Scandinavian Journal of Rheumatology最新文献

{"title":"Recombinant adjuvant zoster vaccine-associated acute mucocutaneous toxicity.","authors":"N Choma, H Kumaresan, E Haury, S Ifteqar","doi":"10.1080/03009742.2025.2580769","DOIUrl":"10.1080/03009742.2025.2580769","url":null,"abstract":"","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":" ","pages":"298-299"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145506720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nephrogenic diabetes insipidus in normocalcaemic multiorgan sarcoidosis: a rare renal manifestation.","authors":"M C Ataca, E Ataca, S Gülle, S M Deger, M O Tarhan","doi":"10.1080/03009742.2025.2595826","DOIUrl":"10.1080/03009742.2025.2595826","url":null,"abstract":"","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":" ","pages":"303-305"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145725776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delayed-onset angioedema and urticaria during long-term hydroxychloroquine therapy in Sjögren's disease.","authors":"A Nigro","doi":"10.1080/03009742.2026.2615493","DOIUrl":"10.1080/03009742.2026.2615493","url":null,"abstract":"","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":" ","pages":"306-307"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146202435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of concomitant peripheral arthritis in early axial spondyloarthritis: results from a 24 month follow-up (Italian arm of SPACE study).","authors":"M Lorenzin, G Cozzi, L Scagnellato, S Vio, V Scapin, A Damasco, G De Conti, A Doria, R Ramonda","doi":"10.1080/03009742.2026.2616969","DOIUrl":"10.1080/03009742.2026.2616969","url":null,"abstract":"<p><strong>Objective: </strong>Although peripheral arthritis (PA) is common in early axial spondyloarthritis (axSpA), its influence on spinal/pelvic structural damage and disease activity remains unclear. We aimed to assess associations between PA, clinical and disease activity indices, and imaging features in early axSpA.</p><p><strong>Method: </strong>Baseline data analysis of the Italian SPACE cohort, including patients with chronic back pain (duration ≥3 months and ≤2 years; age of onset <45 years), was conducted. axSpA was diagnosed by magnetic resonance imaging and X-rays of the sacroiliac joints. Clinical features, disease activity, and functional indices were collected at baseline, and at 12 and 24 months. Characteristics of axSpA in patients with concomitant PA were evaluated over time using descriptive statistics. A logistic regression model was built to assess associations between baseline features and PA.</p><p><strong>Results: </strong>Ninety-one patients had axSpA (83.5% non-radiographic; 16.5% radiographic); 44% had PA. axSpA patients with PA less frequently had human leucocyte antigen B27 positivity (35% vs 43.1%; p = 0.02) and uveitis (5% vs 9.8%; p = 0.03) and more frequently had dactylitis (37.5% vs 0%; p < 0.01) and enthesitis (82.5% vs 56.9%; p = 0.02). Functional and disease activity indices improved overall. PA was independently associated with higher baseline C-reactive protein (p = 0.004) and dactylitis (p = 0.02) in multivariable analysis.</p><p><strong>Conclusion: </strong>axSpA patients with PA more often had other peripheral manifestations and increased disease activity and functional impairment, and revealed possible differences in axial involvement. These differences may be important in treatment decisions and warrant further investigation.</p>","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":" ","pages":"236-246"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147284919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of colchicine adherence and influencing factors in paediatric familial Mediterranean fever.","authors":"Ş Erdem Torun, E Çelikel, Z Ekici Tekin, Ş Ertem, M A Özçelik, E Özçelik, M C Polat, D Öztürk, M Işıklar Ekici, Y Uğur Es, S N Yoğun, B Çelikel Acar","doi":"10.1080/03009742.2026.2618334","DOIUrl":"10.1080/03009742.2026.2618334","url":null,"abstract":"<p><strong>Objective: </strong>This study evaluated colchicine adherence in children and adolescents with familial Mediterranean fever (FMF) using the Medication Adherence Scale in FMF Patients (MASIF), and examined the influence of patient-related factors and family history.</p><p><strong>Method: </strong>A cross-sectional study was conducted among 324 paediatric FMF patients (1-18 years old). Colchicine adherence was measured via MASIF, and demographic, clinical, genetic, and socioeconomic variables were analysed.</p><p><strong>Results: </strong>Of 324 patients (mean age 11.8 ± 3.8 years), 88 (27.2%) showed good adherence and 236 (72.8%) poor adherence. Adherence was not significantly associated with sex, age group, age at diagnosis, disease severity, family history, colchicine intolerance/resistance, or biologic use. Erysipelas-like erythema was present in 28 patients (8.6%) at diagnosis and correlated with better adherence (p = 0.016). Of the 142 patients (43.8%) who self-reported regular colchicine use, MASIF indicated poor adherence in 101 (71.1%). School absenteeism was reported in 41 (46.6%) of the adherent group and 171 (72.5%) of the non-adherent group (p < 0.001).