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Int. J. Funct. Informatics Pers. Medicine最新文献

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Quantitative evaluation of Flat Panel detector scintillator effect on interventional device visualisation in x-ray fluoroscopy 平板探测器闪烁体对x线透视介入装置显像效果的定量评价
Int. J. Funct. Informatics Pers. Medicine Pub Date : 1900-01-01 DOI: 10.1504/IJFIPM.2009.030836
Yuhao Jiang, D. Wilson
{"title":"Quantitative evaluation of Flat Panel detector scintillator effect on interventional device visualisation in x-ray fluoroscopy","authors":"Yuhao Jiang, D. Wilson","doi":"10.1504/IJFIPM.2009.030836","DOIUrl":"https://doi.org/10.1504/IJFIPM.2009.030836","url":null,"abstract":"In Flat Panel (FP) detectors, fluoroscopy image quality is greatly affected by a variety of design and fabrication parameters. Among those parameters, the thickness of scintillator layer is very important and can be readily changed in fabrication. A thick scintillator layer can improve x-ray photon conversion efficiency but also degrade modulation transfer function due to a larger spatial blurring. It is proposed to optimise the selection of scintillator layer thickness for a better visualisation of small interventional devices. We applied quantitative experimental techniques and simulated three detector models including a direct detector and two indirect detectors. Two interventional devices, stent and guidewire, were investigated. Human observer experiments and computational model studies were conducted. Both of them demonstrate that the detection depends on the detector scintillator thickness and the structure of interventional device. At low x-ray exposures, a thick scintillator outperforms a thin scintillator in detection performance. A simulated direct detector has the least blurring in the images and hence gives even better detection performance for the stent detection. The thick indirect detector gives contrast sensitivities equal to those from the direct detector in the studies of guidewire detection and stent deployment.","PeriodicalId":216126,"journal":{"name":"Int. J. Funct. Informatics Pers. Medicine","volume":"205 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128611401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Quantitative detection of bubble dynamics by Doppler ultrasound 多普勒超声定量检测气泡动力学
Int. J. Funct. Informatics Pers. Medicine Pub Date : 1900-01-01 DOI: 10.1504/IJFIPM.2009.030834
Yufeng Zhou
{"title":"Quantitative detection of bubble dynamics by Doppler ultrasound","authors":"Yufeng Zhou","doi":"10.1504/IJFIPM.2009.030834","DOIUrl":"https://doi.org/10.1504/IJFIPM.2009.030834","url":null,"abstract":"Bubble cavitation is one of the major mechanisms for ultrasound-induced bioeffects. Characterising the bubble dynamics, expansion and collapse is of importance in understanding the cavitation phenomenon and estimating the consequent outcome. In this study, Doppler ultrasound method was firstly used to measure the bubble wall velocity. Bubbles were generated in water using a beam of high-intensity focused laser light or inside a vessel phantom using a shock wave generator. Agreement was found between the determination by high-speed photographs and Doppler method. Overall, it is suggested that Doppler ultrasound could be a noninvasive method of quantitatively detecting bubble dynamics in vivo.","PeriodicalId":216126,"journal":{"name":"Int. J. Funct. Informatics Pers. Medicine","volume":"1 6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123741009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Applying context-aware techniques to design remote assisted living applications 应用上下文感知技术设计远程辅助生活应用
Int. J. Funct. Informatics Pers. Medicine Pub Date : 1900-01-01 DOI: 10.1504/IJFIPM.2009.030833
Alexandre Sztajnberg, A. L. Rodrigues, Leila N. Bezerra, O. Loques, Alessandro Copetti, S. T. Carvalho
{"title":"Applying context-aware techniques to design remote assisted living applications","authors":"Alexandre Sztajnberg, A. L. Rodrigues, Leila N. Bezerra, O. Loques, Alessandro Copetti, S. T. Carvalho","doi":"10.1504/IJFIPM.2009.030833","DOIUrl":"https://doi.org/10.1504/IJFIPM.2009.030833","url":null,"abstract":"We present an architecture that includes two essential services to compose the supporting infrastructure required by context-aware applications: a Context Service, that provides access to context information, and a Discovery Service. A reference implementation, based on Web Services technology, was used to develop a remote assisted living application, which relies on ambient sensors, placed in each room, to capture context information and on a combo medical appliance to perform blood pressure measurements on the patient, according to a care plan prescribed by a doctor. The collected set of context data may be transmitted to a monitoring centre and also interpreted locally using medical knowledge; the identification of a patient's abnormal condition can activate local actions or send an emergency message to a monitoring centre. This infrastructure can help a doctor to monitor and assist the patient while he or she is performing daily activities and may also help improving the patient's treatment compliance and quality of life.","PeriodicalId":216126,"journal":{"name":"Int. J. Funct. Informatics Pers. Medicine","volume":"114 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132933855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
