Caner Civan , Madeleine J. Karpinski , Kambiz Rahbar , Wolfgang P. Fendler , Ken Herrmann
{"title":"The value of PSMA PET for risk stratification in prostate cancer: an update and future aspects","authors":"Caner Civan , Madeleine J. Karpinski , Kambiz Rahbar , Wolfgang P. Fendler , Ken Herrmann","doi":"10.1053/j.semnuclmed.2025.12.003","DOIUrl":"10.1053/j.semnuclmed.2025.12.003","url":null,"abstract":"<div><div>PSMA-PET has become a pivotal imaging method for staging and restaging of prostate cancer. Risk stratification of the disease is a crucial for the patients to receive most appropriate treatment, and for the clinicians to follow the patients more precisely. PSMA-PET provides non-invasive biomarkers for the risk assessment of prostate cancer, offering prediction of clinical outcomes. PROMISE criteria have been developed as comprehensive and integrated framework demonstrating association with overall survival. In this review, we aim to provide a brief update of the prognostic value of PSMA-PET for risk assessment in prostate cancer.</div></div>","PeriodicalId":21643,"journal":{"name":"Seminars in nuclear medicine","volume":"56 2","pages":"Pages 229-234"},"PeriodicalIF":5.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145844230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Letter from the Editors","authors":"Kirsten Bouchelouche, M. Michael Sathekge","doi":"10.1053/j.semnuclmed.2026.02.006","DOIUrl":"10.1053/j.semnuclmed.2026.02.006","url":null,"abstract":"","PeriodicalId":21643,"journal":{"name":"Seminars in nuclear medicine","volume":"56 2","pages":"Pages 133-136"},"PeriodicalIF":5.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147370329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Morten Bentestuen , Sara Dahlsgaard-Wallenius , Marie M.K. Stolberg , Helle D. Zacho
{"title":"Nonmalignant findings on FAPI PET: An updated rapid systematic review of the literature","authors":"Morten Bentestuen , Sara Dahlsgaard-Wallenius , Marie M.K. Stolberg , Helle D. Zacho","doi":"10.1053/j.semnuclmed.2025.11.015","DOIUrl":"10.1053/j.semnuclmed.2025.11.015","url":null,"abstract":"<div><div><em>Background/Aim:</em> Fibroblast activation protein inhibitor (FAPI) PET has shown promising diagnostic performance across various cancers. However, uptake in nonmalignant conditions has also been reported, as highlighted in the authors’ previous systematic review from 2022. This updated systematic review summarizes the accumulated evidence on nonmalignant FAPI PET findings, both pitfalls in cancer diagnostic and emerging novel FAPI PET scan indications.</div><div><em>Materials and Methods:</em> A systematic search of PubMed, Embase, and Web of Science was conducted on May 2, 2025. Peer-reviewed English-language studies involving human subjects and using FAPI tracers, specifically targeting FAP, were included. Studies published between April 2022 and May 2025 reporting nonmalignant FAPI PET/CT findings were added to those from the previous 2022 review. Findings were analyzed on a per-lesion basis and grouped by anatomical region.</div><div><em>Results:</em> In total, 380 studies reporting 8,230 nonmalignant FAPI PET findings were included. Most studies originated from China (70%), and 63% were case reports or case series. Although 69% of subjects were scanned due to “cancer”, a clear increase in nonmalignant scan indications was observed. The search identified common pitfalls for cancer diagnostics, including FAPI uptake in infectious and inflammatory diseases, fibrosis, and benign neoplasms, but also emerging nonmalignant FAPI PET indications, including interstitial lung disease, cardiac conditions, and arthritis.</div><div><em>Conclusion:</em> This review provides, to the best of our knowledge, the most comprehensive summary of nonmalignant FAPI PET findings to date. It may serve as a valuable reference for researchers and clinicians interpreting FAPI PET.</div></div>","PeriodicalId":21643,"journal":{"name":"Seminars in nuclear medicine","volume":"56 2","pages":"Pages 364-378"},"PeriodicalIF":5.