Royal Society Open Science最新文献_第5页

Milk metabolite composition of a semi-captive population of Asian elephants. 半圈养亚洲象群体的牛奶代谢物组成。

IF 2.9 3区综合性期刊

Royal Society Open Science Pub Date : 2024-10-30 eCollection Date: 2024-10-01 DOI: 10.1098/rsos.240930

Laura Galante, Diogo João Franco Dos Santos, Elisabeth Mikkonen, Jeannie Horak, Zorica Stijepic, Hans Demmelmair, Andrea Vielhauer, Berthold Koletzko, Htet Thi Zaw, Win Htut, Virpi Lummaa, Mirkka Lahdenperä

{"title":"Milk metabolite composition of a semi-captive population of Asian elephants.","authors":"Laura Galante, Diogo João Franco Dos Santos, Elisabeth Mikkonen, Jeannie Horak, Zorica Stijepic, Hans Demmelmair, Andrea Vielhauer, Berthold Koletzko, Htet Thi Zaw, Win Htut, Virpi Lummaa, Mirkka Lahdenperä","doi":"10.1098/rsos.240930","DOIUrl":"10.1098/rsos.240930","url":null,"abstract":"Lack of maternal milk commonly leads to Asian elephant calves' death in captivity. Currently, available supplements seem inefficient. Hence, we aimed at characterizing the composition of Asian elephant milk to provide information on calves' nutritional needs. Seventy milk samples from 22 Asian elephants living in semi-captivity in their natural environment in Myanmar were collected. Samples were analysed through various techniques including liquid chromatography tandem mass spectrometry, gas chromatography-flame ionization detector, and bicinchoninic acid assay to determine total protein content and various metabolites. Associations with lactation stage (months postpartum) were investigated through repeated measure mixed models. We identified 160 compounds: 22 amino acids, 12 organic acids of the tricarboxylic acid cycle, 27 fatty acids, 15 acyl-carnitines and 84 phospholipids. The milk contained substantial amounts of free glutamate (median: 1727.9, interquartile range (IQR): 1278.4 µmol l-1) and free glycine (2541.7, IQR: 1704.1 µmol l-1). The fatty acid profile was mostly constituted by saturated fatty acids, particularly capric acid (40.1, IQR: 67.3 g l-1). Milk samples also contained high amounts of carnitines, phospholipids and organic acids. The wide array of metabolites identified and quantified, some of which present high concentrations in the milk from this species as opposed to other species, suggests underpinning physiological functions that might be crucial for the survival of Asian elephant calves.","PeriodicalId":21525,"journal":{"name":"Royal Society Open Science","volume":"11 10","pages":"240930"},"PeriodicalIF":2.9,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11522882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

No cardiac phase bias for threat-related distance perception under naturalistic conditions in immersive virtual reality. 在沉浸式虚拟现实的自然条件下，与威胁相关的距离感知不存在心脏相位偏差。

IF 2.9 3区综合性期刊

Royal Society Open Science Pub Date : 2024-10-30 eCollection Date: 2024-10-01 DOI: 10.1098/rsos.241072

Felix Klotzsche, Paweł Motyka, Aleksander Molak, Václav Sahula, Barbora Darmová, Conor Byrnes, Iveta Fajnerová, Michael Gaebler

{"title":"No cardiac phase bias for threat-related distance perception under naturalistic conditions in immersive virtual reality.","authors":"Felix Klotzsche, Paweł Motyka, Aleksander Molak, Václav Sahula, Barbora Darmová, Conor Byrnes, Iveta Fajnerová, Michael Gaebler","doi":"10.1098/rsos.241072","DOIUrl":"10.1098/rsos.241072","url":null,"abstract":"Previous studies have found that threatening stimuli are more readily perceived and more intensely experienced when presented during cardiac systole compared with diastole. Also, threatening stimuli are judged as physically closer than neutral ones. In a pre-registered study, we tested these effects and their interaction using a naturalistic (interactive and three-dimensional) experimental design in immersive virtual reality: we briefly displayed threatening and non-threatening animals (four each) at varying distances (1.5-5.5 m) to a group of young, healthy participants (n = 41) while recording their electrocardiograms (ECGs). Participants then pointed to the location where they had seen the animal (approx. 29 000 trials in total). Our pre-registered analyses indicated that perceived distances to both threatening and non-threatening animals did not differ significantly between cardiac phases-with Bayesian analysis supporting the null hypothesis. There was also no evidence for an association between subjective fear and perceived proximity to threatening animals. These results contrast with previous findings that used verbal or declarative distance measures in less naturalistic experimental conditions. Furthermore, our findings suggest that the cardiac phase-related variation in threat processing may not generalize across different paradigms and may be less relevant in naturalistic scenarios than under more abstract experimental conditions.","PeriodicalId":21525,"journal":{"name":"Royal Society Open Science","volume":"11 10","pages":"241072"},"PeriodicalIF":2.9,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11521594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gone but not forgotten: dynamics of sperm storage and potential ejaculate digestion in the black soldier fly Hermetia illucens. 消失但未被遗忘：黑兵蝇精子储存和潜在射精消化的动态变化。

