RGUHS Journal of Pharmaceutical Sciences最新文献_第3页

Sustained Release Matrix Tablets of Furosemide 速尿缓释基质片

RGUHS Journal of Pharmaceutical Sciences Pub Date : 2015-01-01 DOI: 10.5530/rjps.2015.3.4

D. Nagendrakumar, G. KeshavshettiG, G. ShardorA

引用次数: 3

Drug Discovery and Development Challenges 药物发现和开发挑战

RGUHS Journal of Pharmaceutical Sciences Pub Date : 2015-01-01 DOI: 10.5530/rjps.2015.2.1

R. Thakur

引用次数: 0

Formulation and Evaluation of In situ Gel of Atorvastatin for the Treatment of Periodontitis 阿托伐他汀原位凝胶治疗牙周炎的配方及疗效评价

RGUHS Journal of Pharmaceutical Sciences Pub Date : 2015-01-01 DOI: 10.5530/rjps.2015.2.4

M. Ahmed, R. Chaudhari, Ankit Acharya

{"title":"Formulation and Evaluation of In situ Gel of Atorvastatin for the Treatment of Periodontitis","authors":"M. Ahmed, R. Chaudhari, Ankit Acharya","doi":"10.5530/rjps.2015.2.4","DOIUrl":"https://doi.org/10.5530/rjps.2015.2.4","url":null,"abstract":"Purpose: The main objective of present study is to formulate and evaluate methyl cellulose based in situ periodontal gel of Atorvastatin. Approach: The in situ gel was prepared by using different concentration of methyl cellulose and gel was evaluated for pH, viscosity and rheology, syringeability, drug content, in vitro drug release, and drug release kinetics. Findings: Compatibility study was performed using FTIR and results showed there was no interaction between drug and other excipients. Viscosity of all formulations was found in the range of 320-570 centipoise and all formulations exhibited pseudoplastic behaviour. Gelation time and temperature was found in the range of 6-17 min and 29 o -39 o respectively. All the formulation except formulation G6 and G7 showed satisfactory syringeability due to lower concentration of polymer. Based on the results of release study, formulation G5 was found to be optimum formulation as it released 96.87% drug at the end of 24 h. In vitro release study revealed that release rate of drug from the in situ gel was concentration dependent; as concentration of methyl cellulose increased the drug release rate was retarded. Conclusion: It can be concluded that formulation containing 0.9%w/v of methyl cellulose gave optimized formulation.","PeriodicalId":21459,"journal":{"name":"RGUHS Journal of Pharmaceutical Sciences","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78538189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Preparation and Evaluation of Antidiabetic Activity of Allium cepa-Phospholipid Complex (Phytosome) in Streptozotocin Induced Diabetic Rats 葱a磷脂复合物(Phytosome)对链脲佐菌素诱导的糖尿病大鼠抗糖尿病活性的研究

RGUHS Journal of Pharmaceutical Sciences Pub Date : 2015-01-01 DOI: 10.5530/rjps.2015.4.3

