Scandinavian Journal of Clinical & Laboratory Investigation最新文献_第6页

Reference intervals for plasma total bilirubin in children. 儿童血浆总胆红素的参考区间。

IF 1.4 4区医学

Scandinavian Journal of Clinical & Laboratory Investigation Pub Date : 2026-01-01 Epub Date: 2026-08-06 DOI: 10.1080/00365513.2026.2713142

Line Philipsen, Lærke Andersen, Stine Linding Andersen

{"title":"Reference intervals for plasma total bilirubin in children.","authors":"Line Philipsen, Lærke Andersen, Stine Linding Andersen","doi":"10.1080/00365513.2026.2713142","DOIUrl":"10.1080/00365513.2026.2713142","url":null,"abstract":"Plasma total bilirubin is a commonly requested biochemical test in children used for assessment of hyperbilirubinemia. Physiological adaptations in newborns challenge the interpretation, and more evidence is needed to substantiate the dynamics of plasma total bilirubin throughout childhood and across routinely used analyzers to support the choice of reference interval (RI) in clinical laboratories. This was a retrospective study in the North Denmark Region utilizing routine laboratory results of plasma total bilirubin for establishment of RI in children aged 0-18 years with an indirect approach. Plasma total bilirubin had been measured on routinely used analyzers (method 1: Alinity, Abbott Laboratories, method 2: Atellica, Siemens Healthineers, method 3: Cobas 8000, Roche Diagnostics), and RIs were established non-parametrically as the 2.5th and 97.5th percentile. Plasma total bilirubin from a total of 29,195 children aged 0-18 years (51.0% girls) were evaluated. The established upper RI limit for plasma total bilirubin differed by child's age: 0-1 days (method 1: 62 µmol/L, method 2: 81 µmol/L, and method 3: 73 µmol/L), 6-7 days (method 1: 350 µmol/L, method 2: 384 µmol/L, and method 3: 346 µmol/L), 7-30 days (method 1: 297 µmol/L, method 2: 300 µmol/L, and method 3: 282 µmol/L), 1 month-18 years (method 1: 17 µmol/L, method 2: 17 µmol/L, and method 3: 15 µmol/L). Plasma total bilirubin levels were dynamic within the first month of life and thereafter stable low throughout childhood and adolescence. The dynamics were consistent across routinely used methods, and results provided age-dependent RIs for implementation in clinical laboratories.","PeriodicalId":21474,"journal":{"name":"Scandinavian Journal of Clinical & Laboratory Investigation","volume":" ","pages":"561-569"},"PeriodicalIF":1.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148685499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patterns of phlebotomy service use in Northern Finland: heavy utilization of laboratory services. 芬兰北部采血服务的使用模式：大量使用实验室服务。

IF 1.4 4区医学

Scandinavian Journal of Clinical & Laboratory Investigation Pub Date : 2026-01-01 Epub Date: 2026-03-07 DOI: 10.1080/00365513.2026.2640368

Tuija Männistö

引用次数: 0

Selective association of the eGFRcys/eGFRcr ratio with hyperuricemia but not fasting glucose: a discriminant-validity analysis. eGFRcys/eGFRcr比值与高尿酸血症而非空腹血糖的选择性关联：一项判别效度分析

IF 1.4 4区医学

Scandinavian Journal of Clinical & Laboratory Investigation Pub Date : 2026-01-01 Epub Date: 2026-09-02 DOI: 10.1080/00365513.2026.2727998

