Int. J. Funct. Informatics Pers. Medicine最新文献

{"title":"Development of spatiotemporal validation methods of an agent-based model of epithelial cells: analysis of a colony of keratinocytes","authors":"C. Pichardo-Almarza, R. Smallwood, S. Billings","doi":"10.1504/IJFIPM.2008.022151","DOIUrl":"https://doi.org/10.1504/IJFIPM.2008.022151","url":null,"abstract":"In this paper an Agent-Based Model (ABM) to study Normal Human Keratinocytes (NHK) (tissue cells) is investigated. ABM are widely used for the simulation of systems from several domains (biology, economics, meteorology, etc.). In biology, ABM are useful for predicting the social behaviour of systems; in particular, they seem well adapted to model the behaviour of a cell population. These models exhibit probabilistic behaviour and the validation of simulation results is often a qualitative analysis by experts (biologists). The aim of this paper is to propose new variables and metrics for the development of quantitative methods to validate the model.","PeriodicalId":216126,"journal":{"name":"Int. J. Funct. Informatics Pers. Medicine","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116739515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of bubble cavitation in ultrasound therapy by wavelet technique","authors":"Yufeng Zhou","doi":"10.1504/IJFIPM.2008.022154","DOIUrl":"https://doi.org/10.1504/IJFIPM.2008.022154","url":null,"abstract":"Bubble cavitation is one of the major mechanisms for ultrasound treatment. To understand its characteristics, cavitation signals were picked up using passive cavitation detection and then analysed by wavelet transform. Although the Fast Fourier Transform (FFT) has been used widely in signal analysis, the absence of temporal information is one of its limitations. The inertial cavitation strength detected by wavelet method was ∼60 folds higher than that using FFT. Furthermore, the relationship of waveform profile and acoustic pressure with the corresponding bubble cavitation were investigated. All together, wavelet approach could be new tool for studying bubble cavitation.","PeriodicalId":216126,"journal":{"name":"Int. J. Funct. Informatics Pers. Medicine","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114826846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Personalized Traditional Chinese Medicine System in the case of Cai's gynecology","authors":"Mingyu You, Guozheng Li, Xueqiang Zeng, Lei Ge, Lijuan Bi, Suying Huang, Mary Yang, Jack Y. Yang","doi":"10.1504/IJFIPM.2008.022157","DOIUrl":"https://doi.org/10.1504/IJFIPM.2008.022157","url":null,"abstract":"Diagnostic records of Traditional Chinese Medicine (TCM) practitioners, especially those of masters or veteran practitioners, are precious materials for the TCM researchers and juniors. A novel system (named PTCMS) for preserving the diagnostic processes of veteran practitioners in a personalised way is provided. Based on the summarised TCM specialist's diagnostic template, a custom-built input system embracing the particular expressions of the specialist is set up in the platform. The novel system provides a new way for keeping and researching into the personalised factors in the diagnostic process of TCM masters.","PeriodicalId":216126,"journal":{"name":"Int. J. Funct. Informatics Pers. Medicine","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121963855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tele-doc: an open architecture robotic system for telemedicine applications","authors":"Anan Osothsilp, F. Pourboghrat","doi":"10.1504/IJFIPM.2008.022155","DOIUrl":"https://doi.org/10.1504/IJFIPM.2008.022155","url":null,"abstract":"This paper describes a research study for the development and implementation of a prototype remote-controlled robotic assistant to doctors (Tele-Doc) for telemedicine applications. The development considers implementation issues concerning real-time and continuous patient monitoring and diagnosis, as well as tele-control interfacing techniques, mobile robot motion controller, reprogrammable embedded processing system, and internet-based robotic control centre. The paper also describes bio-data measurement techniques, as well as simple system architecture and its implementation.","PeriodicalId":216126,"journal":{"name":"Int. J. Funct. Informatics Pers. Medicine","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117311792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tomosynthesis reconstruction using an accelerated expectation maximisation algorithm with novel data structure based on sparse matrix ray-tracing method","authors":"Weihua Zhou, Apuroop Balla, Ying Chen","doi":"10.1504/IJFIPM.2008.022152","DOIUrl":"https://doi.org/10.1504/IJFIPM.2008.022152","url":null,"abstract":"Digital Breast Tomosynthesis (DBT) is a novel imaging technology to improve early breast cancer detection. It provides three-dimensional information of the breast to overcome the critical issues of overlapping anatomical structures of the breast. Among current available DBT reconstruction algorithms, Maximum Likelihood Expectation-Maximisation (MLEM) is a time-consuming iterative method to reconstruct three-dimensional image of the breast. In this paper, we proposed an accelerated MLEM algorithm with novel data structure based on sparse matrix ray-tracing method for DBT reconstruction. Compared with the standard MLEM, the proposed algorithm is effective to generate relative fast-speed tomosynthesis reconstruction and maintain the same image quality.","PeriodicalId":216126,"journal":{"name":"Int. J. Funct. Informatics Pers. Medicine","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125017708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scatter radiation effect on interventional device visualisation in X-ray fluoroscopy","authors":"Yuhao Jiang, D. Wilson","doi":"10.1504/IJFIPM.2008.022153","DOIUrl":"https://doi.org/10.1504/IJFIPM.2008.022153","url":null,"abstract":"In X-ray imaging, scattered radiation can significantly degrade image quality. It has been a great challenge to reduce the effect of scatter radiation while maintain low X-ray exposures to patients. Anti-scatter grids and/or digital scatter correction algorithms have been used. We performed stent and guidewire detection experiments to study their performance. Experimental results showed that digital scatter correction could obtain equal or better detection performance than that of the anti-scatter grid. We conclude that digital scatter correction is preferable in interventional X-ray