Scandinavian Journal of Clinical & Laboratory Investigation最新文献

Cold activation in PT-INR samples - Myth or reality in the modern laboratory?

IF 1.3 4区医学

Scandinavian Journal of Clinical & Laboratory Investigation Pub Date : 2025-04-04 DOI: 10.1080/00365513.2025.2487972

Annika Petersson, Karin Strandberg, Magnus Magnusson, Jenny Lerman, Kim Ekblom

引用次数: 0

Evaluation of measurement uncertainty in direct and estimated serum osmolality according to ISO/TS 20914: implications for clinical diagnostics. 根据 ISO/TS 20914 评估直接和估计血清渗透压的测量不确定性：对临床诊断的影响。

IF 1.3 4区医学

Scandinavian Journal of Clinical & Laboratory Investigation Pub Date : 2025-04-04 DOI: 10.1080/00365513.2025.2487988

Mehmet Fatih Alpdemir, Sezen Tutar, Medine Alpdemir

{"title":"Evaluation of measurement uncertainty in direct and estimated serum osmolality according to ISO/TS 20914: implications for clinical diagnostics.","authors":"Mehmet Fatih Alpdemir, Sezen Tutar, Medine Alpdemir","doi":"10.1080/00365513.2025.2487988","DOIUrl":"https://doi.org/10.1080/00365513.2025.2487988","url":null,"abstract":"This study examines the measurement uncertainties (MU) associated with osmolality (OSM), a crucial parameter in clinical diagnostics and treatment. The research compares the uncertainties of directly measured osmolality (dOSM) with those of estimated osmolality (eOSM), which is calculated based on sodium, glucose, and urea levels. Using ISO/TS 20914 guidelines, the study evaluates the MUs of eOSM across different analyzer models and internal quality control (IQC) lots and compares these values with dOSM. In the materials and methods section, sodium, glucose, and urea analyses were performed using two different analyzers (Atellica CH and Advia Chemistry XPT, Siemens Healthineers). OSM was measured using the freezing point depression method (Osmomat Auto, Gonotec) and data were collected to calculate eOSM. MU (k = 2, 95% confidence) calculations were conducted according to the ISO/TS 20914 standard for each system. The results show that the expanded standard MU (k = 2, 95% confidence) for dOSM is low at 5.56 mOSM/L, while the MU for eOSM is 8.54 mOSM/L for the Atellica CH system and 11.13 mOSM/L for the Advia Chemistry XPT system. These findings indicate that eOSM has higher uncertainty, suggesting it should be used with caution in clinical practice.","PeriodicalId":21474,"journal":{"name":"Scandinavian Journal of Clinical & Laboratory Investigation","volume":" ","pages":"1-6"},"PeriodicalIF":1.3,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143784508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-sampling of capillary blood for safety monitoring of DMARD therapy in patients with rheumatic disease: a feasibility and method-comparison study.

IF 1.3 4区医学

Scandinavian Journal of Clinical & Laboratory Investigation Pub Date : 2025-04-01 Epub Date: 2025-02-07 DOI: 10.1080/00365513.2025.2463087

Josefine Bak H Adelhelm, Trine Rennebod Larsen, Ulla Jakobsen, Pernille J Vinholt, Maria Boysen Sandberg, Inger Marie Jensen Hansen, Søren Andreas Just

{"title":"Self-sampling of capillary blood for safety monitoring of DMARD therapy in patients with rheumatic disease: a feasibility and method-comparison study.","authors":"Josefine Bak H Adelhelm, Trine Rennebod Larsen, Ulla Jakobsen, Pernille J Vinholt, Maria Boysen Sandberg, Inger Marie Jensen Hansen, Søren Andreas Just","doi":"10.1080/00365513.2025.2463087","DOIUrl":"10.1080/00365513.2025.2463087","url":null,"abstract":"Our study aimed to compare the quality of patient self-collected capillary samples with venous blood samples. Additionally, we assessed whether patients with rheumatic disease are both capable of and willing to perform capillary self-sampling through subjective and objective assessments. This research explores the future potential of at-home self-sampling. Patients with rheumatic diseases were asked to perform up to four supervised self-collected capillary blood samples, followed by a standard venous sample performed by study personnel. Anti-rheumatic drug treatment monitoring parameters, including biochemistry and hematology, were analyzed using Cobas 8000 and Sysmex XN-9000, respectively. The agreement was evaluated by Bland-Altman plots and compared to critical difference limits. Study personnel and patients answered a survey questionnaire after every visit to evaluate feasibility. In total, 21 patients completed 53 paired capillary and venous samples from November 2019 to December 2020. We found a strong correlation (r > 0.87) and good agreement for most parameters; platelets showed the poorest agreement. Patients experienced little pain, found self-sampling easy and reported no serious complications. Hemolysis affected 12/53 capillary biochemistry samples, and 5/53 capillary hematology samples coagulated. The good agreement for most parameters and excellent feasibility encourages the potential for capillary self-sampling of DMARD monitoring parameters, relevant limitations were hemolysis and aggregating platelets.","PeriodicalId":21474,"journal":{"name":"Scandinavian Journal of Clinical & Laboratory Investigation","volume":" ","pages":"108-115"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143370702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of large language models in medical quizzes for clinical chemistry and laboratory management: implications and applications for healthcare artificial intelligence.

