Seminars in nuclear medicine最新文献_第9页

Long Axial Field of View PET/CT: Technical Aspects in Cardiovascular Diseases 长轴视场 PET/CT：心血管疾病的技术方面。

IF 4.6 2区医学

Seminars in nuclear medicine Pub Date : 2025-01-01 DOI: 10.1053/j.semnuclmed.2024.10.009

Tonantzin Samara Martinez-Lucio MD , Oscar Isaac Mendoza-Ibañez MD , Wanling Liu MD , Samaneh Mostafapour MSc , Zekai Li MSc , Laura Providência MSc , Giordana Salvi de Souza MSc , Philipp Mohr MSc , Magdalena M. Dobrolinska MD, PhD , Bram van Leer MD , Hendrea S.A. Tingen MD , Joyce van Sluis PhD , Charalampos Tsoumpas PhD , Andor W.J.M. Glaudemans MD, PhD , Klaas Pieter Koopmans MD, PhD , Adriaan A. Lammertsma PhD , Riemer H.J.A. Slart MD, PhD

{"title":"Long Axial Field of View PET/CT: Technical Aspects in Cardiovascular Diseases","authors":"Tonantzin Samara Martinez-Lucio MD , Oscar Isaac Mendoza-Ibañez MD , Wanling Liu MD , Samaneh Mostafapour MSc , Zekai Li MSc , Laura Providência MSc , Giordana Salvi de Souza MSc , Philipp Mohr MSc , Magdalena M. Dobrolinska MD, PhD , Bram van Leer MD , Hendrea S.A. Tingen MD , Joyce van Sluis PhD , Charalampos Tsoumpas PhD , Andor W.J.M. Glaudemans MD, PhD , Klaas Pieter Koopmans MD, PhD , Adriaan A. Lammertsma PhD , Riemer H.J.A. Slart MD, PhD","doi":"10.1053/j.semnuclmed.2024.10.009","DOIUrl":"10.1053/j.semnuclmed.2024.10.009","url":null,"abstract":"<div><div>Positron emission tomography / computed tomography (PET/CT) plays a pivotal role in the assessment of cardiovascular diseases (CVD), particularly in the context of ischemic heart disease. Nevertheless, its application in other forms of CVD, such as infiltrative, infectious, or inflammatory conditions, remains limited. Recently, PET/CT systems with an extended axial field of view (LAFOV) have been developed, offering greater anatomical coverage and significantly enhanced PET sensitivity. These advancements enable head-to-pelvis imaging with a single bed position, and in systems with an axial field of view (FOV) of approximately 2 meters, even total body (TB) imaging is feasible in a single scan session. The application of LAFOV PET/CT in CVD presents a promising opportunity to improve systemic cardiovascular assessments and address the limitations inherent to conventional short axial field of view (SAFOV) devices. However, several technical challenges, including procedural considerations for LAFOV systems in CVD, complexities in data processing, arterial input function extraction, and artefact management, have not been fully explored. This review aims to discuss the technical aspects of LAFOV PET/CT in relation to CVD by highlighting key opportunities and challenges and examining the impact of these factors on the evaluation of most relevant CVD.</div></div>","PeriodicalId":21643,"journal":{"name":"Seminars in nuclear medicine","volume":"55 1","pages":"Pages 52-66"},"PeriodicalIF":4.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142627390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of Total Body PET/CT in Inflammatory Disorders 全身 PET/CT 在炎症性疾病中的作用。

IF 4.6 2区医学

Seminars in nuclear medicine Pub Date : 2025-01-01 DOI: 10.1053/j.semnuclmed.2024.11.001

Shervin Zoghi BS , Clemens Mingels MD , Ramsey D. Badawi PhD , Benjamin A. Spencer PhD , Tracy L. Yarbrough MD, PhD , Lorenzo Nardo MD, PhD , Abhijit J. Chaudhari PhD

