Scandinavian Journal of Clinical & Laboratory Investigation最新文献

{"title":"Managing demand for the direct antiglobulin test with a big data-derived predictive equation.","authors":"David Ceacero-Marín, Isabel Puig-Pey Comas, Javier Nieto-Moragas, María J Castro-Castro, Anna Cortés Bosch De Bassea, Mónica Vidal-Pla, Lourdes Sánchez Navarro","doi":"10.1080/00365513.2025.2605640","DOIUrl":"10.1080/00365513.2025.2605640","url":null,"abstract":"<p><strong>Background: </strong>The direct antiglobulin test (DAT) is a key diagnostic tool in evaluating autoimmune haemolytic anaemia. However, indiscriminately ordering this test, together with certain methodological limitations, can compromise the efficiency of the clinical laboratory. This study aimed to develop and validate a predictive equation to identify negative results, optimising the use of DAT while maintaining the quality of care.</p><p><strong>Methods: </strong>Through the laboratory information system (LIS), 1155 data were obtained from patients requesting DAT. A multiple logistic regression analysis was performed based on magnitudes related to haemolytic anaemia to obtain the best predictive model. The predictive equation obtained was: <i>p</i> = 1/(1 + e^-z) where 'P' represents the probability that the DAT is positive and 'z' the equation with the variables included in the model. Subsequently, its diagnostic efficiency was evaluated using a receiver operating characteristic curve. Finally, the equation was validated using a new cohort of data (<i>N</i> = 164).</p><p><strong>Results: </strong>The 'z' value obtained from the best predictive equation was: <math><mrow><mrow><mi>z</mi></mrow><mo>=</mo><mo>-</mo><mn>2.884</mn><mo> </mo><mo>-</mo><mfenced><mrow><mn>0.373</mn><mtext> x Haptoglobin</mtext></mrow></mfenced><mo>+</mo><mfenced><mrow><mn>0.312</mn><mtext> x %Ret</mtext></mrow></mfenced><mo>.</mo></mrow></math> For the selected threshold, the equation demonstrated a sensitivity of 81.6%, a negative predictive value of 95.8%, and an area under the curve [95% confidence interval] of 0.812 [0.760-0.864]. According to the proposed equation, the performance of 61.6% of DAT would be reduced.</p><p><strong>Conclusions: </strong>The proposed equation has an excellent predictive ability for negative DATs. Its simple integration into the LIS confirms its applicability in routine clinical laboratory practice, providing an effective screening tool for optimising DAT demand and managing resources efficiently.</p>","PeriodicalId":21474,"journal":{"name":"Scandinavian Journal of Clinical & Laboratory Investigation","volume":" ","pages":"20-27"},"PeriodicalIF":1.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145782308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the relationship between trimethylamine N-oxide, CD36, and CD38 levels in individuals with a high triglyceride/HDL-cholesterol ratio.","authors":"Gul Akar, Fatma Sengul-Bag, Fikret Akyurek, Bahadir Ozturk","doi":"10.1080/00365513.2026.2616760","DOIUrl":"10.1080/00365513.2026.2616760","url":null,"abstract":"<p><strong>Background and aims: </strong>The Triglyceride/HDL-Cholesterol (TG/HDL-C) ratio is a recognized biomarker for cardiovascular risk, linked to atherogenic dyslipidemia and insulin resistance. Recent evidence also implicates molecules like trimethylamine N-oxide (TMAO), CD36, and CD38 in metabolic inflammation and atherosclerosis. This study investigated the relationship between TMAO, CD36, and CD38 in individuals with a high TG/HDL-C ratio.</p><p><strong>Methods: </strong>A total of 82 volunteer individuals with no known cardiac disease were enrolled in the study (41 dyslipidemic individuals and 41 healthy controls). Serum TMAO levels from participants were quantitatively measured using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The surface expression levels of CD36 and CD38 on the monocyte population were assessed by flow cytometry. The plasma atherogenic index (PAI) was calculated using the log(TG/HDL-C) formula to assess the atherogenic risk status.</p><p><strong>Results: </strong>The TG/HDL-C ratio, TMAO level, and CD38 expressions were significantly higher in the dyslipidemia group compared to the control group (<i>p</i> < 0.05). Additionally, low-density lipoprotein cholesterol levels and HOMA-IR scores were higher in dyslipidemic individuals. According to the PAI assessment, the entire dyslipidemia group was in the high cardiovascular risk category. The TG/HDL-C ratio showed a positive correlation with TMAO and CD38 levels.