Scandinavian Journal of Clinical & Laboratory Investigation最新文献

{"title":"Performance comparison of Mindray EH-2090 Urinalysis analyzers and Sysmex UF-5000.","authors":"Juan Chen, Chen Zhang, Qiaoping Xu, Zhicheng Wu","doi":"10.1080/00365513.2025.2550350","DOIUrl":"https://doi.org/10.1080/00365513.2025.2550350","url":null,"abstract":"<p><p>In this study, we used manual microscopy as the gold standard, and compared the analytical and clinical performance of EH-2090 and UF-5000 to evaluate their application characteristics in daily clinical practice. Results show the EH-2090 has comparable analytical performance to Sysmex UF-5000. In clinical performance, the EH-2090 shows better counting accuracy for urine formed elements except bacteria. Besides, the EH-2090 could provide more accurate assessment especially in samples with yeast cells, crystals and dysmorphic red blood cells.</p>","PeriodicalId":21474,"journal":{"name":"Scandinavian Journal of Clinical & Laboratory Investigation","volume":" ","pages":"1-8"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144967074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of cystatin C as a new marker of glomerular filtration rate, and of shrunken pore syndrome - a new kidney disorder defining selective glomerular hypofiltration syndromes - calls for expansion of the international KDIGO guidelines.","authors":"Anna Åkesson, Carl Öberg, Linnea Malmgren, Christopher Nilsson, Yoshi Itoh, Søren Blirup-Jensen, Veronica Lindström, Magnus Abrahamson, Felicia Leion, Isleifur Olafsson, Henrik Bjursten, David Grubb, Erik Herou, Alain Dardashti, Johann Sigurjonsson, Liana Xhakollari, Agne Laucyte-Cibulskiene, Hans Pottel, Helena Strevens, Danielle Damm, Magnus Förnvik Jonsson, Joanna Siódmiak, Johan Ärnlöv, Anders Larsson, Torbjörn Åkerfeldt, Kim Kultima, Peter Ridefelt, Johanna Helmersson-Karlqvist, Martin Magnusson, Magnus Hansson, Anna Sjöström, Inga Soveri, Olav Tenstad, Johan Mårtensson, Carl-Gustaf Elinder, Lorenz Risch, Martin Risch, Lars-Olof Hansson, Christopher P Price, Ulf Nyman, Jonas Björk, Pierre Delanaye, Arend Bökenkamp, Anders Christensson, Anders Grubb","doi":"10.1080/00365513.2025.2546320","DOIUrl":"https://doi.org/10.1080/00365513.2025.2546320","url":null,"abstract":"<p><p>Cystatin C was identified as a marker of glomerular filtration rate (GFR) in 1979, and the parallel analysis of cystatin C and creatinine led to the identification of shrunken pore syndrome (SPS) - a new kidney disorder - in 2015. Since then, it has been shown that cystatin C in many aspects is superior to creatinine as a marker of GFR and cardiovascular risk. SPS, an entity within the selective glomerular hypofiltration syndromes (SGHS), has been demonstrated to be associated with a strong increase in morbidity and mortality in several populations. Despite the seriousness of SPS and SGHS, and the availability of potential treatments, many patients with these conditions remain undiagnosed, due to the limitations of the international Kidney Disease Improving Global Outcomes Organization (KDIGO) guidelines. Given the significant clinical advantages of cystatin C in diagnosing and treating kidney disorders, there is a need to expand the KDIGO guidelines to include cystatin C measurements alongside creatinine at least in the initial patient evaluation but also in follow-up evaluations. This would improve the early detection and management of patients with kidney diseases, ultimately enhancing patient outcomes. The present discourse summarizes the development of this understanding from the original observations in 1979 and 2015 to the latest findings.</p>","PeriodicalId":21474,"journal":{"name":"Scandinavian Journal of Clinical & Laboratory Investigation","volume":" ","pages":"1-11"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144967109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hb Tacoma is difficult to detect and may cause false results with different HbA1c methods.","authors":"Britta Landin, Soheir Beshara, Johan Eskils, Maria Nilsson, Sara Karlsson, Niklas Bark, Per Bjellerup","doi":"10.1080/00365513.2025.2547317","DOIUrl":"https://doi.org/10.1080/00365513.2025.2547317","url":null,"abstract":"<p><p>The haemoglobin variant Hb Tacoma [HBB:c.93G > T;CD30(Arg > Ser) was detected in approximately 1 in 1000 patients tested