{"title":"Role of Total Body PET/CT in Inflammatory Disorders","authors":"Shervin Zoghi BS , Clemens Mingels MD , Ramsey D. Badawi PhD , Benjamin A. Spencer PhD , Tracy L. Yarbrough MD, PhD , Lorenzo Nardo MD, PhD , Abhijit J. Chaudhari PhD","doi":"10.1053/j.semnuclmed.2024.11.001","DOIUrl":"10.1053/j.semnuclmed.2024.11.001","url":null,"abstract":"<div><div>Inflammatory disorders historically have been difficult to monitor with conventional PET imaging due to limitations including radiation exposure, lack of validated imaging biomarkers, low spatial resolution, and long acquisition durations. However, the recent development of long-axial field-of-view (LAFOV) PET/CT scanners may allow utilization of novel noninvasive biomarkers to diagnose, predict outcomes, and monitor therapeutic response of inflammatory conditions. LAFOV PET scanners can image most of the human body (if not the entire body) simultaneously in one bed position, with improved signal collection efficiency compared to conventional PET scanners. This allows for imaging with shorter acquisition durations, decreased injected radiotracer dose, prolonged uptake times, or a combination of any of these. In addition, LAFOV PET scanners enable whole-body dynamic imaging. Altogether, these intrinsically superior capabilities in assessing both local and systemic diseases, have allowed these scanners to make increasingly significant contributions to the assessment of inflammatory conditions. This review aims to further explore the role and benefits of LAFOV scanners for imaging various inflammatory conditions while addressing future developments and challenges faced by this technology.</div></div>","PeriodicalId":21643,"journal":{"name":"Seminars in nuclear medicine","volume":"55 1","pages":"Pages 41-51"},"PeriodicalIF":4.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11645246/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter from the Editors 编辑来信

IF 4.6 2区医学

Seminars in nuclear medicine Pub Date : 2025-01-01 DOI: 10.1053/j.semnuclmed.2024.11.003

Kirsten Bouchelouche MD, DMSc, M. Michael Sathekge MD, PhD

引用次数: 0

Total-Body PET/CT: Pros and Cons 全身 PET/CT：利与弊

IF 4.6 2区医学

Seminars in nuclear medicine Pub Date : 2025-01-01 DOI: 10.1053/j.semnuclmed.2024.07.003

Rodney J. Hicks AM, MBBS (Hons), MD, FRACP, FAAHMS, FICIS , Robert E. Ware MBBS, FCP, FAANMS , Jason Callahan BAppSci (MedRad), PhD

引用次数: 0

Total Body Positron Emission Tomography/Computed Tomography: Current Status in Oncology 全身正电子发射断层扫描/计算机断层扫描：肿瘤学现状》。

IF 4.6 2区医学

Seminars in nuclear medicine Pub Date : 2025-01-01 DOI: 10.1053/j.semnuclmed.2024.10.006

Cristina Nanni MD , Andrea Farolfi MD , Paolo Castellucci MD , Stefano Fanti MD

{"title":"Total Body Positron Emission Tomography/Computed Tomography: Current Status in Oncology","authors":"Cristina Nanni MD , Andrea Farolfi MD , Paolo Castellucci MD , Stefano Fanti MD","doi":"10.1053/j.semnuclmed.2024.10.006","DOIUrl":"10.1053/j.semnuclmed.2024.10.006","url":null,"abstract":"<div><div>Positron Emission Tomography (PET) is a crucial imaging modality in oncology, providing functional insights by detecting metabolic activity in tissues. Total-body (TB) PET and large field-of-view PET have emerged as advanced techniques, offering whole-body imaging in a single acquisition. TB PET enables simultaneous imaging from head to toe, providing comprehensive information on tumor distribution, metastasis, and treatment response. This is particularly valuable in oncology, where metastatic spread often requires evaluation of multiple body areas. By covering the entire body, TB PET improves diagnostic accuracy, reduces scan time, and increases patient comfort. Furthermore, these new tomographs offer a marked increase in sensitivity, thanks to their ability to capture a larger volume of data simultaneously. This heightened sensitivity enables the detection of smaller lesions and more subtle metabolic changes, improving diagnostic accuracy in the early stages of cancer or in the evaluation of minimal residual disease. Moreover, the increased sensitivity allows for lower radiotracer doses without compromising image quality, reducing patient exposure to radiation or very quick acquisitions. Another significant advantage is the possibility of dynamic acquisitions, which allow for continuous monitoring of tracer kinetics over time. This provides critical information about tissue perfusion, metabolism, and receptor binding in real time. Dynamic imaging is particularly useful for assessing treatment response in oncology, as it enables the evaluation of tumor behavior over a period rather than a single static snapshot, offering insights into tumor aggressiveness and potential therapeutic targets. This review is focused on the current applications of TB and large field-of-view PET scanners in oncology.</div></div>","PeriodicalId":21643,"journal":{"name":"Seminars in nuclear medicine","volume":"55 1","pages":"Pages 31-40"},"PeriodicalIF":4.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142627399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long Axial Field-of-View PET/CT: New Opportunities for Pediatric Imaging 长轴视野 PET/CT：儿科成像的新机遇。