</p><p><strong>Conclusion: </strong>The positive relationship between the TG/HDL-C ratio and TMAO and CD38 levels suggests that these parameters could be evaluated together to reflect cardiovascular risk. However, given the cross-sectional design of the study, these findings indicate associations rather than causal relationships, and metabolic and inflammatory markers may reflect early stages of subclinical atherosclerosis in individuals without known cardiovascular disease.</p>","PeriodicalId":21474,"journal":{"name":"Scandinavian Journal of Clinical & Laboratory Investigation","volume":" ","pages":"42-52"},"PeriodicalIF":1.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145966263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kidney damage biomarkers in predicting renal complications of allogeneic hematopoietic cell transplantation: a pilot prospective observational study.","authors":"Dorota Szcześ, Marcin Żórawski, Ewa Koc-Żórawska, Monika Paskudzka, Longin Niemczyk, Agnieszka Tomaszewska, Magdalena Tormanowska, Ewa Karakulska-Prystupiuk, Piotr Kacprzyk, Kazimierz Hałaburda, Olga Ciepiela, Marlena Kwiatkowska-Stawiarczyk, Anna Rodziewicz-Lurzyńska, Jarosław Biliński, Grzegorz Władysław Basak, Jolanta Małyszko","doi":"10.1080/00365513.2026.2623598","DOIUrl":"10.1080/00365513.2026.2623598","url":null,"abstract":"<p><p>Kidney dysfunction is a significant complication of allogeneic hematopoietic cell transplantation (alloHCT). Standard serum creatinine (sCr) testing is imperfect due to latency from the event causing damage to sCr increase. The purpose of this study was to evaluate the role of kidney damage biomarkers in the field of alloHCT. Seventy adult alloHCT candidates from 2 centers were recruited. 34 patients constituted pilot cohort and 36 - validation cohort. In pilot cohort serum and urine samples obtained at baseline and 7 timepoints were tested using ELISA assays for LFABP-1, KIM-1, NAG, uromodulin, TIMP-2 and IGFBP-7. Urine concentrations were corrected to urine creatinine concentration (uCr). Results were analyzed as predictors of acute kidney injury (AKI) within 100 days from alloHCT using receiver operating curve (ROC). LFABP-1, KIM-1, uromodulin, NAG and TIMP-2 performed significant predictive value for AKI. The best results were obtained for LFABP-1 and NAG and these biomarkers were tested in validation cohort where the results were borderline significant. Given the heterogeneity of the studied population, calculations for the whole group were performed: ROC for day +7/baseline ratio of urinary LFABP-1 and NAG in predicting AKI within 100 days from alloHCT was 0.673 and 0.678 respectively (<i>p</i> < 0.05). ROC for baseline urinary LFABP-1 in predicting early AKI was 0.721 (<i>p</i> < 0.05). Findings from our study confirm that patients undergoing alloHCT frequently experience subclinical kidney damage. However, due to the multifactorial nature of renal insults and preexisting kidney impairment, the predictive value of studied biomarkers in this population is limited.</p>","PeriodicalId":21474,"journal":{"name":"Scandinavian Journal of Clinical & Laboratory Investigation","volume":" ","pages":"53-65"},"PeriodicalIF":1.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146119857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of oxidative stress parameters in neonatal indirect hyperbilirubinemia treated with phototherapy.","authors":"Emine Özçelik, Salim Neşelioğlu, Özcan Erel, Ayşegül Zenciroğlu","doi":"10.1080/00365513.2026.2623600","DOIUrl":"10.1080/00365513.2026.2623600","url":null,"abstract":"<p><p>Phototherapy is the most commonly used treatment for indirect (unconjugated) hyperbilirubinemia (IHB) in newborns. This study aims to determine the impact of IHB and phototherapy on oxidative stress balance by thiol-disulfide homeostasis and ischemia-modified albümin (IMA). This prospective study included 107 hospitalised newborns with IHB who received phototherapy and 55 controls. Neonates aged 0-28 days with a gestational age above 35 weeks were included in the patient group. Oxidative stress parameters were assessed in the control group as well as before and after phototherapy in the patient group. Sex, gestational age, and birth weight were similar between IHB group and control groups (<i>p</i> > 0.05). Native thiol and total thiol levels were significantly higher in the IHB group compared to controls (<i>p</i> < 0.05). After phototherapy, native thiol, total thiol, and Index 3 values were significantly reduced (<i>p</i> < 0.05), while disulfide levels, disulfide/native thiol ratio, disulfide/total thiol ratio, and IMA values significantly increased (<i>p</i> < 0.05). Oxidative stress <i>via</i> thiol-disulphide homeostasis is increasing in patients hospitalised due to IHB and receiving phototherapy. Our findings suggest that both IHB and phototherapy contribute to oxidative stress imbalance. Phototherapy should be used based on clinical indications and for the minimum needed duration.