RGUHS Journal of Pharmaceutical Sciences最新文献_第6页

Formulation and Evaluation of Mucoadhesive Buccal Tablets containing pantoprazole 含泮托拉唑黏附含片的配方及评价

RGUHS Journal of Pharmaceutical Sciences Pub Date : 2012-10-04 DOI: 10.5530/RJPS.2012.3.7

Y. Mamatha, B. P. Rao, K. Ramesh, S. Rajarajan, Beny Baby, Y. V. Reddy

引用次数: 5

Formulation and Evaluation of Core In Cup Pulsatile Drug Delivery System of Metoprolol Tartarate 酒石酸美托洛尔杯芯脉动给药系统的研制与评价

RGUHS Journal of Pharmaceutical Sciences Pub Date : 2012-10-04 DOI: 10.5530/RJPS.2012.3.6

Prashant A. Borgaonkar, S. Bushetti

引用次数: 0

Human Resource, Innovation Eco-System and Fostering Creativity: A Professional Challenge 人力资源、创新生态系统与培养创造力:一个专业挑战

RGUHS Journal of Pharmaceutical Sciences Pub Date : 2012-10-04 DOI: 10.5530/RJPS.2012.3.1

S. Kulkarni

{"title":"Human Resource, Innovation Eco-System and Fostering Creativity: A Professional Challenge","authors":"S. Kulkarni","doi":"10.5530/RJPS.2012.3.1","DOIUrl":"https://doi.org/10.5530/RJPS.2012.3.1","url":null,"abstract":"We are living in very challenging times in the modern history of our nation. Forty per cent of our population (nearly 500 million) is in the age group of 15 to 40 years (average age would be between 25 and 29 years). The young generation with new the dreams, aspirations, expectations and political sensitivity expects the nation to fulfi l their hopes and aspirations. Young India would be a huge human resource (talent) in nation building. If moulded properly, they could not only be strength for the nation but also provide global leadership in critical areas of human endeavours. It is a great opportunity and equally a challenge. Any failure in this endeavour would be a demographic disaster. The National Knowledge Commission (NKC-2005) constituted by the honourable Prime Minister of India had ambitious vision of transforming India in to a knowledge-based society. Its ultimate goal was to address the three fundamental challenges of expansion, equity (inclusion without compromising quality) and excellence in education at all levels, more so at higher education. In order to achieve this base of our educational system has to be strengthened so that the height of the pyramid of excellence could be enhanced. It is an enormous task before the educationists, institutions, Universities and the Received Date : 20-06-2012","PeriodicalId":21459,"journal":{"name":"RGUHS Journal of Pharmaceutical Sciences","volume":"8 1","pages":"01-02"},"PeriodicalIF":0.0,"publicationDate":"2012-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78917068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design, Development and Evaluation of Selegiline Hydrochloride Transdermal Patch 盐酸塞来吉兰透皮贴剂的设计、研制与评价

RGUHS Journal of Pharmaceutical Sciences Pub Date : 2012-10-04 DOI: 10.5530/RJPS.2012.3.5

S. Mohammed, Sandip Murtale, D. Hiremath, R. Udupi

{"title":"Design, Development and Evaluation of Selegiline Hydrochloride Transdermal Patch","authors":"S. Mohammed, Sandip Murtale, D. Hiremath, R. Udupi","doi":"10.5530/RJPS.2012.3.5","DOIUrl":"https://doi.org/10.5530/RJPS.2012.3.5","url":null,"abstract":"Many monoamine oxidase inhibitors (MAOIs) have been used to treat major depressive disorder (MDD). However, the prescription of MAOIs has decreased considerably as a result of side effects such as tyramine-induced hypertensive crisis, known as “Cheese Effect”. The drug delivery system itself can affect the effi cacy and bioavailability of certain drugs when medications are given by oral, intravesical and intravaginal routes. Therefore there is a need for advanced drug delivery techniques that can avoid toxic effects and improve the bioavailability at the same time. In this context, the transdermal patches of selegiline hydrochloride (SH) were prepared by the solvent casting method using hydroxy propyl methyl cellulose (HPMC), polyvinyl alcohol (PVA) and methyl cellulose (MC) as reservoir polymers in different ratios (1:1, 1:2 and 1:3). Rate controlling membrane was caste by using 2% ethyl cellulose (EC) membrane. The prepared patches possessed satisfactory physicochemical characteristics. The formulation exhibited fl exibility, uniform weight, thickness, smoothness, drug content (93 to 97 %), little moisture loss and moisture absorption. The in-vitro permeation studies in phosphate buffer (pH 7.4) revealed formulations released drug in the range of 86.77 to 96.79% and followed diffusion mechanism. Formulations with 1:1 and 1:2 ratio released drug up to 10 to 20 h only. The optimized formulation F6 containing PVA (1:3) showed good release rate of 90.08% for 24 h. The patches were seemingly free of potential hazardous skin irritation. FT-IR and DSC studies revealed no interaction between the drug and polymers used.","PeriodicalId":21459,"journal":{"name":"RGUHS Journal of Pharmaceutical Sciences","volume":"1 1","pages":"48-56"},"PeriodicalIF":0.0,"publicationDate":"2012-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78477558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Synthesis, Spectral and Antimicrobial Screening Studies of Some Acylated D-Glucose Derivatives 一些酰基化d -葡萄糖衍生物的合成、光谱及抗菌筛选研究

