Scandinavian Journal of Clinical & Laboratory Investigation最新文献

Increased serum anti-angiogenic factor levels in insulin-resistant obese children and adolescents with or without liver steatosis (NAFL). 伴有或不伴有肝脂肪变性（NAFL）的胰岛素抵抗型肥胖儿童和青少年血清抗血管生成因子水平升高。

IF 1.3 4区医学

Scandinavian Journal of Clinical & Laboratory Investigation Pub Date : 2025-05-14 DOI: 10.1080/00365513.2025.2502947

Samed Emre Darılmaz, Melike Zeynep Tugrul Aksakal, Gozde Ceylan, Canan Kucukgergin, Aylin Yetim Sahin, Seldag Bekpinar

{"title":"Increased serum anti-angiogenic factor levels in insulin-resistant obese children and adolescents with or without liver steatosis (NAFL).","authors":"Samed Emre Darılmaz, Melike Zeynep Tugrul Aksakal, Gozde Ceylan, Canan Kucukgergin, Aylin Yetim Sahin, Seldag Bekpinar","doi":"10.1080/00365513.2025.2502947","DOIUrl":"https://doi.org/10.1080/00365513.2025.2502947","url":null,"abstract":"This study aimed to investigate the effect of obesity on angiogenesis and its relationship with liver steatosis in obese children and adolescents. The study ıncluded 81 obese ın chıldren and 30 healthy controls. Obese subjects were subdıvıded by ultrasound ınto three groups: no steatosıs, grade 1 lıver steatosıs (NAFL), and grade 2 NAFL. Obese individuals, regardless of the presence of NAFL, exhibited significant insulin resistance (p < .01) compared to their lean counterparts. All obese subjects showed elevated serum ALT, wıth a sıgnıfıcantly greater ın those wıth NAFL. Marked dyslipidemia by decreased high-density lipoprotein (HDL) levels and elevated triglycerides, was observed in obese individuals with NAFL. The serum levels of angiopoietin-1 (Ang-1) and vascular endothelial growth factor-165b (VEGF165b) were measured as anti-angiogenic markers, while vascular endothelial growth factor-A (VEGF-A), fibroblast growth factor-2 (FGF-2) and P-selectin were assessed as pro-angiogenic factors. Compared to normal-weight children (5558 ± 674 pg/mL), Ang-1 levels were significantly elevated in all obese subgroups (8861 ± 1026; 8105 ± 615; 7388 ± 924, respectıvely). However, no significant differences in Ang-1 levels were observed among the obese subgroups. Ang-1 and VEGF165b levels were significantly higher in insulin-resistant individuals (7575 ± 747 pg/mL and 293 ± 44.4 pg/mL, respectively) compared to insulin-sensitive subjects (6143 ± 557 pg/mL and 179 ± 31.4 pg/mL, respectively). These findings suggest that insulin resistance in obese children is associated with altered angiogenic signaling. However, no significant differences in the serum levels of angiogenic factors were observed between obese groups with and without NAFL.","PeriodicalId":21474,"journal":{"name":"Scandinavian Journal of Clinical & Laboratory Investigation","volume":" ","pages":"1-6"},"PeriodicalIF":1.3,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The frequency of JAK2 V617F mutation and its association with low EPO levels in polycythemia vera patients. 真性红细胞增多症患者JAK2 V617F突变频率及其与低EPO水平的关系

IF 1.3 4区医学

Scandinavian Journal of Clinical & Laboratory Investigation Pub Date : 2025-05-08 DOI: 10.1080/00365513.2025.2502945

