RGUHS Journal of Pharmaceutical Sciences最新文献_第8页

Evaluation of Analgesic and Antipyretic Activity of Tridax Procumbens Leaves Extract 原春三叶提取物的镇痛解热作用评价

RGUHS Journal of Pharmaceutical Sciences Pub Date : 2011-11-25 DOI: 10.5530/RJPS.2011.3.9

N. Singh, P. Deepak, K. Jain, H. Nagar, Arti T. Patel, Ratibad Bhopal

引用次数: 11

Salbutamol Sulphate Controlled Release Hydrophilic Matrix Tablets 硫酸沙丁胺醇控释亲水性基质片

RGUHS Journal of Pharmaceutical Sciences Pub Date : 2011-11-25 DOI: 10.5530/RJPS.2011.3.4

S. A. El-Halim, M. Amin, O. N. E. Gazayerly, A. Abd, El Gawad

{"title":"Salbutamol Sulphate Controlled Release Hydrophilic Matrix Tablets","authors":"S. A. El-Halim, M. Amin, O. N. E. Gazayerly, A. Abd, El Gawad","doi":"10.5530/RJPS.2011.3.4","DOIUrl":"https://doi.org/10.5530/RJPS.2011.3.4","url":null,"abstract":"A B S T R A C T Salbutamol sulphate (SS), a directly acting sympathomimetic drug, is a good candidate for controlled release formulations due to its short half-life but it is challenging because of its high water solubility. The aim of this work is to design oral controlled-release matrix tablets of SS using hydrophilic polymers, and thus increasing patient compliance by reducing its frequency of administration. Tablets were prepared by direct compression technique using hydroxypropyl methylcellulose, sodium carboxymethylcellulose, guar gum and xanthan gum. The compatibility of the drug with the various used excipients was studied using differential scanning calorimetry (DSC). The effects of polymer concentration, polymer viscosity and binary mixtures of some polymers on the in vitro drug release were studied. Results of DSC confirmed drug-excipients compatibility. The different prepared tablet formulae exhibited content uniformity within the acceptable limit and showed good mechanical properties. Increasing the polymer concentration from 25% to 60%, as well as increasing HPMC viscosity resulted in significant retardation (p<0.05) of the drug release. The matrix tablets formulated using HPMC K100M and guar gum in a ratio of 1:1 succeeded to control drug release up to 80.8% in 12 h. Results of stability studies of the selected formula recommend that the formulated tablets must be stored protected from light under ambient conditions.","PeriodicalId":21459,"journal":{"name":"RGUHS Journal of Pharmaceutical Sciences","volume":"85 1","pages":"194-201"},"PeriodicalIF":0.0,"publicationDate":"2011-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73675069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Utilization of Superdisintegrants in the Design, Evaluation and Optimization of Orodispersible Tablets containing Simvastatin-Cyclodextrin Inclusion Complexes 超崩解剂在辛伐他汀-环糊精包合物口腔分散片设计、评价与优化中的应用

RGUHS Journal of Pharmaceutical Sciences Pub Date : 2011-11-25 DOI: 10.5530/RJPS.2011.3.6