IF 1.3 4区医学

Scandinavian Journal of Clinical & Laboratory Investigation Pub Date : 2025-04-01 Epub Date: 2025-02-19 DOI: 10.1080/00365513.2025.2466054

Won Young Heo, Hyung-Doo Park

{"title":"Assessment of large language models in medical quizzes for clinical chemistry and laboratory management: implications and applications for healthcare artificial intelligence.","authors":"Won Young Heo, Hyung-Doo Park","doi":"10.1080/00365513.2025.2466054","DOIUrl":"10.1080/00365513.2025.2466054","url":null,"abstract":"Large language models (LLMs) have demonstrated high performance across various fields due to their ability to understand, generate, and manipulate human language. However, their potential in specialized medical domains, such as clinical chemistry and laboratory management, remains underexplored. This study evaluated the performance of nine LLMs using zero-shot prompting on 109 clinical problem-based quizzes from peer-reviewed journal articles in the Laboratory Medicine Online (LMO) database. These quizzes covered topics in clinical chemistry, toxicology, and laboratory management. The models, including GPT-4o, Claude 3 Opus, and Gemini 1.5 Pro, along with their earlier or smaller versions, were assigned roles as clinical chemists or laboratory managers to simulate real-world decision-making scenarios. Among the evaluated models, GPT-4o achieved the highest overall accuracy, correctly answering 81.7% of the quizzes, followed by GPT-4 Turbo (76.1%), Claude 3 Opus (74.3%), and Gemini 1.5 Pro (69.7%), while the lowest performance was observed with Gemini 1.0 Pro (51.4%). GPT-4o performed exceptionally well across all quiz types, including single-select, open-ended, and multiple-select questions, and demonstrated particular strength in quizzes involving figures, tables, or calculations. These findings highlight the ability of LLMs to effectively apply their pre-existing knowledge base to specialized clinical chemistry inquiries without additional fine-tuning. Among the evaluated models, GPT-4o exhibited superior performance across different quiz types, underscoring its potential utility in assisting healthcare professionals in clinical decision-making.","PeriodicalId":21474,"journal":{"name":"Scandinavian Journal of Clinical & Laboratory Investigation","volume":" ","pages":"125-132"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143459402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reference intervals for holotranscobalamin and total vitamin B12 in 6-12-year-old children in Norway: the Health Oriented Pedagogical Project (HOPP). 挪威 6-12 岁儿童全血钴胺素和总维生素 B12 的参考区间：健康导向教学项目 (HOPP)。

IF 1.3 4区医学

Scandinavian Journal of Clinical & Laboratory Investigation Pub Date : 2025-04-01 Epub Date: 2025-03-14 DOI: 10.1080/00365513.2025.2475454

Martin Frank Strand, Helle Borgstrøm Hager, Per Morten Fredriksen, Morten Lindberg