</p>","PeriodicalId":21474,"journal":{"name":"Scandinavian Journal of Clinical & Laboratory Investigation","volume":" ","pages":"66-71"},"PeriodicalIF":1.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146086876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuron-specific enolase measured in serum compared to plasma for neuroprognostication in out-of-hospital cardiac arrest.","authors":"Yusuf A Isse, Christian Hassager, Jacob E Møller, Ruth Frikke-Schmidt, Benjamin Nyholm, Frederik T Søndergaard, Johannes Grand, Simon Mølstrøm, Laust E R Obling, Rasmus P Beske, Henrik Schmidt, Jesper Kjaergaard, Martin A S Meyer","doi":"10.1080/00365513.2025.2611807","DOIUrl":"10.1080/00365513.2025.2611807","url":null,"abstract":"<p><strong>Aim: </strong>Neuron-specific enolase (NSE) is an acknowledged biomarker for prognosticating neurological outcome after cardiac arrest, with elevated concentrations associated with poor outcome. This study assesses and compares the prognostic performance of NSE measured in serum and plasma for 1-year all-cause mortality among patients resuscitated from out-of-hospital cardiac arrest (OHCA).</p><p><strong>Methods: </strong>This investigation is based on post hoc analyses of the Blood Pressure and Oxygenation Targets After Out-of-Hospital Cardiac Arrest (BOX) trial, performed in patients remaining comatose after resuscitation. NSE was measured 48 h after admission using three distinct methods; 1) Serum-NSE measured in fresh serum samples, 2) frozen-plasma-NSE, measured in freeze-thaw EDTA-plasma from stored biobank samples, and 3) in a subset of the samples also as frozen-serum-NSE, measured in freeze-thaw serum from stored biobank samples.</p><p><strong>Results: </strong>A total of 381 comatose OHCA patients were included, with an overall one-year mortality of 33.1%. Serum-NSE concentrations were significantly higher than frozen-plasma-NSE, with median concentrations of 21.2 µg/L (IQR: 15.7-45.5) versus 19.1 µg/L (IQR: 11.2-39.6), <i>p</i> < 0.001, respectively. Notably, the difference between serum-NSE and frozen-plasma-NSE increased with higher NSE concentrations. The mean difference was 65.8 µg/L with 95% limits of agreement of +/- 125.75 µg/L among patients with NSE > 60 µg/L. For predicting 1-year all-cause mortality, the AUROC for serum-NSE was 0.93 and 0.83 for frozen-plasma-NSE with a significant difference in AUROC of 0.10 (CI: 0.06; 0.14), <i>p</i> < 0.001. In a sub-group analysis (<i>n</i> = 67), there was no significant difference when comparing AUROC between serum-NSE and frozen-serum-NSE (difference of 0.03 [CI: -0.04; 0.09], <i>p</i> = 0.44). However, within this sub-group, frozen-serum-NSE performed better than frozen-plasma-NSE with an AUROC difference of 0.08 (CI: -0.15; -0.01), <i>p</i> = 0.02.</p><p><strong>Conclusions: </strong>Serum-NSE had greater accuracy in predicting 1-year mortality than frozen-plasma-NSE.</p>","PeriodicalId":21474,"journal":{"name":"Scandinavian Journal of Clinical & Laboratory Investigation","volume":" ","pages":"28-35"},"PeriodicalIF":1.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145949094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biological variation estimates of direct and indirect LDL cholesterol by Friedewald and Martin-Hopkins formulas in healthy individuals.","authors":"Filiz Alkan Baylan, Mehmet Özcan, Şerif Ercan, Ayşe Ciriz, Esin Avcı, Müjgan Ercan","doi":"10.1080/00365513.2025.2605638","DOIUrl":"10.1080/00365513.2025.2605638","url":null,"abstract":"<p><p>Understanding biological variation (BV) is crucial for accurate clinical decision-making and for establishing analytical quality standards. This study established the BV of low-density lipoprotein cholesterol (LDL-C), assessed using both direct measurement and calculated values obtained from the Friedewald and Martin-Hopkins formulas in healthy individuals. A total of twenty-six healthy Turkish subjects (15 females and 