United States Health Information Knowledgebase (USHIK) 美国健康信息知识库(USHIK)
Int. J. Funct. Informatics Pers. Medicine Pub Date : 1900-01-01 DOI: 10.1504/IJFIPM.2010.040212
Chuck Penoza, R. Barnes, Martin Chaparro, Jerry Carney, B. Levin, Matt Chudy, S. LaBonte
{"title":"United States Health Information Knowledgebase (USHIK)","authors":"Chuck Penoza, R. Barnes, Martin Chaparro, Jerry Carney, B. Levin, Matt Chudy, S. LaBonte","doi":"10.1504/IJFIPM.2010.040212","DOIUrl":"https://doi.org/10.1504/IJFIPM.2010.040212","url":null,"abstract":"The United States Health Information Knowledgebase (USHIK) is an online, publicly accessible registry/repository of healthcare metadata originally developed by Center for Medicare and Medicaid Services (CMS) and the Department of Defense (DoD) and currently maintained by the Agency for Healthcare Research and Quality (AHRQ). It contains metadata for various healthcare standards, measures, forms and other data sets. Its users include researchers, Standards Development Organisations (SDOs), clinicians, Electronic Health Record (EHR) developers and users, and various Federal- and state-level government entities. USHIK provides the capability to visually organise summary metadata, analyse metadata sets and interactively compare metadata sets. This functionality can be used for analysing and harmonising standards, measures and other healthcare data sets.","PeriodicalId":216126,"journal":{"name":"Int. J. Funct. Informatics Pers. Medicine","volume":"100 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126034186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Report of 2009 International Workshop on Bioinformatics and Systems Biology in Traditional Chinese Medicine Research 2009中医药研究生物信息学与系统生物学国际研讨会报告
Int. J. Funct. Informatics Pers. Medicine Pub Date : 1900-01-01 DOI: 10.1504/IJFIPM.2009.030825
Dan Xi, Su-shing Chen
{"title":"Report of 2009 International Workshop on Bioinformatics and Systems Biology in Traditional Chinese Medicine Research","authors":"Dan Xi, Su-shing Chen","doi":"10.1504/IJFIPM.2009.030825","DOIUrl":"https://doi.org/10.1504/IJFIPM.2009.030825","url":null,"abstract":"The International Workshop on Bioinformatics and Systems Biology in Traditional Chinese Medicine (TCM) Research in conjunction with the 2009 International Joint Conferences on System Biology, Bioinformatics and Intelligent Computing (IJCBS2009), was held at Tongji University, Shanghai, China on August 3, 2009. This review discusses and summarises the scientific talks and achievements presented at the workshop and the impact of this workshop.","PeriodicalId":216126,"journal":{"name":"Int. J. Funct. Informatics Pers. Medicine","volume":"112 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130201038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
A multitier YinYang-N-element cellular architecture for the Chinese meridian system 中国经络系统的多层阴阳- n元细胞结构
Int. J. Funct. Informatics Pers. Medicine Pub Date : 1900-01-01 DOI: 10.1504/IJFIPM.2009.030828
Wen-Ran Zhang, Su-shing Chen, Hongzhao Zang
{"title":"A multitier YinYang-N-element cellular architecture for the Chinese meridian system","authors":"Wen-Ran Zhang, Su-shing Chen, Hongzhao Zang","doi":"10.1504/IJFIPM.2009.030828","DOIUrl":"https://doi.org/10.1504/IJFIPM.2009.030828","url":null,"abstract":"A multitier YinYang-N-Element cellular architecture is proposed for the Chinese meridian system as a platform for elaboration. Based on this platform, the theoretical and experimental aspects of the Chinese meridian system are discussed. It is argued that when scientists emphasise the importance of \"experimental verification of any theory\" they must not forget that, after thousands of years of medical practice, acupuncture in particular and TCM in general still do not possess a unique formal logical foundation. It is, therefore, concluded that YinYang and TCM researchers are obligated to make an effort to use some 'pure thought' to grab the reality in mathematical terms instead of only trying to 'distill' the principles from 'experience' or, alternatively, only trying to fit TCM into western medicine.","PeriodicalId":216126,"journal":{"name":"Int. J. Funct. Informatics Pers. Medicine","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132641473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Data shuffling and statistical analysis on microarray data for gene selection: a comparative study on filtering methods 基因选择微阵列数据的数据洗牌与统计分析:过滤方法的比较研究
Int. J. Funct. Informatics Pers. Medicine Pub Date : 1900-01-01 DOI: 10.1504/IJFIPM.2010.039119
Z. Ding, Yanqing Zhang, Yichuan Zhao