for HbA1c at Karolinska University Hospital, Stockholm. Incidentally, five homozygous individuals were found, none of them presenting with severe haematological abnormalities. When the cation exchange chromatographic method Bio-Rad Variant II was used, chromatograms representing Hb Tacoma heterozygotes were easily misinterpreted as normal, although the HbA1c results were about 40% lower than those obtained by immunoassays. This is explained by the fact that the glycated form of Hb Tacoma coelutes with the LA1c fraction, while the main fraction of Hb Tacoma is not separated from normal HbA. Automatic calculation of the ratio LA1c/HbA1c was soon introduced and samples, where this ratio exceeded certain limits, were further investigated. In case of Hb Tacoma, HbA1c results were obtained from immunoassays. Several other HbA1c methods were evaluated using samples from Hb Tacoma heterozygotes. Unlike the Variant II method, the HbA1c results from the Bio-Rad D-100 method did not significantly differ from immunoassay. However, the results for Hb Tacoma samples deviated in an unpredictable way. The cation exchange chromatographic method Tosoh G11 constantly showed a positive bias. Hb Tacoma did not significantly affect the HbA1c results using immunoassays like Tina-quant Gen. 3 (Roche) and DCA Vantage (Siemens), an affinity method (Afinion 2, Abbott) or an enzymatic method (Alinity c, Abbott). Although the capillary electrophoresis HbA1c method (Sebia Capillarys 3 Tera) did not demonstrate any significant bias, the imprecision for this method was unacceptably high for samples with Hb Tacoma.</p>","PeriodicalId":21474,"journal":{"name":"Scandinavian Journal of Clinical & Laboratory Investigation","volume":" ","pages":"1-10"},"PeriodicalIF":1.4,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144967135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The implication of abnormal routine coagulation parameters in Dabie bandavirus infection.","authors":"Tianzhu Zhang, Huan Bai, Bin Wang, Dengju Li, Ning Tang","doi":"10.1080/00365513.2025.2548013","DOIUrl":"10.1080/00365513.2025.2548013","url":null,"abstract":"<p><p>Prolonged activated partial thromboplastin time (APTT) and thrombin time (TT), normal prothrombin time (PT) and elevated D-dimer level are typical manifestation of routine coagulation parameters in patients infected with Dabie bandavirus (DBV), infection-induced coagulation activation and consumption, and a heparin-like effect due to endogenous heparan are the common explanations. To understand the exact implication of abnormal coagulation parameters in patients infected with DBV and their correlation with bleeding tendency and prognosis. One hundred and twenty-one consecutive DBV-infected patients were enrolled in this prospective, single-center, observational study. Routine coagulation parameters, levels of heparan sulfate (HS) and thrombin-antithrombin (TAT) complex, and thrombin generation (TG) test of these patients on admission were detected, and their hemorrhagic events during hospitalization were recorded. In the enrolled patients, both of APTT and TT were significantly positively correlated with HS, while significantly negatively correlated with endogenous thrombin potential (ETP) of TG test (<i>p</i> < .05). In addition, there was a strong correlation between D-dimer and TAT (<i>r</i> = 0.841). The patients with hemorrhagic events during hospitalization had significantly higher APTT and D-dimer and lower platelet count and ETP on admission than those without, and only ETP was the independent predictor (<i>p</i> < .05). The prolongation of APTT and TT of DBV-infected patients reflected decreased TG potential, and increased D-dimer level reflected an increase in thrombin activity. An accurate understanding of the implication of these coagulation parameters is helpful for the rational management of DBV infection.