Recai Aci, Adem Keskin, Özlem Sezer, Taner Karakaya, Samet Semiz, Halit Kızılet

{"title":"The frequency of JAK2 V617F mutation and its association with low EPO levels in polycythemia vera patients.","authors":"Recai Aci, Adem Keskin, Özlem Sezer, Taner Karakaya, Samet Semiz, Halit Kızılet","doi":"10.1080/00365513.2025.2502945","DOIUrl":"https://doi.org/10.1080/00365513.2025.2502945","url":null,"abstract":"Myeloid cell overgrowth in polycythemia vera (PV) is identified by a clonal disorder. The mutation in the Janus tyrosine kinase 2 (JAK2) gene known as V617F has been demonstrated to be responsible for the molecular development of the illness. This study investigates how frequently the JAK2 V617F mutation occurs and its association with erythropoietin (EPO) and hematological parameters in PV patients. Two hundred and forty-five patients who presented to the genetic outpatient clinic with a prediagnosis of PV were included in this study. Blood samples from all patients were screened for the G-T point mutation (V617F) in the JAK2 gene on chromosome 9 by allele-specific polymerase chain reaction (PCR). In addition, EPO levels, biochemical and hematological parameters of the patients were analyzed. JAK-2 mutation was detected in 28.9% (71) of patients diagnosed with PV. The mean age of the JAK2 V617F positive group was 64.09 ± 13.66 years, negative group was 66.62 ± 16.60 years. No statistically significant difference was found between the groups in terms of age and gender. When laboratory parameters were analyzed, ferritin, Fe, MCV, MCH, MCHC and EPO values were found to be lower in the JAK2 V617F positive group compared to the negative group, while RBC, RDW, MPV, PLT, HGB and UIBC values were found to be higher. The main observation of the study was that the JAK2 V617F mutation was present in 71 out of 215 PV patients (28.98%), confirming the observation of lower EPO levels in PV patients, and the results of the study are in close agreement with previous studies.","PeriodicalId":21474,"journal":{"name":"Scandinavian Journal of Clinical & Laboratory Investigation","volume":" ","pages":"1-4"},"PeriodicalIF":1.3,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of preanalytical factors on the stability of acetylcholine receptor antibodies in serum. 分析前因素对血清乙酰胆碱受体抗体稳定性的影响。

IF 1.3 4区医学

Scandinavian Journal of Clinical & Laboratory Investigation Pub Date : 2025-05-07 DOI: 10.1080/00365513.2025.2500011

David Lyse Overgaard, Tina Parkner, Josefine Jul Jarbæk Nielsen, Henning Andersen, Cindy Soendersoe Knudsen

{"title":"Impact of preanalytical factors on the stability of acetylcholine receptor antibodies in serum.","authors":"David Lyse Overgaard, Tina Parkner, Josefine Jul Jarbæk Nielsen, Henning Andersen, Cindy Soendersoe Knudsen","doi":"10.1080/00365513.2025.2500011","DOIUrl":"https://doi.org/10.1080/00365513.2025.2500011","url":null,"abstract":"This study investigated the preanalytical stability of acetylcholine receptor antibodies (AChRAb) in patient samples, a crucial biomarker for diagnosing Myasthenia Gravis (MG). The objective was to evaluate the impact of delayed centrifugation, storage temperature, and repeated freeze-thaw cycles on the accuracy of AChRAb test results. Blood samples were collected from nine MG patients, and four stability studies were conducted. These studies examined: (I) the effect of delayed centrifugation on whole blood (up to 7 h at room temperature), (II) storage of serum at room temperature (up to 7 days), (III) storage of serum at -20 °C (up to 26 weeks), and (IV) the impact on serum of repeated freeze-thaw cycles (up to 3 cycles). AChRAb levels were measured using ELISA, and the results were analysed for statistical variation against baseline measurements using bias limits of ±15%. The findings revealed that AChRAb remained stable for up to 7 hours of delayed centrifugation, 5 days at room temperature, 13 weeks at -20 °C, and after 3 freeze-thaw cycles. However, the antibody levels showed instability after 7 days at room temperature and 26 weeks at -20 °C, where the percentage differences exceeded acceptable limits. Analytical variation, especially at low antibody levels, and differences between ELISA kit lots were potential factors contributing to these findings. In conclusion, AChRAb shows good stability if care is taken to avoid prolonged storage and handling times to maintain diagnostic accuracy.","PeriodicalId":21474,"journal":{"name":"Scandinavian Journal of Clinical & Laboratory Investigation","volume":" ","pages":"1-5"},"PeriodicalIF":1.3,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144028066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Platelet indices at admission and their performance associated with predicting all-cause mortality in the ICU: a large cross-sectional cohort study. 入院时血小板指数及其表现与预测ICU全因死亡率相关：一项大型横断面队列研究

IF 1.3 4区医学

Scandinavian Journal of Clinical & Laboratory Investigation Pub Date : 2025-05-04 DOI: 10.1080/00365513.2025.2500029

