RGUHS Journal of Pharmaceutical Sciences最新文献_第5页

Simultaneous Estimation and Validation of Niacin and Atorvastatin Calcium by UV-Spectroscopy in Pure and Tablet Dosage Form Using Methanol: Water Mixture as Solvent 以甲醇:水为溶剂，紫外光谱法同时测定烟酸和阿托伐他汀钙在纯剂型和片剂中的含量

RGUHS Journal of Pharmaceutical Sciences Pub Date : 2014-08-25 DOI: 10.5530/RJPS.2014.2.6

M. Ranganath, R. Chowdary

{"title":"Simultaneous Estimation and Validation of Niacin and Atorvastatin Calcium by UV-Spectroscopy in Pure and Tablet Dosage Form Using Methanol: Water Mixture as Solvent","authors":"M. Ranganath, R. Chowdary","doi":"10.5530/RJPS.2014.2.6","DOIUrl":"https://doi.org/10.5530/RJPS.2014.2.6","url":null,"abstract":"Purpose of This paper: Two simple, precise, rapid, sensitive and accurate simultaneous estimation by UV spectrophotometric methods were developed and validated for niacin (NCN) and atorvastatin calcium (ATR) in pure and tablet dosage form using methanol: water (40:60 v/v)mixture as solvent. Design and methodology: Two methods were developed, Method 1: was based on the simultaneous equation (Veroirdt's) method where as Method 2:was based on Q-analysis method. Findings: The absorption maxima were found to be 262 nm and 246 nm for niacin and atorvastatin calcium respectively. Both the drugs showed isosbestic point at 250 nm. Beer’s range was in the concentration range of 10-50 μg/ml for niacin and 4-20 μg/ml for atorvastatin calcium with correlation coefficient within the range of 0.9974 – 0.9998 for both the drugs. Recovery studies were performed to assess the accuracy of the methods, the results were found to be between 99.39 ± 0.7614 and 100.63 ± 0.3876 for niacin; 97. 71 ± 0.3131 and 99.06 ± 0.5625 for atorvastatin calcium. Research implications/limitations: The above two methods has been validated according to ICH guidelines. Practical implications: Hence the above methods can be used for routine analysis of NCN and ATR in pharmaceutical industries and research institutions.","PeriodicalId":21459,"journal":{"name":"RGUHS Journal of Pharmaceutical Sciences","volume":"2 1","pages":"70-77"},"PeriodicalIF":0.0,"publicationDate":"2014-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73190990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Drug efficacy and safety research frontiers: soul of pharmaceutical care 药物疗效与安全性研究前沿:药学服务的灵魂

RGUHS Journal of Pharmaceutical Sciences Pub Date : 2014-08-25 DOI: 10.5530/RJPS.2014.2.1

R. Thakur

{"title":"Drug efficacy and safety research frontiers: soul of pharmaceutical care","authors":"R. Thakur","doi":"10.5530/RJPS.2014.2.1","DOIUrl":"https://doi.org/10.5530/RJPS.2014.2.1","url":null,"abstract":"To unveil more information about efficacy, safety and side effects of an approved new drug it is essential that all patients who are treated with such a drug are compulsorily supervised and monitored by prescribing physicians, dispensing pharmacists and nurses and duly documented for all major and minor events during the course of therapy to correlate real time safety and efficacy with clinical trial data, collected up to phase III. Mere dependence on spontaneous reporting is insufficient, because it suffers from the vice of poor-quality reports and underreporting. Moreover, it is difficult to estimate rates and frequencies of ADRs, on this basis. Drug’s effect on specific demographics should be specifically studied and documented to obtain real time data on safety and efficacy. Pregnant & lactating women and specially those taking other medications along with the new drug need to be studied as special populations to identify effects on the fetus, infants and interaction between the drugs. As a result of extensive treatment on large population, long-term and unique/rare events/effects may be identified, which may be instrumental in ensuring safety and efficacy of therapy. This also assists in finding new markets, new indications and product extension. Thus the research fields like post marketing surveillance (PMS) and Phase IV studies have vast opportunity and practice based research must focus on this. INTRODUCTION","PeriodicalId":21459,"journal":{"name":"RGUHS Journal of Pharmaceutical Sciences","volume":"5 1","pages":"36-38"},"PeriodicalIF":0.0,"publicationDate":"2014-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90621436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vitro Reactivation of Chlorpyrifos-inhibited Rat Brain Acetylcholinesterase from 2-Quinolone Substituted Thiazole derivatives 2-喹诺酮取代噻唑衍生物对毒死蜱抑制大鼠脑乙酰胆碱酯酶的体外再激活作用