P. Habbu, Smita Madagundi, R. Shastry, Rashmi Vanakudri, V. Kulkarni

{"title":"Preparation and Evaluation of Antidiabetic Activity of Allium cepa-Phospholipid Complex (Phytosome) in Streptozotocin Induced Diabetic Rats","authors":"P. Habbu, Smita Madagundi, R. Shastry, Rashmi Vanakudri, V. Kulkarni","doi":"10.5530/rjps.2015.4.3","DOIUrl":"https://doi.org/10.5530/rjps.2015.4.3","url":null,"abstract":"Purpose: A phytoformulation, Allium cepa-phospholipid complex (ACP) was prepared, characterized and evaluated for its antidiabetic activity in Streptozotocin (STZ) induced rats. Methodology: ACP was prepared and characterized by SEM, DSC and FT-IR. It was then screened for in vitro free radical scavenging, antidiabetic activity (50 mg/kg and 100 mg/kg, p.o.) in normoglycemic and STZ induced diabetic animals. Concentration of quercetin in ACP was estimated in serum by HPLC. Findings: SEM data showed that ACP has irregular size vesicles consisting of HSPC and ACE intercalated in the lipid layer. ACP showed one endothermal peak in DSC studies. ACP showed good in vitro antioxidant activity. In OGTT, treatment with ACE (Allium cepa extract), ACP and glibenclamide significantly improved the glucose tolerance in normal animals. In STZ induced diabetic rats, a single dose of ACE and ACP treatment exhibited reduction in SG levels at different time intervals compared to basal levels. Administration of both the doses of ACE and ACP for fifteen days exhibited greater percentage reduction in glycemia and restored to near normal value of all tested lipid parameters. Higher serum concentration of quercetin was observed for ACP in bioavailability studies as compared to ACE. Conclusion: ACP has shown significant antioxidant, antidiabetic activity and hypolipidemic activity in STZ induced rats as compared to ACE at the dose studied.","PeriodicalId":21459,"journal":{"name":"RGUHS Journal of Pharmaceutical Sciences","volume":"71 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80411268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Eucalyptol: Safety and Pharmacological Profile 桉树精油:安全性和药理学概况

RGUHS Journal of Pharmaceutical Sciences Pub Date : 2015-01-01 DOI: 10.5530/rjps.2015.4.2

Mridul Bhowal, M. Gopal

引用次数: 50

Targeted Drug Delivery Systems Mediated Through Nasal Delivery for Improved Absorption: an Update 通过鼻腔给药介导改善吸收的靶向给药系统:最新进展

RGUHS Journal of Pharmaceutical Sciences Pub Date : 2015-01-01 DOI: 10.5530/rjps.2015.1.2

N. Rakesh, Arshad Khan

{"title":"Targeted Drug Delivery Systems Mediated Through Nasal Delivery for Improved Absorption: an Update","authors":"N. Rakesh, Arshad Khan","doi":"10.5530/rjps.2015.1.2","DOIUrl":"https://doi.org/10.5530/rjps.2015.1.2","url":null,"abstract":"Purpose: This review article focuses on providing updated information about targeting the nasal mucosa for drug delivery. The article would serve as a tool for researchers and students to gain insight into the various aspects of nasal drug delivery. Approach: The anatomy and physiology of the nasal region have been discussed, followed by a discussion of the factors and barriers affecting the drug absorption, strategies to improve the drug absorption, various excipients employed in nasal formulations, different types of nasal formulations and applications of nasal delivery. Findings: The high permeability, high vascularity, very low enzymatic activity, accessible surface area and avoidance of first pass hepatic metabolism are the main factors for which it is being considered as a superior delivery route for many drugs in the recent decades. The effects which are mainly systemic encourage the deployment of this route of administration. This route of drug delivery has been also been exploited for delivering the drugs to the central nervous system bypassing the Blood Brain Barrier (BBB). Different forms of dosage forms such as sprays, powders, gels, solutions are administered through this route. Conclusion: Intranasal delivery of drugs is a promising alternative to other routes of administration because, it is rapid and non-invasive and leads to increased bioavailability of poorly bioavailable drugs. The dose of the drug used is minimal compared to other routes hence the systemic side effects are reduced. Compared to parenteral administration it has better compliance and improved patient acceptability. More fundamental research will lead to better understanding of this route and eventually more marketed products.","PeriodicalId":21459,"journal":{"name":"RGUHS Journal of Pharmaceutical Sciences","volume":"66 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90913141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Evaluation and Failure Risk of Microbiological Air Quality in Production Area of Pharmaceutical Plant 制药厂生产区微生物空气质量评价及失效风险分析

RGUHS Journal of Pharmaceutical Sciences Pub Date : 2015-01-01 DOI: 10.5530/rjps.2015.4.5

M. Eissa, A. Mahmoud, A. S. Nouby

引用次数: 3

Formulation and Evaluation of Mucoadhesive Vaginal Films of Ketoconazole 酮康唑黏附阴道膜的研制及评价

RGUHS Journal of Pharmaceutical Sciences Pub Date : 2015-01-01 DOI: 10.5530/rjps.2015.2.5