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145715694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Any Role of FDG PET in Renal Cancer?","authors":"Yoshiko Ueno , Munenobu Nogami , Kohei Hirota , Toshiki Hyodo , Keitaro Sofue , Takuto Hara , Takamichi Murakami","doi":"10.1053/j.semnuclmed.2025.11.006","DOIUrl":"10.1053/j.semnuclmed.2025.11.006","url":null,"abstract":"<div><div>[<sup>18</sup>F] Fluorodeoxyglucose positron emission tomography/computed tomography ([<sup>18</sup>F] FDG-PET/CT) has traditionally been considered suboptimal for the evaluation of renal tumors due to intense physiological tracer accumulation in the urinary tract. However, incidental detection of renal masses can occur during [<sup>18</sup>F] FDG-PET examinations, and recognizing that FDG uptake varies according to tumor type can aid differential diagnosis. In patients with renal failure or those undergoing dialysis, reduced urinary excretion lowers background activity, paradoxically improving the visualization of renal tumors. Recent studies have demonstrated that high-grade and sarcomatoid renal cell carcinomas (RCCs) exhibit intense [<sup>18</sup>F] FDG uptake associated with poor prognosis, whereas benign and low-grade lesions show relatively low uptake. Although [<sup>18</sup>F] FDG-PET/CT has limited sensitivity for nodal staging, it provides high diagnostic accuracy for distant metastases, including osteolytic bone lesions. During postoperative surveillance and restaging, PET/CT contributes to early detection of recurrence and assists in therapeutic decision-making, particularly in high-risk or dialysis patients. In therapeutic monitoring, changes in metabolic parameters—such as SUV<sub>max</sub>, metabolic tumor volume, and total lesion glycolysis—correlate with progression-free and overall survival during tyrosine kinase inhibitor or immune checkpoint inhibitor therapy. These parameters complement Response Evaluation Criteria in Solid Tumors (RECIST) and support metabolic response criteria such as PET Response Criteria in Solid Tumors (PERCIST). Moreover, novel tracers developed to overcome the intrinsic limitations of [<sup>18</sup>F] FDG, including [<sup>11</sup>C] Acetate, [<sup>18</sup>F] Fluoromisonidazole, and prostate-specific membrane antigen ligands, have shown promise in differentiating fat-poor angiomyolipoma, evaluating tumor hypoxia, and detecting FDG-negative metastases. This review discusses the current role, limitations, and future perspectives of [<sup>18</sup>F] FDG-PET in the management of renal tumors, with particular focus on RCC.</div></div>","PeriodicalId":21643,"journal":{"name":"Seminars in nuclear medicine","volume":"56 2","pages":"Pages 152-161"},"PeriodicalIF":5.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145649382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
James Warwick , Jennifer Holness , Helena McMeekin
{"title":"Measurement of GFR: pitfalls & quality control (a practical approach)","authors":"James Warwick , Jennifer Holness , Helena McMeekin","doi":"10.1053/j.semnuclmed.2025.11.018","DOIUrl":"10.1053/j.semnuclmed.2025.11.018","url":null,"abstract":"<div><div>For certain clinical scenarios accurate and precise GFR measurement is required. In the majority of situations this is calculated from the plasma clearance of an exogenous marker that undergoes glomerular filtration, using the slope-intercept (SI) or single-sample (SS) methods. This paper is intended to complement a previous Seminars paper with a specific focus on practical ways to avoid potential pitfalls and quality control measures that can be implemented to minimize the risk of GFR measurement errors. The underlying causes of GFR errors can be understood in terms of measurement errors or procedural errors. All measurements are accompanied by inherent errors that are related to the finite precision of the measuring instruments used. Kept within an acceptable range, measurement errors make a small contribution to GFR error when compared to expected biological variation. Procedural errors consist of a diverse group of deviations from correct procedure ranging from selection of an inappropriate methodology through to missteps at many points in the investigation procedure. Procedural errors can significantly affect the accuracy of GFR measurements. Errors are primarily avoided by regular equipment quality control and careful adherence to clear standard operating procedures. Quality control parameters integrated into a calculation spreadsheet can play a useful secondary role to flag potential measurement or procedural errors.