Usman Ali

{"title":"Platelet indices at admission and their performance associated with predicting all-cause mortality in the ICU: a large cross-sectional cohort study.","authors":"Usman Ali","doi":"10.1080/00365513.2025.2500029","DOIUrl":"https://doi.org/10.1080/00365513.2025.2500029","url":null,"abstract":"Platelet indices at admission offer the most opportune time for clinical decision-making, as they provide earliest insights, unlike later assessments during the intensive care unit (ICU) stay. There is emerging evidence suggesting the utility of platelet indices in predicting mortality. The objective of this study was, for the first time as far as the literature indicates, to elucidate the utility of seven platelet indices at admission in a large ICU cohort using Sysmex XN-series analysers. This cross-sectional study enrolled 592 ICU patients. The association of platelet indices at admission with the in-ICU and 90-day mortality was evaluated using logistic regression and receiver operating characteristic curve analysis. Of the platelet indices studied, absolute-immature platelet fraction (A-IPF), and mean platelet volume (MPV) and percentage-immature platelet fraction (%-IPF) were shown to be independently associated with predicting the in-ICU and 90-day mortality, respectively. The A-IPF cut-off value for predicting the in-ICU mortality was >6.4 × 109/L (adjusted area under the curve (aAUC) 0.736, and adjusted Odds Ratio (aOR) 1.04), and the MPV and %-IPF cut-off values for predicting the 90-day mortality were >9.5 fL (aAUC 0.759, and aOR 1.26) and >6.3% (aAUC 0.762, and aOD 1.06), respectively (all p < 0.05). Admission A-IPF was the best predictor of in-ICU mortality, while admission MPV and %-IPF were the best predictors of 90-day mortality. These indices, all measured at admission, provide the earliest possible data relevant to mortality prediction. These are routinely available indices which deserve to be considered for new future ICU scoring systems.","PeriodicalId":21474,"journal":{"name":"Scandinavian Journal of Clinical & Laboratory Investigation","volume":" ","pages":"1-11"},"PeriodicalIF":1.3,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of serum antinuclear antibodies in Guillain-Barré syndrome and chronic inflammatory demyelinating polyradiculoneuropathy: a retrospective case-control study. 格林-巴勒综合征和慢性炎性脱髓鞘性多根神经病变血清抗核抗体的比较：一项回顾性病例对照研究。

IF 1.3 4区医学

Scandinavian Journal of Clinical & Laboratory Investigation Pub Date : 2025-05-04 DOI: 10.1080/00365513.2025.2496267

Yu Tu, Xuan Gong, Jiewei Peng, Peipei Zhu, Wenyan Zhuo, Xueying Yu

{"title":"Comparison of serum antinuclear antibodies in Guillain-Barré syndrome and chronic inflammatory demyelinating polyradiculoneuropathy: a retrospective case-control study.","authors":"Yu Tu, Xuan Gong, Jiewei Peng, Peipei Zhu, Wenyan Zhuo, Xueying Yu","doi":"10.1080/00365513.2025.2496267","DOIUrl":"https://doi.org/10.1080/00365513.2025.2496267","url":null,"abstract":"Serum antinuclear antibodies (ANAs) facilitate the diagnosis and evaluation of patients with many systemic autoimmune conditions. However, there are no systematic reports concerning differences in Guillain-Barré syndrome (GBS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Therefore, we assessed the differences in serum ANAs in GBS and CIDP patients and control subjects in a Chinese cohort. A retrospective enrollment of 417 patients was conducted for this study, consisting of 158 clinically confirmed GBS patients, 115 CIDP patients, and 144 non-GBS and CIDP inpatients as a control group. The measurement of serum ANAs, including autoantibodies against the Ro52 protein (anti-Ro52 antibody), anti-Sjogren's-syndrome-related antigen A antibodies (anti-SSA), anti-mitochondrial antibody M2 (AMA-M2), etc., was performed on all enrolled patients. Additionally, erythrocyte sedimentation rate (ESR), anti-streptolysin O (ASO), and C-reactive protein (CRP) values were also assessed. The results revealed significantly higher positive rates of Anti-Ro52 antibody, AMA-M2, and Anti-SSA antibody in the GBS group compared to the CIDP and control groups (adjusted p < 0.001). In the GBS group, Anti-Ro52 and AMA-M2 antibody positivity was moderate to severe, while anti-SSA antibody positivity was mild. In the GBS group, the most common finding for a serum ANAs burden score was 3 (58, 36.71%), which was higher than the CIDP group where a score of 1 was the most common finding (14, 12.17%). Anti-Ro52 antibodies, anti-SSA antibodies, and AMA-M2 were closely associated with GBS. Differential positivity of serum ANAs in GBS and CIDP patients was proposed to provide a reference for clinical diagnosis and treatment methods.","PeriodicalId":21474,"journal":{"name":"Scandinavian Journal of Clinical & Laboratory Investigation","volume":" ","pages":"1-6"},"PeriodicalIF":1.3,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144044424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of large language models in medical quizzes for clinical chemistry and laboratory management: implications and applications for healthcare artificial intelligence. 临床化学和实验室管理医学测验中大型语言模型的评估：对医疗人工智能的影响和应用。