IF 2.9 3区综合性期刊

Royal Society Open Science Pub Date : 2024-10-30 eCollection Date: 2024-10-01 DOI: 10.1098/rsos.241205

Frédéric Manas, Harmony Piterois, Carole Labrousse, Laureen Beaugeard, Rustem Uzbekov, Christophe Bressac

{"title":"Gone but not forgotten: dynamics of sperm storage and potential ejaculate digestion in the black soldier fly Hermetia illucens.","authors":"Frédéric Manas, Harmony Piterois, Carole Labrousse, Laureen Beaugeard, Rustem Uzbekov, Christophe Bressac","doi":"10.1098/rsos.241205","DOIUrl":"10.1098/rsos.241205","url":null,"abstract":"Understanding the dynamics of sperm storage is essential to unravel the complexity of post-copulatory sexual selection processes in internally fertilized species. This physiological process goes from sperm transfer during copulation to its use for fertilization. In this context, the spatiotemporal dynamics of sperm storage were described in the black soldier fly (BSF) with fluorescence and transmission electron microscopy (TEM). BSF females have compartmentalized spermathecae with a transfer compartment, the fishnet canals, and a storage compartment, the reservoirs. Spermatozoa were counted both during and after mating in the two compartments. In addition to seminal fluids, the male transfers a mass of sperm in the fishnet canals, then only 49% of the transferred spermatozoa reach the reservoirs over two days. TEM observations of the fishnet canals revealed potential digestive functions, explaining the decline in the number and viability of spermatozoa in this compartment but not in the reservoirs. After one mating, females laid up to three fertile clutches, showing no constraints on sperm quantity or quality. Spermatic and ultrastructural investigations strongly suggest that BSF ejaculate acts both as a sperm plug and as a nuptial gift, reinforcing the interest in studying this farming insect as a new model for sexual selection.","PeriodicalId":21525,"journal":{"name":"Royal Society Open Science","volume":"11 10","pages":"241205"},"PeriodicalIF":2.9,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11521600/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Astrocytes induce desynchronization and reduce predictability in neuron-astrocyte networks cultured on microelectrode arrays. 在微电极阵列上培养的神经元-星形胶质细胞网络中，星形胶质细胞会诱发非同步化并降低可预测性。

IF 2.9 3区综合性期刊

Royal Society Open Science Pub Date : 2024-10-30 eCollection Date: 2024-10-01 DOI: 10.1098/rsos.240839

Barbara Genocchi, Annika Ahtiainen, Annika Niemi, Michael T Barros, Jarno M A Tanskanen, Kerstin Lenk, Jari Hyttinen, Narayan Puthanmadam Subramaniyam