</div></div><div>For certain clinical scenarios accurate and precise GFR measurement is required. In the majority of situations this is calculated from the plasma clearance of an exogenous marker that undergoes glomerular filtration, using the slope-intercept (SI) or single-sample (SS) methods. This paper is intended to complement a previous Seminars paper with a specific focus on practical ways to avoid potential pitfalls and quality control measures that can be implemented to minimize the risk of GFR measurement errors. The underlying causes of GFR errors can be understood in terms of measurement errors or procedural errors. All measurements are accompanied by inherent errors that are related to the finite precision of the measuring instruments used. Kept within an acceptable range, measurement errors make a small contribution to GFR error when compared to expected biological variation. Procedural errors consist of a diverse group of deviations from correct procedure ranging from selection of an inappropriate methodology through to missteps at many points in the investigation procedure. Procedural errors can significantly affect the accuracy of GFR measurements. Errors are primarily avoided by regular equipment quality control and careful adherence to clear standard operating procedures. Quality control parameters integrated into a calculation spreadsheet can play a useful secondary role to flag potential measurement or procedural errors.</div>","PeriodicalId":21643,"journal":{"name":"Seminars in nuclear medicine","volume":"56 2","pages":"Pages 289-300"},"PeriodicalIF":5.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145725344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Y. Katayeu , V. Grünwald , K.M. Pabst , U.U. Yesilyurt , M. Al-Nader , W.P. Fendler , B.A. Hadaschik , K. Herrmann , A.T. Küper
{"title":"New targets of PET imaging for renal cancer","authors":"Y. Katayeu , V. Grünwald , K.M. Pabst , U.U. Yesilyurt , M. Al-Nader , W.P. Fendler , B.A. Hadaschik , K. Herrmann , A.T. Küper","doi":"10.1053/j.semnuclmed.2025.11.007","DOIUrl":"10.1053/j.semnuclmed.2025.11.007","url":null,"abstract":"<div><div>Renal cell carcinoma (RCC) is a clinically heterogeneous malignancy with rising global incidence. Conventional imaging modalities such as CT and MRI provide primarily anatomical information but are limited in their ability to characterize tumors at the molecular level. Positron emission tomography/ computed tomography (PET/CT) imaging offers a promising alternative by enabling non-invasive molecular diagnostics. This review summarizes recent advances in PET-based imaging of RCC and highlights tracers with potential for future clinical application.</div><div>Fluorodeoxyglucose (2-[<sup>18</sup>F]FDG) PET/CT, although well established in oncology, demonstrates limited sensitivity for primary RCC but may be useful for detecting distant metastases and local recurrence. Consequently, increasing attention has shifted toward more specific molecular tracers that may improve diagnostic performance.</div><div>Among these, fibroblast activation protein inhibitor (FAPI)-based PET imaging has shown higher sensitivity than 2-[<sup>18</sup>F]FDG PET across several RCC subtypes, although current evidence remains restricted to small or early-phase studies.</div><div>Sodium-18F-fluoride ([<sup>18</sup>F]NaF) PET/CT has demonstrated excellent detection rates for bone metastases in RCC, yet evidence is currently sparse.</div><div>Furthermore, CD70-targeted immunoPET/CT—using tracers such as [<sup>68</sup>Ga]Ga-NOTA-RCCB6—has shown high specificity for clear cell RCC (ccRCC) and superior performance compared with 2-[<sup>18</sup>F]FDG PET/CT in the identification of metastatic disease; however, broader clinical validation is still required.</div><div>Carbonic anhydrase IX (CAIX)-targeted PET/CT provides high specificity for ccRCC, particularly in the detection of small lesions, staging, and post-immunotherapy follow-up. Emerging theranostic approaches employing [<sup>68</sup>Ga]/[<sup>177</sup>Lu]-labeled CAIX ligands may further enable integrated diagnostic and radionuclide therapeutic strategies.</div><div>In conclusion, molecular imaging is increasingly recognized as a valuable tool in the diagnosis and management of RCC. Larger, multicenter studies are essential to define its role in routine clinical practice and to fully explore its potential in future theranostic applications.