{"title":"Reference intervals for holotranscobalamin and total vitamin B12 in 6-12-year-old children in Norway: the Health Oriented Pedagogical Project (HOPP).","authors":"Martin Frank Strand, Helle Borgstrøm Hager, Per Morten Fredriksen, Morten Lindberg","doi":"10.1080/00365513.2025.2475454","DOIUrl":"10.1080/00365513.2025.2475454","url":null,"abstract":"Vitamin B12 (B12) is essential for DNA synthesis in all cells and for the development and maintenance of a healthy nervous system. B12 is transported in the circulation bound to two carrier proteins, haptocorrin and transcobalamin, measured as the biomarkers total B12 and holotranscobalamin (holoTC). The latter measures the fraction of cobalamin available for tissue uptake and is considered to have a better sensitivity and specificity for diagnosing vitamin deficiency. The concentration of both carrier proteins depends on age, but data on paediatric reference values for holoTC are still sparse. Blood samples were obtained from 1320 healthy school children, mainly Caucasians (age 6-12 years old) in three different municipalities in Norway. The holoTC and total B12 levels were determined by chemiluminescent microparticle immunoassay on the Architect 2000 analyser. Age specific paediatric reference intervals (RIs) were estimated by calculating the 2.5 and 97.5 percentiles by the nonparametric method with corresponding 90% confidence intervals, according to the Clinical and Laboratory Standards Institute C28-A3C guidelines. The 95% RIs for total B12 were 295-1066 pmol/L for children 6-8 years old, and 249-879 pmol/L for children 9-12 years old. Reference intervals for holoTC were ≥56 pmol/L for children 6-8 years old, and ≥37 pmol/L for children 9-12 years old. Age specific RIs will aid clinicians in interpretation of cobalamin results in children aged 6-12 years old.","PeriodicalId":21474,"journal":{"name":"Scandinavian Journal of Clinical & Laboratory Investigation","volume":" ","pages":"138-142"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of two automated immunoassays for quantifying ProGRP, SCC and HE4 in serum: impact on diagnostic accuracy.

IF 1.3 4区医学

Scandinavian Journal of Clinical & Laboratory Investigation Pub Date : 2025-04-01 Epub Date: 2025-02-15 DOI: 10.1080/00365513.2025.2466008

Jaime I Sainz de Medrano, Javier Laguna, Judit Julian, Xavier Filella, Aleix Fabregat, María Luquin, Harol H Hurtado, Alba García Humanes, Manuel Morales-Ruiz, Esther Fernández-Galán

{"title":"Comparison of two automated immunoassays for quantifying ProGRP, SCC and HE4 in serum: impact on diagnostic accuracy.","authors":"Jaime I Sainz de Medrano, Javier Laguna, Judit Julian, Xavier Filella, Aleix Fabregat, María Luquin, Harol H Hurtado, Alba García Humanes, Manuel Morales-Ruiz, Esther Fernández-Galán","doi":"10.1080/00365513.2025.2466008","DOIUrl":"10.1080/00365513.2025.2466008","url":null,"abstract":"ProGRP (Progastrin-releasing peptide), SCC (Squamous Cell Carcinoma Antigen), and HE4 (Human epididymis protein 4) are serum tumor markers (STMs) frequently used in clinical practice, particularly for detection and monitoring of ovarian and lung neoplasms. In clinical laboratories, their quantification is commonly performed using automated immunoassays. Nevertheless, variations in results obtained by different immunoassays can impact diagnostic accuracy and effectiveness of patient monitoring. Our aim is to assess differences in STMs concentrations between two automated immunoassays: the Elecsys (Roche) and the Architect (Abbott), which are integrated into the Cobas e402 and Architect i2000SR systems respectively. We included 401 serum samples from patients with different clinical conditions: patients with cancer (n = 170), benign diseases (n = 100) and a control group (n = 131). ProGRP, SCC, and HE4 concentrations were quantified in parallel by both analyzers. To evaluate the clinical impact of changing these methodologies, overall concordance, the kappa index and ROC (Receiver Operating Characteristic) curves were calculated. While some discrepancies were noted in specific cases, overall, we obtained a good correlation for three STMs, with a Pearson coefficient for proGRP (r = 0.99), SCC (r = 0.95) and HE4 (r = 0.973). We also obtained a similar performance in the differential diagnosis of cancer, according to the results of the ROC analyses for Cobas and Archictect assays respectively: proGRP (AUC = 0.92; 0.91), SCC (AUC = 0.90; 0.92) and HE4 (AUC = 0.92; 0.93).","PeriodicalId":21474,"journal":{"name":"Scandinavian Journal of Clinical & Laboratory Investigation","volume":" ","pages":"116-124"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The HUNT study: long-term within-subject variation of thyroid stimulating hormone (TSH).

