Seminars in Ophthalmology最新文献

{"title":"Emerging Insights in Thyroid Eye Disease Research from 2010 to 2022: Trends, Hot Spots, and Research Situation.","authors":"Yu-Xuan Wan, Guo-Qing Li, Sai-Li Duan, Shi Chang","doi":"10.1080/08820538.2025.2490669","DOIUrl":"10.1080/08820538.2025.2490669","url":null,"abstract":"<p><strong>Purpose: </strong>Thyroid eye disease, the most frequent extra-thyroid manifestation of Graves' disease, has puzzled physicians and scientists and could potentially make patients sight-threatened. This study aimed to aid researchers and readers in this field to improve their understanding of thyroid eye disease research trends and provide ideas for future research from unique perspectives.</p><p><strong>Methods: </strong>The top 100 most-cited papers on Graves' ophthalmopathy from January 1, 2010, to December 31, 2022, were retrieved from the Web of Science Core Collection database. Two authors defined and analyzed these data independently via CiteSpace, Vosviewer, and Tableau.</p><p><strong>Results: </strong>A total of 1861 publications linked with Graves' ophthalmopathy research were identified. All of these 100 top-cited papers were published between 2010 and 2022, and the United States of America (USA), Italy, Germany, England, Netherlands, and China made significant contributions to Graves' ophthalmopathy research. The journal with the highest number of published papers is the Journal of Clinical Endocrinology & Metabolism (<i>n</i> = 22). The USA was the most productive country in this topic (<i>n</i> = 29). The Johannes Gutenberg University of Mainz had the largest number of publications (<i>n</i> = 8) and citations (<i>n</i> = 1610). The most cited article was 'MECHANISMS OF DISEASE Graves' Ophthalmopathy'. The clustered network and timeline of keywords showed the prevalence, diagnosis, and treatment of thyroid eye disease, which were the research core themes during the past 12 years.</p><p><strong>Conclusions: </strong>This study provided insights into the most influential studies related to thyroid eye disease via analyzing the top 100 most-cited papers in thyroid eye disease research.</p>","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"802-814"},"PeriodicalIF":2.3,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144010070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global Research Trends in Endoscopic and External Dacryocystorhinostomy: A Bibliometric Analysis.","authors":"Ahmet Ufuk Kılıçtaş, Furkan Ozer","doi":"10.1080/08820538.2025.2474032","DOIUrl":"10.1080/08820538.2025.2474032","url":null,"abstract":"<p><strong>Aim: </strong>To carry out an exhaustive bibliometric analysis of the existing literature on endoscopic dacryocystorhinostomy (DCR), with a view to comparing this with the trend in external DCR.</p><p><strong>Methods: </strong>A total of 1,230 publications on endoscopic DCR and 1,036 on external DCR were retrieved from the Web of Science databases and analyzed. Data on publication types, indexing categories, journal and publisher contributions, temporal trends, authorship networks, frequently used keywords, and country-level contributions were evaluated. Co-authorship and keyword co-occurrence networks were visualized to identify collaboration patterns and thematic focuses. Citation metrics, including the top 100 most-cited publications, were also assessed.</p><p><strong>Results: </strong>Original articles accounted for over 85% of the publications in both endoscopic and external DCR literature. The research is predominantly concentrated in ophthalmology (44.4%) and otorhinolaryngology (32.1%) for endoscopic DCR, with most publications indexed in the Science Citation Index Expanded (77.3%). The number of endoscopic DCR publications peaked in 2020, while external DCR peaked in 2015. Ali Mohammad Javed emerged as the most prolific author with 78 publications, and the co-authorship network revealed strong interdisciplinary collaborations. India led the publication output for both endoscopic (16.9%) and external (15.7%) DCR, followed by the United States and Turkey. Frequently used keywords such as \"dacryocystorhinostomy\" and \"epiphora\" highlighted the primary clinical focus.</p><p><strong>Conclusion: </strong>The bibliometric analysis highlights the increasing trend in publications over the last decade, indicating an escalating interest in minimally invasive methods, with endoscopic DCR being a prominent approach for the management of nasolacrimal duct obstruction. Key contributors, impactful journals, and strong collaborations drive innovation in the field. However, research gaps remain in patient-reported metrics, and contributions from underrepresented regions. Addressing these areas through international and multidisciplinary efforts will advance the field further.