{"title":"Astrocytes induce desynchronization and reduce predictability in neuron-astrocyte networks cultured on microelectrode arrays.","authors":"Barbara Genocchi, Annika Ahtiainen, Annika Niemi, Michael T Barros, Jarno M A Tanskanen, Kerstin Lenk, Jari Hyttinen, Narayan Puthanmadam Subramaniyam","doi":"10.1098/rsos.240839","DOIUrl":"10.1098/rsos.240839","url":null,"abstract":"In this article, we aim to study how astrocytes control electrophysiological activity during neuronal network formation. We used a combination of spike/burst analysis, classification of spike waveforms based on various signal properties and tools from information theory to demonstrate how astrocytes modulate the electrical activity of neurons using microelectrode array (MEA) signals. We cultured rat primary cortical neurons and astrocytes on 60-electrode MEAs with different neuron/astrocyte ratios ranging from 'pure' neuronal cultures to co-cultures containing 50% neurons and 50% astrocytes. Our results show that astrocytes desynchronize the network and reduce predictability in the signals and affect the repolarization phase of the action potentials. Our work highlights that it is crucial to go beyond standard MEA analysis to assess how astrocytes control neuronal cultures and investigate any dysfunction that could potentially result in neuronal hyperactivity.","PeriodicalId":21525,"journal":{"name":"Royal Society Open Science","volume":"11 10","pages":"240839"},"PeriodicalIF":2.9,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11521599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A mathematical model for pancreatic cancer during intraepithelial neoplasia. 上皮内瘤变期胰腺癌数学模型。

IF 2.9 3区综合性期刊

Royal Society Open Science Pub Date : 2024-10-30 eCollection Date: 2024-10-01 DOI: 10.1098/rsos.240702

Joshua Briones-Andrade, Guillermo Ramírez-Santiago, J Roberto Romero-Arias

{"title":"A mathematical model for pancreatic cancer during intraepithelial neoplasia.","authors":"Joshua Briones-Andrade, Guillermo Ramírez-Santiago, J Roberto Romero-Arias","doi":"10.1098/rsos.240702","DOIUrl":"10.1098/rsos.240702","url":null,"abstract":"Cancer is the result of complex interactions of intrinsic and extrinsic cell processes, which promote sustained proliferation, resistance to apoptosis, reprogramming and reorganization. The evolution of any type of cancer emerges from the role of the microenvironmental conditions and their impact of some molecular complexes on certain signalling pathways. The understanding of the early onset of cancer requires a multiscale analysis of the cellular microenvironment. In this paper, we analyse a qualitative multiscale model of pancreatic adenocarcinoma by modelling the cellular microenvironment through elastic cell interactions and their intercellular communication mechanisms, such as growth factors and cytokines. We focus on the low-grade dysplasia (PanIN 1) and moderate dysplasia (PanIN 2) stages of pancreatic adenocarcinoma. To this end, we propose a gene-regulatory network associated with the processes of proliferation and apoptosis of pancreatic cells and its kinetics in terms of delayed differential equations to mimic cell development. Likewise, we couple the cell cycle with the spatial distribution of cells and the transport of growth factors to show that the adenocarcinoma evolution is triggered by inflammatory processes. We show that the oncogene RAS may be an important target for developing anti-inflammatory strategies that limit the emergence of more aggressive adenocarcinomas.","PeriodicalId":21525,"journal":{"name":"Royal Society Open Science","volume":"11 10","pages":"240702"},"PeriodicalIF":2.9,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11528534/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Strategic housing decisions and the evolution of urban settlements: optimality modelling and empirical application in Ulaanbaatar, Mongolia. 战略性住房决策与城市住区的演变：蒙古乌兰巴托的优化模型与经验应用。

IF 2.9 3区综合性期刊

Royal Society Open Science Pub Date : 2024-10-30 eCollection Date: 2024-10-01 DOI: 10.1098/rsos.241415

Natalia Fedorova, Anne Kandler, Richard McElreath

{"title":"Strategic housing decisions and the evolution of urban settlements: optimality modelling and empirical application in Ulaanbaatar, Mongolia.","authors":"Natalia Fedorova, Anne Kandler, Richard McElreath","doi":"10.1098/rsos.241415","DOIUrl":"10.1098/rsos.241415","url":null,"abstract":"Investments in housing influence migration and landscape construction, making them a key component of human-environment interactions. However, the strategic decision-making that builds residential landscapes is an underdeveloped area of research in evolutionary approaches to human behaviour. Our contribution to this literature is a theoretical model and an empirical test of this model using data from Ulaanbaatar, Mongolia. We develop a model of strategic housing decisions using stochastic dynamic programming (SDP) to explore the trade-offs between building, moving and saving over time, finding different trade-offs depending on optimization scenarios and housing costs. Household strategies are then estimated using data on 825 households that settled in the Ger districts of Ulaanbaatar between 1942 and 2020. The Ger districts are areas of self-built housing that feature both mobile dwellings (gers) and immobile houses (bashins). Using approximate Bayesian computation (ABC), we find the parameters of our dynamic programming model that best fit the empirical data. The model is able to capture the time horizon of housing changes and their bi-directionality, showing that moving from a fixed to mobile dwelling can also be an optimal strategy. However, the model underpredicts household persistence in dwelling types. We discuss deviations from model predictions and identify a more detailed exploration of risk and population mixes of strategies as key steps for future research.","PeriodicalId":21525,"journal":{"name":"Royal Society Open Science","volume":"11 10","pages":"241415"},"PeriodicalIF":2.9,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11522881/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A distributed integral control mechanism for regulation of cholesterol concentration in the human retina. 调节人类视网膜胆固醇浓度的分布式整体控制机制。