</p><p><strong>Conclusion: </strong>Colchicine non-adherence is frequent in paediatric FMF and largely unrelated to patient factors. Objective tools such as MASIF reveal higher non-adherence rates than self-reports and are essential for accurate evaluation in clinical decision making.</p>","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":" ","pages":"289-297"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146202403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated serum immunoglobulin A predicts extra-articular manifestations in axial spondyloarthritis.","authors":"A Pistone, M Soyfoo, L Tant","doi":"10.1080/03009742.2026.2677298","DOIUrl":"https://doi.org/10.1080/03009742.2026.2677298","url":null,"abstract":"<p><strong>Objective: </strong>To determine whether serum immunoglobulin A (IgA) identifies an extra-articular-prone phenotype in axial spondyloarthritis (axSpA) and assess its clinical utility.</p><p><strong>Method: </strong>We retrospectively analysed 402 patients with axSpA. Elevated IgA was defined as > 4.0 g/L. Associations with extra-articular manifestations (EAMs) were evaluated by logistic regression, and time to first EAM by Kaplan-Meier and Cox models. Discrimination and clinical utility were assessed.</p><p><strong>Results: </strong>During follow-up, 45.5% of patients developed ≥1 EAM and 8.7% developed ≥2. Elevated IgA occurred in 15.0% overall but was more common in patients with multiple EAMs (40.6%) than in those without (10.9%) or with a single EAM (14.7%); corresponding odds ratios were 5.57 (95% CI 2.41-12.89, p < 0.001) and 3.98 (1.66-9.54). Elevated IgA predicted ≥2 EAMs with 40.6% sensitivity, 89.0% specificity, and an area under the curve of 0.65, rising to 0.78 when combined with C-reactive protein (CRP). Kaplan-Meier analysis showed reduced EAM-free survival with elevated IgA (p = 0.008). In Cox models, elevated IgA independently predicted incident EAMs (hazard ratio 2.28, 95% CI 1.18-4.40, p = 0.014). Decision-curve analysis indicated a positive net benefit. Crohn's disease was overrepresented among patients with elevated IgA (33.3% vs 11.4%, p < 0.0001).</p><p><strong>Conclusion: </strong>Elevated serum IgA delineates an intestinally biased, extra-articular-prone axSpA phenotype and provides actionable information beyond CRP, supporting the integration of IgA-based risk stratification into EAM surveillance.</p>","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":" ","pages":"1-8"},"PeriodicalIF":1.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148369681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodal imaging in the diagnosis of iliopsoas bursitis complicating biological therapy in rheumatoid arthritis: a case report with therapeutic implications.","authors":"Ü C Ateş, S Gülle, C Koçak Ateş","doi":"10.1080/03009742.2026.2690725","DOIUrl":"https://doi.org/10.1080/03009742.2026.2690725","url":null,"abstract":"","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":" ","pages":"1-2"},"PeriodicalIF":1.5,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148353655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cervical spine instability in axial spondyloarthritis: prevalence, patterns, and predictive factors in a high-risk cohort.","authors":"S Ketenci, A Kababıyık, H Oğuzman, M Pekdiker","doi":"10.1080/03009742.2026.2674341","DOIUrl":"https://doi.org/10.1080/03009742.2026.2674341","url":null,"abstract":"<p><strong>Objective: </strong>Although axial spondyloarthritis (axSpA) is an inflammatory disease primarily affecting the spine, studies investigating cervical spine instability (CSI) are limited, and no research has comprehensively evaluated all forms of CSI. This study aimed to determine the frequency and associated factors of CSI in axSpA patients.</p><p><strong>Method: </strong>This retrospective cross-sectional study, conducted in a single tertiary rheumatology unit, included adult axSpA patients with inflammatory back pain duration of > 10 years and receiving biological or targeted synthetic therapy. Patients with any concomitant disease that could affect the spine were excluded. CSI lesions were assessed using lateral neutral, full extension, full flexion, and open-mouth anteroposterior cervical radiographs. Radiographs were evaluated by two blinded rheumatologists.</p><p><strong>Results: </strong>In total, 159 axSpA cases (ankylosing spondylitis: 89.3%; non-radiographic axSpA: 10.7%) were included in the study; 57.9% were male, mean age was 47 years, and mean disease duration was 17 years. A total of 33 CSI lesions was detected in 31 patients (19.5%); the most common was anterior atlantoaxial subluxation (54.5%), followed by subaxial (33.3%) and vertical subluxation (6.1%). In univariate logistic regression analysis; disease duration (p = 0.004), age at first symptom (p = 0.02), uveitis (p = 0.049), and sacroiliitis stage (p = 0.039) were associated with CSI. In multivariate analysis, disease duration was identified as a potential independent predictor of CSI (p = 0.027).</p><p><strong>Conclusion: </strong>These results highlight the need for increased clinical awareness of CSI in axSpA, and support consideration of cervical imaging in patients with prolonged disease duration, severe sacroiliitis, or uveitis.