from 2014 to 2023. Incarcerated cases were identified using the keywords \"prison\", \"jail\", \"inmate\", and \"incarcerate\". Year of injury, diagnosis, product code, and demographic information were gathered and compared between the incarcerated and general US populations using SPSS version 29 (IBM Corp.). A narrative analysis categorized cases of ocular trauma in the incarcerated by common causes of injury.Results: Between 2014 and 2023, there were an estimated 1,644,841 cases of consumer-product related ocular injury the US, with 2683 cases occurring in the incarcerated. A higher percentage of ocular injury cases in the incarcerated involved African American individuals (43.42% vs. 17.18%), males (92.22% vs 68.54%), alcohol use (4.11% vs. 0.64%), drug use (3.91% vs. 0.82%), and hospitalization (4.96% vs. 1.39%). Contusions were less common in the incarcerated population (27.21% vs. 41.31%), while foreign body injuries were more common (24.38% vs. 18.75%). Penal labor, including cleaning (13.74%), welding (8.25%), yardwork (5.92%), and power grinding (5.72%), accounted for 36.36% of injuries. 26.50% of injuries were sports-related, with basketball involved in 16.82%.Conclusions: The epidemiology of ocular injury in the incarcerated differs from the general US population. Penal labor and sports-related ocular injury represent a majority of cases, underscoring the need for protective eyewear.","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"339-344"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142954488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent Progression of Pathogenesis and Treatment for Diabetic Cataracts. 糖尿病性白内障发病机制和治疗的最新进展。

IF 1.9 4区医学

Seminars in Ophthalmology Pub Date : 2025-05-01 Epub Date: 2024-11-12 DOI: 10.1080/08820538.2024.2427789

Yike Li, An-Peng Pan, A-Yong Yu

{"title":"Recent Progression of Pathogenesis and Treatment for Diabetic Cataracts.","authors":"Yike Li, An-Peng Pan, A-Yong Yu","doi":"10.1080/08820538.2024.2427789","DOIUrl":"10.1080/08820538.2024.2427789","url":null,"abstract":"Background: Cataracts are still the main cause of blindness worldwide. The incidence of cataracts in the diabetic population is 3-5 times higher than in healthy people. With the increasing incidence of diabetes and the development of aging, as well as the higher risk of surgical and postoperative complications of diabetic patients undergoing surgery, it is still necessary to study the occurrence and development mechanism of diabetic cataracts as well as potential therapeutic targets and therapeutic drugs.Methods: A retrospective review of the literature from PubMed (2017-2024).Results: We summarized the the current literature on the molecular mechanism and prevention and treatment of diabetic cataracts.Conclusions: The aqueous humor metabolism changes, oxidative stress, reactive oxygen species generation increase, the conversion of polyol pathway, as well as non-coding RNA expression changes play important roles in diabetic cataract and these processes is closely linked with each other. Inhibitors or drugs target to these processes, such as aldose reductase inhibitors, antioxidants, natural flavonoid compounds, as well as nanotechnology-based therapeutic product, have shown promising prospects in the prevention and treatment of diabetic cataract.","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"275-282"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142627710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lacrimal History - Part 28: Doyens of Dacryology Series - Hirohiko Kakizaki (1970-). 泪史-第28部分：泪学系列的先驱- Kakizaki Hirohiko（1970-）。

IF 1.9 4区医学

Seminars in Ophthalmology Pub Date : 2025-05-01 Epub Date: 2024-12-10 DOI: 10.1080/08820538.2024.2440201

Mohammad Javed Ali

引用次数: 0

Evaluation and Comparison of the Comprehensiveness of Canadian and American Ophthalmology Residency Program Websites. 加拿大与美国眼科住院医师计划网站的综合评价与比较。

IF 1.9 4区医学

Seminars in Ophthalmology Pub Date : 2025-05-01 Epub Date: 2024-12-27 DOI: 10.1080/08820538.2024.2447725

Brendan K Tao, David Gou, Jacqueline Chen, Rachel Phord-Toy, Janaya Lo, Chia-Chen Tsai, Edsel Ing, Christian El-Hadad

{"title":"Evaluation and Comparison of the Comprehensiveness of Canadian and American Ophthalmology Residency Program Websites.","authors":"Brendan K Tao, David Gou, Jacqueline Chen, Rachel Phord-Toy, Janaya Lo, Chia-Chen Tsai, Edsel Ing, Christian El-Hadad","doi":"10.1080/08820538.2024.2447725","DOIUrl":"10.1080/08820538.2024.2447725","url":null,"abstract":"Purpose: We descriptively and comparatively evaluated the comprehensiveness of Canadian and US-accredited ophthalmology residency program websites as of August 28, 2024.Methods: Using Canadian Resident Matching Service (n = 15) and US Fellowship and Residency Electronic Interactive Database (n = 125), we assessed website content across seven criteria: recruitment, faculty, residents, education/research, teaching, benefits, and community. Two independent reviewers used a 40-point system, with Kruskal-Wallis and post-hoc pairwise tests for analysis by country and funding model.Results: US programs more frequently had highly comprehensive websites than Canadian programs (US: 74.4%, Canada: 40%). Canadian programs mostly achieved moderate comprehensiveness (Canada: 60%, US: 22.4%). Larger program size and US origin were significantly linked to higher comprehensiveness scores (p < .01).Conclusion: Our findings suggest that US-based, larger programs offer more extensive online resources. We recommend standardized guidelines to improve residency program website transparency and accessibility for medical learners.","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"332-338"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142897100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0