ScienceOpen Posters最新文献

{"title":"Automatic dependent surveillance broadcast","authors":"K. Joseph","doi":"10.14293/s2199-1006.1.sor-.ppbfhps.v1","DOIUrl":"https://doi.org/10.14293/s2199-1006.1.sor-.ppbfhps.v1","url":null,"abstract":"The proposed next-generation air traffic control system depends crucially on a surveillance technology called ADS-B. Real-timeADS-Bis now the preferred method of surveillance for air traffic control in the NAS General aviation is safer withADS-Btraffic, weather, and flight-information services Safety and efficiency improve with advancedADS-Bapplications","PeriodicalId":21568,"journal":{"name":"ScienceOpen Posters","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75972371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Organ Bioprinting: The Next Generation Revolution in Medical Science","authors":"M. Patel","doi":"10.14293/s2199-1006.1.sor-.ppvvodz.v1","DOIUrl":"https://doi.org/10.14293/s2199-1006.1.sor-.ppvvodz.v1","url":null,"abstract":"The idea about lab grown organs is possibly the end of drug testing on the experimental animals or the human participants. Solution of organ shortage and the desperate ending state of organ donations worldwide can be solved. 3D Bioprinting is a revolutionary mind blowing medical technology emerged in the last few years. It involves the creation of living tissues, like bones, blood vessels, heart or skin with the help of additive manufacturing which is also known as 3D Bioprinting. Unlike other printing technology for the objects, Bioprinting not only needs living cells, they also need environment for nurturing to stay them alive, like food, water and oxygen. Nowadays, these kinds of conditions are provided by microgel, such as gelatin enriched with proteins, vitamins and many other compounds for life sustaining. Furthermore, for creating the fostering conditions and fastest efficient cell growth, scientist plant cells around 3D scaffolds which made of biodegradable polymers or collagen so that organ can able to grow in fully functional living tissue. Bioprinting is time-consuming and difficult also, but by doing proper research all problems can be solved for making organs available in transplantation process. Mass production of the organs for medical purpose likely to solve in the coming next decade. Also it is too much difficult to print the complex organs. Also if the technology available more easily, tissue engineering will become more feasible than entire organ printing. Bionic ear, synthetic skin, bladder or cornea might be the first tissues to be bio printed or completely grown in the lab on demand. These tissues having small numbers of cell types, it can be the first one for fully grown bio printed organs. After this success, bio printing of more complex organs can be done in future.","PeriodicalId":21568,"journal":{"name":"ScienceOpen Posters","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78903815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"mRNA Vaccine: The Next Generation Vaccine Revolution in Medical Science & Vaccinology","authors":"M. Patel","doi":"10.14293/s2199-1006.1.sor-.ppsvhlh.v1","DOIUrl":"https://doi.org/10.14293/s2199-1006.1.sor-.ppsvhlh.v1","url":null,"abstract":"Vaccination is one of the major success stories of modern medicine. It has the ability for reducing the incidence of infectious diseases such as measles, and helps in eradicating others like smallpox. Conventional vaccine approaches have not been as effective against rapidly evolving pathogens like influenza or emerging disease threats such as the Ebola, Zika Viruses or Novel Coronavirus. RNA based vaccines could have an impact in these areas due to their shorter manufacturing times and greater effectiveness. Beyond infectious diseases RNA vaccines have potential as Novel therapeutic options for major disease such as cancer for development of personalized medicine. At the time of epidemic like Ebola or pandemic like 2019-Novel Coronavirus (2019-nCoV) mRNA vaccine technology is the most effective way to develop a vaccine at the possible earliest time. As compared to the traditional way of vaccine development, next generation technology for developing vaccine is more essential. A novel pandemic cause by virus has been reported in Wuhan, China; in late December 2019. Within time duration of few weeks, the newly identified virus designated as 2019-Novel Coronavirus (2019-nCoV) and it was declared as pandemic by World Health Organization (WHO). At the time of late January 2020, WHO announced it as the international emergency outbreak because of the rapid spread and increases at the global level. There is no any preventive vaccine is present or any approved therapy/treatment for this viral emergency which is very infectious globally. The principle behind RNA vaccine is to use natural mRNA as a data carrier which can give instructions to the human body for the production of its proteins to fight against various diseases. RNA based vaccines provide good safety when it comes to their delivery in the cytoplasm. RNA vaccines comprise as mRNA vaccine which can offer robust safety profile with minimal genetic construction to express the desired antigen. There are few mRNA vaccines which were developed by few Biotechnology