J. S. Patil, V. Kattimani, S. S. Shiralashetti, S. Marapur, M. V. Kamalapur

{"title":"Utilization of Superdisintegrants in the Design, Evaluation and Optimization of Orodispersible Tablets containing Simvastatin-Cyclodextrin Inclusion Complexes","authors":"J. S. Patil, V. Kattimani, S. S. Shiralashetti, S. Marapur, M. V. Kamalapur","doi":"10.5530/RJPS.2011.3.6","DOIUrl":"https://doi.org/10.5530/RJPS.2011.3.6","url":null,"abstract":"A B S T R A C T Simvastatin is a BCS class II drug, having low aqueous solubility [1.45μg/ml] and therefore low oral bioavailability [5%]. In present study attempt has been made to prepare orodispers in cyclodextrin complexes. For enhancing solubility of drug, inclusion complexes of drug were prepared using hydroxy propyl β-cyclodextrin. The inclusion coplexes prepared by solvent evaporation method exhibited highest enhancement in solubility (520μg/ml) and also showed fastest dissolution profile (99.30% of drug release in 120 min) in comparison of pure drug and other formulations. These copmlexes were characterized by solubility study, differential scanning calorimetry, and X-ray diffractometry. So, this complex was worked further for formulation of simvastatin orodispersible tablets. To aid in faster disintegration of tablets, superdisintegrants in 2 different proportions were used and their effect on 2 2 disintegration was studied. The formulation was optimized using 3 factorial design. In 3 factorial design, amount of superdisintegrant (X1) and amount of effervescing agent (X2) were selected as independent variables. The time of disintegration (Y1) and percentage of friability (Y2) were selected as dependent variables. The data clearly indicated that the disintegration time and percentage friability values strongly depend on the selected independent variables. Hence, use of hydroxyl propyl β-cyclodextrin and addition of superdisitigrants is useful technique in enhancement of dissolution rate of simvastatin. ible tablets of simvastat","PeriodicalId":21459,"journal":{"name":"RGUHS Journal of Pharmaceutical Sciences","volume":"43 1","pages":"209-215"},"PeriodicalIF":0.0,"publicationDate":"2011-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77174276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Study of wound healing activity of aqueous and alcoholic bark extracts of Acacia catechu on rats 儿茶树皮水提液和醇提液对大鼠创面愈合活性的研究

RGUHS Journal of Pharmaceutical Sciences Pub Date : 2011-11-25 DOI: 10.5530/RJPS.2011.3.8

Kumar Reddy M Baswanth, Gowda Kp Shivalinge, K. Ankit

{"title":"Study of wound healing activity of aqueous and alcoholic bark extracts of Acacia catechu on rats","authors":"Kumar Reddy M Baswanth, Gowda Kp Shivalinge, K. Ankit","doi":"10.5530/RJPS.2011.3.8","DOIUrl":"https://doi.org/10.5530/RJPS.2011.3.8","url":null,"abstract":"A B S T R A C T In this study wound healing activity of aqueous and alcoholic extracts of bark of Acacia catechu (Fabaceae) was evaluated. This plant is common in the forests of India and Burma. It is used as a mouthwash for mouth, gum, sore throat, gingivitis, dental and oral infections. It is useful in cough, diarrhea, ulcers, boils and eruptions of the skin. . Successive extraction of bark of A. catechu was carried out using different solvents viz., alcohol and water. Results confirm the presence of phytoconstituents like glycosides, carbohydrates, proteins, saponins, phytosterols, tannins, gums in the acacia catechu bark. The aqueous and alcoholic extracts of Acacia catechu bark in the form of an ointment with two different concentrations (2% and 4% w/w) were evaluated for wound healing potential in excision wound model, incision model and dead space wound model in rats. The aqueous extract of Acacia catechu at 4% w/w in both excision and incision wound models showed significant th wound healing activity. In excision model contraction of wound area (P < 0.001) at 16 day was (98 ± 0.2583), time for complete epithelization was significant (18.17 ± 0.307) and breaking strength was significant at (566.8 ± 3.902) in incision model rats. In dead space wound model both AQEAC 400mg/kg and ALEAC 400mg/kg doses showed significant increase in hydroxyproline content (4.107 ± 0.068, 4.020 ± 0.093), breaking strength (502.5 ± 5.524, 495.2 ± 7.418) and the tissue dry weight was found significant at (236.7 ± 11.16, 208.3 ± 17.78). The enhanced wound healing activity may be due to antimicrobial activity and anti inflammatory activity of the phytoconstituents present, which may be due to their individual or additive effect fastens the process of wound healing.","PeriodicalId":21459,"journal":{"name":"RGUHS Journal of Pharmaceutical Sciences","volume":"4 1","pages":"220-225"},"PeriodicalIF":0.0,"publicationDate":"2011-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81817938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Extraction and characterization of Hybiscus Rosa-Sinensis leaves mucilage for Pharmaceutical applications 药用水仙叶胶液的提取及特性研究

