Scandinavian Journal of Rheumatology最新文献

Anti-synthetase syndrome with fungal infection and viral encephalitis: a case report. 抗合成酶综合征并发真菌感染和病毒性脑炎1例。

IF 2.2 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2025-07-18 DOI: 10.1080/03009742.2025.2524950

Y Ding, L Jia, L Zhou

引用次数: 0

Disease Activity Score in 28 joints using C-reactive protein based remission state and still residual swollen joints: theoretically possible, but does it occur in the real world? 使用基于c反应蛋白的缓解状态和残余肿胀关节的28个关节的疾病活动评分：理论上可能，但它在现实世界中发生吗？

IF 2.2 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2025-07-07 DOI: 10.1080/03009742.2025.2506206

Psm Groenen, N den Broeder, Mhm Wientjes, A A den Broeder

引用次数: 0

Impact of tumour necrosis factor-α inhibitors on non-invasive indices of hepatic steatosis and fibrosis in patients with ankylosing spondylitis. 肿瘤坏死因子-α抑制剂对强直性脊柱炎患者肝脂肪变性和纤维化非侵袭性指标的影响。

IF 2.2 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2025-07-03 DOI: 10.1080/03009742.2025.2515687

D A Anastasilakis, G Sakellariou, A D Anastasilakis, I Katsigianni, E Pagkalidou, S A Polyzos

{"title":"Impact of tumour necrosis factor-α inhibitors on non-invasive indices of hepatic steatosis and fibrosis in patients with ankylosing spondylitis.","authors":"D A Anastasilakis, G Sakellariou, A D Anastasilakis, I Katsigianni, E Pagkalidou, S A Polyzos","doi":"10.1080/03009742.2025.2515687","DOIUrl":"https://doi.org/10.1080/03009742.2025.2515687","url":null,"abstract":"Objective: Tumour necrosis factor-α (TNF-α) has been associated with non-alcoholic fatty liver disease (NAFLD) and its severity. This study aimed to evaluate for first time changes in non-invasive indices of hepatic steatosis and fibrosis in patients with ankylosing spondylitis (AS) after treatment with TNF-α inhibitors.Methods: In this retrospective study, non-invasive indices of steatosis and fibrosis were evaluated in patients with AS treated with TNF-α inhibitors before the initiation of treatment (baseline) and after at least 6 months of treatment (endpoint). Steatosis was evaluated with hepatic steatosis index (HSI) and fibrosis with three indices [fibrosis-4 (FIB-4) index, aspartate aminotransferase to platelet ratio index (APRI), and body mass index (BMI)-aspartate aminotransferase-to-alanine aminotransferase ratio-diabetes mellitus (BARD)]. The efficacy of TNF-α inhibitors was evaluated by serum C-reactive protein (CRP) and Ankylosing Spondylitis Disease Activity Score with CRP.Results: Fifty-two patients were included in this study and were treated with TNF-α inhibitors for 8.1 months (interquartile range 6.5-11.3 months). There was no change in HSI between baseline and endpoint, whereas FIB-4 (from 0.64 ± 0.23 to 0.83 ± 0.48; p < 0.001) and APRI (from 0.16 ± 0.06 to 0.23 ± 0.13; p < 0.001) increased; BARD was not affected. These results were independent of different TNF-α inhibitors, sex, BMI, and age.Conclusions: TNF-α inhibitors may have a neutral impact on hepatic steatosis, but a negative impact on hepatic fibrosis indices, findings requiring validation in prospective clinical studies with liver imaging or paired liver biopsies.","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":" ","pages":"1-9"},"PeriodicalIF":2.2,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144554359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ratio between biological and targeted synthetic disease-modifying anti-rheumatic drugs and glucocorticoid use in various countries: results from METEOR. 生物和靶向合成与改善疾病的抗风湿药物和糖皮质激素在各国使用的比例：METEOR的结果。

IF 2.2 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2025-07-03 DOI: 10.1080/03009742.2025.2515730

I S Nevins, M Boers, D Vega-Morales, L L Winchow, A Chopra, A M Rodrigues, Twj Huizinga, S A Bergstra