RGUHS Journal of Pharmaceutical Sciences Pub Date : 2012-10-04 DOI: 10.5530/RJPS.2012.3.12

S. Kawsar, A. Kabir, M. Bhuiyan, M. Hossain, A. Siddiqa, M. Anwar

引用次数: 11

Once-Daily Sustained Release Matrix Tablets of Metoprolol Succinate 每日一次琥珀酸美托洛尔缓释基质片

RGUHS Journal of Pharmaceutical Sciences Pub Date : 2012-10-04 DOI: 10.5530/RJPS.2012.3.9

D. Nagendrakumar, S. A. Rudani, S. Shirsand, Para

{"title":"Once-Daily Sustained Release Matrix Tablets of Metoprolol Succinate","authors":"D. Nagendrakumar, S. A. Rudani, S. Shirsand, Para","doi":"10.5530/RJPS.2012.3.9","DOIUrl":"https://doi.org/10.5530/RJPS.2012.3.9","url":null,"abstract":"The purpose of the present study was to design and evaluate once-daily sustained release matrix tablets of metoprolol succinate by direct compression method, to overcome its side effects, to increase its bioavailability, to reduce the dosing frequency and improve the patient compliance. The tablets were prepared using hydroxypropyl methylcellulose (HPMC) K4M and K10M (synthetic), guar gum and xanthan gum (natural) carbopol 934p and Eudragit L-100 lactose as a channeling agent. Prepared matrix tablets were evaluated for various parameters like hardness, thickness, weight variation, friability and percent drug content. Tablet formulations were subjected to in-vitro drug release studies as per USP guidelines. All the prepared formulations showed fi rst-order release kinetics with matrix diffusion mechanism of drug release. The formulation F 12 containing drug: xanthan gum ratio of 1:3:1, carbopol 934p 1:3:1 offered the required in-vitro drug release rate according to the offi cial limits of drug release as per USP and selected as a promising formulation among the fi fteen formulations. The combination of release retarding polymer and release modifying agent can effectively control the drug release for freely watersoluble drugs over a period of 24 h in case of once-daily sustained release matrix tablet formulations which are the upcoming dosage forms for patient compliance in all aspects.","PeriodicalId":21459,"journal":{"name":"RGUHS Journal of Pharmaceutical Sciences","volume":"401 1","pages":"81-88"},"PeriodicalIF":0.0,"publicationDate":"2012-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76529727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Simultaneous first derivative UV spectrophotometric estimation of ramipril and olmesartan 雷米普利和奥美沙坦的一阶导数紫外分光光度法同时测定

RGUHS Journal of Pharmaceutical Sciences Pub Date : 2012-03-21 DOI: 10.5530/RJPS.2012.1.11

R. Santosh, Cc Simpi, N. Kalyane

引用次数: 7

Study of the binding properties of hydroxypropyl guar and its utilization in the formulation and evaluation of metoprolol tartarate tablets 羟丙基瓜尔胶结合性能的研究及其在酒石酸美托洛尔片中的应用

RGUHS Journal of Pharmaceutical Sciences Pub Date : 2012-03-21 DOI: 10.5530/RJPS.2012.1.6