</div></div>","PeriodicalId":21643,"journal":{"name":"Seminars in nuclear medicine","volume":"56 2","pages":"Pages 144-151"},"PeriodicalIF":5.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145662084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Nuclear Nephrology Artificial Intelligence Ecosystem","authors":"Geoffrey M Currie , Eric M Rohren","doi":"10.1053/j.semnuclmed.2025.11.002","DOIUrl":"10.1053/j.semnuclmed.2025.11.002","url":null,"abstract":"<div><div>The contemporary scope of nuclear nephrology extends from non-imaging techniques for glomerular filtration rate calculation through dynamic renal scintigraphy and cortical imaging with planar or single photon emission computed tomography (SPECT) approaches to emerging applications in positron emission tomography (PET) renography and theranostics-based renal toxicity risk assessment. Artificial intelligence (AI) shares a long history with nuclear nephrology that started with expert systems and statistical machine learning (ML) approaches, transitioned through feed forward neural networks (FFNN), landed with convolutional neural networks (CNNs) and deep learning (DL), and has emerging opportunities across the gamut of generative AI like large language models (LLMs), diffusion models, generative adversarial networks (GANs) and multimodal models like vision language models (VLMs).</div><div>A range of AI tools across the nuclear nephrology ecosystem describe bespoke AI algorithms, commercial AI products, embedded AI tools from vendors, general-purpose and cross-domain AI frameworks. Applications in clinical workflow, research and development, and imaging are explored, highlighting the potential of AI in detection, classification, segmentation, prediction, data analysis and image enhancement. Emerging AI opportunities from generative AI, LLMs, VLMs, and segmentation foundation models such as the SAM, offer exciting multi-modal, few-shot learning that may re-imagine nuclear nephrology. There remains the need for considerable development and validation for widespread clinical utility of AI opportunities, and the need for consideration of ethical limitations and social justice.</div></div>","PeriodicalId":21643,"journal":{"name":"Seminars in nuclear medicine","volume":"56 2","pages":"Pages 313-328"},"PeriodicalIF":5.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145687943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tugce Telli , Caner Civan , Ken Herrmann , Wolfgang P. Fendler
{"title":"Treatment response assessment according to updated PROMISE criteria","authors":"Tugce Telli , Caner Civan , Ken Herrmann , Wolfgang P. Fendler","doi":"10.1053/j.semnuclmed.2025.11.017","DOIUrl":"10.1053/j.semnuclmed.2025.11.017","url":null,"abstract":"<div><div>The advent of prostate-specific membrane antigen (PSMA) positron emission tomography (PET) imaging has revolutionized the evaluation and management of prostate cancer, enabling superior lesion detection and characterization across various disease stages. In response to the growing need for standardized interpretation, the Prostate Cancer Molecular Imaging Standardized Evaluation (PROMISE) criteria were introduced in 2018, offering a structured approach to staging and risk assessment. As PSMA-targeted imaging becomes more central in response assessment and theranostics, updated PROMISE criteria have been proposed to reflect treatment-related changes and incorporate newer therapies like PSMA radioligand therapy (RLT). This review provides an in-depth overview of the updated PROMISE criteria, highlighting key changes, their rationale, and their application in assessing treatment response. Comparative discussion with other response criteria, including RECIST, PERCIST, and RECIP, is included. We also address practical challenges, potential pitfalls, and future directions for integrating PROMISE with emerging technologies such as artificial intelligence and radiomics. By refining response evaluation in prostate cancer, the updated PROMISE criteria represent a significant step toward precision imaging and personalized therapy.</div></div>","PeriodicalId":21643,"journal":{"name":"Seminars in nuclear medicine","volume":"56 1","pages":"Pages 9-17"},"PeriodicalIF":5.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145757574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Runjun Yang , Xinyi Lu , Wenxin Tang , Lorenzo Nardo , Yunze Xie , Akram Al-Ibraheem , Lichao Zhang , Wenjin Zhao , Axel Rominger , Lijie Tan , Han Tang , Ida Nur Syafinaz Binti Muhammad Fuad , Subapriya Suppiah , Eric Cruz , Yu Lin , Haojun Yu , Hongcheng Shi