RGUHS Journal of Pharmaceutical Sciences Pub Date : 2014-08-25 DOI: 10.5530/RJPS.2014.2.4

M. Katagi, Jennifer Fernandes, D. Satyanarayana, Girish Bolakatti, Shivalingrao NagabhushanMamle

引用次数: 0

Azadirachta indica: A Plant With Versatile Potential 印楝:一种具有多用途潜力的植物

RGUHS Journal of Pharmaceutical Sciences Pub Date : 2014-08-25 DOI: 10.5530/RJPS.2014.2.2

S. Dubey, P. Kashyap

{"title":"Azadirachta indica: A Plant With Versatile Potential","authors":"S. Dubey, P. Kashyap","doi":"10.5530/RJPS.2014.2.2","DOIUrl":"https://doi.org/10.5530/RJPS.2014.2.2","url":null,"abstract":"Purpose: The purpose of this article is to present a recent update on the various uses of the indigenous plant Azadirachta indica, and to highlight its importance in various therapeutic fields in traditional as well as modern system of medicine. Design/methodology/approach: The literature review of the plant has been presented covering all the fields of research where this plant has been exploited so far. Findings: The plant possesses powerful antidermatonic and anthelmintic, insect repellent, anti-bacterial, anti-fungal, anti-viral, anti-septic, anti-inflammatory, anti-ulcer and strengthens the body’s overall immune responses. It is widely used in treating chronic malaria, bed bugs ulcer, bad teeth, syphilis, leprosy, spermicidal in preventing pregnancies and other diseases. Externally it’s the oil applied as an antiseptic for urticaria and chronic skin diseases like eczema, scabies, ring worm and maggot infested wounds. It is also used for killing lice, fleas, ticks insecticide and bacterial growth in mouth. Research limitations/implications: This tree’s beneficial values have been known for 4000 years is described by the native as the village pharmacy due to its wide spectrum of medicinal qualities. Practical implications: Over 65 patents have been derived from its various uses, which clearly indicates its practical utility in our daily lives. Social Implications: It has been traditionally used by families for curing household ailments, spermicidal in preventing pregnancies. Originality/value: The paper is an overview of various researches being carried out on the Neem.","PeriodicalId":21459,"journal":{"name":"RGUHS Journal of Pharmaceutical Sciences","volume":"2021 1","pages":"39-46"},"PeriodicalIF":0.0,"publicationDate":"2014-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87861842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Formulation and In vitro Evaluation of Loratadine Gels for Ophthalmic Use 眼用氯雷他定凝胶的制备及体外评价

RGUHS Journal of Pharmaceutical Sciences Pub Date : 2014-08-25 DOI: 10.5530/RJPS.2014.2.5

