Seminars in nuclear medicine最新文献

Recent Advances and Future Trends of[¹⁸F]-Labeled PET Agents for Renal Imaging. [18F]标记PET肾显像剂的最新进展及未来趋势。

IF 5.9 2区医学

Seminars in nuclear medicine Pub Date : 2025-10-15 DOI: 10.1053/j.semnuclmed.2025.09.008

Takahiro Higuchi, Xinyu Chen, Sophie C Siegmund, Konrad Klimek, Daniel Gröner, Steven P Rowe, Michael Fischereder, Rudolf A Werner

引用次数: 0

Advances in Dosimetry and Imaging for ²⁰³Pb and ²¹²Pb Radiotheranostics. 203Pb和212Pb放射治疗学剂量学与影像学研究进展。

IF 5.9 2区医学

Seminars in nuclear medicine Pub Date : 2025-10-07 DOI: 10.1053/j.semnuclmed.2025.09.006

Keamogetswe Ramonaheng, Milani Qebetu, Kaluzi Banda, Pryaska Goorhoo, Khomotso Legodi, Sipho Mdanda, Sandile Sibiya, Yonwaba Mzizi, Honest Ndlovu, Joseph Kabunda, Mengdie Yang, Kuangyu Shi, Mike Sathekge

{"title":"Advances in Dosimetry and Imaging for 203Pb and 212Pb Radiotheranostics.","authors":"Keamogetswe Ramonaheng, Milani Qebetu, Kaluzi Banda, Pryaska Goorhoo, Khomotso Legodi, Sipho Mdanda, Sandile Sibiya, Yonwaba Mzizi, Honest Ndlovu, Joseph Kabunda, Mengdie Yang, Kuangyu Shi, Mike Sathekge","doi":"10.1053/j.semnuclmed.2025.09.006","DOIUrl":"https://doi.org/10.1053/j.semnuclmed.2025.09.006","url":null,"abstract":"Targeted alpha therapy (TAT) with 212Pb is rapidly emerging as a potent modality for cancer treatment due to the high linear energy transfer and short path length of α-particles, which enable precise tumor cell killing while sparing surrounding healthy tissue. Its elementally identical theranostic partner, 203Pb, functions as a γ-emitting surrogate for quantitative SPECT imaging, providing essential information for patient-specific dosimetry and treatment planning. Advances in SPECT imaging, ranging from NaI(Tl)-based dual-head systems to CZT multi-detector gamma cameras, have enhanced spatial resolution, quantitative accuracy, and lesion detectability, enabling rapid patient scanning and improved activity quantification for dosimetry. Clinical dosimetry workflows that integrate serial 203Pb SPECT/CT acquisitions, pharmacokinetic modeling, and image-based activity quantification facilitate reliable generation of time-activity curves and absorbed dose estimates. Organ-level and voxel-based dosimetry, combined with advanced reconstruction and microdosimetric modeling, further refine dose calculations, supporting individualized therapy planning. Collectively, these developments highlight the translational potential of the 203Pb/212Pb theranostic pair. The aim of this review is to provide a comprehensive assessment of 212Pb-TAT, encompassing clinical applications, surrogate imaging with 203Pb, gamma camera performance, dosimetry workflows, and predictive activity quantification, illustrating how these advances collectively enable quantitative, patient-specific, and theranostic-integrated radionuclide therapy.","PeriodicalId":21643,"journal":{"name":"Seminars in nuclear medicine","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145252584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of PSMA-Targeted Alpha Therapy Using [²¹¹At]PSMA-5. [2111at]PSMA-5靶向α治疗的进展。

IF 5.9 2区医学

Seminars in nuclear medicine Pub Date : 2025-09-30 DOI: 10.1053/j.semnuclmed.2025.09.005

Tadashi Watabe, Sadahiro Naka, Yoshifumi Shirakami, Kazuko Kaneda, Masashi Murakami, Atsushi Toyoshima, Jens Cardinale, Frederik L Giesel

