Design and Evaluation of Orodispersible Tablets of Sumatriptan Succinate

The demand for Orodispersible tablet (ODT) has been growing during the last decade. Sumatriptan Succinate used in the treatment of migraine and cluster headache. Sumatriptan Succinate is a 5-HT 1 receptor agonist, undergo extensive fi rst pass metabolism with an oral bioavailability of 14%. In present work an attempt has been made to prepare Orodispersible tablets of Sumatriptan Succinate with increased rate of dissolution May leads to increase bioavailability by using sodium starch glycolate, Crosscarmellose sodium and Crospovidone as Superdisintegrants by direct compression methods. The prepared tablets were evaluated for various parameters like hardness, friability, average weight, thickness, in vitro disintegration time, wetting time, water absorption ratio, uniformity of drug content, in vitro dissolution study, drug-polymer interaction, in vitro drug release, IR studies and short term stability and compatibility studies. Superdisintegrant of Croscarmellose sodium containing Sumatriptan Succinate compressed tablets showed highest in vitro drug release of 93% within 30 min. and there is no variation in the position of characteristic absorption bands it reveals that there is no interaction between drug and polymer.