{"title":"Total-Body PET/CT Metabolic Response in Esophageal Squamous Cell Carcinoma","authors":"Runjun Yang , Xinyi Lu , Wenxin Tang , Lorenzo Nardo , Yunze Xie , Akram Al-Ibraheem , Lichao Zhang , Wenjin Zhao , Axel Rominger , Lijie Tan , Han Tang , Ida Nur Syafinaz Binti Muhammad Fuad , Subapriya Suppiah , Eric Cruz , Yu Lin , Haojun Yu , Hongcheng Shi","doi":"10.1053/j.semnuclmed.2025.11.010","DOIUrl":"10.1053/j.semnuclmed.2025.11.010","url":null,"abstract":"<div><div>Esophageal squamous cell carcinoma (ESCC) exhibits heterogeneous responses to neoadjuvant therapy, necessitating early and accurate assessment. [<sup>18</sup>F]fluorodeoxyglucose ([<sup>18</sup>F]FDG) PET/CT enables quantitative assessment of tumor glucose metabolism, correlating with pathological remission and long-term outcomes, while [<sup>18</sup>F] or [<sup>68</sup>Ga]Ga-labeled fibroblast activation protein inhibitor (FAPI) PET/CT evaluates stromal metabolism, providing complementary information. Total-body PET/CT (uEXPLORER, United Imaging Healthcare Co.Ltd., Shanghai, China) with 194-cm long-axial field-of-view (LAFOV) offers long axial coverage, up to 68-fold higher sensitivity than conventional systems. It enables low-dose, rapid imaging, dynamic whole-body parametric imaging, and improves detection of small, low-uptake lesions as well as metastatic lesions in the distal upper or lower extremities in a single bed position. Delayed and dual-time imaging protocols, alone and/or combined with deep learning–based synthetic CT, further improve lesion detectability while minimizing radiation exposure. This narrative review summarizes evidence from conventional PET/CT studies, highlights the technical and clinical advantages of total-body PET/CT, and discusses its feasibility, quantitative capabilities, and potential to guide response-adapted management in ESCC based on our institutional experience.</div></div>","PeriodicalId":21643,"journal":{"name":"Seminars in nuclear medicine","volume":"56 1","pages":"Pages 72-85"},"PeriodicalIF":5.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145649388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"PET-CT radiomics for immunotherapy response","authors":"Alessia Artesani , Michela Olivieri , Priscilla Guglielmo , Manuela Marenco , Laura Evangelista","doi":"10.1053/j.semnuclmed.2025.11.024","DOIUrl":"10.1053/j.semnuclmed.2025.11.024","url":null,"abstract":"<div><div><em>Introduction:</em> The aim of this review is to provide a comprehensive synthesis of the current literature on the use of PET radiomics for predicting response to immunotherapy in cancer patients, as well as to discuss the main challenges emerging from data analysis and propose potential directions for its broader integration into clinical practice.</div><div><em>Materials and methods:</em> papers regarding the use of radiomics and immunotherapy by using PET/CT were selected. Some criteria were used for the selection, such as five years from the date of publication and 2) inclusion of several patients (more than 100).</div><div><em>Results:</em> Totally 24 papers were selected by using the following criteria. Most studies (<em>N</em> = 18/24; 75%) were related to the utility of radiomics for predicting immunotherapy in patients affected by lung cancer. In this setting, radiomics was able to predict the expression of PDL-1, with an important effect on the invasive procedures. In four studies, radiomics was used for predicting the prediction of response to CAR-T in patients affected by lymphoma. Emerging results are now available in patients with colon-rectal tumors and endometrial cancers, although with still limited evidence.</div><div><em>Conclusions:</em> radiomics holds substantial potential for characterizing the tumor immune microenvironment and predicting response to immunotherapy, especially in lung cancer and lymphoma.</div></div>","PeriodicalId":21643,"journal":{"name":"Seminars in nuclear medicine","volume":"56 1","pages":"Pages 97-104"},"PeriodicalIF":5.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145757672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}