</p>","PeriodicalId":21474,"journal":{"name":"Scandinavian Journal of Clinical & Laboratory Investigation","volume":" ","pages":"1-6"},"PeriodicalIF":1.4,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144875035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-sampling of capillary blood for safety monitoring of DMARD therapy in patients with rheumatic disease: a feasibility and method-comparison study.","authors":"Josefine Bak H Adelhelm, Trine Rennebod Larsen, Ulla Jakobsen, Pernille J Vinholt, Maria Boysen Sandberg, Inger Marie Jensen Hansen, Søren Andreas Just","doi":"10.1080/00365513.2025.2463087","DOIUrl":"10.1080/00365513.2025.2463087","url":null,"abstract":"<p><p>Our study aimed to compare the quality of patient self-collected capillary samples with venous blood samples. Additionally, we assessed whether patients with rheumatic disease are both capable of and willing to perform capillary self-sampling through subjective and objective assessments. This research explores the future potential of at-home self-sampling. Patients with rheumatic diseases were asked to perform up to four supervised self-collected capillary blood samples, followed by a standard venous sample performed by study personnel. Anti-rheumatic drug treatment monitoring parameters, including biochemistry and hematology, were analyzed using Cobas 8000 and Sysmex XN-9000, respectively. The agreement was evaluated by Bland-Altman plots and compared to critical difference limits. Study personnel and patients answered a survey questionnaire after every visit to evaluate feasibility. In total, 21 patients completed 53 paired capillary and venous samples from November 2019 to December 2020. We found a strong correlation (<i>r</i> > 0.87) and good agreement for most parameters; platelets showed the poorest agreement. Patients experienced little pain, found self-sampling easy and reported no serious complications. Hemolysis affected 12/53 capillary biochemistry samples, and 5/53 capillary hematology samples coagulated. The good agreement for most parameters and excellent feasibility encourages the potential for capillary self-sampling of DMARD monitoring parameters, relevant limitations were hemolysis and aggregating platelets.</p>","PeriodicalId":21474,"journal":{"name":"Scandinavian Journal of Clinical & Laboratory Investigation","volume":" ","pages":"108-115"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143370702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of large language models in medical quizzes for clinical chemistry and laboratory management: implications and applications for healthcare artificial intelligence.","authors":"Won Young Heo, Hyung-Doo Park","doi":"10.1080/00365513.2025.2466054","DOIUrl":"10.1080/00365513.2025.2466054","url":null,"abstract":"<p><p>Large language models (LLMs) have demonstrated high performance across various fields due to their ability to understand, generate, and manipulate human language. However, their potential in specialized medical domains, such as clinical chemistry and laboratory management, remains underexplored. This study evaluated the performance of nine LLMs using zero-shot prompting on 109 clinical problem-based quizzes from peer-reviewed journal articles in the Laboratory Medicine Online (LMO) database. These quizzes covered topics in clinical chemistry, toxicology, and laboratory management. The models, including GPT-4o, Claude 3 Opus, and Gemini 1.5 Pro, along with their earlier or smaller versions, were assigned roles as clinical chemists or laboratory managers to simulate real-world decision-making scenarios. Among the evaluated models, GPT-4o achieved the highest overall accuracy, correctly answering 81.7% of the quizzes, followed by GPT-4 Turbo (76.1%), Claude 3 Opus (74.3%), and Gemini 1.5 Pro (69.7%), while the lowest performance was observed with Gemini 1.0 Pro (51.4%). GPT-4o performed exceptionally well across all quiz types, including single-select, open-ended, and multiple-select questions, and demonstrated particular strength in quizzes involving figures, tables, or calculations. These findings highlight the ability of LLMs to effectively apply their pre-existing knowledge base to specialized clinical chemistry inquiries without additional fine-tuning. Among the evaluated models, GPT-4o exhibited superior performance across different quiz types, underscoring its potential utility in assisting healthcare professionals in clinical decision-making.