11 males) underwent fasting LDL-C measurement, along with calculated LDL-C derived from serum cholesterol, triglycerides, and high-density lipoprotein cholesterol, using samples collected concurrently on 10 weekly occasions. All measurements were conducted in duplicate by the enzymatic colorimetric method. Within-subject (CV_I) and between-subject (CV_G) BV estimates, with 95% confidence intervals (CI), were determined by CV-ANOVA following evaluation of trends, homogeneity of variance, and outlier removal. No significant gender-related differences were observed in the BV components for either direct or calculated LDL-C. According to direct LDL-C, Friedewald LDL-C, and Martin Hopkins LDL-C, CV_I values were 8.7%, 9.3% and 9.0%, and the CV_G values were 14.7% for direct LDL-C, 18.5% for Friedewald LDL-C, 18.6% for Martin Hopkins LDL-C. These values supported the use of updated analytical performance specifications and reference change values (RCV). All LDL-C exhibited marked individuality (II < 0.6). By applying a rigorously standardized experimental protocol, the inter-individual variability observed supports the preferred use of RCVs over conventional population-based reference intervals for serial monitoring. These results have important implications for enhancing the clinical utility of LDL-C measurements, regarding cardiovascular risk assessment and individualized therapeutic decision-making.</p>","PeriodicalId":21474,"journal":{"name":"Scandinavian Journal of Clinical & Laboratory Investigation","volume":" ","pages":"1-8"},"PeriodicalIF":1.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145828217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the stability of sediment urinary elements using BD vacutainer^® UAP preservative tubes based on Cohen's Kappa (<i>κ</i>) coefficient.","authors":"Jari Intra, Pietro Iezzi, Francesca Basta, Lidia Fossati, Davide Martinez, Elisa Zucchetti, Laura Zullo, Marco Casati","doi":"10.1080/00365513.2026.2684332","DOIUrl":"10.1080/00365513.2026.2684332","url":null,"abstract":"<p><p><b>Background:</b> Urinalysis is a fundamental diagnostic tool, yet its reliability is heavily dependent on the pre-analytical phase. International guidelines recommend processing within two hours. This study evaluates the stability of urinary sediment elements over 72 h using BD Vacutainer^® UAP preservative tubes. <b>Methods:</b> A total of 150 urinary specimens were collected into BD Vacutainer^® UAP tubes (containing chlorhexidine, ethyl paraben, and sodium propionate). Samples were analyzed at 0, 24, 48, and 72 h using the Sysmex UF-5000 fluorescence flow cytometer at room temperature. Stability was assessed using Cohen's Kappa (<i>κ</i>) statistics, with <i>κ</i> > 0.80 defined as the threshold for good clinical agreement. <b>Results:</b> Cellular elements showed stability up to 24 h, but significant time-dependent degradation after 24 h. White Blood Cells were the most labile, showing a 36.7% loss of detectability at 48 h (<i>κ</i> = 0.62). Red Blood Cells (RBCs) and transitional cells exhibited a critical inflection point at 48 h with a 22.7% loss (<i>κ</i> = 0.77). In contrast, squamous epithelial cells and casts (cellular and non-cellular) remained highly stable up to 72 h (<i>κ</i> ≥ 0.97). Non-cellular analytes, including bacteria, crystals, yeasts, and spermatozoa, showed absolute stability (0% loss, <i>κ</i> = 1.00) throughout the entire 72-hour period. <b>Conclusions:</b> The use of BD Vacutainer^® UAP tubes successfully mitigates osmotic lysis and alkaline degradation, extending the reliable analytical window up to 24 h.</p>","PeriodicalId":21474,"journal":{"name":"Scandinavian Journal of Clinical & Laboratory Investigation","volume":" ","pages":"436-439"},"PeriodicalIF":1.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148157870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reference intervals for haptoglobin in neonates and children 30 days to 18 years old.","authors":"Jad El Maamari, Vasiliki Karlaftis, Chiara Braida, Joel Smith, Susan Matthews, Stephen Hearps, Janet Burgess, Ellen Maxwell, Ray Czajko, Paul Monagle, Vera Ignjatovic, Chantal Attard","doi":"10.1080/00365513.2026.2681039","DOIUrl":"10.1080/00365513.2026.2681039","url":null,"abstract":"<p><strong>Background: </strong>Discovered in 1938, haptoglobin is a liver-produced α2-glycoprotein that binds free hemoglobin, mitigating its toxic effects, and serves as a biomarker for hemolysis. The current study, under the HAPPI Kids initiative, aimed to define paediatric reference intervals for haptoglobin through the collection of samples from healthy children and neonates, with the overall aim to improve diagnostic accuracy in young patients.