IF 2.9 3区综合性期刊

Royal Society Open Science Pub Date : 2024-10-30 eCollection Date: 2024-10-01 DOI: 10.1098/rsos.240432

Ronél Scheepers, Noa L Levi, Robyn P Araujo

{"title":"A distributed integral control mechanism for regulation of cholesterol concentration in the human retina.","authors":"Ronél Scheepers, Noa L Levi, Robyn P Araujo","doi":"10.1098/rsos.240432","DOIUrl":"10.1098/rsos.240432","url":null,"abstract":"Tight homeostatic control of cholesterol concentration within the complex tissue microenvironment of the retina is the hallmark of a healthy eye. By contrast, dysregulation of biochemical mechanisms governing retinal cholesterol homeostasis likely contributes to the aetiology and progression of age-related macular degeneration (AMD). While the signalling mechanisms maintaining cellular cholesterol homeostasis are well-studied, a systems-level description of molecular interactions regulating cholesterol balance within the human retina remains elusive. Here, we provide a comprehensive overview of all currently-known molecular-level interactions involved in cholesterol regulation across the major compartments of the human retina, encompassing the retinal pigment epithelium (RPE), photoreceptor cell layer, Müller cell layer and Bruch's membrane. We develop a comprehensive chemical reaction network (CRN) of these interactions, involving 71 molecular species, partitioned into 10 independent subnetworks. These subnetworks collectively ensure robust homeostasis of 14 forms of cholesterol across distinct retinal cellular compartments. We provide mathematical evidence that three independent antithetic integral feedback controllers tightly regulate ER cholesterol in retinal cells, with additional independent mechanisms extending this regulation to other forms of cholesterol throughout the retina. Our novel mathematical model of retinal cholesterol regulation provides a framework for understanding the mechanisms of cholesterol dysregulation in diseased eyes and for exploring potential therapeutic strategies.","PeriodicalId":21525,"journal":{"name":"Royal Society Open Science","volume":"11 10","pages":"240432"},"PeriodicalIF":2.9,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11521609/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modelling human navigation and decision dynamics in a first-person herding task. 模拟第一人称放牧任务中的人类导航和决策动态。

IF 2.9 3区综合性期刊

Royal Society Open Science Pub Date : 2024-10-30 eCollection Date: 2024-10-01 DOI: 10.1098/rsos.231919

Ayman Bin Kamruddin, Hannah Sandison, Gaurav Patil, Mirco Musolesi, Mario di Bernardo, Michael J Richardson

{"title":"Modelling human navigation and decision dynamics in a first-person herding task.","authors":"Ayman Bin Kamruddin, Hannah Sandison, Gaurav Patil, Mirco Musolesi, Mario di Bernardo, Michael J Richardson","doi":"10.1098/rsos.231919","DOIUrl":"10.1098/rsos.231919","url":null,"abstract":"This study investigated whether dynamical perceptual-motor primitives (DPMPs) could also be used to capture human navigation in a first-person herding task. To achieve this aim, human participants played a first-person herding game, in which they were required to corral virtual cows, called targets, into a specified containment zone. In addition to recording and modelling participants' movement trajectories during gameplay, participants' target-selection decisions (i.e. the order in which participants corralled targets) were recorded and modelled. The results revealed that a simple DPMP navigation model could effectively reproduce the movement trajectories of participants and that almost 80% of the participants' target-selection decisions could be captured by a simple heuristic policy. Importantly, when this policy was coupled to the DPMP navigation model, the resulting system could successfully simulate and predict the behavioural dynamics (movement trajectories and target-selection decisions) of participants in novel multi-target contexts. Implications of the findings for understanding complex human perceptual-motor behaviour and the development of artificial agents for robust human-machine interaction are discussed.","PeriodicalId":21525,"journal":{"name":"Royal Society Open Science","volume":"11 10","pages":"231919"},"PeriodicalIF":2.9,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11522880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modelling COVID-19 mutant dynamics: understanding the interplay between viral evolution and disease transmission dynamics. COVID-19突变体动态建模：了解病毒进化与疾病传播动态之间的相互作用。