{"title":"Ratio between biological and targeted synthetic disease-modifying anti-rheumatic drugs and glucocorticoid use in various countries: results from METEOR.","authors":"I S Nevins, M Boers, D Vega-Morales, L L Winchow, A Chopra, A M Rodrigues, Twj Huizinga, S A Bergstra","doi":"10.1080/03009742.2025.2515730","DOIUrl":"10.1080/03009742.2025.2515730","url":null,"abstract":"Objective: To investigate globally the ratio between biological and targeted synthetic disease-modifying anti-rheumatic drugs (btsDMARDs) and glucocorticoid (GC) use in patients with rheumatoid arthritis (RA), in relation to country-level socioeconomic status (SES).Method: Data on btsDMARD and GC use between 1 January 2007 and 13 September 2021 were extracted from the international observational METEOR RA registry. The ratio between the proportion of patients who had ever used a btsDMARD and those who had ever used a GC and never a btsDMARD, during 2 years of follow-up, was calculated per country. Associations between the btsDMARD/GC ratios and country-level indicators of SES were assessed with linear regression.Results: Data from 10 856 patients covering eight geographically spread countries, of whom 8484 were from India, showed a wide range of drug use during 2 years of follow-up: btsDMARD (with or without GC), from 1% (South Africa, India) to 26% (Massachusetts, USA); GC and never btsDMARD use, 19% (UK) to 92% (South Africa). Higher country-level SES was related to a higher btsDMARD/GC ratio. For every additional 10 000 International $, GDP per capita, household net adjusted disposable income, and health expenditure per capita, the estimated increase in btsDMARD/GC ratio (range 0-1) was 0.1 (95% CI 0.05;0.1), 0.2 (95% CI 0.08;0.3), and 0.6 (95% CI 0.4;0.8), respectively.Conclusion: In this analysis based on eight different countries, we show that the btsDMARD/GC ratio varies widely across countries. This was strongly associated with general country-level indicators of level of wealth, i.e. greater wealth was associated with a higher ratio.","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":" ","pages":"1-8"},"PeriodicalIF":2.2,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144554375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A patient with multiple sclerosis successfully treated with tofacitinib for rheumatoid arthritis. 多发性硬化症患者成功地用托法替尼治疗类风湿关节炎。

IF 2.2 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2025-07-01 Epub Date: 2025-04-01 DOI: 10.1080/03009742.2025.2463733

G T Sakellariou, N Chaitidis, I Katsigianni, I Tsifountoudis, P Vounotrypidis

引用次数: 0

Early diagnosis of rheumatoid arthritis: associations between patients' perceptions of initial symptoms and the timing of seeking help from the general practitioner. 类风湿关节炎的早期诊断：患者对初始症状的认知与向全科医生寻求帮助的时机之间的关系

IF 2.2 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2025-07-01 Epub Date: 2025-02-27 DOI: 10.1080/03009742.2025.2464457

S D Pedersen, B D Nielsen, M L Assmann, E M Hauge, A de Thurah

{"title":"Early diagnosis of rheumatoid arthritis: associations between patients' perceptions of initial symptoms and the timing of seeking help from the general practitioner.","authors":"S D Pedersen, B D Nielsen, M L Assmann, E M Hauge, A de Thurah","doi":"10.1080/03009742.2025.2464457","DOIUrl":"10.1080/03009742.2025.2464457","url":null,"abstract":"Objectives: Early diagnosis is essential to the prognosis of rheumatoid arthritis (RA), but little is known about patients' perceptions of the first symptoms. Illness representations shape patients' help-seeking behaviour. The Illness Perception Questionnaire - Revised (IPQ-R) can measure these, allowing us to understand the patients' role in diagnostic delays. The aim of this study was to explore the connection between RA patients' perceptions of initial symptoms and the time taken to seek help from a general practitioner (GP).Method: 1163 recently diagnosed individuals with RA, identified from the Danish Rheumatology Database, DANBIO, filled out a questionnaire. We used adjusted multivariable linear regression to calculate the median ratio (MR) for those with the highest scores within each IPQ-R subscale compared to the lowest scores.Results: Altogether, 404 patients answered the questionnaire. The overall median patient delay was 63 [interquartile range (IQR) 17-214] days. Younger patients experienced longer delays than older [84 (IQR 30-361) vs 54 (14-162) days]. High expectations of treatment control led to 54% lower median time to first GP contact compared to low expectations [adjusted median ratio (MR) 0.54, 95% confidence interval (CI) 0.29-0.99]. High perceptions of symptom variability at disease onset led to a higher median time to first GP contact (adjusted MR 1.61, 95% CI 0.93-2.78).Conclusion: People with RA symptoms may delay seeing their GP due to low expectations of treatment effectiveness and significant symptom variability. Information campaigns could educate patients on recognizing warning signs and encourage them to seek medical attention.","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":" ","pages":"242-251"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Work in the picture? The reporting of and effects on work outcomes in exercise therapy trials in people with rheumatoid arthritis or axial spondyloarthritis: a systematic review. 画中的工作？类风湿关节炎或轴性脊柱炎患者运动治疗试验的报告及其对工作结果的影响：系统综述。