</p>","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"782-794"},"PeriodicalIF":2.3,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persistent Corneal Epithelial Defect Following Pars Plana Vitrectomy: A Narrative Review.","authors":"Makan Ziafati, Reza Mirshahi, Maria Vittoria Cicinelli, Rezvaneh Nazari","doi":"10.1080/08820538.2025.2470253","DOIUrl":"10.1080/08820538.2025.2470253","url":null,"abstract":"<p><strong>Purpose: </strong>Persistent corneal epithelial defects (PCEDs) following pars plana vitrectomy (PPV) represent a significant clinical challenge, potentially leading to corneal scarring, vision loss, and other severe complications. This review aims to summarize the prevalence, associated risk factors, and management strategies for PCEDs in the context of PPV, providing evidence-based guidance for clinicians.</p><p><strong>Methods: </strong>A comprehensive systematic review was conducted using PubMed and Embase databases, identifying English-language studies addressing PCEDs after PPV.</p><p><strong>Results: </strong>The prevalence of PCEDs post-PPV varied widely, from 0% to 78.37%, influenced by intrinsic factors such as diabetes mellitus, which impairs corneal nerve function and healing, and extrinsic factors like intraoperative tamponade with C3F8. Management strategies ranged from conservative options like bandage contact lenses to advanced treatments like topical insulin.</p><p><strong>Conclusion: </strong>PCEDs after PPV are multifactorial and demand individualized management. Advanced therapies, particularly serum-based treatments, and topical insulin, show promising outcomes. Further prospective research is warranted to refine these treatments.</p>","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"743-755"},"PeriodicalIF":2.3,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leveraging Artificial Intelligence for Diabetic Retinopathy Screening and Management: History and Current Advances.","authors":"Ramachandran Rajalakshmi, Thyparambil Aravindakshan PramodKumar, Abdul Subhan Naziyagulnaaz, Ranjit Mohan Anjana, Rajiv Raman, Suchetha Manikandan, Viswanathan Mohan","doi":"10.1080/08820538.2024.2432902","DOIUrl":"10.1080/08820538.2024.2432902","url":null,"abstract":"<p><strong>Aim: </strong>Regular screening of large number of people with diabetes for diabetic retinopathy (DR) with the support of available human resources alone is a global challenge. Digital health innovation is a boon in screening for DR. Multiple artificial intelligence (AI)-based deep learning (DL) algorithms have shown promise for accurate diagnosis of referable DR (RDR). The aim of this review is to evaluate the use of AI for DR screening and the various currently available automated DR detection algorithms.</p><p><strong>Methods: </strong>We reviewed articles published up to May 15th 2024, on the use of AI for DR by searching PubMed, Medline, Embase, Scopus, and Google Scholar using keywords like diabetic retinopathy, retinal imaging, teleophthalmology, automated detection, artificial intelligence, deep learning and fundus photography.</p><p><strong>Results: </strong>This narrative review, traces the advent of AI and its use in digital health, the key concepts in AI and DL algorithm development for diagnosis of DR, some crucial AI algorithms that have been validated for detection of DR and the benefits and challenges of use of AI in detection and management of DR. While there are many approved AI algorithms that are in use globally for DR detection, IDx-DR, EyeArt, and AEYE Diagnostic Screening (AEYE-DS) are the algorithms that have been approved so far by USFDA for automated DR screening.</p><p><strong>Conclusion: </strong>AI has revolutionized screening of DR by enabling early automated detection. Continuous advances in AI technology, combined with high-quality retinal imaging, can lead to early diagnosis of sight-threatening DR, appropriate referrals, and better outcomes.</p>","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"719-726"},"PeriodicalIF":2.3,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142710974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Managing vitreoretinal complications in uveal melanoma: Surgical treatment and practical considerations.","authors":"Rodrigo Anguita, Hung-Da Chou, Vishal R Raval, Vidhi Bajpai, Lorenzo Ferro Desideri, Enrico Bernardi, Rumana N Hussain, Min Kim, Adrian T Fung, Basil K Williams, Maura Di Nicola, Mandeep S Sagoo, Lyndon da Cruz, Bertil Damato, Jens Folke Kiilgaard","doi":"10.1080/08820538.2024.2381774","DOIUrl":"10.1080/08820538.2024.2381774","url":null,"abstract":"<p><strong>Background: </strong>In the past few decades, the primary management for uveal melanoma has evolved from enucleation to eye-preserving treatments. However, despite achieving a high rate of local tumour control, complications following eye-preserving treatments still occur and are partly responsible for functional loss and secondary enucleation.