Formulation and Evaluation of In situ Gel of Atorvastatin for the Treatment of Periodontitis

Abstract

Purpose: The main objective of present study is to formulate and evaluate methyl cellulose based in situ periodontal gel of Atorvastatin. Approach: The in situ gel was prepared by using different concentration of methyl cellulose and gel was evaluated for pH, viscosity and rheology, syringeability, drug content, in vitro drug release, and drug release kinetics. Findings: Compatibility study was performed using FTIR and results showed there was no interaction between drug and other excipients. Viscosity of all formulations was found in the range of 320-570 centipoise and all formulations exhibited pseudoplastic behaviour. Gelation time and temperature was found in the range of 6-17 min and 29 o -39 o respectively. All the formulation except formulation G6 and G7 showed satisfactory syringeability due to lower concentration of polymer. Based on the results of release study, formulation G5 was found to be optimum formulation as it released 96.87% drug at the end of 24 h. In vitro release study revealed that release rate of drug from the in situ gel was concentration dependent; as concentration of methyl cellulose increased the drug release rate was retarded. Conclusion: It can be concluded that formulation containing 0.9%w/v of methyl cellulose gave optimized formulation.