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Int. J. Funct. Informatics Pers. Medicine最新文献

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Electrocardiographic simulation on personalised heart-torso structures using coupled meshfree-BEM platform 基于耦合无网格边界元平台的个性化心-躯干结构的心电图仿真
Int. J. Funct. Informatics Pers. Medicine Pub Date : 2009-08-03 DOI: 10.1504/IJFIPM.2009.027591
Linwei Wang, Heye Zhang, Ken C. L. Wong, Huafeng Liu, P. Shi
{"title":"Electrocardiographic simulation on personalised heart-torso structures using coupled meshfree-BEM platform","authors":"Linwei Wang, Heye Zhang, Ken C. L. Wong, Huafeng Liu, P. Shi","doi":"10.1504/IJFIPM.2009.027591","DOIUrl":"https://doi.org/10.1504/IJFIPM.2009.027591","url":null,"abstract":"The foremost premise for the success of noninvasive volumetric myocardial Transmembrane (TMP) imaging from Body Surface Potential (BSP) recordings is a realistic yet efficient TMP-to-BSP mapping model that balances model accuracy with reconstruction feasibility. This papers presents a novel coupled meshfree-BEM platform to this forward electrocardiographic modelling. Its numerical accuracy and convergence is quantitatively assessed against analytical solutions on a synthetic geometry. Electrocardiographic simulations of various cardiac conditions on personalised heart-torso structures are consistent with existent experimental studies. In further real data validations on three post myocardial infarction patients, simulated BSP exhibit high accuracy compared to measured BSP.","PeriodicalId":216126,"journal":{"name":"Int. J. Funct. Informatics Pers. Medicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125973524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
Patient-specific modelling of blood flow dynamics in intra-cranial aneurysms: an example of image-based personalised medicine 颅内动脉瘤血流动力学的患者特异性建模:基于图像的个体化医学的一个例子
Int. J. Funct. Informatics Pers. Medicine Pub Date : 2009-08-03 DOI: 10.1504/IJFIPM.2009.027589
C. Karmonik, Y. J. Zhang, T. Redel, R. Kroeger, R. Grossman
{"title":"Patient-specific modelling of blood flow dynamics in intra-cranial aneurysms: an example of image-based personalised medicine","authors":"C. Karmonik, Y. J. Zhang, T. Redel, R. Kroeger, R. Grossman","doi":"10.1504/IJFIPM.2009.027589","DOIUrl":"https://doi.org/10.1504/IJFIPM.2009.027589","url":null,"abstract":"The visualisation of blood flow dynamics in intracranial aneurysm using computational fluid dynamics is an example of personalised medicine based on biomedical image analysis. A small percentage of these aneurysms rupture. Blood flow dynamics is thought to play an important role in the rupture process by exerting Wall Shear Stresses (WSS) on the endothelial cells. In this study, the effects of instabilities in the velocity waveform in the parent artery of an aneurysm of the Internal Carotid Artery (ICA) and variations of the computational mesh are investigated with respect to WSS at the aneurysm wall.","PeriodicalId":216126,"journal":{"name":"Int. J. Funct. Informatics Pers. Medicine","volume":"107 51","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120824166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A framework for quantitative and visual analysis of white matter integrity using Diffusion Tensor Imaging 使用扩散张量成像对白质完整性进行定量和可视化分析的框架
Int. J. Funct. Informatics Pers. Medicine Pub Date : 2009-08-03 DOI: 10.1504/IJFIPM.2009.027590
Xuwei Liang, N. Kang, S. Rose, Jun Zhang
{"title":"A framework for quantitative and visual analysis of white matter integrity using Diffusion Tensor Imaging","authors":"Xuwei Liang, N. Kang, S. Rose, Jun Zhang","doi":"10.1504/IJFIPM.2009.027590","DOIUrl":"https://doi.org/10.1504/IJFIPM.2009.027590","url":null,"abstract":"A new quantitative and visual analysis technique is developed to study the white matter integrity along fibre bundles using Diffusion Tensor Imaging (DTI) tractography. Our approach takes advantages of DTI tractography and geodesic path mapping, which establishes group-wise correspondences to allow direct cross-subject evaluation of diffusion properties. The 3D volumetric fibre bundle is approximated by streamlines reconstructed using DTI. We present the fibre bundle mask strategy to measure thin fibre bundles in group analysis. A novel isonode visualisation method is developed to facilitate the visual inspection of local white matter alterations within a neural pathway.","PeriodicalId":216126,"journal":{"name":"Int. J. Funct. Informatics Pers. Medicine","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114166676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Hyperspectral Image segmentation and its application in abdominal surgery 高光谱图像分割及其在腹部外科中的应用
Int. J. Funct. Informatics Pers. Medicine Pub Date : 2009-08-03 DOI: 10.1504/IJFIPM.2009.027592