{"title":"Development of PSMA-Targeted Alpha Therapy Using [211At]PSMA-5.","authors":"Tadashi Watabe, Sadahiro Naka, Yoshifumi Shirakami, Kazuko Kaneda, Masashi Murakami, Atsushi Toyoshima, Jens Cardinale, Frederik L Giesel","doi":"10.1053/j.semnuclmed.2025.09.005","DOIUrl":"https://doi.org/10.1053/j.semnuclmed.2025.09.005","url":null,"abstract":"Astatine (211At) is an alpha-emitting nuclide with a 7.2-hour half-life that can be produced using a 30-MeV cyclotron. In recent years, the number of production sites worldwide has been increasing, attracting growing attention to 211At. We have developed a novel 211At-labeled PSMA-targeted agent ([211At]PSMA-5). After conducting preclinical evaluations of its antitumor efficacy and safety, we initiated a first-in-human, investigator-initiated clinical trial in patients with metastatic castration-resistant prostate cancer. To date, the drug has been administered to a total of nine patients, and we have reported high accumulation of [211At]PSMA-5 in recurrent and metastatic lesions. While further efforts are required for the social implementation of 211At-based targeted alpha therapy, including the establishment of a supply chain and the accumulation of additional clinical evidence, PSMA-targeted alpha therapy using 211At represents a promising treatment modality owing to its cyclotron-based production, sustainability, and clean decay characteristics.","PeriodicalId":21643,"journal":{"name":"Seminars in nuclear medicine","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145207337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nectin-4, Bladder Cancer, and Nuclear Medicine: A Theranostic Frontier. Nectin-4，膀胱癌和核医学：治疗前沿。

IF 5.9 2区医学

Seminars in nuclear medicine Pub Date : 2025-09-26 DOI: 10.1053/j.semnuclmed.2025.09.003

Joseph Kabunda, Honest Ndlovu, Karishma Singh, Sandile Sibiya, Sipho Mdanda, Kamo Ramonaheng, Akram Al-Ibraheem, Ken Herrmann, Kgomotso Mokoala, Mike Sathekge

{"title":"Nectin-4, Bladder Cancer, and Nuclear Medicine: A Theranostic Frontier.","authors":"Joseph Kabunda, Honest Ndlovu, Karishma Singh, Sandile Sibiya, Sipho Mdanda, Kamo Ramonaheng, Akram Al-Ibraheem, Ken Herrmann, Kgomotso Mokoala, Mike Sathekge","doi":"10.1053/j.semnuclmed.2025.09.003","DOIUrl":"https://doi.org/10.1053/j.semnuclmed.2025.09.003","url":null,"abstract":"Bladder cancer is among the top ten most common cancers globally, with advanced or metastatic disease associated with dismal survival outcomes. Current diagnostic imaging and therapies have significant limitations, highlighting the urgent need for novel theranostic targets. Nectin-4, a cell adhesion molecule frequently overexpressed in bladder cancer, especially urothelial carcinoma (∼60%-87% of tumors), has emerged as a promising biomarker and therapeutic target. This review critically evaluates the role of Nectin-4 in bladder cancer and explores its exciting potential in nuclear medicine for combined molecular imaging and targeted radionuclide therapy-embracing the \"theranostic\" paradigm. Nectin-4 is abundantly and selectively expressed in most urothelial carcinomas, correlating with advanced disease and poorer prognosis. Clinically validated by the FDA-approved antibody-drug conjugate enfortumab vedotin, Nectin-4 targeting achieves objective response rates around 40%-50% and significantly improves survival in refractory advanced urothelial carcinoma. Recent clinical advances in Nectin-4-targeted PET imaging (such as 68Ga-labeled agents) have demonstrated excellent tumor localization and specificity, enabling precise patient selection for targeted therapies. Additionally, emerging radionuclide therapeutics (eg, 225Ac- and 177Lu-based agents) show promising preclinical and early clinical efficacy, robust tumor targeting, and favorable safety profiles. Targeting Nectin-4 represents a new frontier in the management of bladder cancer, bridging the gap between precise molecular diagnostics and personalized targeted radionuclide therapy. Ongoing clinical trials and translational research are rapidly advancing this promising theranostic strategy towards routine clinical application, with significant potential to enhance patient selection, treatment monitoring, and ultimately, clinical outcomes.","PeriodicalId":21643,"journal":{"name":"Seminars in nuclear medicine","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glypican-3: Novel Theranostic Agent for Hepatocellular Carcinoma. Glypican-3：一种新的肝细胞癌治疗剂。

IF 5.9 2区医学

Seminars in nuclear medicine Pub Date : 2025-09-26 DOI: 10.1053/j.semnuclmed.2025.09.004