LingYi Feng, QianRong Xie, YuJing Wang

{"title":"Selective association of the eGFRcys/eGFRcr ratio with hyperuricemia but not fasting glucose: a discriminant-validity analysis.","authors":"LingYi Feng, QianRong Xie, YuJing Wang","doi":"10.1080/00365513.2026.2727998","DOIUrl":"10.1080/00365513.2026.2727998","url":null,"abstract":"Shrunken Pore Syndrome (SPS), an eGFRcys/eGFRcr ratio < 0.6, is hypothesized to reflect selective glomerular filtration discordance, though its mechanism remains debated. Because an informative biomarker should associate with mechanistically related outcomes but not unrelated ones, we tested whether the continuous eGFRcys/eGFRcr ratio is selectively associated with hyperuricemia (HUA) but not elevated fasting glucose (IFG, a negative control). Routine fasting data from 29,534 health-examination adults were analyzed; eGFR was estimated using the CKD-EPI 2021 creatinine and 2012 cystatin C equations. HUA (primary outcome) and IFG (≥6.1 mmol/L) were modeled by multivariable logistic regression adjusted for age, sex, lipids and absolute eGFRcr, with pre-specified propensity-score matching (PSM) on age, sex and eGFRcr and a strict-IFG analysis excluding diabetes. HUA occurred in 6,632 participants (22.5%), IFG in 2,760 (9.3%) and binary SPS in 241 (0.82%). Each 0.1-unit ratio decrease raised HUA odds by 38% (OR 1.38, 95% CI 1.35-1.42; lowest-vs-highest quartile OR 2.83), whereas the IFG association was null (OR 1.03, p = 0.127). In the eGFRcr-matched PSM cohort excluding diabetes, SPS remained associated with HUA (OR 2.30, p < 0.001) but not strict IFG (OR 1.28, p = 0.29); findings were robust across tertile, spline, TyG-adjusted and age-stratified analyses. The eGFRcys/eGFRcr ratio is therefore graded-associated with hyperuricemia but not fasting glucose, supporting its interpretation as a phenotypic marker of selective glomerular filtration discordance rather than a generic metabolic-risk index. Prospective validation is required.","PeriodicalId":21474,"journal":{"name":"Scandinavian Journal of Clinical & Laboratory Investigation","volume":" ","pages":"627-641"},"PeriodicalIF":1.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148881544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fucosylated α-1-acid glycoprotein as a noninvasive fibrosis marker in chronic viral hepatitis. 聚焦α-1-酸性糖蛋白作为慢性病毒性肝炎无创纤维化标志物的研究

IF 1.4 4区医学

Scandinavian Journal of Clinical & Laboratory Investigation Pub Date : 2026-01-01 Epub Date: 2026-09-24 DOI: 10.1080/00365513.2026.2735016

Catharina Alexandersson, Mats Haglund, Eva Åström, Karin Lindahl, Kristina Cardell, Peter Påhlsson, Ingvar Rydén

{"title":"Fucosylated α-1-acid glycoprotein as a noninvasive fibrosis marker in chronic viral hepatitis.","authors":"Catharina Alexandersson, Mats Haglund, Eva Åström, Karin Lindahl, Kristina Cardell, Peter Påhlsson, Ingvar Rydén","doi":"10.1080/00365513.2026.2735016","DOIUrl":"10.1080/00365513.2026.2735016","url":null,"abstract":"We have previously developed a potential non-invasive fibrosis marker in the form of a lectin immunoassay for the detection of fucosylated α1-acid glycoprotein in plasma (P-AGP-FR). We aimed to investigate the diagnostic accuracy of P-AGP-FR for liver cirrhosis and fibrosis in a clinical setting of patients with chronic viral hepatitis. One hundred twenty-four patients, 80 with chronic hepatitis B and 44 with chronic hepatitis C, were recruited at two centers. P-AGP-FR levels were evaluated in relation to fibrosis or cirrhosis according to liver biopsy or transient elastography, and its diagnostic accuracy was compared with other noninvasive biochemical fibrosis markers; APRI and FIB-4. AGP fucosylation was elevated in patients with fibrosis, and the correlation of P-AGP-FR values with fibrosis levels was significant in all groups. The probability for fibrosis increased with higher P-AGP-FR values, with an odds ratio (OR) of 2.79. Receiver operating characteristic (ROC) curve analysis was done for the diagnostic accuracy of P-AGP-FR for fibrosis according to biopsy and liver elastography, respectively. Area under the ROC curve (AUROC) was 0.74 (95% CI: 0.58-0.91) for fibrosis according to biopsy and 0.72 (95% CI: 0.58-0.85) for fibrosis according to liver elastography. Optimal cutoff by Youden for fibrosis according to liver biopsy was 1.95, sensitivity 63.6% and specificity 85.7%. For fibrosis according to liver elastography, optimal cutoff was 1.44, sensitivity 54.6% and specificity 78.8%. In conclusion, AGP fucosylation measured as P-AGP-FR was significantly higher in patients with hepatic fibrosis and cirrhosis, and we found a significant correlation between P-AGP-FR and fibrosis stage.","PeriodicalId":21474,"journal":{"name":"Scandinavian Journal of Clinical & Laboratory Investigation","volume":" ","pages":"677-685"},"PeriodicalIF":1.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149031400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Percentile charts for eGFR. eGFR的百分位数图表。