H. Akbari, Y. Kosugi, K. Kojima, N. Tanaka
{"title":"Hyperspectral Image segmentation and its application in abdominal surgery","authors":"H. Akbari, Y. Kosugi, K. Kojima, N. Tanaka","doi":"10.1504/IJFIPM.2009.027592","DOIUrl":"https://doi.org/10.1504/IJFIPM.2009.027592","url":null,"abstract":"The anatomical variations and unpredictable nature of surgeries make the visibility very important, especially to correctly diagnose problems intraoperatively. In this paper, hyperspectral imaging is proposed as a visual supporting tool to detect different organs and tissues during surgeries. This technique can aid the surgeon to find ectopic tissues and to diagnose tissue abnormalities. Two cameras were used to capture images within 400-1700 nm spectral range. The high-dimensional data were classified using a Support Vector Machine (SVM). This method was evaluated for the detection of the spleen, colon, small intestine, urinary bladder and peritoneum in abdominal surgeries on pigs.","PeriodicalId":216126,"journal":{"name":"Int. J. Funct. Informatics Pers. Medicine","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122384690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
Association analysis between Intragenomic Gene Conversions and pathogenicity in genomes of Escherichia coli and Shigella spp.: a scientific workflow approach 大肠杆菌和志贺氏菌基因组内基因转化与致病性的关联分析:一种科学的工作流方法
Int. J. Funct. Informatics Pers. Medicine Pub Date : 2009-01-28 DOI: 10.1504/IJFIPM.2009.022837
Jamal Alhiyafi, Cavitha Sabesan, Shiyong Lu, J. Ram
{"title":"Association analysis between Intragenomic Gene Conversions and pathogenicity in genomes of Escherichia coli and Shigella spp.: a scientific workflow approach","authors":"Jamal Alhiyafi, Cavitha Sabesan, Shiyong Lu, J. Ram","doi":"10.1504/IJFIPM.2009.022837","DOIUrl":"https://doi.org/10.1504/IJFIPM.2009.022837","url":null,"abstract":"The RECOMBFLOW scientific workflow system was used to test a previously suggested hypothesis that pathogenic Escherichia coli have more Intragenomic Gene Conversions (IGC) than non-pathogenic strains. Although some pathogens (O157:H7 and some Urinary Tract Infection (UTI) strains) had high IGC, two UTI strains and six Shigella (pathogens in the E. coli clade) were near non-pathogenic E. coli levels. Functional bacterial gene families with IGC in >4 genomes included efflux pumps, L-serine deaminases, FeS binding subunits of oxidoreductases and glutamate synthase, porins and related membrane proteins, Rhs elements, and L-ribulose-5-phosphate-4-epimerase. Shigella had lower IGCs in these families than non-pathogenic E. coli.","PeriodicalId":216126,"journal":{"name":"Int. J. Funct. Informatics Pers. Medicine","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131422022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel approaches for the microcalcification problem of non-palpable lesions 不可触及病变微钙化问题的新方法
Int. J. Funct. Informatics Pers. Medicine Pub Date : 2009-01-28 DOI: 10.1504/IJFIPM.2009.022835
W. Land, E. Verheggen
{"title":"Novel approaches for the microcalcification problem of non-palpable lesions","authors":"W. Land, E. Verheggen","doi":"10.1504/IJFIPM.2009.022835","DOIUrl":"https://doi.org/10.1504/IJFIPM.2009.022835","url":null,"abstract":"Fusion of hard and soft information using correlation pattern recognition and fuzzy logic in an integrated detection/classification system based on the DDSM database of pleomorphic microcalcifications provides a detection rate of 0.47 false positives per image at 100% sensitivity using classical matched filter methods on wavelet denoised full mammograms. Advanced correlation filtering yields 0.85 and 0.58 false positives per image at 100% and 87% sensitivity. Classification results generalisable to unseen images at 71.4% specificity for 100% and 96% sensitivity are in a range likely to be clinically acceptable, based on human vision performance of 73.3% specificity at 97.6% sensitivity.","PeriodicalId":216126,"journal":{"name":"Int. J. Funct. Informatics Pers. Medicine","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129798699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Nanoporous membrane-encapsulated feeder cells for culture of human embryonic stem cells 用于人胚胎干细胞培养的纳米多孔膜包封饲养细胞
Int. J. Funct. Informatics Pers. Medicine Pub Date : 2009-01-28 DOI: 10.1504/IJFIPM.2009.022838
Jing Zhou, R. Xu, Yong Wang