IF 4.6 2区医学

Seminars in nuclear medicine Pub Date : 2025-01-01 DOI: 10.1053/j.semnuclmed.2024.10.007

André Henrique Dias MD, PhD , Kim Francis Andersen MD , Marie Øbro Fosbøl MD, PhD , Lars Christian Gormsen MD, PhD, Professor , Flemming Littrup Andersen MSc, PhD, Assoc. Prof , Ole Lajord Munk MSc, PhD, Professor

引用次数: 0

Total Body PET/CT: A Role in Musculoskeletal Diseases 全身 PET/CT：在肌肉骨骼疾病中的作用

IF 4.6 2区医学

Seminars in nuclear medicine Pub Date : 2025-01-01 DOI: 10.1053/j.semnuclmed.2024.05.009

Sanaz Katal MD-MPH , Parth Patel BS , Jonathan Lee BS , Kim Taubman MBBS , Ali Gholamrezanezhad MD

{"title":"Total Body PET/CT: A Role in Musculoskeletal Diseases","authors":"Sanaz Katal MD-MPH , Parth Patel BS , Jonathan Lee BS , Kim Taubman MBBS , Ali Gholamrezanezhad MD","doi":"10.1053/j.semnuclmed.2024.05.009","DOIUrl":"10.1053/j.semnuclmed.2024.05.009","url":null,"abstract":"<div><div>Recent advancements in PET technology have culminated in the development of total-body PET (TB-PET) systems, which overcome many limitations of traditional scanners. These TB-PET scanners, while still becoming widely available, represent the forefront of clinical imaging across numerous medical institutions worldwide. Early clinical applications have demonstrated their enhanced image quality, precise lesion quantification, and overall superior performance relative to conventional scanners. The capabilities of TB-PET technology, including extended scan range, ultrahigh sensitivity, exceptional temporal resolution, and dynamic imaging, offer significant potential to tackle unresolved clinical challenges in medical imaging. In this discussion, we aim to explore the emerging applications, opportunities, and future perspectives of TB-PET/CT in musculoskeletal disorders<span> (MSDs). Clinical applications for both oncologic and non-oncologic musculoskeletal diseases are discussed, including inflammatory arthritis<span><span>, infections, osteoarthritis, </span>osteoporosis<span><span>, and skeletal muscle disorders. From the ability to visualize small musculoskeletal structures and the entire axial and </span>appendicular skeleton, TB-PET shows significant potential in the diagnosis and management of MSD conditions as it becomes more widely available.</span></span></span></div></div>","PeriodicalId":21643,"journal":{"name":"Seminars in nuclear medicine","volume":"55 1","pages":"Pages 86-97"},"PeriodicalIF":4.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141470547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of Myocardial Perfusion in Patients After CABG: An Update and Clinical Implications 冠脉搭桥后心肌灌注评估：最新进展及临床意义。

IF 4.6 2区医学

Seminars in nuclear medicine Pub Date : 2024-12-24 DOI: 10.1053/j.semnuclmed.2024.11.002

Ain Ejaz MD, Aliza Hasnain Naqvi MD, Hima Sanjana Perumalla MD, Timothy M. Bateman MD