A. El-Gawad, O. Soliman, M. Shams, D. Maria

{"title":"Formulation and In vitro Evaluation of Loratadine Gels for Ophthalmic Use","authors":"A. El-Gawad, O. Soliman, M. Shams, D. Maria","doi":"10.5530/RJPS.2014.2.5","DOIUrl":"https://doi.org/10.5530/RJPS.2014.2.5","url":null,"abstract":"Background: Loratadine is an oral H 1 antihistaminic drug which exhibits poor water solubility and very low dissolution rate. Objectives: An attempt was made in the current research study to prepare loratadine as ophthalmic gels for the treatment of ocular allergic conjunctivitis. Method: Loratadine ophthalmic gels were prepared using different polymers in various proportions and combinations. The solubility study, partition coefficient, drug content, viscosity and pH of the prepared formulations as well as the release characteristics of the drug in phosphate buffer solution having pH 7.4 were measured and its release kinetics was analyzed. Results: The solubility of loratadine increased linearly as a function of b-cyclodextrin (b-CyD) concentration. Gels containing loratadine-b-CyD complex had lower viscosity relative to gels containing free drug only. The pH values of the prepared gel formulations were within the acceptable range. Loratadine released from gel formulations containing its complex in a percentage higher than that released from gel formulations containing free drug only. This indicates a higher solubilizing effect of b-CyD. Conclusion: The obtained results encouraged a further In vivo study to investigate the efficacy of loratadine in these gel formulations for the treatment of ocular allergic conjunctivitis.","PeriodicalId":21459,"journal":{"name":"RGUHS Journal of Pharmaceutical Sciences","volume":"6 1","pages":"62-69"},"PeriodicalIF":0.0,"publicationDate":"2014-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86921321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Liposomal Drug Delivery System-A Review 脂质体给药系统综述

RGUHS Journal of Pharmaceutical Sciences Pub Date : 2014-08-25 DOI: 10.5530/RJPS.2014.2.3

Deepthi, K. An

引用次数: 19

Design and Evaluation of Orodispersible Tablets of Sumatriptan Succinate 琥珀酸舒马匹坦多孔分散片的设计与评价

RGUHS Journal of Pharmaceutical Sciences Pub Date : 2012-10-04 DOI: 10.5530/RJPS.2012.3.4

Sreenivasa Rao, Patil Kg, Dattatreya B. Udgirkar, P. Patil, K. V. Biradar

{"title":"Design and Evaluation of Orodispersible Tablets of Sumatriptan Succinate","authors":"Sreenivasa Rao, Patil Kg, Dattatreya B. Udgirkar, P. Patil, K. V. Biradar","doi":"10.5530/RJPS.2012.3.4","DOIUrl":"https://doi.org/10.5530/RJPS.2012.3.4","url":null,"abstract":"The demand for Orodispersible tablet (ODT) has been growing during the last decade. Sumatriptan Succinate used in the treatment of migraine and cluster headache. Sumatriptan Succinate is a 5-HT 1 receptor agonist, undergo extensive fi rst pass metabolism with an oral bioavailability of 14%. In present work an attempt has been made to prepare Orodispersible tablets of Sumatriptan Succinate with increased rate of dissolution May leads to increase bioavailability by using sodium starch glycolate, Crosscarmellose sodium and Crospovidone as Superdisintegrants by direct compression methods. The prepared tablets were evaluated for various parameters like hardness, friability, average weight, thickness, in vitro disintegration time, wetting time, water absorption ratio, uniformity of drug content, in vitro dissolution study, drug-polymer interaction, in vitro drug release, IR studies and short term stability and compatibility studies. Superdisintegrant of Croscarmellose sodium containing Sumatriptan Succinate compressed tablets showed highest in vitro drug release of 93% within 30 min. and there is no variation in the position of characteristic absorption bands it reveals that there is no interaction between drug and polymer.","PeriodicalId":21459,"journal":{"name":"RGUHS Journal of Pharmaceutical Sciences","volume":"74 1","pages":"41-47"},"PeriodicalIF":0.0,"publicationDate":"2012-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88571661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Phytochemical Screening, Antimicrobial and Antioxidant Activity of Indigofera Linnaei 林奈靛蓝植物化学筛选及抗菌抗氧化活性研究

RGUHS Journal of Pharmaceutical Sciences Pub Date : 2012-10-04 DOI: 10.5530/RJPS.2012.3.11

