Sustained Release Matrix Tablets of Furosemide

Abstract

Objective: The objective of the present study was to develop and evaluate once-daily sustained release matrix tablets of furosemide using hydroxypropylmethyl cellulose K4M, xanthan gum and sodium alginate as release retarding polymers. Methodology: The matrix tablet formulations were prepared by using different drug: polymer ratios (1:1, 1:2, 1:3, 1:4 and 1:5). The prepared matrix tablets were evaluated for pre-compression parameters like angle of repose, bulk density, tap density and post-compression parameters like hardness, thickness, weight variation, friability, percent drug content and in vitro drug release studies as per USP guidelines. Results: The in vitro drug release data of all the prepared tablet formulations of furosemide were subjected to goodness of fit test by linear regression analysis according to zeroorder and first-order kinetics. Conclusion: The formulation SF 2 containing drug: sodium alginate ratio of 1:2 offered the required in vitro drug release rate according to the official limits of drug release as per USP and selected as a promising formulation among the fifteen formulations which shows 85% drug release in 12 hrs.