N. Swamy, T. Dharmarajan, K. Paranjothi

{"title":"Study of the binding properties of hydroxypropyl guar and its utilization in the formulation and evaluation of metoprolol tartarate tablets","authors":"N. Swamy, T. Dharmarajan, K. Paranjothi","doi":"10.5530/RJPS.2012.1.6","DOIUrl":"https://doi.org/10.5530/RJPS.2012.1.6","url":null,"abstract":"Derivatization of guar to hydroxypropyl guar enhances the interaction coeffi cient and checks the hydration rate of the polymer molecule. Hydroxypropyl guar is investigated for its binding property along with sodium carboxymethylcellulose (1% w/w) as the parallel binding agent. Tablets of metoprolol tartarate were prepared by wet granulation. Pre-compression parameters such as rate of fl ow, angle of repose, Carr’s index, Hausner’s ratio, residual moisture content and assay determinations were carried out. Hydroxypropyl guar bound granules revealed lower Carr’s index value and Hausner’s ratio in comparison to sodium carboxymethylcellulose bound granules thereby indicating better free fl owing properties. In respect to post compression parameters, tablets made with hydroxypropyl guar displayed superior hardness, lesser deviation of tablet weight about the mean, a higher value of (Crushing strength: Friability)/Disintegration time, a faster drug dissolution in comparison to sodium carboxymethylcellulose bound tablets. While guar with its high intrinsic viscosity restricts its use as a retardant component in matrix tablets, hydroxypropyl guar with its enhanced interaction coeffi cient and controlled hydration rate has yielded a promising adjuvant for binding metoprolol tartarate tablets with improved in vitro performance.","PeriodicalId":21459,"journal":{"name":"RGUHS Journal of Pharmaceutical Sciences","volume":"1 1","pages":"45-54"},"PeriodicalIF":0.0,"publicationDate":"2012-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89640641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Pharmaceutical discovery and development 药物发现和开发

RGUHS Journal of Pharmaceutical Sciences Pub Date : 2012-03-21 DOI: 10.5530/RJPS.2012.1.2

P. Balakumar, G. Jagadeesh

引用次数: 0

Design and optimization of levofl oxacin gastroretentive tablets 左旋沙星胃保留片的设计与优化

RGUHS Journal of Pharmaceutical Sciences Pub Date : 2012-03-21 DOI: 10.5530/RJPS.2012.1.5

D. Nagendrakumar, S. Shirsand, Paramonova Ms, Chauhan Ad

{"title":"Design and optimization of levofl oxacin gastroretentive tablets","authors":"D. Nagendrakumar, S. Shirsand, Paramonova Ms, Chauhan Ad","doi":"10.5530/RJPS.2012.1.5","DOIUrl":"https://doi.org/10.5530/RJPS.2012.1.5","url":null,"abstract":"In the present study, gastroretentive fl oating tablets of levofl oxacin hemihydrate were designed with objective of retention of tablet in acidic pH to improve bioavailability with reduction in dosing frequency. Hydroxypropyl methyl cellulose of different viscosity grades (K4M and K100LV) was used as polymer and sodium bicarbonate as gas generating agent to reduce fl oating lag time. Tablets were prepared by direct compression method. The prepared formulations were evaluated for hardness, friability, weight variation, drug content, swelling index, in-vitro drug release, short-term stability, fl oating lag time and in-vitro buoyancy. A 3 2 factorial design was applied to systematically optimize the drug release profi le. The proportions of release retardant material HPMC K100LV(X 1 ), sodium bicarbonate (X 2 ) were selected as independent variables and t 50% (Y 1 ), and t 70% (Y 2 ) were selected as dependent variables. The promising formulation containing levofl oxacin hemihydrate (100 mg), HPMC K100LV (100 mg) and sodium bicarbonate (80 mg) has t 50% (5.95 h), t 70% (8.52 h) , fl oating lag time was only 10.33 sec and released more than 90% drug in 12 h. This study proved that gastroretentive drug delivery system of levofl oxacin hemihydrate was designed using HPMC K100LV, which provided excellent gastroretentive property, thus improved the bioavailability of drug.","PeriodicalId":21459,"journal":{"name":"RGUHS Journal of Pharmaceutical Sciences","volume":"47 1","pages":"38-45"},"PeriodicalIF":0.0,"publicationDate":"2012-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81418086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1