RGUHS Journal of Pharmaceutical Sciences Pub Date : 2011-11-25 DOI: 10.5530/RJPS.2011.3.10

L. Prabakaran, V. Murthy, M. Karpakavalli

{"title":"Extraction and characterization of Hybiscus Rosa-Sinensis leaves mucilage for Pharmaceutical applications","authors":"L. Prabakaran, V. Murthy, M. Karpakavalli","doi":"10.5530/RJPS.2011.3.10","DOIUrl":"https://doi.org/10.5530/RJPS.2011.3.10","url":null,"abstract":"A B S T R A C T The present research was related to a process of production of crude, pharmaceutically useful dry water soluble mucilage/polysaccharide from leaves of hybiscus rosa-sinensis. Extraction of water soluble mucilage/polysaccharide from leaves was performed using water, phosphate buffer solutions of pH 4.0, pH6.8 and pH 9.2 as solvents for better yield. Physicochemical characterizations and other studies such as viscosity and effect of temperature on viscosity, pH, swelling in different physiological pH conditions were discussed. The dry water soluble mucilage/polysaccharide was then used as suspending agent and solubility enhancing agent to improve the bioavailability of some model drugs which are poorly soluble in water. Highest percent yield of the dry water soluble mucilage/polysaccharide was obtained in distilled/demineralized water (14.7%) and phosphate buffer pH 9.2 (16.4%). Powder characterization study (26.32°, 0.54 g/mL, 0.73 g/mL, 22.62%, and 1.08 of angle of repose, lose bulk density, tapped bulk density, carr's index and hausner's ratio respectively) ensured the mucilage/polysaccharide suitable for Tablet formulation and higher viscosity and swelling index at distilled/demineralized water and phosphate buffer pH 7.4 respectively ensures the suitability for suspension formulation (1.0% solution gave 356cps). Hence, the extracted dry water soluble mucilage/polysaccharide from leaves of hybiscus rosa-sinensis would be useful for pharmaceutical applications with economic, toxic less and biocompatible.","PeriodicalId":21459,"journal":{"name":"RGUHS Journal of Pharmaceutical Sciences","volume":"174 1","pages":"232-238"},"PeriodicalIF":0.0,"publicationDate":"2011-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86055475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Pharmaco-photodynamics of photo-oxidised snake venom products: Comparative evaluation. 光氧化蛇毒产品的药效学-光动力学:比较评价。

RGUHS Journal of Pharmaceutical Sciences Pub Date : 2011-11-25 DOI: 10.5530/RJPS.2011.3.2

S. Gawade

引用次数: 1

Evaluation of Health Screening services to Diabetic and Hypertensive Patients in a selected Community Pharmacy set up in a District head quarters of North Karnataka 北卡纳塔克邦某地区总部选定的社区药房对糖尿病和高血压患者的健康筛查服务评价

RGUHS Journal of Pharmaceutical Sciences Pub Date : 2011-11-25 DOI: 10.5530/RJPS.2011.3.13