IF 1.4 4区医学

Scandinavian Journal of Clinical & Laboratory Investigation Pub Date : 2026-01-01 Epub Date: 2026-09-21 DOI: 10.1080/00365513.2026.2727994

Arne Åsberg, Øyvind Skadberg

引用次数: 0

Glucose-enhanced BISAP score for early prediction of severe acute pancreatitis. 葡萄糖增强BISAP评分用于早期预测严重急性胰腺炎。

IF 1.4 4区医学

Scandinavian Journal of Clinical & Laboratory Investigation Pub Date : 2026-01-01 Epub Date: 2026-05-11 DOI: 10.1080/00365513.2026.2669910

Kadir Nıgız, Salim Satar, Selen Acehan, Muge Gulen, Sarper Sevdımbas, Mehmet Gorur

{"title":"Glucose-enhanced BISAP score for early prediction of severe acute pancreatitis.","authors":"Kadir Nıgız, Salim Satar, Selen Acehan, Muge Gulen, Sarper Sevdımbas, Mehmet Gorur","doi":"10.1080/00365513.2026.2669910","DOIUrl":"10.1080/00365513.2026.2669910","url":null,"abstract":"This study aimed to identify early predictors of severe acute pancreatitis (SAP). Additionally, we examined whether admission laboratory parameters improve the prognostic performance of established severity scoring systems in patients presenting to the emergency department. A prospective observational cohort study was conducted in the ED of a tertiary care hospital between 15 September 2023 and 15 September 2024. A total of 208 adult patients diagnosed with AP were enrolled. Demographic characteristics, clinical findings, laboratory parameters, imaging results, complications, and outcomes were recorded. Variables associated with SAP were examined using univariate analysis followed by backward stepwise multivariate logistic regression. Predictive accuracy was assessed using receiver operating characteristic (ROC) analysis. Of the 208 patients, 52.4% were female, and the median age was 57 years (IQR: 41-68.8). SAP occurred in 11.1% of cases. In multivariate analysis, both the BISAP score (OR: 4.398; 95% CI: 2.205-8.775; p < 0.001) and admission glucose level (OR: 1.009; 95% CI: 1.003-1.016; p = 0.007) were independent predictors of SAP. A combined model incorporating BISAP and glucose demonstrated very good discriminative performance (AUC: 0.889; 95% CI: 0.850-0.972), with 87% sensitivity and 70.3% specificity. BISAP alone also showed strong predictive ability (AUC: 0.833; 95% CI: 0.727-0.938). A glucose-enhanced BISAP model provides a practical and highly accurate early risk-stratification tool for predicting severe disease among ED patients with AP. Incorporating admission glucose into BISAP may support timelier clinical decision-making and improve early management strategies.","PeriodicalId":21474,"journal":{"name":"Scandinavian Journal of Clinical & Laboratory Investigation","volume":" ","pages":"334-343"},"PeriodicalIF":1.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147869579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Performance evaluation of the new Sysmex XR9000 hematology system in a clinical setting in comparison with Sysmex XN9100. 新Sysmex XR9000血液学系统在临床环境中的性能评估与Sysmex XN9100的比较。