fluoroscopy. Further experimental validation may be made possible by using the images from a clinical fluoroscopy system.","PeriodicalId":216126,"journal":{"name":"Int. J. Funct. Informatics Pers. Medicine","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123164558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DACE: Differential Allelic Co-Expression test for estimating regulatory associations of SNP and biological pathway","authors":"J. Woo, T. Zheng, Ju Han Kim","doi":"10.1504/IJFIPM.2008.022156","DOIUrl":"https://doi.org/10.1504/IJFIPM.2008.022156","url":null,"abstract":"To identify genomic regions associated with individual gene's expressions, genetical genomic approaches have been developed. The approach treats each gene expression value as a trait to determine the genetic factor that explains the variance of the mRNA expression. However, genes often demonstrate coordinated activities and the patterns and levels of coordination are also regulated. In this research, we present a method, the Differential Allelic Co-Expression (DACE) test that identifies the regulatory association derived by alteration of co-expression patterns within a molecular pathway according to allelic difference of a certain SNP.","PeriodicalId":216126,"journal":{"name":"Int. J. Funct. Informatics Pers. Medicine","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124317155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional informatics and personalised medicine are key synergistic components of translational medicine","authors":"N. Botros, Ying Chen, Mary Yang","doi":"10.1504/IJFIPM.2008.022150","DOIUrl":"https://doi.org/10.1504/IJFIPM.2008.022150","url":null,"abstract":"Supported by the National Science Foundation (NSF) of United States of American and the International Society of Intelligent Biological Medicine (ISIBM), the IEEE 7th Bioinformatics and Bioengineering at Harvard Medical School was the only IEEE international conference designed dynamically in response to the cutting edge research and education in translational bioinformatics and bioengineering. The Harvard event contains a number of research workshops such as the workshop on Nano-Bio-Info Integration for Personalised Medicine organised by the National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, the workshop on progress toward petascale applications organised by Indiana University and Georgia Tech and the research workshop organised by the Oak Ridge National Laboratory, US Department of Energy and the Southern Illinois University. The Harvard event focused on special topics to resonate its theme: Functional informatics and personalised medicine are key synergistic components of translational medicine. It also fostered the collaboration and interaction between the functional informatics and personalised domains. The academic event attracted more than 500 scientists, researchers and medical doctors world-wide to present, discuss and exchange their research during 14-17 October, 2007 at Harvard Medical School. This special issue contains peer-reviewed full-length research papers focusing on modern translational medicine and treatment technique varying from molecular aspects to telemedicine, medical imaging and clinical applications. Those papers were originated from presentations and competitions for the research awards at Harvard. Authors were invited to expand their presentations into full research papers with significant additional scientific details. All papers were rigorously reviewed by at least three professors from the 273 members of scientific review and program committee. Those papers represent important original scientific contributions to the modern healthcare fields. More information regarding the Harvard event can be found at the White Paper of the IEEE 7th International Conference on Bioinformatics and Bioengineering at Harvard Medical School Conference at BMC Genomics http://www.biomedcentral.com/1471-2164/9/S2/I1","PeriodicalId":216126,"journal":{"name":"Int. J. Funct. Informatics Pers. Medicine","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129278251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Actin-Interacting Proteins in flagellated pathogenic Leishmania spp.: a genome-based bioinformatics report on profilins, formins and katanins","authors":"E. Vasconcelos, A. Pacheco, J. Gouveia, Fabiana F. Araújo, M. C. Diniz, M. Kamimura, M. Costa, R. Araujo-Filho, D. M. Oliveira","doi":"10.1504/IJFIPM.2008.021389","DOIUrl":"https://doi.org/10.1504/IJFIPM.2008.021389","url":null,"abstract":"In search for genomic and proteomic evidences of flagellar genes/proteins in Leishmania spp., we have used available databases and bioinformatics tools to distinguish Actin-Interacting Proteins (AIPs) that are flagellar and, also, probable virulence factors. Here we present results of sequence and structural analyses of profilins, formins and katanins, whose sequences were in silico selected for predicting viable roles on flagellum assembly, disassembly and dynamics in terms of intraflagellar mechanisms. Taken together, our results provide the first bioinformatics analyses of Leishmania profilin, katanin and formin genes and their gene products to contribute to a more detailed annotation of these important AIPs.","PeriodicalId":216126,"journal":{"name":"Int. J. Funct. Informatics Pers. Medicine","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128233934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protein subcelluar localisation prediction with improved performance","authors":"Jing Hu, Changhui Yan","doi":"10.1504/IJFIPM.2008.021395","DOIUrl":"https://doi.org/10.1504/IJFIPM.2008.021395","url":null,"abstract":"Predicting the subcellular localisation of proteins is crucial for the determination of protein functions. In this paper, we present a computational method for protein localisation prediction. We start with a simple approach that predicts protein localisation based on Euclidian distance computed from residue composition. Then the performance is gradually improved by introducing a weighted Euclidian distance, including homologous information, and using feature selection. The final method achieves 90.3% accuracy in assigning proteins into five subcellular locations. Comparisons with CELLO, PSORT-B and P-CLASSIFIER show that our method outperforms the others.","PeriodicalId":216126,"journal":{"name":"Int. J. Funct. Informatics Pers. Medicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128431818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}