</p>","PeriodicalId":21474,"journal":{"name":"Scandinavian Journal of Clinical & Laboratory Investigation","volume":" ","pages":"125-132"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143459402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reference intervals for holotranscobalamin and total vitamin B12 in 6-12-year-old children in Norway: the Health Oriented Pedagogical Project (HOPP).","authors":"Martin Frank Strand, Helle Borgstrøm Hager, Per Morten Fredriksen, Morten Lindberg","doi":"10.1080/00365513.2025.2475454","DOIUrl":"10.1080/00365513.2025.2475454","url":null,"abstract":"<p><p>Vitamin B12 (B12) is essential for DNA synthesis in all cells and for the development and maintenance of a healthy nervous system. B12 is transported in the circulation bound to two carrier proteins, haptocorrin and transcobalamin, measured as the biomarkers total B12 and holotranscobalamin (holoTC). The latter measures the fraction of cobalamin available for tissue uptake and is considered to have a better sensitivity and specificity for diagnosing vitamin deficiency. The concentration of both carrier proteins depends on age, but data on paediatric reference values for holoTC are still sparse. Blood samples were obtained from 1320 healthy school children, mainly Caucasians (age 6-12 years old) in three different municipalities in Norway. The holoTC and total B12 levels were determined by chemiluminescent microparticle immunoassay on the Architect 2000 analyser. Age specific paediatric reference intervals (RIs) were estimated by calculating the 2.5 and 97.5 percentiles by the nonparametric method with corresponding 90% confidence intervals, according to the Clinical and Laboratory Standards Institute C28-A3C guidelines. The 95% RIs for total B12 were 295-1066 pmol/L for children 6-8 years old, and 249-879 pmol/L for children 9-12 years old. Reference intervals for holoTC were ≥56 pmol/L for children 6-8 years old, and ≥37 pmol/L for children 9-12 years old. Age specific RIs will aid clinicians in interpretation of cobalamin results in children aged 6-12 years old.</p>","PeriodicalId":21474,"journal":{"name":"Scandinavian Journal of Clinical & Laboratory Investigation","volume":" ","pages":"138-142"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of two automated immunoassays for quantifying ProGRP, SCC and HE4 in serum: impact on diagnostic accuracy.","authors":"Jaime I Sainz de Medrano, Javier Laguna, Judit Julian, Xavier Filella, Aleix Fabregat, María Luquin, Harol H Hurtado, Alba García Humanes, Manuel Morales-Ruiz, Esther Fernández-Galán","doi":"10.1080/00365513.2025.2466008","DOIUrl":"10.1080/00365513.2025.2466008","url":null,"abstract":"<p><p>ProGRP (Progastrin-releasing peptide), SCC (Squamous Cell Carcinoma Antigen), and HE4 (Human epididymis protein 4) are serum tumor markers (STMs) frequently used in clinical practice, particularly for detection and monitoring of ovarian and lung neoplasms. In clinical laboratories, their quantification is commonly performed using automated immunoassays. Nevertheless, variations in results obtained by different immunoassays can impact diagnostic accuracy and effectiveness of patient monitoring. Our aim is to assess differences in STMs concentrations between two automated immunoassays: the Elecsys (Roche) and the Architect (Abbott), which are integrated into the Cobas e402 and Architect i2000SR systems respectively. We included 401 serum samples from patients with different clinical conditions: patients with cancer (<i>n</i> = 170), benign diseases (<i>n</i> = 100) and a control group (<i>n</i> = 131). ProGRP, SCC, and HE4 concentrations were quantified in parallel by both analyzers. To evaluate the clinical impact of changing these methodologies, overall concordance, the kappa index and ROC (Receiver Operating Characteristic) curves were calculated. While some discrepancies were noted in specific cases, overall, we obtained a good correlation for three STMs, with a Pearson coefficient for proGRP (<i>r</i> = 0.99), SCC (<i>r</i> = 0.95) and HE4 (<i>r</i> = 0.973). We also obtained a similar performance in the differential diagnosis of cancer, according to the results of the ROC analyses for Cobas and Archictect assays respectively: proGRP (AUC = 0.92; 0.91), SCC (AUC = 0.90; 0.92) and HE4 (AUC = 0.92; 0.93).