IF 1.4 4区医学

Scandinavian Journal of Clinical & Laboratory Investigation Pub Date : 2026-01-01 Epub Date: 2026-04-21 DOI: 10.1080/00365513.2026.2659588

Maria Boysen Sandberg, Pernille Just Vinholt

{"title":"Performance evaluation of the new Sysmex XR9000 hematology system in a clinical setting in comparison with Sysmex XN9100.","authors":"Maria Boysen Sandberg, Pernille Just Vinholt","doi":"10.1080/00365513.2026.2659588","DOIUrl":"10.1080/00365513.2026.2659588","url":null,"abstract":"This study evaluted the Sysmex XR-9000 hematology analyzer in a clinical setting, comparing it with the XN-9100 system using patient samples from routine laboratory. The evaluation followed CLSI H26-A2 and ICSH guidelines, incorporating state-of-the-art (SOTA) and EFLM biological variation criteria. The XR-9000 met LLoQ criteria for leukocyte and platelet counts using the White cell Differential channel by Fluorescence (WDF) and platelet fluorescence (PLT-F) channels, with CV% below 7% for WBC at 0.1 x109/L and platelets at 1.5 x109/L. Linearity was excellent across all parameters (r2 > 0.99) and imprecision reported by the manufacturer was verified. For Mean Corpuscular Volume (MCV), Mean Corpuscular Hemoglobin (MCH), and Mean Corpuscular Hemoglobin Concentration (MCHC), CV% values reached 0.7%, 1.3%, and 1.7%, respectively, exceeding EFLM criteria of 0.4%, 0.3%, and 0.5%. The low concentration controls for neutrophils counts (NEUT) and platelets exceeded SOTA limits of 2.5% and 3%, respectively, with CV% up to 3.6% and 4.1%. Clinically relevant levels for platelets, hemoglobin, and NEUT showed acceptable imprecision with CV% <5, ≤1.3, and <9, respectively. Accuracy testing confirmed agreement with manufacturer's controls and an EQA program, with immature granulocytes as the only exception due to its level falling below LLoQ. Method comparison between the XR-9000 and XN-9100 systems demonstrated strong agreement, with minor discrepancies in MCHC, basophils count (BASO), and platelets. In conclusion, the XR-9000 demonstrated reliable performance across key metrics, meeting clinical requirements for accurate diagnosis and monitoring in hematology.","PeriodicalId":21474,"journal":{"name":"Scandinavian Journal of Clinical & Laboratory Investigation","volume":" ","pages":"263-272"},"PeriodicalIF":1.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147779721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reference intervals for lysosomal glucocerebrosidase activity in the healthy population. 健康人群溶酶体糖脑苷酶活性的参考区间。

IF 1.4 4区医学

Scandinavian Journal of Clinical & Laboratory Investigation Pub Date : 2026-01-01 Epub Date: 2026-03-15 DOI: 10.1080/00365513.2026.2644626

Vinu Rajendran, Divya T Nair, Prinu Jose, Shouvik Basu, M L Saju, Geetha Mandagini, Cibin T Raghavan, Syam Krishnan, Srinivas Gopala, Madhusoodanan Urulangodi