IF 1.3 4区医学

Scandinavian Journal of Clinical & Laboratory Investigation Pub Date : 2025-04-01 Epub Date: 2025-03-08 DOI: 10.1080/00365513.2025.2475473

Arne Åsberg, Marius Berg, Gunhild Garmo Hov, Ingrid Alsos Lian, Lena Løfblad, Gustav Mikkelsen

{"title":"The HUNT study: long-term within-subject variation of thyroid stimulating hormone (TSH).","authors":"Arne Åsberg, Marius Berg, Gunhild Garmo Hov, Ingrid Alsos Lian, Lena Løfblad, Gustav Mikkelsen","doi":"10.1080/00365513.2025.2475473","DOIUrl":"10.1080/00365513.2025.2475473","url":null,"abstract":"Data on the long-term within-subject biological variation (CVI) of serum thyroid stimulating hormone (S-TSH) are scarce. In the EFLM Biological Variation Database, the longest observation period was one year. We estimated a coefficient of variation that included analytical variation (CVI+A) using data from 16,976 individuals in the Trøndelag Health Study (HUNT), where S-TSH was measured on two occasions with an average interval of 10.6 (range 9.3-12.3) years. These individuals reported their health to be 'good' or 'very good' on both occasions and were not registered with any diagnoses or use of medications (according to Norwegian Prescribed Drug Registry) related to the thyroid. We used the software refineR to identify an assumed nonpathological subpopulation in the distribution of distances from each observation to the center of the bivariate distribution of the two S-TSH-values. From this subpopulation, individuals with a distance ≤ the 95 percentile in the distribution of distances were selected for estimation of CVI+A. The difference in percent of the mean (DPM) was calculated for each individual, and CVI+A as the standard deviation in the distribution of DPMs divided by 20.5. This method was robust against systematic bias between the two measurements. CVI+A was 21-23% for different groups of age and sex. Accounting for CVA would imply a CVI 0.1-0.8% less than CVI+A. Our estimates are well within the 12-29.3% range of CVI reported from the seven studies in the meta-analysis of the EFLM Biological Variation Database.","PeriodicalId":21474,"journal":{"name":"Scandinavian Journal of Clinical & Laboratory Investigation","volume":" ","pages":"143-147"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The predictive value of postoperative soluble urokinase plasminogen activator receptor concentration for postoperative complications following valvular surgery.

IF 1.3 4区医学

Scandinavian Journal of Clinical & Laboratory Investigation Pub Date : 2025-04-01 Epub Date: 2025-03-15 DOI: 10.1080/00365513.2025.2479042

Clara Erixon, Louise Thelaus, Emilia Johannesson, Johan Nilsson, Karl Teurneau-Hermansson, Adam Linder, Sigurdur Ragnarsson, Niklas Sterner, Igor Zindovic, Alain Dardashti

{"title":"The predictive value of postoperative soluble urokinase plasminogen activator receptor concentration for postoperative complications following valvular surgery.","authors":"Clara Erixon, Louise Thelaus, Emilia Johannesson, Johan Nilsson, Karl Teurneau-Hermansson, Adam Linder, Sigurdur Ragnarsson, Niklas Sterner, Igor Zindovic, Alain Dardashti","doi":"10.1080/00365513.2025.2479042","DOIUrl":"10.1080/00365513.2025.2479042","url":null,"abstract":"Soluble urokinase plasminogen activator receptor (suPAR) is an inflammatory marker that has been shown to predict poorer outcomes in cardiovascular disease and after cardiac surgery. The relationship between suPAR concentrations and postoperative complications after valvular surgery, however, remains unclear. This study aims to evaluate the predictive value of suPAR concentrations for infection, acute kidney injury (AKI) and prolonged mechanical ventilation after valvular surgery. This prospective, observational, single-centre study included 414 patients who underwent valvular cardiac surgery at Skåne University Hospital between 1 February 2020 and 22 September 2021. Early postoperative suPAR levels were measured, and multivariable logistic regression was used to identify significant risk factors for postoperative infection, AKI and prolonged mechanical ventilation. Left ventricular ejection fraction (LVEF) 30-50% (OR 3.57 [1.29-9.86], p = 0.014) and suPAR concentration (OR 1.41 [1.56-1.71], p <0.001) were found to be predictive risk factors for developing postoperative infection. Additionally, suPAR concentration (OR 1.23 [1.05-1.43], p = 0.008), cardiopulmonary bypass (CPB) time (OR 1.01 [1.00-1.02], p = 0.004) and age (OR 1.04 [1.01-1.08], p = 0.007) were found to be predictive risk factors for postoperative AKI. However, suPAR concentration did not predict prolonged mechanical ventilation. Plasma suPAR levels after cardiac valve surgery were found to be predictive of postoperative AKI and infection. Our results indicate that early postoperative suPAR measurements may be a valuable tool for identifying patients at higher risk for developing postoperative complications.","PeriodicalId":21474,"journal":{"name":"Scandinavian Journal of Clinical & Laboratory Investigation","volume":" ","pages":"160-167"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Monitoring CD3+, CD4+ and CD8+ T lymphocytes count after prolonged blood storage.