companies, showing positive results against COVID-19 and it is there in 4th phase clinical trial which possibly be the first vaccine available in the market in between mid-2021.","PeriodicalId":21568,"journal":{"name":"ScienceOpen Posters","volume":"61 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77698083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Box-Jenkins ARIMA Modelling: Forecasting FDI in India","authors":"Deepanshu Sharma, Kritika Phulli","doi":"10.14293/s2199-1006.1.sor-.ppzckjy.v1","DOIUrl":"https://doi.org/10.14293/s2199-1006.1.sor-.ppzckjy.v1","url":null,"abstract":"In the rapidly advancing dynamics of the economy trends of countries, the forecasting econometric techniques hold significant importance in the field of advance economics and management. Thus, this study intends to create Box Jenkins time series ARIMA model for analysing and predicting the trend of net FDI (Foreign Direct Investment) in India. The model was generated on the dataset of FDI inflow of India from the year 1950 to 2020. The trend was analysed for the generation of the model that best fitted the forecasting. The study highlights the minimum AIC value and involves ADF test (Augmented Dickey-Fuller) to transform FDI data into stationary form for model generation. It proposes ARIMA (1,1,4) model for optimal forecasting of net FDI inflow in India with an accuracy of 96.5%. The model thus predicts the steady-state exponential growth of FDI inflow in the coming 2020-25.","PeriodicalId":21568,"journal":{"name":"ScienceOpen Posters","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75666055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patterns of Ocular Dominance Domains and Cytochrome Oxidase Blobs in Striate Cortex of The Prosimian Primate Galago","authors":"J. Olavarria, H. Qi, V. Casagrande, J. Kaas","doi":"10.14293/s2199-1006.1.sor-.ppyi9kb.v1","DOIUrl":"https://doi.org/10.14293/s2199-1006.1.sor-.ppyi9kb.v1","url":null,"abstract":"Previous anatomical studies of ocular dominance columns (ODCs) in V1 of galagos did not investigate the overall tangential arrangement of eye-specific input in different cortical layers of V1. Likewise, studies using optical imaging of intrinsic signals have not provided information on the pattern of ODCs in layer 4 and deeper layers because this technique detects mostly activity patterns of neurons in the superficial layers. Here we demonstrate the patterns of ODCs across the cortical layers following intraocular injections of the transneuronal tracer WGA-HRP, and correlate these patterns with the array of CO blobs in tangential sections of the flattened cortex. In sections through supragranular V1, the WGA-HRP labeling appears as an array of distinct patches that most likely represent the patchy koniocellular input to layer 3 shown by previous studies. In layer 4, WGA-HRP labeling forms interconnected bands whose overall arrangement resembles the pattern of ODCs in cats. Comparison of the HRP and CO labeling patterns revealed that in supragranular layers, virtually all CO blobs overlap with WGA-HRP labeled patches. Since only one eye was injected with WGA-HRP, these data suggest that CO blobs receive input from both eyes. Moreover, in layer 4, CO blobs are not necessarily centered on ODCs, but often span the borders between left and right columns. Our results provide new information on the distribution and correlation of eye specific input across cortical layers in galago V1, and support the view that the alignment between ODCs and CO blobs seen in macaques is not a general feature of primate V1.","PeriodicalId":21568,"journal":{"name":"ScienceOpen Posters","volume":"64 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83708659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retino-thalamo-cortical and callosal connections visualized with manganese-enhanced magnetic resonance imaging and validated with tract tracing techniques","authors":"R. Laing, D. Cross, J. Olavarria","doi":"10.14293/s2199-1006.1.sor-.ppfbvat.v1","DOIUrl":"https://doi.org/10.14293/s2199-1006.1.sor-.ppfbvat.v1","url":null,"abstract":"Ocular dominance columns correlate with patchy callosal connections in Long Evans rats (Laing et al., 2015). We explored in vivo manganese-enhanced magnetic resonance imaging (MEMRI) as a possible strategy for longitudinal studies of plastic changes in the retino-thalamo-cortical and callosal pathways. MnCl\u0000 2 was injected either intraocularly or intracortically to label these pathways, respectively. The transport of the paramagnetic ion Mn\u0000 2+ was evaluated by comparing images acquired both before and 36 or 12 hours after intraocular or cortical injections, respectively. Images were acquired on a 3T magnet (Philips Achieva, Philips Healthcare, Andover, MA), using a custom surface coil and a T1-weighted MPRAGE image sequence (TR/TE = 23/11 ms; Ti=1000 ms; FA= 10 deg acquired matrix 432x432 mm over 118 slices, voxel size 0.11x0.11x0.2 mm\u0000 3 ). To validate the transport of Mn\u0000 2+ , each animal also received either an intraocular injection of the transneuronal tracer WGA-HRP, or cortical injections of HRP. Following monocular injections of MnCl\u0000 2 , MRI images showed significant, bilateral accumulations of Mn\u0000 2+ in regions of the SC, LGN and visual cortex that corresponded with regions labeled with HRP. In adult rats monocularly enucleated at birth, we injected MnCl\u0000 2 in the hemisphere contralateral to the remaining eye in an attempt to detect anomalies reported previously in the callosal pattern ipsilateral to the remaining eye. After the scans, the hemisphere injected with MnCl\u0000 2 was injected with HRP. MRI images revealed Mn\u0000 2+ patterns that closely resembled the callosal patterns demonstrated with HRP in the same animal. Our results suggest that both transneuronal retino-thalamo-cortical, as well as cortico-cortical transport of Mn\u0000 2+ provide potentially useful strategies for longitudinal studies of plastic changes in these pathways.","PeriodicalId":21568,"journal":{"name":"ScienceOpen Posters","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80574135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of callosal connections and optical imaging maps in visual cortex of mice lacking retinal activity waves due to deficiency in the ß2 subunit of the nicotinic acetylcholine receptor","authors":"J. Olavarria, Jianhua Cang, V. Kalatsky, M. Stryker","doi":"10.14293/s2199-1006.1.sor-.pplouc4.v1","DOIUrl":"https://doi.org/10.14293/s2199-1006.1.sor-.pplouc4.v1","url":null,"abstract":"Studies of visual callosal connections proposed that bilateral projections from temporal retina promote the formation of callosal linkages between cortical loci that are retinotopically matched and non-mirror symmetric with respect to the brain midline. It is therefore possible for a spontaneously active retinal locus to simultaneously activate retinotopically corresponding loci in both cortices, leading to Hebbian-like stabilization of connections between them before the eyes open. Interhemispheric correlated activity could stem from single ganglion cells that send axon branches to both sides, or from closely located cells that project to one side or the other, but which fire in synchrony due to spontaneously generated retinal activity waves. We hypothesized that lack of retinal waves could induce callosal map anomalies similar to those produced by neonatal enucleation. We studied mice lacking retinal waves due to deficiency in the s2 subunit of the nicotinic acetylcholine receptor. The organization of callosal projections revealed with small tracer injections was correlated with V1 maps made by imaging intrinsic optical responses to drifting stimuli. Consistent with studies showing that retinofugal and geniculocortical projections are less focused in s2 -/- mice, we found that the overall callosal pattern in V1 is markedly broader in s2 -/- mice than in wild type mice. However, the fine topography of the callosal map in s2 -/- mice is similar to that in wild type and s2 -/+ mice, indicating that lack of retinal waves is not sufficient for inducing the reversal in the callosal map caused by neonatal enucleation.","PeriodicalId":21568,"journal":{"name":"ScienceOpen Posters","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83258907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiorespiratory coupling is influenced by body position and slow paced 0.1Hz breathing in a state specific manner","authors":"T. Bojić, Zoran Matić, M. Stojković, Mirjana M. Platiša, Aleksandar Kalauzi, M. Lazarevic, M. Moser","doi":"10.14293/s2199-1006.1.sor-.ppqroqh.v1","DOIUrl":"https://doi.org/10.14293/s2199-1006.1.sor-.ppqroqh.v1","url":null,"abstract":"Cardiorespiratory coupling (CRC), a set of cardiac and respiratory rhythms that optimise the body oxygenation and the adaptability of the cardiorespiratory system to the external and internal environment, is represented in the linear domain by coefficient Qpr, the number of heartbeats per respiratory cycle (1, 2). Slow 0.1Hz breathing in supine position (Supin01) and active standing (Stand) represent the states of maximal RRI vagal and sympathetic modulation, respectively, in physiological quiescence; standing with 0.1Hz breathing (stand01) is characterized by qualitatively specific pattern of CRC(3). \u0000 The aim of our work was to investigate the Qpr in 4 states: supine position with spontaneous breathing (supin), stand, supin01and stand01. Methods: The ECG (RRI) and respiration signals were simultaneously recorded in 20 healthy human subjects in four conditions. Data acquisition and processing was performed as in (3). Results: Parameter Supin (mean95%CI) Stand (mean95%CI) Supin01 (mean95%CI) Stand01 (mean95%CI) RRI [s] 0.980.13 0.720.10 1.060.13 0.750.09 sd RRI [s] 0.060.02 0.040.02 0.090.03 0.070.02 BBI [s] 4.681.53 4.581.80 9.850.71 9.950.20 sdBBI [s] 1.110.69 1.351.29 1.440.94 1.060.44 Qpr 4.811.67 6.392.43 9.411.20 13.481.66 sdQpr 1.140.67 1.931.73 1.390.71 1.540.53 Table 1. Mean value and 95%CI of RRI, BBI and Qpr for 20 healthy subjects in four physiological states: Supin-supine position with spontaneous breathing, Stand- standing with spontaneous breathing, Supin01-supine position with 0.1Hz breathing, Stand01-standing with slow 0.1Hz breathing. Parameter Supin-Stand Supin-Supin01 Supin-Stand01 Supin01-Stand01 RRI 0.000 0.0 04 0.000 0.000 sd RRI 0.0 04 0.00 0 0.351 0.0 10 BBI 0.391 0.000 0.000 0.313 sdBBI 0.232 0.433 0.911 0.135 Qpr 0.0 00 0.000 