IF 1.3 4区医学

Scandinavian Journal of Clinical & Laboratory Investigation Pub Date : 2025-04-01 Epub Date: 2025-02-19 DOI: 10.1080/00365513.2025.2466054

Won Young Heo, Hyung-Doo Park

{"title":"Assessment of large language models in medical quizzes for clinical chemistry and laboratory management: implications and applications for healthcare artificial intelligence.","authors":"Won Young Heo, Hyung-Doo Park","doi":"10.1080/00365513.2025.2466054","DOIUrl":"10.1080/00365513.2025.2466054","url":null,"abstract":"Large language models (LLMs) have demonstrated high performance across various fields due to their ability to understand, generate, and manipulate human language. However, their potential in specialized medical domains, such as clinical chemistry and laboratory management, remains underexplored. This study evaluated the performance of nine LLMs using zero-shot prompting on 109 clinical problem-based quizzes from peer-reviewed journal articles in the Laboratory Medicine Online (LMO) database. These quizzes covered topics in clinical chemistry, toxicology, and laboratory management. The models, including GPT-4o, Claude 3 Opus, and Gemini 1.5 Pro, along with their earlier or smaller versions, were assigned roles as clinical chemists or laboratory managers to simulate real-world decision-making scenarios. Among the evaluated models, GPT-4o achieved the highest overall accuracy, correctly answering 81.7% of the quizzes, followed by GPT-4 Turbo (76.1%), Claude 3 Opus (74.3%), and Gemini 1.5 Pro (69.7%), while the lowest performance was observed with Gemini 1.0 Pro (51.4%). GPT-4o performed exceptionally well across all quiz types, including single-select, open-ended, and multiple-select questions, and demonstrated particular strength in quizzes involving figures, tables, or calculations. These findings highlight the ability of LLMs to effectively apply their pre-existing knowledge base to specialized clinical chemistry inquiries without additional fine-tuning. Among the evaluated models, GPT-4o exhibited superior performance across different quiz types, underscoring its potential utility in assisting healthcare professionals in clinical decision-making.","PeriodicalId":21474,"journal":{"name":"Scandinavian Journal of Clinical & Laboratory Investigation","volume":" ","pages":"125-132"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143459402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-sampling of capillary blood for safety monitoring of DMARD therapy in patients with rheumatic disease: a feasibility and method-comparison study. 自采毛细血管血液用于风湿病患者DMARD治疗的安全监测：可行性和方法比较研究

IF 1.3 4区医学

Scandinavian Journal of Clinical & Laboratory Investigation Pub Date : 2025-04-01 Epub Date: 2025-02-07 DOI: 10.1080/00365513.2025.2463087

Josefine Bak H Adelhelm, Trine Rennebod Larsen, Ulla Jakobsen, Pernille J Vinholt, Maria Boysen Sandberg, Inger Marie Jensen Hansen, Søren Andreas Just