K. Mahendra, S. Ramakrishna, P. Sushilkumar, A. Sandeep, S. K. Bhimaray, Ravindra Katti

{"title":"Evaluation of Health Screening services to Diabetic and Hypertensive Patients in a selected Community Pharmacy set up in a District head quarters of North Karnataka","authors":"K. Mahendra, S. Ramakrishna, P. Sushilkumar, A. Sandeep, S. K. Bhimaray, Ravindra Katti","doi":"10.5530/RJPS.2011.3.13","DOIUrl":"https://doi.org/10.5530/RJPS.2011.3.13","url":null,"abstract":"A B S T R A C T Health screening services are the services provided by health professionals to screen the health status of individuals with or without positive signs and symptoms of a disease and typically which is affordable, comprehensive, reliable and inexpensive flexible test. The objective of the study is to screen the health status of diabetic and hypertensive patients in a selected community pharmacy set up. It is a prospective, investigational and community based study conducted for a period of one year. The community pharmacy set up and patients were selected based on the inclusion and exclusion criteria. Ninety eight patients were screened, 58(59.18%) diabetic with hypertension, 26(26.53%) hypertension and 14 (14.28%) diabetic, males 62(63.26%) and females 36(36.73%), systolic blood pressure normal 2(2.04%), prehypertension 42(42.85%), stage 1 hypertension 42(42.85%) and stage 2- 12(12.24%) and diastolic normal 12(12.24%), prehypertension 41(41.83%), stage 1 hypertension 38(38.77%) and stage 2 hypertension 07(07.14%). Random blood sugar level screened in 72 patients and found normal 10(13.88%), moderate 41(56.94%), severe 21(29.16%). This study finding suggest that the community pharmacy health screening services should be provided to enhance public awareness on the seriousness of diabetes and hypertension, its complications and to know their health status.","PeriodicalId":21459,"journal":{"name":"RGUHS Journal of Pharmaceutical Sciences","volume":"25 1","pages":"248-251"},"PeriodicalIF":0.0,"publicationDate":"2011-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88340998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isolation and Chemical Characterization of Essential oil of Saussurea simpsoniana 雪莲挥发油的分离及化学性质研究

RGUHS Journal of Pharmaceutical Sciences Pub Date : 2011-11-25 DOI: 10.5530/RJPS.2011.3.11

M. S. Sandhyavali, P. S. Sundari, Prabhakar Bhavikatti

{"title":"Isolation and Chemical Characterization of Essential oil of Saussurea simpsoniana","authors":"M. S. Sandhyavali, P. S. Sundari, Prabhakar Bhavikatti","doi":"10.5530/RJPS.2011.3.11","DOIUrl":"https://doi.org/10.5530/RJPS.2011.3.11","url":null,"abstract":"A B S T R A C T Inflorescence of Saussurea simpsoniana (Asteraceae) grown in Himalayas were used traditionally in treatment of fever, snake bite etc.The present work was undertaken to extract essential oil from Saussurea simpsoniana and identifying its chemical composition.Essential oil was extracted by hydrodistillation. Chemical constituents of the essential oil were separated and identified by means of gas chromarography / Mass spectroscopy (GC-MS). The chromatographic analysis of oil showed the presence of totally 18 constituents. The main components were 5, 8, 11, 14, 17- eicosapentaenoic acid methyl ester (65.42%), 9, 12, 15- octadecatrien-1-ol (14.64%), caryophyllene oxide (2.19%), cedren-13-ol (2.12%) and verrucarol (1.96%). The remaining 13 compounds were found to be in minute quantities. The physicochemical properties of the oil were determined as Specific gravity 1.023g/cc, Specific rotation 21.02, Optical rotation 0.0214 and Refractive index 1.5216. The study indicates that sesquiterpenoids are major components accounting for 88% in the isolated oil. Physicochemical standards were determined for the isolated oil.","PeriodicalId":21459,"journal":{"name":"RGUHS Journal of Pharmaceutical Sciences","volume":"18 1","pages":"239-242"},"PeriodicalIF":0.0,"publicationDate":"2011-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82932009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Formulation Design and Optimization of Fast Dissolving Effervescent Tablets of Clonazepam 氯硝西泮快溶泡腾片的处方设计与优化

RGUHS Journal of Pharmaceutical Sciences Pub Date : 2011-11-25 DOI: 10.5530/RJPS.2011.3.5