</p>","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":" ","pages":"1-8"},"PeriodicalIF":1.5,"publicationDate":"2026-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148278722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world clinical outcomes of patients with disproportionate articular pain in rheumatoid arthritis: ANSWER cohort study.","authors":"K Murata, T Fujii, K Ebina, Y Etani, M Katayama, Y Nozaki, C Ashida, T Okano, M Hashimoto, T Kotani, H Shiba, Y Son, N Yoshida, I Shirasugi, S Hayashi, W Yamamoto, S Nakabo, K Murakami, A Onishi, M Tanaka, A Morinobu, S Matsuda","doi":"10.1080/03009742.2026.2680764","DOIUrl":"https://doi.org/10.1080/03009742.2026.2680764","url":null,"abstract":"<p><strong>Purpose: </strong>In rheumatoid arthritis (RA), some patients experience joint pain that is disproportionate to the number of swollen joints, known as disproportionate articular pain (DP). This study aimed to clarify the prevalence and persistence of DP and to compare the outcomes across biological and targeted synthetic disease-modifying anti-rheumatic drugs (b/tsDMARDs).</p><p><strong>Materials and methods: </strong>From the ANSWER cohort in Japan, 5489 RA patients who initiated b/tsDMARDs between January 2010 and June 2024 were screened. DP was defined as having at least seven more tender joints (TJC) than swollen joints at baseline, and 432 patients met this criterion. Persistence of DP at 3 and 6 months was evaluated. Comparative analyses were conducted across mechanisms of action (MOAs): tumour necrosis factor-α inhibitors (TNFi), cytotoxic T-lymphocyte-associated antigen-4 immunoglobulin (CTLA4-Ig), interleukin-6 inhibitors (IL-6i), and Janus kinase inhibitors (JAKi).</p><p><strong>Results: </strong>DP was identified in 7.8% of RA patients. At 3 months, DP persisted in 40.7% (TNFi), 36.5% (CTLA4-Ig), 48.0% (IL-6i), and 54.4% (JAKi). At 6 months, corresponding rates were 43.8%, 38.7%, 49.3%, and 61.1%. Multivariate analysis showed that higher TJC and previous treatment with two or more b/tsDMARDs were associated with persistent DP, whereas higher C-reactive protein was protective. Within JAKi, baricitinib showed lower DP persistence compared with other JAKi.</p><p><strong>Conclusion: </strong>DP was present in approximately 8% of RA patients. Persistent DP was associated with higher TJC, greater number of previous b/tsDMARDs, and lower inflammation. No MOA was clearly superior; however, baricitinib may confer a relative benefit within the JAKi class.</p>","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":" ","pages":"1-12"},"PeriodicalIF":1.5,"publicationDate":"2026-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148278655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and histopathological features of a population-based cohort of 95 consecutive patients with immunoglobulin G4-related disease in Stockholm, Sweden, during a five-year period.","authors":"S Fahlstedt, J A Mohammad, E Seyhoglu, A Bengtsson, L Dani, L Vasaitis, J Mofors","doi":"10.1080/03009742.2026.2673625","DOIUrl":"https://doi.org/10.1080/03009742.2026.2673625","url":null,"abstract":"<p><strong>Objective: </strong>To describe the epidemiology, organ involvement, histopathological patterns, and clinical management of immunoglobulin G4-related disease (IgG4-RD) in Stockholm County, Sweden.</p><p><strong>Method: </strong>Patients with an International Classification of Diseases, 10th revision, Swedish Edition (ICD-10-SE) diagnosis of IgG4-RD recorded between 2019 and 2023 were identified from the Swedish National Patient Register, encompassing all diagnoses recorded in inpatient and specialist outpatient care. Clinical data, laboratory results, histopathology reports, and treatment information were obtained through systematic medical record review.</p><p><strong>Results: </strong>In total, 112 patients with a registered IgG4-RD diagnosis were identified, of which 95 diagnoses were confirmed after medical record review. The cohort was predominantly male (68%), and 60% had disease involvement of two or more organs. Elevated serum IgG4 was present in 71% of patients. The pancreas, hepatobiliary system, and kidneys were the most frequently affected organs, while salivary gland involvement was comparatively uncommon. Among patients who underwent biopsy (76%), a majority showed histopathological features supportive of IgG4-RD, although only a minority fulfilled multiple histopathological criteria. Comorbidities at the time of diagnosis were similar to those observed in the general older population, although an elevated prevalence of nasal polyposis and asthma was observed. Most patients received systemic glucocorticoids, either alone or in combination with rituximab. Overall, the prognosis was favourable, with high remission rates.</p><p><strong>Conclusion: </strong>IgG4-RD in Stockholm County shows a pancreatohepatobiliary-renal dominant pattern, with relatively few glandular cases compared to Asian and US cohorts. Histopathological confirmation was supportive in most biopsied patients, although many affected organs were not biopsied.</p>","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":" ","pages":"1-6"},"PeriodicalIF":2.1,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148259330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}