IF 1.3 4区医学

Scandinavian Journal of Clinical & Laboratory Investigation Pub Date : 2025-04-01 Epub Date: 2025-03-08 DOI: 10.1080/00365513.2025.2477630

Claudio Ilardo, Marion Baumelou, Nathalia Arias Rojas, Rachida El Youssfi, Margaux Dirat

{"title":"Monitoring CD3+, CD4+ and CD8+ T lymphocytes count after prolonged blood storage.","authors":"Claudio Ilardo, Marion Baumelou, Nathalia Arias Rojas, Rachida El Youssfi, Margaux Dirat","doi":"10.1080/00365513.2025.2477630","DOIUrl":"10.1080/00365513.2025.2477630","url":null,"abstract":"Introduction: Monitoring CD3+, CD4+ and CD8+ T lymphocytes count is used in patients with known HIV infection, to determine efficacy of antiretroviral medication. Sometimes, due to the long distance, more time is needed for the sample to reach a more equipped laboratory. The aim of our study was to evaluate the impact of prolonged pre-analytical storage of blood at temperature, 96 h at room temperature, on the quality of results for the three parameters.Methods: The analysis of 60 EDTA-anticoagulated blood samples, stored at room temperature (15-25 °C) after sampling, was conducted after 24 h and 96 h, respectively. The BD FACSLyric™ system was used to identify and enumerate CD3+, CD4+, and CD8+ T lymphocytes.Results: Following a 96-hour period, no notable discrepancies were observed in the data for CD3+, CD4+, and CD8+ T lymphocytes. Passing-Bablok regression analysis showed no significant difference in y-intercept and slope. The Pearson correlation coefficient (r) demonstrated a significant and strong correlation with rho values of 0.994, 0.992, and 0.996, respectively. The analytical agreements demonstrated that all results fell within the total allowable margin of total error.Conclusion: The results of this study demonstrated that diagnostic samples, monitored for CD3+, CD4+ and CD8+ T lymphocytes, could be stored for up to 96 h without compromising the quality of the results.","PeriodicalId":21474,"journal":{"name":"Scandinavian Journal of Clinical & Laboratory Investigation","volume":" ","pages":"172-174"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CgA₁₀₀ - eGFR-adjusted serum chromogranin A.

IF 1.3 4区医学

Scandinavian Journal of Clinical & Laboratory Investigation Pub Date : 2025-04-01 Epub Date: 2025-02-24 DOI: 10.1080/00365513.2025.2466058

Arne Åsberg, Gustav Mikkelsen, Lena Løfblad

{"title":"CgA100 - eGFR-adjusted serum chromogranin A.","authors":"Arne Åsberg, Gustav Mikkelsen, Lena Løfblad","doi":"10.1080/00365513.2025.2466058","DOIUrl":"10.1080/00365513.2025.2466058","url":null,"abstract":"The concentration of chromogranin A in serum (s-CgA) is a general marker of neuroendocrine neoplasms. Unfortunately, s-CgA is increased in several other clinical conditions, including renal failure. The physician who assesses s-CgA values must consider the patients' renal function. How this should be done is not clear. We developed an adjustment formula from the association between median s-CgA and the estimated glomerular filtration rate (eGFR) in 2708 patients where s-CgA was measured by the CgA II KRYPTOR method. We used multivariable fractional polynomial quantile regression with the model ln(s-CgA) = c0 + c1 × sex + c2 × age + c3 × eGFR, thus accounting for sex and age. The final adjustment formula could be simplified to s-CgA100 = (eGFR / 100) × s-CgA, where s-CgA100 is an indication of what s-CgA would be if eGFR in the same patient was 100 mL/minute/1.73 m2. In patients with eGFR > 100 mL/minute/1.73 m2 no adjustment was done. We tested the formula on another patient population (n = 1563), where s-CgA was measured by a RIA method. S-CgA100 proved to be independent of eGFR in that population. The clinical validity of s-CgA100 must await further investigations.","PeriodicalId":21474,"journal":{"name":"Scandinavian Journal of Clinical & Laboratory Investigation","volume":" ","pages":"133-137"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0