{"title":"Nanoporous membrane-encapsulated feeder cells for culture of human embryonic stem cells","authors":"Jing Zhou, R. Xu, Yong Wang","doi":"10.1504/IJFIPM.2009.022838","DOIUrl":"https://doi.org/10.1504/IJFIPM.2009.022838","url":null,"abstract":"Current methods for the extended culture of human embryonic stem cells (hESCs) are far from optimal. Therefore, we proposed to use nanoporous membrane for the co-culture of feeder cells and hESCs. In this proof-of-concept study, we first studied the stability, biocompatibility and permeability of an alginate-poly-L-lysine-alginate membrane. This membrane was then used to encapsulate feeder cells to examine the cell viability and TGF-β secretion. Finally, the encapsulated feeder-conditioned media were used to culture hESCs. The data indicate that nanoporous membrane is a potential tool for the co-culture of feeder cells and hESCs in a safe, efficient, and continuous manner.","PeriodicalId":216126,"journal":{"name":"Int. J. Funct. Informatics Pers. Medicine","volume":"191 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128149518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Cementless modular total hip arthroplasty: a retrieval analysis 无骨水泥模块化全髋关节置换术:检索分析
Int. J. Funct. Informatics Pers. Medicine Pub Date : 2009-01-28 DOI: 10.1504/IJFIPM.2009.022836
M. Paliwal, D. Allan, P. Filip
{"title":"Cementless modular total hip arthroplasty: a retrieval analysis","authors":"M. Paliwal, D. Allan, P. Filip","doi":"10.1504/IJFIPM.2009.022836","DOIUrl":"https://doi.org/10.1504/IJFIPM.2009.022836","url":null,"abstract":"This paper reports the analysis of a modular S-ROM hip implant, which was retrieved at revision, secondary to aseptic loosening approximately after 24-months of implantation. Microscopic analysis confirmed the presence of pitting, fretting corrosion, plastic deformation, and stress induced corrosion cracking. Energy-dispersive x-ray microanalysis of the stem surface revealed the release of metal ions. High resolution inductively coupled plasma mass spectroscopy confirmed elevated titanium ion levels (4.66 ppb) in blood serum. Finite element analysis of the implant showed that the micromotion and stress levels were the maximum at the proximal-lateral region of the taper junction, in congruence with the observation.","PeriodicalId":216126,"journal":{"name":"Int. J. Funct. Informatics Pers. Medicine","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128803465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Support Vector Regression based QSAR of anti-Haemophilus Influenzae activity of orally administered cephalosporins 基于支持向量回归的口服头孢菌素抗流感嗜血杆菌活性QSAR
Int. J. Funct. Informatics Pers. Medicine Pub Date : 2009-01-28 DOI: 10.1504/IJFIPM.2009.022840
Qin Yang, W. Lu, X. Liu, T. Gu
{"title":"Support Vector Regression based QSAR of anti-Haemophilus Influenzae activity of orally administered cephalosporins","authors":"Qin Yang, W. Lu, X. Liu, T. Gu","doi":"10.1504/IJFIPM.2009.022840","DOIUrl":"https://doi.org/10.1504/IJFIPM.2009.022840","url":null,"abstract":"Support Vector Regression (SVR), a novel robust machine learning technology, was applied to QSAR on the anti-Haemophilus Influenzae (HI) activity of 69 orally active cephalosporins. The optimal model was built with three descriptors-MR, qC7 and qO9, which came from 23 descriptors available. The prediction accuracy of the model was discussed on the basis of Leave-One-Out Cross-Validation (LOOCV) and the independent test dataset. Eighteen newly designed molecules are highly recommended for synthesis scientists based on the SVR model obtained.","PeriodicalId":216126,"journal":{"name":"Int. J. Funct. Informatics Pers. Medicine","volume":"4 6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133595969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Synthesis of simplified human Growth Hormone secretion mechanism on FPGAs 在fpga上合成简化的人类生长激素分泌机制
Int. J. Funct. Informatics Pers. Medicine Pub Date : 2009-01-28 DOI: 10.1504/IJFIPM.2009.022839
N. Botros, Yonglian Wang
{"title":"Synthesis of simplified human Growth Hormone secretion mechanism on FPGAs","authors":"N. Botros, Yonglian Wang","doi":"10.1504/IJFIPM.2009.022839","DOIUrl":"https://doi.org/10.1504/IJFIPM.2009.022839","url":null,"abstract":"In this paper, we present a simulation and hardware realisation on a compact electronic chip of a simplified growth hormone secretion mechanism. After realisation, the chip operates as a stand-alone device that mimics the function of the mechanism. The chip can be implemented to explore the function of the mechanism. To simulate the mechanism, a mathematical model has been developed. Four hormones have been considered, Growth Hormone (GH), Growth Hormone Releasing Hormone (GHRH), Somatotropin Release-Inhibiting Factor (SRIF) and Insulin like Growth Factor (IGF-1). After realisation, the chip is tested. The chip behaves identically to the operation of the simulated mechanism.","PeriodicalId":216126,"journal":{"name":"Int. J. Funct. Informatics Pers. Medicine","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126396586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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