</p><p><strong>Methods: </strong>Blood was collected from 335 children aged 30 days to 18 years and 20 neonates from February 2015 through December 2016. Samples were analysed on 3 automated analysers: a) Roche Cobas c501/c502, b) Roche Cobas c701, and c) Beckman Coulter Unicel DXL 600/800.</p><p><strong>Results: </strong>Age and sex specific haptoglobin reference ranges were reported with a 95% confidence interval.</p><p><strong>Conclusion: </strong>We report continuous age-specific reference intervals for serum haptoglobin in neonates and children. The data suggests that haptoglobin levels have limited clinical value in children under 13-15 years, as they are often naturally low and may fall below the assay detection threshold.</p>","PeriodicalId":21474,"journal":{"name":"Scandinavian Journal of Clinical & Laboratory Investigation","volume":" ","pages":"394-400"},"PeriodicalIF":1.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148144547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum Krebs von den Lungen-6 and interstitial lung disease: a brief review.","authors":"Qi-Jia Wang, Zhi-Yu Duan, Yi-Lu Hao, Ya-Nan Xu, Ran-Tong Bao, Wei Jiao, Jing Wang, Wen-Qi Zheng, Hong-Bin Li, Gu-La Da, Zhi-De Hu","doi":"10.1080/00365513.2026.2686250","DOIUrl":"10.1080/00365513.2026.2686250","url":null,"abstract":"<p><p>Krebs von den Lungen-6 (KL-6) is a protein released by type II alveolar cells in response to injury or inflammatory stimuli. This release results in a significant increase in serum KL-6 levels, making it a useful biomarker for diagnosing and evaluating the prognosis of various respiratory diseases. It is particularly relevant for the diagnosis, stratification and treatment of interstitial lung disease (ILD). This review provides a concise review of the clinical value of serum KL-6 in the management of ILD, emphasizing its potential to improve patient care and outcomes.</p>","PeriodicalId":21474,"journal":{"name":"Scandinavian Journal of Clinical & Laboratory Investigation","volume":" ","pages":"317-322"},"PeriodicalIF":1.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148259450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HALP score predicts 30-day readmission risk in patients with acute exacerbation of chronic obstructive pulmonary disease: a single-center retrospective study.","authors":"Bingzhen Zheng, Ru Li","doi":"10.1080/00365513.2026.2630332","DOIUrl":"10.1080/00365513.2026.2630332","url":null,"abstract":"<p><p>Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide, with acute exacerbations (AECOPD) significantly contributing to disease burden and healthcare costs. This study aimed to explore the predictive role of the hemoglobin, albumin, lymphocyte, and platelet (HALP) score in 30-day readmission risk in AECOPD patients. AECOPD patients were categorized into Rehospitalization and N-Rehospitalization groups based on 30-day COPD-related readmission. The HALP score on the day of ICU admission (acute phase) was calculated as (hemoglobin × albumin × lymphocyte count)/platelet count. Spearman correlation analysis was performed to evaluate associations of acute-phase HALP scores with acute-phase APACHE IV scores and stable-phase FEV₁/FVC. ROC curves were plotted to compare HALP and CRP in predicting 30-day readmission. COX regression was conducted to identify independent risk factors for readmission. The Rehospitalization group exhibited significantly lower HALP scores. Acute-phase HALP scores were negatively correlated with acute-phase APACHE IV and positively with stable-phase FEV₁/FVC. HALP scores declined progressively with higher GOLD grades. HALP scores demonstrated superior predictive accuracy for 30-day readmission compared to CRP. Multivariate analysis confirmed HALP as an independent predictor of 30-day readmission. Overall, HALP score reduction correlates with AECOPD severity and independently predicts 30-day readmission, serving as a valuable biomarker for short-term rehospitalization risk.</p>","PeriodicalId":21474,"journal":{"name":"Scandinavian Journal of Clinical & Laboratory Investigation","volume":" ","pages":"126-135"},"PeriodicalIF":1.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147326897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}