{"title":"Self-sampling of capillary blood for safety monitoring of DMARD therapy in patients with rheumatic disease: a feasibility and method-comparison study.","authors":"Josefine Bak H Adelhelm, Trine Rennebod Larsen, Ulla Jakobsen, Pernille J Vinholt, Maria Boysen Sandberg, Inger Marie Jensen Hansen, Søren Andreas Just","doi":"10.1080/00365513.2025.2463087","DOIUrl":"10.1080/00365513.2025.2463087","url":null,"abstract":"Our study aimed to compare the quality of patient self-collected capillary samples with venous blood samples. Additionally, we assessed whether patients with rheumatic disease are both capable of and willing to perform capillary self-sampling through subjective and objective assessments. This research explores the future potential of at-home self-sampling. Patients with rheumatic diseases were asked to perform up to four supervised self-collected capillary blood samples, followed by a standard venous sample performed by study personnel. Anti-rheumatic drug treatment monitoring parameters, including biochemistry and hematology, were analyzed using Cobas 8000 and Sysmex XN-9000, respectively. The agreement was evaluated by Bland-Altman plots and compared to critical difference limits. Study personnel and patients answered a survey questionnaire after every visit to evaluate feasibility. In total, 21 patients completed 53 paired capillary and venous samples from November 2019 to December 2020. We found a strong correlation (r > 0.87) and good agreement for most parameters; platelets showed the poorest agreement. Patients experienced little pain, found self-sampling easy and reported no serious complications. Hemolysis affected 12/53 capillary biochemistry samples, and 5/53 capillary hematology samples coagulated. The good agreement for most parameters and excellent feasibility encourages the potential for capillary self-sampling of DMARD monitoring parameters, relevant limitations were hemolysis and aggregating platelets.","PeriodicalId":21474,"journal":{"name":"Scandinavian Journal of Clinical & Laboratory Investigation","volume":" ","pages":"108-115"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143370702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reference intervals for holotranscobalamin and total vitamin B12 in 6-12-year-old children in Norway: the Health Oriented Pedagogical Project (HOPP). 挪威 6-12 岁儿童全血钴胺素和总维生素 B12 的参考区间：健康导向教学项目 (HOPP)。

IF 1.3 4区医学

Scandinavian Journal of Clinical & Laboratory Investigation Pub Date : 2025-04-01 Epub Date: 2025-03-14 DOI: 10.1080/00365513.2025.2475454

Martin Frank Strand, Helle Borgstrøm Hager, Per Morten Fredriksen, Morten Lindberg

{"title":"Reference intervals for holotranscobalamin and total vitamin B12 in 6-12-year-old children in Norway: the Health Oriented Pedagogical Project (HOPP).","authors":"Martin Frank Strand, Helle Borgstrøm Hager, Per Morten Fredriksen, Morten Lindberg","doi":"10.1080/00365513.2025.2475454","DOIUrl":"10.1080/00365513.2025.2475454","url":null,"abstract":"Vitamin B12 (B12) is essential for DNA synthesis in all cells and for the development and maintenance of a healthy nervous system. B12 is transported in the circulation bound to two carrier proteins, haptocorrin and transcobalamin, measured as the biomarkers total B12 and holotranscobalamin (holoTC). The latter measures the fraction of cobalamin available for tissue uptake and is considered to have a better sensitivity and specificity for diagnosing vitamin deficiency. The concentration of both carrier proteins depends on age, but data on paediatric reference values for holoTC are still sparse. Blood samples were obtained from 1320 healthy school children, mainly Caucasians (age 6-12 years old) in three different municipalities in Norway. The holoTC and total B12 levels were determined by chemiluminescent microparticle immunoassay on the Architect 2000 analyser. Age specific paediatric reference intervals (RIs) were estimated by calculating the 2.5 and 97.5 percentiles by the nonparametric method with corresponding 90% confidence intervals, according to the Clinical and Laboratory Standards Institute C28-A3C guidelines. The 95% RIs for total B12 were 295-1066 pmol/L for children 6-8 years old, and 249-879 pmol/L for children 9-12 years old. Reference intervals for holoTC were ≥56 pmol/L for children 6-8 years old, and ≥37 pmol/L for children 9-12 years old. Age specific RIs will aid clinicians in interpretation of cobalamin results in children aged 6-12 years old.","PeriodicalId":21474,"journal":{"name":"Scandinavian Journal of Clinical & Laboratory Investigation","volume":" ","pages":"138-142"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The HUNT study: long-term within-subject variation of thyroid stimulating hormone (TSH). HUNT研究：受试者体内促甲状腺激素（TSH）的长期变化。

IF 1.3 4区医学

Scandinavian Journal of Clinical & Laboratory Investigation Pub Date : 2025-04-01 Epub Date: 2025-03-08 DOI: 10.1080/00365513.2025.2475473

Arne Åsberg, Marius Berg, Gunhild Garmo Hov, Ingrid Alsos Lian, Lena Løfblad, Gustav Mikkelsen