</p><p><strong>Methods: </strong>A literature review by a broad international panel.</p><p><strong>Results: </strong>We summarised the current literature on utilizing vitreoretinal (VR) surgery for managing the complications of uveal melanoma. We also provided insights from the authors' personal experience and practical recommendations for clinical care.</p><p><strong>Conclusions: </strong>With the advancement of VR instruments and surgical techniques and the combination of VR and ocular oncology knowledge (\"Onco-VR\"), it is now possible to manage or even prevent complications such as vitreous haemorrhage, retinal detachment, and toxic tumour syndrome.</p>","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"709-718"},"PeriodicalIF":2.3,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142081460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Prevalence of Myopia and Its Association with Sleep Duration, Physical Activity, and Eye Exercises.","authors":"Juan Cao, Xiaolian Xie, Jing Li, Ling Zhang, Qi Chen, Juan Ma, Haiping Zhao, Jiangping Li, Leina Jia","doi":"10.1080/08820538.2025.2492256","DOIUrl":"10.1080/08820538.2025.2492256","url":null,"abstract":"<p><strong>Purpose: </strong>Myopia is the most common visual impairment among Chinese children and adolescents. The purpose of this study is to explore key interventions for myopia prevalence, especially for early-onset myopia.</p><p><strong>Methods: </strong>Univariate and multivariate analyses were conducted to evaluate potential associations between risk factor exposure and myopia. Lasso regression was performed to prioritize the risk features, and the selected leading influencing factors were used to establish the assembled simulation model. Finally, the rms package of R was used to construct a nomogram forecasting model to predict the risk of myopia.</p><p><strong>Results: </strong>The prevalence of myopia among children and adolescents in Ningxia has shown a rapid upward trend in the past 25 years, from 50.3% in 1995 to 61.4% in 2019, with a growth rate of 10%. Children and adolescents with high grades had a high risk of myopia, which was 3.783 times higher in college school students than that of primary school students. Getting enough sleep time during school days per day (OR = 0.722, 95% CI: 0.620-0.840), be active in physical activity (OR = 0.823, 95% CI: 0.709-0.953), and do eye exercises (OR = 0.725, 95% CI: 0.570-0.919) were the top three protective factors. The AUCs of integrated simulation model for myopia was 0.707.</p><p><strong>Conclusions: </strong>The prevalence of myopia among children and adolescents were high in Ningxia Hui Autonomous Region of Northwest China, and the findings illustrate that reaching the recommended sleep time during school days, being active in physical exercise, and doing eye exercises among different ages are the leading three protective factors for myopia. Such data are critical and valuable for public health agencies to formulate intervention strategies for preventing high myopia and subsequent myopic maculopathy, cataract, retinal detachment, and glaucoma, including promotion of eye exercise, physical activity, enough sleep duration, and health education.</p>","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"815-822"},"PeriodicalIF":2.3,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144023910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lacrimal History - Part 17: Doyens of Dacryology Series - Dominique Anel (1679-1730) Through the Eyes of His Contemporaries.","authors":"Mohammad Javed Ali","doi":"10.1080/08820538.2025.2510028","DOIUrl":"10.1080/08820538.2025.2510028","url":null,"abstract":"","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"683-686"},"PeriodicalIF":2.3,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144187874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the Label: Inconsistencies in AREDS2 Eye Supplements and a Call for Standardisation.","authors":"David Beckers, David Lockington, Florian Kretz, Lena Beckers","doi":"10.1080/08820538.2025.2577391","DOIUrl":"https://doi.org/10.1080/08820538.2025.2577391","url":null,"abstract":"<p><strong>Purpose: </strong>Age-related macular degeneration (AMD) remains a major cause of vision impairment among older adults globally. While treatment exists for the more aggressive, exudative form, options for managing nonexudative AMD are limited. One of the few interventions with scientific backing is the AREDS2 micronutrient formula, which has demonstrated an ability to slow disease progression in patients with intermediate AMD.This investigation set out to systematically assess over-the-counter supplements in the UK that are promoted for macular support, measuring how closely their contents align with the evidence-based AREDS2 formulation.