{"title":"Assessment of Myocardial Perfusion in Patients After CABG: An Update and Clinical Implications","authors":"Ain Ejaz MD, Aliza Hasnain Naqvi MD, Hima Sanjana Perumalla MD, Timothy M. Bateman MD","doi":"10.1053/j.semnuclmed.2024.11.002","DOIUrl":"10.1053/j.semnuclmed.2024.11.002","url":null,"abstract":"<div><div>Stress radionuclide myocardial perfusion imaging (MPI) has been well-established as a useful modality for assessing the status of the coronary circulation in post-coronary artery bypass graft (CABG) patients. CABG by itself escalates progression of atherosclerosis or thrombosis in bypassed native coronary arteries. In most cases MPI will be employed in post-CABG patients who are experiencing symptoms. The major clinical question is whether there is myocardial ischemia, and if so, what is the extent and severity, and are there high-risk markers that would encourage diagnostic coronary and graft angiography. Recent important advances in MPI, including introduction of routine attenuation correction, CZT instrumentation, PET MPI, and PET quantitative blood flow have further enhanced the value of MPI for this population. The purpose of this review is to provide information on these advances relevant to the post-CABG patient, to describe common image findings, and to explore the diagnostic and prognostic significance of different findings in this unique population.</div></div>","PeriodicalId":21643,"journal":{"name":"Seminars in nuclear medicine","volume":"55 3","pages":"Pages 460-469"},"PeriodicalIF":4.6,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142897016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Radiomics and Artificial Intelligence Landscape for [18F]FDG PET/CT in Multiple Myeloma 多发性骨髓瘤[18F]FDG PET/CT 的放射组学和人工智能前景。

IF 4.6 2区医学

Seminars in nuclear medicine Pub Date : 2024-12-13 DOI: 10.1053/j.semnuclmed.2024.11.005

Christos Sachpekidis MD , Hartmut Goldschmidt MD , Lars Edenbrandt MD , Antonia Dimitrakopoulou-Strauss MD

{"title":"Radiomics and Artificial Intelligence Landscape for [18F]FDG PET/CT in Multiple Myeloma","authors":"Christos Sachpekidis MD , Hartmut Goldschmidt MD , Lars Edenbrandt MD , Antonia Dimitrakopoulou-Strauss MD","doi":"10.1053/j.semnuclmed.2024.11.005","DOIUrl":"10.1053/j.semnuclmed.2024.11.005","url":null,"abstract":"<div><div>[<sup>18</sup>F]FDG PET/CT is a powerful imaging modality of high performance in multiple myeloma (MM) and is considered the appropriate method for assessing treatment response in this disease. On the other hand, due to the heterogeneous and sometimes complex patterns of bone marrow infiltration in MM, the interpretation of PET/CT can be particularly challenging, hampering interobserver reproducibility and limiting the diagnostic and prognostic ability of the modality. Although many approaches have been developed to address the issue of standardization, none can yet be considered a standard method for interpretation or objective quantification of PET/CT. Therefore, advanced diagnostic quantification approaches are needed to support and potentially guide the management of MM. In recent years, radiomics has emerged as an innovative method for high-throughput mining of image-derived features for clinical decision making, which may be particularly helpful in oncology. In addition, machine learning and deep learning, both subfields of artificial intelligence (AI) closely related to the radiomics process, have been increasingly applied to automated image analysis, offering new possibilities for a standardized evaluation of imaging modalities such as CT, PET/CT and MRI in oncology. In line with this, the initial but steadily growing literature on the application of radiomics and AI-based methods in the field of [<sup>18</sup>F]FDG PET/CT in MM has already yielded encouraging results, offering a potentially reliable tool towards optimization and standardization of interpretation in this disease. The main results of these studies are presented in this review.</div></div>","PeriodicalId":21643,"journal":{"name":"Seminars in nuclear medicine","volume":"55 3","pages":"Pages 387-395"},"PeriodicalIF":4.6,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artificial Intelligence and Workforce Diversity in Nuclear Medicine 核医学中的人工智能和劳动力多样性。

IF 4.6 2区医学

Seminars in nuclear medicine Pub Date : 2024-11-19 DOI: 10.1053/j.semnuclmed.2024.10.005

K Elizabeth Hawk , Geoffrey M Currie

引用次数: 0