{"title":"Reference intervals for lysosomal glucocerebrosidase activity in the healthy population.","authors":"Vinu Rajendran, Divya T Nair, Prinu Jose, Shouvik Basu, M L Saju, Geetha Mandagini, Cibin T Raghavan, Syam Krishnan, Srinivas Gopala, Madhusoodanan Urulangodi","doi":"10.1080/00365513.2026.2644626","DOIUrl":"10.1080/00365513.2026.2644626","url":null,"abstract":"Reference intervals, representing the normal range of values across age and gender groups, are essential for determining whether parameters from an individual are within physiological limits or not. Lysosomal glucocerebrosidase (GCase) activity has diagnostic relevance for Gaucher's disease (GD); it is also important in Parkinson's disease (PD) and other neurodegenerative disorders, particularly for assessing lysosomal functions. Although accurate laboratory tests are available for GCase, the absence of established reference intervals limits their application in clinical diagnostics and research. In this study, we measured GCase activity using leucocytes from healthy blood donors (n = 530) belonging to the 18-65 years age group. This study establishes a reference range for GCase activity in the healthy population, with a median of 2.29 nmol/107cells/h (Inter-quartile range: 1.21-4.01; 95% reference interval of 0.093-8.945 nmol/107cells/h). There was a slight decline in GCase activity beyond the age of 45 years. Females displayed higher GCase activity compared to males among all age groups. Haemoglobin, blood group and body weight showed no significant correlation with GCase activity. Our results increase the clinical and research utility of GCase assay, relevant to the screening of individuals with suspected lysosomal storage disorders and research in PD and other neurodegenerative conditions. The availability of reliable reference intervals may also facilitate a better understanding of lysosomal biology in health and disease.","PeriodicalId":21474,"journal":{"name":"Scandinavian Journal of Clinical & Laboratory Investigation","volume":" ","pages":"245-252"},"PeriodicalIF":1.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147463739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Digital misinformation and parental resistance to newborn heel-prick screening: an Instagram content analysis. 数字错误信息和父母对新生儿高跟鞋穿刺筛查的抵制：Instagram内容分析。

IF 1.4 4区医学

Scandinavian Journal of Clinical & Laboratory Investigation Pub Date : 2026-01-01 Epub Date: 2026-06-23 DOI: 10.1080/00365513.2026.2692692

Arzu Kul Uçtu, Rabia Ceren Buyrukoğlu

引用次数: 0

Direct and indirect estimation of reference limits for hematologic parameters in adults included in the HUNT study. HUNT研究中成人血液学参数参考限的直接和间接估计。

IF 1.4 4区医学

Scandinavian Journal of Clinical & Laboratory Investigation Pub Date : 2026-01-01 Epub Date: 2026-09-17 DOI: 10.1080/00365513.2026.2725886

Gunhild Garmo Hov, Arne Åsberg, Ingrid Alsos Lian, Lena Løfblad, Håvard Kjesbu Skjellegrind, Gustav Mikkelsen

{"title":"Direct and indirect estimation of reference limits for hematologic parameters in adults included in the HUNT study.","authors":"Gunhild Garmo Hov, Arne Åsberg, Ingrid Alsos Lian, Lena Løfblad, Håvard Kjesbu Skjellegrind, Gustav Mikkelsen","doi":"10.1080/00365513.2026.2725886","DOIUrl":"10.1080/00365513.2026.2725886","url":null,"abstract":"Reliable reference limits for hematological parameters are essential for clinical interpretation. In this study, we estimated reference limits for hemoglobin, erythrocytes and MCH using direct and indirect methods on data from the Trøndelag Health Study (HUNT). Results from 53,591 men and non-pregnant women participating in HUNT4 survey were used to estimate reference limits using two indirect methods (refineR and TMC13). A healthy defined subset of 15,755 participants (29%) was used to establish reference limits using the direct method. Reference limits were estimated separately for men and women in three age groups. Due to limited sample size, only direct estimates were generated for participants ≥80 years. Among women the estimated 2.5 percentile of hemoglobin, using the direct method, was 119 g/L in those aged 19-49 years and 122 g/L in those aged 50-79 years. Corresponding estimates from the indirect methods were 120 and 121 g/L in women aged 19-49 years and 121 g/L in those aged 50-79 years. In men aged 19-49 years, all methods estimated the 2.5 percentile of hemoglobin at 137 g/L. In men aged 50-79 years the direct estimate was 135 g/L, while indirect methods estimated slightly lower values (132 and 133 g/L). Overall, indirect and direct estimates were largely consistent, with some exceptions. The observed age-related variation in reference limits for both sexes supports the need for age-specific reference intervals. We propose revised reference limits for hemoglobin based on these findings.","PeriodicalId":21474,"journal":{"name":"Scandinavian Journal of Clinical & Laboratory Investigation","volume":" ","pages":"613-620"},"PeriodicalIF":1.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148991210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0