</p><p><strong>Methods: </strong>Products marketed as beneficial for AMD were collected and analyzed. Their labeled ingredients and dosages were directly compared with the standardized nutrient profile outlined in the AREDS2 clinical trials.</p><p><strong>Results: </strong>The analysis revealed that most commercially available supplements deviated markedly from the AREDS2 formula. On average, vitamin C levels were 52.3% lower than recommended, vitamin E levels were 61.2% lower, and zinc content was reduced by 40.1%. Only a small subset of products fully matched both the composition and dosage of the reference formulation.</p><p><strong>Conclusion: </strong>These findings highlight a significant gap between marketed claims and clinical evidence. Most supplements do not meet the established AREDS2 standards, potentially limiting their efficacy. Some were promoted specifically for AMD, while others used general \"macular health\" claims, adding to patient confusion. This inconsistency underscores the need for regulatory measures to enforce standardized labeling and formulation requirements to ensure informed clinical recommendations.</p>","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"1-4"},"PeriodicalIF":2.3,"publicationDate":"2025-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145313504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unravelling Stevens-Johnson Syndrome: Clinicopathological Insights and Therapeutic Advances.","authors":"Ranjan Kumar Behera, Parul Chawla Gupta, Manu Saini, Anu Malik, Pankaj Gupta","doi":"10.1080/08820538.2025.2565502","DOIUrl":"https://doi.org/10.1080/08820538.2025.2565502","url":null,"abstract":"<p><strong>Introduction: </strong>Stevens-Johnson syndrome and Toxic Epidermal Necrolysis are a group of immunologically driven, multisystemic and dermatological blistering diseases. Certain classes of drugs and occasional viral infections are usually the inciting factors. The clinical presentation is generally nonspecific and can progress to severe ocular and vision-threatening complications, with prognosis depending upon several factors. Several grading systems exist to assess the impact of the disease, both in the acute and chronic phases. Diagnosis can be made based on clinical history, examination, and a questionnaire-based approach involving different bodily systems.</p><p><strong>Methods: </strong>A literature search was conducted using various relevant keywords across different electronic databases. A total of 83 articles were included in the study.</p><p><strong>Results: </strong>This comprehensive review highlights the various aspects of Stevens-Johnson syndrome, including disease burden, etiopathogenesis, clinical presentation, disease grading, diagnosis, and management of both the acute and chronic phases.</p><p><strong>Discussion: </strong>Timely management by a multidisciplinary team is required to prevent long-term complications. Amniotic membrane transplantation is beneficial in the acute phase, in conjunction with medications, and in the chronic phase for surgical interventions such as eyelid malposition, persistent corneal epithelial defects, and lid margin keratinisation. For end-stage disease, procedures such as eyelid surgeries, amniotic membrane transplantation, mucous membrane grafting, and keratoprosthesis can help in ocular salvage.</p>","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"1-15"},"PeriodicalIF":2.3,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145308994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lacrimal History - Part 70: Doyens of Dacryology Series - Donald Stilwell Gunn (1862-1939) and His Concepts of Lacrimal Obstructions in the Young.","authors":"Mohammad Javed Ali","doi":"10.1080/08820538.2025.2576418","DOIUrl":"https://doi.org/10.1080/08820538.2025.2576418","url":null,"abstract":"","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"1-4"},"PeriodicalIF":2.3,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145309029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}