</p>","PeriodicalId":21474,"journal":{"name":"Scandinavian Journal of Clinical & Laboratory Investigation","volume":" ","pages":"116-124"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The HUNT study: long-term within-subject variation of thyroid stimulating hormone (TSH).","authors":"Arne Åsberg, Marius Berg, Gunhild Garmo Hov, Ingrid Alsos Lian, Lena Løfblad, Gustav Mikkelsen","doi":"10.1080/00365513.2025.2475473","DOIUrl":"10.1080/00365513.2025.2475473","url":null,"abstract":"<p><p>Data on the long-term within-subject biological variation (CV_I) of serum thyroid stimulating hormone (S-TSH) are scarce. In the EFLM Biological Variation Database, the longest observation period was one year. We estimated a coefficient of variation that included analytical variation (CV_I+A) using data from 16,976 individuals in the Trøndelag Health Study (HUNT), where S-TSH was measured on two occasions with an average interval of 10.6 (range 9.3-12.3) years. These individuals reported their health to be 'good' or 'very good' on both occasions and were not registered with any diagnoses or use of medications (according to Norwegian Prescribed Drug Registry) related to the thyroid. We used the software refineR to identify an assumed nonpathological subpopulation in the distribution of distances from each observation to the center of the bivariate distribution of the two S-TSH-values. From this subpopulation, individuals with a distance ≤ the 95 percentile in the distribution of distances were selected for estimation of CV_I+A. The difference in percent of the mean (DPM) was calculated for each individual, and CV_I+A as the standard deviation in the distribution of DPMs divided by 2^0.5. This method was robust against systematic bias between the two measurements. CV_I+A was 21<b>-</b>23% for different groups of age and sex. Accounting for CV_A would imply a CV_I 0.1-0.8% less than CV_I+A. Our estimates are well within the 12-29.3% range of CV_I reported from the seven studies in the meta-analysis of the EFLM Biological Variation Database.</p>","PeriodicalId":21474,"journal":{"name":"Scandinavian Journal of Clinical & Laboratory Investigation","volume":" ","pages":"143-147"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The predictive value of postoperative soluble urokinase plasminogen activator receptor concentration for postoperative complications following valvular surgery.","authors":"Clara Erixon, Louise Thelaus, Emilia Johannesson, Johan Nilsson, Karl Teurneau-Hermansson, Adam Linder, Sigurdur Ragnarsson, Niklas Sterner, Igor Zindovic, Alain Dardashti","doi":"10.1080/00365513.2025.2479042","DOIUrl":"10.1080/00365513.2025.2479042","url":null,"abstract":"<p><p>Soluble urokinase plasminogen activator receptor (suPAR) is an inflammatory marker that has been shown to predict poorer outcomes in cardiovascular disease and after cardiac surgery. The relationship between suPAR concentrations and postoperative complications after valvular surgery, however, remains unclear. This study aims to evaluate the predictive value of suPAR concentrations for infection, acute kidney injury (AKI) and prolonged mechanical ventilation after valvular surgery. This prospective, observational, single-centre study included 414 patients who underwent valvular cardiac surgery at Skåne University Hospital between 1 February 2020 and 22 September 2021. Early postoperative suPAR levels were measured, and multivariable logistic regression was used to identify significant risk factors for postoperative infection, AKI and prolonged mechanical ventilation. Left ventricular ejection fraction (LVEF) 30-50% (OR 3.57 [1.29-9.86], <i>p</i> = 0.014) and suPAR concentration (OR 1.41 [1.56-1.71], <i>p</i> <0.001) were found to be predictive risk factors for developing postoperative infection. Additionally, suPAR concentration (OR 1.23 [1.05-1.43], <i>p</i> = 0.008), cardiopulmonary bypass (CPB) time (OR 1.01 [1.00-1.02], <i>p</i> = 0.004) and age (OR 1.04 [1.01-1.08], <i>p</i> = 0.007) were found to be predictive risk factors for postoperative AKI. However, suPAR concentration did not predict prolonged mechanical ventilation. Plasma suPAR levels after cardiac valve surgery were found to be predictive of postoperative AKI and infection. Our results indicate that early postoperative suPAR measurements may be a valuable tool for identifying patients at higher risk for developing postoperative complications.</p>","PeriodicalId":21474,"journal":{"name":"Scandinavian Journal of Clinical & Laboratory Investigation","volume":" ","pages":"160-167"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}