Sandhyavali, P. Sivakamisundari, P. Sharma, V. Murugan

{"title":"Phytochemical Screening, Antimicrobial and Antioxidant Activity of Indigofera Linnaei","authors":"Sandhyavali, P. Sivakamisundari, P. Sharma, V. Murugan","doi":"10.5530/RJPS.2012.3.11","DOIUrl":"https://doi.org/10.5530/RJPS.2012.3.11","url":null,"abstract":"The present study deals with the preliminary phytochemical study of Indigofera linnaei of family Fabaceae which is commonly known as Birdsville indigo. The Indigofera species has been cited in various literatures for its use in treating rheumatism, arthritis, infl ammation, tumor and liver diseases. The Pharmacognostical study revealed presence of important constituents like alkaloids, saponins, fl avonoids, terpenoids, steroids and tannins. The aerial part of the plant was macerated with methanol to get the methanolic extract. The Antimicrobial Activity of methanolic extract of Indigofera linnaei was performed using agar well diffusion method. The extract was tested against 4 different species of human pathogenic bacteria including two species of gram-negative (E.coli and Klebsiella pneumoniae) and two species of gram-positive bacteria (Staphylococcus aureus and Bacillus subtilis). The zone of inhibition was observed and the response was compared with the standard drug, Streptomycin. The observations revealed that the extract showed considerable antibacterial activity against Bacillus subtilis. The extract exhibited moderate activity in case of Staphylococcus aureus. However, very mild activity was observed against gram negative organisms. The two extracts i.e. chloroform and methanol extract of Indigofera linnaei were studied for their antioxidant potential. The activityof two extracts were compared by in vitro methods namely DPPH and Hydrogen Peroxide Assay. Ascorbic acid was used as standard in DPPH method. The in vitro antioxidant study revealed that the extract showed good antioxidant activity as compared to the chloroform extract which showed less inhibitory effect in DPPH method while in hydrogen peroxide assay, chloroform extract showed good antioxidant activity compared to methanol extract.","PeriodicalId":21459,"journal":{"name":"RGUHS Journal of Pharmaceutical Sciences","volume":"18 1","pages":"100-106"},"PeriodicalIF":0.0,"publicationDate":"2012-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79105550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Navigating Your Way Through Online Resources for Biomedical Research 通过生物医学研究的在线资源导航你的方式

RGUHS Journal of Pharmaceutical Sciences Pub Date : 2012-10-04 DOI: 10.5530/RJPS.2012.3.2

P. Balakumar, Sharon Marcus, G. Jagadeesh

引用次数: 2

Microspheres: Mucoadhesion Based Controlled Drug Delivery System 微球:基于黏附的受控给药系统

RGUHS Journal of Pharmaceutical Sciences Pub Date : 2012-10-04 DOI: 10.5530/RJPS.2012.3.3

N. Jain, Neha Gulati, D. Kumar, Upendra Nagaich

{"title":"Microspheres: Mucoadhesion Based Controlled Drug Delivery System","authors":"N. Jain, Neha Gulati, D. Kumar, Upendra Nagaich","doi":"10.5530/RJPS.2012.3.3","DOIUrl":"https://doi.org/10.5530/RJPS.2012.3.3","url":null,"abstract":"A well designed controlled drug delivery system can overcome several problems of conventional therapy and also enhance the therapeutic effi cacy of active pharmaceutical compounds. There are various approaches for the delivery of therapeutic substance to the target site in a controlled release fashion. One such approach is using microspheres as carriers for drugs or active pharmaceutical compound. However, the success of this drug delivery system is limited due to their short residence time at the site of absorption. Thus, mucoadhesion characteristics are coupled to microspheres to develop a novel delivery system referred to as “mucoadhesive microspheres”. These mucoadhesive carriers provide an intimate contact with the mucus layer and specifi c targeting of drugs to the absorption site. In recent years, mucoadhesive microspheres have been developed for oral, buccal, nasal, ocular, rectal and vaginal for either systemic or local effects. Present work highlights the numerous aspects of microspheres i.e. method of preparation, delivery route, various polymers used for preparation and applications. Moreover, recent patents granted till now are also discussed in detail.","PeriodicalId":21459,"journal":{"name":"RGUHS Journal of Pharmaceutical Sciences","volume":"15 1","pages":"28-40"},"PeriodicalIF":0.0,"publicationDate":"2012-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89573495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9