{"title":"The HUNT study: long-term within-subject variation of thyroid stimulating hormone (TSH).","authors":"Arne Åsberg, Marius Berg, Gunhild Garmo Hov, Ingrid Alsos Lian, Lena Løfblad, Gustav Mikkelsen","doi":"10.1080/00365513.2025.2475473","DOIUrl":"10.1080/00365513.2025.2475473","url":null,"abstract":"Data on the long-term within-subject biological variation (CVI) of serum thyroid stimulating hormone (S-TSH) are scarce. In the EFLM Biological Variation Database, the longest observation period was one year. We estimated a coefficient of variation that included analytical variation (CVI+A) using data from 16,976 individuals in the Trøndelag Health Study (HUNT), where S-TSH was measured on two occasions with an average interval of 10.6 (range 9.3-12.3) years. These individuals reported their health to be 'good' or 'very good' on both occasions and were not registered with any diagnoses or use of medications (according to Norwegian Prescribed Drug Registry) related to the thyroid. We used the software refineR to identify an assumed nonpathological subpopulation in the distribution of distances from each observation to the center of the bivariate distribution of the two S-TSH-values. From this subpopulation, individuals with a distance ≤ the 95 percentile in the distribution of distances were selected for estimation of CVI+A. The difference in percent of the mean (DPM) was calculated for each individual, and CVI+A as the standard deviation in the distribution of DPMs divided by 20.5. This method was robust against systematic bias between the two measurements. CVI+A was 21-23% for different groups of age and sex. Accounting for CVA would imply a CVI 0.1-0.8% less than CVI+A. Our estimates are well within the 12-29.3% range of CVI reported from the seven studies in the meta-analysis of the EFLM Biological Variation Database.","PeriodicalId":21474,"journal":{"name":"Scandinavian Journal of Clinical & Laboratory Investigation","volume":" ","pages":"143-147"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The predictive value of postoperative soluble urokinase plasminogen activator receptor concentration for postoperative complications following valvular surgery. 术后可溶性尿激酶纤溶酶原激活剂受体浓度对瓣膜手术术后并发症的预测价值。

IF 1.3 4区医学

Scandinavian Journal of Clinical & Laboratory Investigation Pub Date : 2025-04-01 Epub Date: 2025-03-15 DOI: 10.1080/00365513.2025.2479042

Clara Erixon, Louise Thelaus, Emilia Johannesson, Johan Nilsson, Karl Teurneau-Hermansson, Adam Linder, Sigurdur Ragnarsson, Niklas Sterner, Igor Zindovic, Alain Dardashti

{"title":"The predictive value of postoperative soluble urokinase plasminogen activator receptor concentration for postoperative complications following valvular surgery.","authors":"Clara Erixon, Louise Thelaus, Emilia Johannesson, Johan Nilsson, Karl Teurneau-Hermansson, Adam Linder, Sigurdur Ragnarsson, Niklas Sterner, Igor Zindovic, Alain Dardashti","doi":"10.1080/00365513.2025.2479042","DOIUrl":"10.1080/00365513.2025.2479042","url":null,"abstract":"Soluble urokinase plasminogen activator receptor (suPAR) is an inflammatory marker that has been shown to predict poorer outcomes in cardiovascular disease and after cardiac surgery. The relationship between suPAR concentrations and postoperative complications after valvular surgery, however, remains unclear. This study aims to evaluate the predictive value of suPAR concentrations for infection, acute kidney injury (AKI) and prolonged mechanical ventilation after valvular surgery. This prospective, observational, single-centre study included 414 patients who underwent valvular cardiac surgery at Skåne University Hospital between 1 February 2020 and 22 September 2021. Early postoperative suPAR levels were measured, and multivariable logistic regression was used to identify significant risk factors for postoperative infection, AKI and prolonged mechanical ventilation. Left ventricular ejection fraction (LVEF) 30-50% (OR 3.57 [1.29-9.86], p = 0.014) and suPAR concentration (OR 1.41 [1.56-1.71], p <0.001) were found to be predictive risk factors for developing postoperative infection. Additionally, suPAR concentration (OR 1.23 [1.05-1.43], p = 0.008), cardiopulmonary bypass (CPB) time (OR 1.01 [1.00-1.02], p = 0.004) and age (OR 1.04 [1.01-1.08], p = 0.007) were found to be predictive risk factors for postoperative AKI. However, suPAR concentration did not predict prolonged mechanical ventilation. Plasma suPAR levels after cardiac valve surgery were found to be predictive of postoperative AKI and infection. Our results indicate that early postoperative suPAR measurements may be a valuable tool for identifying patients at higher risk for developing postoperative complications.","PeriodicalId":21474,"journal":{"name":"Scandinavian Journal of Clinical & Laboratory Investigation","volume":" ","pages":"160-167"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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