IF 2.9 3区综合性期刊

Royal Society Open Science Pub Date : 2024-10-30 eCollection Date: 2024-10-01 DOI: 10.1098/rsos.240919

Fernando Saldaña, Nico Stollenwerk, Maíra Aguiar

{"title":"Modelling COVID-19 mutant dynamics: understanding the interplay between viral evolution and disease transmission dynamics.","authors":"Fernando Saldaña, Nico Stollenwerk, Maíra Aguiar","doi":"10.1098/rsos.240919","DOIUrl":"10.1098/rsos.240919","url":null,"abstract":"Understanding virus mutations is critical for shaping public health interventions. These mutations lead to complex multi-strain dynamics often under-represented in models. Aiming to understand the factors influencing variants' fitness and evolution, we explore several scenarios of virus spreading to gain qualitative insight into the factors dictating which variants ultimately predominate at the population level. To this end, we propose a two-strain stochastic model that accounts for asymptomatic transmission, mutations and the possibility of disease import. We find that variants with milder symptoms are likely to spread faster than those with severe symptoms. This is because severe variants can prompt affected individuals to seek medical help earlier, potentially leading to quicker identification and isolation of cases. However, milder or asymptomatic cases may spread more widely, making it harder to control the spread. Therefore, increased transmissibility of milder variants can still result in higher hospitalizations and fatalities due to widespread infection. The proposed model highlights the interplay between viral evolution and transmission dynamics. Offering a nuanced view of factors influencing variant spread, the model provides a foundation for further investigation into mitigating strategies and public health interventions.","PeriodicalId":21525,"journal":{"name":"Royal Society Open Science","volume":"11 10","pages":"240919"},"PeriodicalIF":2.9,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11529628/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Using the basic reproduction ratio to quantify transmission and identify data gaps for epizootic haemorrhagic disease virus. 利用基本繁殖率量化传播情况并确定流行性出血病病毒的数据缺口。

IF 2.9 3区综合性期刊

Royal Society Open Science Pub Date : 2024-10-30 eCollection Date: 2024-10-01 DOI: 10.1098/rsos.241217

Simon Gubbins

{"title":"Using the basic reproduction ratio to quantify transmission and identify data gaps for epizootic haemorrhagic disease virus.","authors":"Simon Gubbins","doi":"10.1098/rsos.241217","DOIUrl":"10.1098/rsos.241217","url":null,"abstract":"Epizootic haemorrhagic disease virus (EHDV) is an arbovirus transmitted by Culicoides biting midges that has recently emerged in Europe. Here, the basic reproduction ratio (R 0) was used to quantify the transmission of EHDV and its dependence on temperature for cattle and deer. Using data from the published literature the parameters needed to calculate R 0 were estimated with Bayesian methods to incorporate uncertainty in the calculations. The Sobol method of sensitivity analysis was used to determine the parameters having the greatest influence on R 0 and, hence, to identify important data gaps. Depending on the strain, the maximum R 0 for EHDV varied from 0.7 to 2.5 in cattle and 1.3 to 4.3 in deer. The maximum R 0 occurred at temperatures between 22 and 25°C, while the lowest temperature at which R 0 exceeded one was between 16 and 20°C. The sensitivity analysis identified the threshold temperature for virus replication, the probability of transmission from host to vector and the vector- to- host ratio as the most important parameters influencing R 0. Furthermore, there are only limited data on EHDV in European deer species and on transmission in wildlife and at the livestock/wildlife interface. These data gaps should be the focus of future research.","PeriodicalId":21525,"journal":{"name":"Royal Society Open Science","volume":"11 10","pages":"241217"},"PeriodicalIF":2.9,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11522985/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0