{"title":"Data shuffling and statistical analysis on microarray data for gene selection: a comparative study on filtering methods","authors":"Z. Ding, Yanqing Zhang, Yichuan Zhao","doi":"10.1504/IJFIPM.2010.039119","DOIUrl":"https://doi.org/10.1504/IJFIPM.2010.039119","url":null,"abstract":"Computational analysis have been broadly used to discover disease-relevant genes from microarray expression data. In this paper, we extend a traditional statistical metric to a second level to measure gene-disease relations, testing such relation whether can be replicated by randomly shuffling the gene expression data. The traditional metric can be considered as a first-level metric; the relevance of each gene is then verified through the second-level significance testing based on the first-level metric calculated on the original data and shuffled data. We show that this method can also produce high classification performance, compared with other filter-based methods.","PeriodicalId":216126,"journal":{"name":"Int. J. Funct. Informatics Pers. Medicine","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129089553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Protein model assessment via machine learning techniques 基于机器学习技术的蛋白质模型评估
Int. J. Funct. Informatics Pers. Medicine Pub Date : 1900-01-01 DOI: 10.1504/IJFIPM.2010.039121
Anjum Reyaz-Ahmed, R. Harrison, Yanqing Zhang
{"title":"Protein model assessment via machine learning techniques","authors":"Anjum Reyaz-Ahmed, R. Harrison, Yanqing Zhang","doi":"10.1504/IJFIPM.2010.039121","DOIUrl":"https://doi.org/10.1504/IJFIPM.2010.039121","url":null,"abstract":"We attempt to solve the problem of protein model assessment using machine learning techniques and information from sequence and structure of the protein. The goal is to generate a machine that understands structures from PDB and given a new model, predicts whether or not it belongs to the class of PDB structures. We show two such machines (SVM and FDT); results appear promising for further analysis. To reduce computational overhead, multiprocessor environment and basic feature selection method is used. The prediction accuracy using improved FDT is above 80% and results are better when compared with other machine learning techniques.","PeriodicalId":216126,"journal":{"name":"Int. J. Funct. Informatics Pers. Medicine","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122375588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A systematic in-vitro and in-silico approaches on evaluation of commercially available Metformin Hcl tablets 对市售盐酸二甲双胍片的系统体外和计算机评价方法
Int. J. Funct. Informatics Pers. Medicine Pub Date : 1900-01-01 DOI: 10.1504/IJFIPM.2010.039120
R. Seenivasagam, K. Hemavathi
{"title":"A systematic in-vitro and in-silico approaches on evaluation of commercially available Metformin Hcl tablets","authors":"R. Seenivasagam, K. Hemavathi","doi":"10.1504/IJFIPM.2010.039120","DOIUrl":"https://doi.org/10.1504/IJFIPM.2010.039120","url":null,"abstract":"The main objectives of the investigational study are in-vitro and in-vivo evaluation of Metformin Hcl tablets on Non-Insulin Dependent Diabetic Mellitus (NIDDM). Various tablet parameters were evaluated through in-vitro tests on marketed brands of Metformin Hcl tablets. The results obtained earlier are correlated with variation in dissolution profiles the dissolution profiles of the marketed brands with regard to any possible bio-equivalence are analysed. In-silico studies are important to locate molecular targets for NIDDM. Through homology modelling and active-site prediction, the suitable protein and receptor for Metformin Hcl were identified.","PeriodicalId":216126,"journal":{"name":"Int. J. Funct. Informatics Pers. Medicine","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123207375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The logic of YinYang and the science of TCM: An eastern road to the unification of nature, agents and medicine 阴阳逻辑与中医科学:一条通向自然、灵药统一的东方之路
Int. J. Funct. Informatics Pers. Medicine Pub Date : 1900-01-01 DOI: 10.1504/IJFIPM.2009.030827
Wen-Ran Zhang
{"title":"The logic of YinYang and the science of TCM: An eastern road to the unification of nature, agents and medicine","authors":"Wen-Ran Zhang","doi":"10.1504/IJFIPM.2009.030827","DOIUrl":"https://doi.org/10.1504/IJFIPM.2009.030827","url":null,"abstract":"Many wonder whether Traditional Chinese Medicine (TCM) is science; many TCM practitioners are eager to fit TCM into western medicine for acceptance; some TCM scholars suggested to abandon YinYang in favour of western tradition; some researchers suggested to avoid relativistic and quantum theories in TCM research in favour of established scientific theories. Faced with these tough choices, this paper unveils the salient nature of YinYang related to Greek philosophy and identifies its critical role in logic, TCM, and modern science. Surprisingly, it is shown that YinYang bipolar relativity has opened an eastern road toward quantum gravity – Einstein's unfinished scientific unification of general relativity and quantum mechanics. Furthermore, it is shown that not only does YinYang bipolar quantum gravity constitute a physical theory but also a mental, logical, social, and biological quantum theory.","PeriodicalId":216126,"journal":{"name":"Int. J. Funct. Informatics Pers. Medicine","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125953877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
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