Luca Filippi

{"title":"Glypican-3: Novel Theranostic Agent for Hepatocellular Carcinoma.","authors":"Luca Filippi","doi":"10.1053/j.semnuclmed.2025.09.004","DOIUrl":"https://doi.org/10.1053/j.semnuclmed.2025.09.004","url":null,"abstract":"Glypican-3 (GPC3) is a membrane-anchored heparan sulfate proteoglycan overexpressed in many hepatocellular carcinomas (HCCs) while minimally present in normal adult liver, making it an attractive target for integrated diagnostic and therapeutic (\"theranostic\") strategies. This review synthesizes preclinical and early clinical efforts to exploit GPC3 for targeted PET imaging and radionuclide therapy. Imaging approaches have evolved from 89Zr- and 124I-labeled full antibodies-demonstrating robust, delayed tumor localization-to smaller scaffolds (F(ab')₂, single-domain antibodies, peptides) paired with 18F or 68Ga for same-day, high-contrast imaging. First-in-human studies, including 124I-codrituzumab and 68Ga-RAYZ-8009, confirmed tumor-specific accumulation but remained limited in scale. Therapeutic investigations spanned beta-emitters (90Y, 177Lu) and high-LET alpha-emitters (225Ac, 227Th), showing potent antitumor effects in orthotopic and xenograft models yet raising dosimetric and toxicity concerns-especially for long-circulating antibody carriers and alpha therapies. Key translational challenges include hepatic background clearance, intra-patient heterogeneity of GPC3 expression, rigorous dosimetry, toxicology in larger species, and radionuclide supply logistics. The available evidence suggests a preferential pathway, involving the selection of a limited set of lead vectors, their pairing with suitable radionuclides, validation in orthotopic/PDX models using standardized endpoints, and the integration of comprehensive dosimetric and toxicologic studies before proceeding to broader human trials. GPC3-directed theranostics thus offers a compelling, disease-specific route to precision management of HCC, provided translational rigor addresses the outlined safety and quantitative imaging gaps.","PeriodicalId":21643,"journal":{"name":"Seminars in nuclear medicine","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Review of Advances in Lung Function Imaging and Its Applications for Functional Lung Avoidance in Radiation Therapy. 肺功能影像学研究进展及其在放射治疗中肺功能回避的应用。

IF 5.9 2区医学

Seminars in nuclear medicine Pub Date : 2025-09-25 DOI: 10.1053/j.semnuclmed.2025.09.002

Zhi Chen, Zihan Li, Yu-Hua Huang, Tianyu Xiong, Xinzhi Teng, Bing Li, John Kipritidis, Paul J Keall, Joseph M Reinhardt, Hong Ge, Ge Ren, Jing Cai

{"title":"A Review of Advances in Lung Function Imaging and Its Applications for Functional Lung Avoidance in Radiation Therapy.","authors":"Zhi Chen, Zihan Li, Yu-Hua Huang, Tianyu Xiong, Xinzhi Teng, Bing Li, John Kipritidis, Paul J Keall, Joseph M Reinhardt, Hong Ge, Ge Ren, Jing Cai","doi":"10.1053/j.semnuclmed.2025.09.002","DOIUrl":"https://doi.org/10.1053/j.semnuclmed.2025.09.002","url":null,"abstract":"Lung function imaging, with a specific focus on quantifying ventilation and perfusion, has gained increasing recognition within the field of functional lung avoidance radiation therapy (FLART), a technique that incorporates functional information to minimize radiation exposure to healthy lung tissue. This review critically analyzes multiple categories of clinical imaging modalities, including nuclear medicine imaging, computed tomography, and magnetic resonance imaging, which can assess the spatial distribution of lung functions. Each modality presents unique strengths in providing valuable information for FLART, yet they also have their limitations, which are detailed in this review. Furthermore, we discuss the current challenges limiting the broader implementation of lung function imaging and FLART in clinical practice. Future research directions and potential solutions are also outlined, to enable lung function imaging to play a more significant role in FLART, leading to personalized lung cancer management and improved patient outcomes.","PeriodicalId":21643,"journal":{"name":"Seminars in nuclear medicine","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145177979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to '18F-FDG PET for Dementia Evaluation: Co-pathologies, New Diseases, and Its Roles in The Era of Anti-Amyloid Treatment' [Seminar in Nuclear Medicine volume 55 (2025):526 -537/Article number YSNUC_51208]. “18F-FDG PET用于痴呆评估：共病理，新疾病及其在抗淀粉样蛋白治疗时代的作用”的勘误表[核医学研讨会卷55(2025):526 -537/文章编号YSNUC_51208]。

IF 5.9 2区医学

Seminars in nuclear medicine Pub Date : 2025-09-25 DOI: 10.1053/j.semnuclmed.2025.09.001

Tanyaluck Thientunyakit, Weerasak Muangpaisan, Satoshi Minoshima

引用次数: 0

Expanding the Horizon of Targeted Radionuclide Therapy: Immunotherapy Combinations and FAP-Targeted Approaches. 扩大靶向放射性核素治疗的视野：免疫治疗组合和fap靶向方法。

IF 5.9 2区医学

Seminars in nuclear medicine Pub Date : 2025-09-22 DOI: 10.1053/j.semnuclmed.2025.08.003