Arshad Khan, C. Saha

{"title":"Formulation and Evaluation of Mucoadhesive Vaginal Films of Ketoconazole","authors":"Arshad Khan, C. Saha","doi":"10.5530/rjps.2015.2.5","DOIUrl":"https://doi.org/10.5530/rjps.2015.2.5","url":null,"abstract":"Purpose: The aim of the present study was to formulate and evaluate mucoadhesive films containing Ketoconazole (KT) for the treatment of vaginal infections. Method: The vaginal films were made by solvent casting technique with different ratios of chitosan as mucoadhesive polymer. The prepared films were evaluated for their weight uniformity, thickness uniformity, drug content, folding endurance, in vitro diffusion, in vitro mucoadhesion study, in vitro dissolution and accelerated stability studies at 40 o ± 2 o /75% ± 5% for three months. Results: Compatibility studies by FTIR showed that there was no significant interaction between drug and polymer used. The weight of films was found to be between 1.03 g to 2.47 g. The thickness of films ranged between 0.15 mm to 0.32 mm. The drug content was found to be between 80.5% to 93.7% w/w. The folding endurance of films was found to be between 72.6 and 175.66. Mucoadhesive strength of films ranged between 17.45 g to 26.72 g. F4 was selected as the best formulation based on the evaluation studies and it showed zero order release. Conclusion: Based on the in vitro results it was concluded that the mucoadhesive films prepared with chitosan can be used as controlled drug delivery system and frequency of drug administration can be minimized leading to better patient compliance.","PeriodicalId":21459,"journal":{"name":"RGUHS Journal of Pharmaceutical Sciences","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88291985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Formulation and in vitro Evaluation of Modified Release Oral Hydrogel Driven Drug Delivery Systems of Diethylcarbamazine Citrate 枸橼酸二乙基卡马嗪口服水凝胶缓释系统的制备及体外评价

RGUHS Journal of Pharmaceutical Sciences Pub Date : 2015-01-01 DOI: 10.5530/rjps.2015.2.2

Raja Rajeswari Kamisetti, Winnie Vilasitha, S. Muvvala, R. Alluri, Durga Bhavani Penmatsa

{"title":"Formulation and in vitro Evaluation of Modified Release Oral Hydrogel Driven Drug Delivery Systems of Diethylcarbamazine Citrate","authors":"Raja Rajeswari Kamisetti, Winnie Vilasitha, S. Muvvala, R. Alluri, Durga Bhavani Penmatsa","doi":"10.5530/rjps.2015.2.2","DOIUrl":"https://doi.org/10.5530/rjps.2015.2.2","url":null,"abstract":"Objective: Hydrogels are three dimensional polymer matrices that are capable of imbibing large quantity of water, and biological fluids and used in the modifying release of the drugs. The present work was aimed to study oral hydrogel driven drug delivery systems of Diethylcarbamazine Citrate as a model drug. Methodology: The Hydrogels were composed of Poly acrylamide, Hydroxyethyl methacrylate using ionotropic gelation method using starch. Results: Thermographs showed no incompatibility between the drug and the polymers. Scanning Electron photomicrographs showed a rough contour surface. Drug release studied by High Pressure Liquid Chromatography using acetonitrile/0•01M phosphate buffer pH 6•8 at 210 nm showed that Formulation 9 released 98.67% of the dose in 16 h as compared to the marketed formulation which released 98.66% up to 6 h. The release followed first order kinetics and non-fickian diffusion by super case-II transport mechanism. Accelerated stability studies performed as per ICH guidelines at 40° ± 2° and 75 ± 5% RH and at ambient conditions of 25° ± 2° and 60 ± 5% RH showed that the hydrogel was stabile. Conclusion: It is concluded that hydrogel can be recommended as modified release dosage forms for industrial applications.","PeriodicalId":21459,"journal":{"name":"RGUHS Journal of Pharmaceutical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90717679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Good Publication Practices 良好出版守则

RGUHS Journal of Pharmaceutical Sciences Pub Date : 2015-01-01 DOI: 10.5530/rjps.2015.4.1

R. Thakur

引用次数: 0