S. Shirsand, P. Swamy, D. Kusum, S. Sarasija

{"title":"Formulation Design and Optimization of Fast Dissolving Effervescent Tablets of Clonazepam","authors":"S. Shirsand, P. Swamy, D. Kusum, S. Sarasija","doi":"10.5530/RJPS.2011.3.5","DOIUrl":"https://doi.org/10.5530/RJPS.2011.3.5","url":null,"abstract":"A B S T R A C T Fast dissolving tablets of clonazepam were prepared by effervescent method with a view to enhance patient compliance. A 3² full factorial design was applied to investigate the combined effect of two formulation variables: amount of crospovidone and 1:1 mixture of sodium bicarbonate and anhydrous citric acid. Crospovidone (2-8% w/w) was used as superdisintegrant and mixture of sodium bicarbonate and anhydrous citric acid (16-48% w/w) as effervescent material, along with directly compressible mannitol to enhance mouth feel. The tablets were evaluated for hardness, friability, thickness, drug content uniformity and in vitro dispersion time. Based on in vitro dispersion time (approximately 10 sec); the formulation containing 8% w/w crospovidone and 48% w/w effervescent material was found to be promising and tested for in vitro drug release pattern (in pH 6.8 phosphate buffer),accelerated stability (at 40oC/75% relative humidity for 6 months) and drug-excipient interaction (FT-IR analysis). Surface response plots are presented to graphically represent the effect of independent variables on the in vitro dispersion time. The validity of the generated mathematical model was tested by preparing two extra-design check point formulations. The optimized tablet formulation was compared with conventional commercial tablet for drug release profiles. This formulation showed nearly nine-fold faster drug release (t 1.9 min) compared to the conventional commercial 50%","PeriodicalId":21459,"journal":{"name":"RGUHS Journal of Pharmaceutical Sciences","volume":"177 1","pages":"202-208"},"PeriodicalIF":0.0,"publicationDate":"2011-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79884003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

In vivo and in vitro inhibitory potential of Punica granatum Linn roots against melanoma tumor cells 石榴根对黑色素瘤细胞的体内外抑制作用

RGUHS Journal of Pharmaceutical Sciences Pub Date : 2011-11-25 DOI: 10.5530/RJPS.2011.3.7

H. Suresh, B. Shivakumar, S. Shivakumar

{"title":"In vivo and in vitro inhibitory potential of Punica granatum Linn roots against melanoma tumor cells","authors":"H. Suresh, B. Shivakumar, S. Shivakumar","doi":"10.5530/RJPS.2011.3.7","DOIUrl":"https://doi.org/10.5530/RJPS.2011.3.7","url":null,"abstract":"Ethanol and aqueous extracts of roots of Punica granatum linn ( punicaceae) are evaluated for In vivo anticancer activity against melanoma cells in mice and In vitro inhibitory activity on MDA- MB – 435 human melanoma cells by MTT [3-(4,5-dimethyl thiazol-2-yl)2,5-diphenyl tetrazolium bromide] colorimetric assay. Ethanol extract significantly reduced tumor growth in mice as compared with positive control and was prominently inhibitory against human melanoma cell lines (In vitro) at the concentration range between 10 to 40 µg /ml. whereas aqueous extract exhibited less activity at the same concentration. Simultaneously, the In vitro inhibition of ethanol extract against vero cell line proliferation was lower in comparison with cancer cell lines. The more significant inhibitory activity ( in vitro and in vivo) of ethanol extract of roots of Punica granatum against melanoma cells may be attributed towards the collective presence of polyphenols, alkaloids and sterols. Remarkably, the ethanol extract of roots of Punica granatum exhibited lower inhibitory effect on vero cell lines and also equipotent with standard drug to inhibit melanoma growth in mice. These observations qualify the plant to be used as chemopreventive agent in cancer therapy.","PeriodicalId":21459,"journal":{"name":"RGUHS Journal of Pharmaceutical Sciences","volume":"74 1","pages":"216-219"},"PeriodicalIF":0.0,"publicationDate":"2011-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86331495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1