Ayça Arçay Öztürk, Wendy Delbart, Patrick Flamen

{"title":"Expanding the Horizon of Targeted Radionuclide Therapy: Immunotherapy Combinations and FAP-Targeted Approaches.","authors":"Ayça Arçay Öztürk, Wendy Delbart, Patrick Flamen","doi":"10.1053/j.semnuclmed.2025.08.003","DOIUrl":"https://doi.org/10.1053/j.semnuclmed.2025.08.003","url":null,"abstract":"Targeted radionuclide therapy (TRT) has emerged as a promising cancer treatment modality and is increasingly recognized as an immunomodulatory tool, similar to external beam radiotherapy (EBRT). Both forms of radiation can reshape the tumor immune microenvironment, providing a rationale for their combination with immune checkpoint inhibitors (ICIs) to harness synergistic effects while mitigating immunosuppressive mechanisms. Outcomes of such combinations depend on radiation dose/fractionation, treatment sequencing, target selection, and the choice of immunotherapeutic/radiopharmaceutical agents. Among novel TRT strategies, fibroblast activation protein-TRT (FAP-TRT) stands out for its targeting of cancer-associated fibroblasts (CAFs), key components of the tumor stroma involved in immune evasion and therapy resistance. Unlike conventional TRTs that directly target tumor cells, FAP-TRT acts on CAFs, potentially modulating the tumor microenvironment to enhance the immunomodulatory effects of radiation. This review examines the immunological effects of radiation-via EBRT or TRT-and the rationale for combining TRT with ICIs. We highlight preclinical and clinical studies demonstrating both the synergistic potential and context-specific limitations of TRT-ICI combinations. Emphasis is placed on the emerging role of FAP-TRT in remodeling the tumor microenvironment, converting \"cold\" tumors into \"hot\" phenotypes, and enhancing immune infiltration. Preclinical models show synergy between FAP-TRT and ICIs, but challenges remain, including clarifying FAP-TRT's effects on CAF subpopulations, optimizing radiopharmaceutical design, and addressing shared issues with TRT/EBRT-ICI combinations, such as dosing, sequencing, and target selection. The integration of TRT and immunotherapy-particularly FAP-TRT combinations-offers a compelling avenue for precision oncology and warrants further translational and clinical investigation.","PeriodicalId":21643,"journal":{"name":"Seminars in nuclear medicine","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145131881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CD70-Targeted Radiotheranostics: Now and Future. cd70靶向放射治疗：现在与未来。

IF 5.9 2区医学

Seminars in nuclear medicine Pub Date : 2025-09-18 DOI: 10.1053/j.semnuclmed.2025.08.001

Binyu Shi, Xinyuan Zhou, Junjun Zhou, Gang Huang, Jianjun Liu, Jin Zhang, Weijun Wei

引用次数: 0

Radiolabeled Antibody-Drug Conjugates in the Treatment of Solid Tumors. 放射标记抗体-药物偶联物在实体肿瘤治疗中的应用。

IF 5.9 2区医学

Seminars in nuclear medicine Pub Date : 2025-09-12 DOI: 10.1053/j.semnuclmed.2025.08.002

Ismaheel O Lawal, Sofiullah Abubakar, Honest Ndlovu, Aisha Ismaila, Mike M Sathekge

{"title":"Radiolabeled Antibody-Drug Conjugates in the Treatment of Solid Tumors.","authors":"Ismaheel O Lawal, Sofiullah Abubakar, Honest Ndlovu, Aisha Ismaila, Mike M Sathekge","doi":"10.1053/j.semnuclmed.2025.08.002","DOIUrl":"https://doi.org/10.1053/j.semnuclmed.2025.08.002","url":null,"abstract":"Antibody-drug conjugates (ADCs) utilize monoclonal antibodies (mAbs) that target tumor-specific antigens to deliver potent cytotoxic chemotherapy payloads to the tumor, while sparing normal tissues. The chemotherapy agents employed in ADCs are very potent, causing a tumoricidal effect at low drug concentrations. Several ADCs have been approved for the treatment of different solid tumors over the last decade following the superior efficacy and safety they demonstrated above standard-of-care treatment modalities in several clinical trials. Despite their efficacy, some patients do not respond to treatment with ADCs, as objective response rate typically range from 30% to 50%, and as low as 20% in some instances. Some patients who initially respond to treatment develop acquired resistance during their treatment, necessitating strategies to improve response rates and overcome treatment resistance. Radiation from radionuclides, with their ability to evoke a synergistic antitumor effect when used in combination with cytotoxic chemotherapy and induce a tumoricidal effect in tumor cells remote from the tumor they are bound to (crossfire effect), has the potential to improve the outcomes of ADC treatment. An expanding body of evidence, reporting the successful radiolabeling of established and experimental ADCs, is emerging in the literature. These studies have demonstrated improved antitumor effect of radiolabeled ADC relative to cold ADC, paving the way for further exploration, including in clinical settings.","PeriodicalId":21643,"journal":{"name":"Seminars in nuclear medicine","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145058617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0