0.000 0.000 sdQpr 0.0 06 0.370 0.0 33 0.191 Table 2. Probability values ​​(p) of statistically significant differences between different physiological states. Wilcoxon test on a sample of 20 subjects. Color-indicated statistically significant changes in values ​​(p <0.05) whose changes were related and discussed. - increase of mean value, -decrease of mean value. Our results show that Qpr is state dependent and that it increases with the behavioral task complexity. Postural change tunes Qpr by RRI modulation, while 0.1Hz breathing dominantly by the increase of BBI. Stand01 is characterized by concomitant adjustment of both RRI and BBI. These data imply that Qpr regulation is \"loosely\" and selectively coordinated in stand and supin01(\"dual control\") while integrated in stand01 (\"unitary control\"(4)). Analogously to nonlinear CRC(3), Qpr is probably operated by hierarchically higher diencephalo-telencephalic autonomic networks. References: 1. Moser M et al, Biol Rhythm Res 1995;26(1):100-111. 2. Scholkmann F et al, Front Physiol 2019;10:371. 3. Matić Z et al, Front Physiol 2020;11:24. 4. Feldman JL et al, Annu Rev Physiol 1988;50,593606.","PeriodicalId":21568,"journal":{"name":"ScienceOpen Posters","volume":"796 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77537327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FRG analysis of a multi-matrix model for 3d Lorentzian quantum gravity","authors":"A. G. A. Pithis, Antonio D. Pereira, A. Eichhorn","doi":"10.14293/s2199-1006.1.sor-.pp53mpx.v1","DOIUrl":"https://doi.org/10.14293/s2199-1006.1.sor-.pp53mpx.v1","url":null,"abstract":"At criticality, discrete quantum gravity models are expected to give rise to continuum spacetime. Recent progress has established the functional Renormalization Group method in the context of such models as a practical tool to study their critical properties and to chart their phase diagrams. Here, we apply these techniques to the multi-matrix model with ABAB-interaction potentially relevant for Lorentzian quantum gravity in 3 dimensions. We characterize the fixed-point structure and phase diagram of this model, paving the way for functional RG studies of more general multi-matrix or tensor models encoding causality.","PeriodicalId":21568,"journal":{"name":"ScienceOpen Posters","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84678605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rapid improvement program. How to standardise a joint replacement pathway across 10 hospitals in 6 months.","authors":"T. Wainwright, R. Middleton, Mark J. Ferreira","doi":"10.14293/s2199-1006.1.sor-.pp0h6is.v1","DOIUrl":"https://doi.org/10.14293/s2199-1006.1.sor-.pp0h6is.v1","url":null,"abstract":"Introduction There is strong evidence for implementing standardised enhanced recovery pathways after hip and knee replacement surgery. However, many units still do not use defined clinical pathways. A project was therefore undertaken to introduce a standard clinical pathway across a group of private hospitals. Background BMI Healthcare identified that there was significant variation across their 60 hospitals in regard to length of stay following hip and knee replacement. Diagnostic investigations into this variation revealed significant variation in the care processes and procedures used at individual hospitals and across units. Therefore, ten hospitals were chosen as sentinel sites, and a standardised pathway was introduced. In each hospital the entire multi- disciplinary team was involved in the project. Intervention A 6-month rapid improvement program was undertaken. The first step identified best practice for the provision of hip and knee replacement pathways. An evaluation of current clinical pathways against the gold standard established from the scoping exercise was then completed in each unit. A central improvement team in each hospital were trained in quality improvement techniques and they facilitated the changes in each hospital. The pathway was introduced along with improved documentation and performance measures. This was followed by an evaluation of the new pathway.Regular monitoring was completed centrally via email and telephone, as well as monthly site visits where the hospital team presented their progress, and difficulties with implementation were addressed. Effects of changes The new pathway was successfully implemented by all 10 hospitals. This is evidenced by full compliance to the new pathway, which was measured in each unit using variance analysis and process controlmeasures. The new pathway resulted in a 14% reduction to length of hospital stay across the nine sites, excellent clinical outcomes, and high patient and staff satisfaction. Message for others Facilitating change in ten separate hospitals concurrently is possible if sound quality improvement methodology is used, along with regular monitoring, and the involvement of the whole MDT team in each hospital. The role of ongoing monitoring from external experts and monthly performance reports for each hospital was a very powerful method for making change happen.","PeriodicalId":21568,"journal":{"name":"ScienceOpen Posters","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85984591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}