IF 2.2 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2025-07-01 Epub Date: 2025-02-04 DOI: 10.1080/03009742.2024.2445940

N F Bakker, J Knoop, J W Schoones, Tpm Vliet Vlieland, Sfe van Weely

{"title":"Work in the picture? The reporting of and effects on work outcomes in exercise therapy trials in people with rheumatoid arthritis or axial spondyloarthritis: a systematic review.","authors":"N F Bakker, J Knoop, J W Schoones, Tpm Vliet Vlieland, Sfe van Weely","doi":"10.1080/03009742.2024.2445940","DOIUrl":"10.1080/03009742.2024.2445940","url":null,"abstract":"Objective: Many people with rheumatoid arthritis (RA) or axial spondyloarthritis (axSpA) face limitations in societal participation, including work. Supervised exercise therapy improves symptoms and physical functioning, but its impact on work outcomes is unclear. This systematic review aims to examine the reporting of and effects on work outcomes in exercise therapy trials.Method: Eight databases were searched up to February 2024 for randomized controlled trials (RCTs) evaluating the (cost-)effectiveness of supervised exercise therapy interventions in adults with RA/axSpA. The reporting of work and other social participation outcomes, the content of the exercise therapy intervention, and their effects on work outcomes were extracted. Within- and between-group results on work outcomes were summarized.Results: In total, 41 (22 RA, 19 axSpA) RCTs on supervised exercise therapy were included, none of which was specifically targeted at work. Two RCTs in people with RA included work outcomes (absenteeism and employment hours). None of the RCTs in axSpA reported work outcomes. A work-related item or subscale was reported in 6/22 of the RA and 7/19 of the axSpA trials. Outcomes on societal participation (including work) were reported in 13/22 of the RA and 18/19 of the axSpA trials. Effects on work were reported on different outcomes and results were inconclusive.Conclusion: Work outcomes are rarely reported in exercise therapy trials in people with RA/axSpA. To determine the effects of supervised exercise therapy on work, future studies should include work outcomes. International consensus on which outcome to use could increase the comparability of results.","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":" ","pages":"225-241"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Crowned dens syndrome: a rare yet intriguing condition of the spine. 冠齿综合征：一种罕见但有趣的脊柱疾病。

IF 2.2 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2025-07-01 Epub Date: 2025-03-26 DOI: 10.1080/03009742.2025.2465130

E A Acar, F C Tasgöz, S Uslu, O Soysal Gündüz

引用次数: 0

Synovial chondromatosis in a patient with atypical rheumatoid arthritis confirmed by clinical, radiographic, and pathological evidence: a case report. 经临床、影像学和病理证实的非典型类风湿性关节炎患者的滑膜软骨瘤病：1例报告。

IF 2.2 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2025-07-01 Epub Date: 2025-05-09 DOI: 10.1080/03009742.2025.2491181

C H Li, J L Gao, C Ren, S M Yang, Y Y Hou, Z H He, J X Zhao, Y P Yang

引用次数: 0

Exploratory study of predictors of decreased ability to perform activities of daily living in people living with hand osteoarthritis. 手骨关节炎患者日常生活能力下降预测因素的探索性研究。

IF 2.2 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2025-07-01 Epub Date: 2025-04-24 DOI: 10.1080/03009742.2025.2484127

U Andersen, A Døssing, H Gudbergsen, V Hagelskjaer, H Bliddal, E E Wæhrens

{"title":"Exploratory study of predictors of decreased ability to perform activities of daily living in people living with hand osteoarthritis.","authors":"U Andersen, A Døssing, H Gudbergsen, V Hagelskjaer, H Bliddal, E E Wæhrens","doi":"10.1080/03009742.2025.2484127","DOIUrl":"10.1080/03009742.2025.2484127","url":null,"abstract":"Objective: People with hand osteoarthritis (OA) report decreased ability to perform activities of daily living (ADL). However, few are referred to occupational therapy by their general practitioner. This study aimed to identify clinical predictors of decreased ADL ability in people with hand OA as markers of the need for referral to occupational therapy.Method: A cross-sectional study was conducted as an independent add-on to a randomized controlled trial of adults with hand OA (the COLOR trial). Measures of self-reported (ADL Interview) and observed (Assessment of Motor and Process Skills) ADL ability were collected. Data representing potential predictors identified by stakeholders were extracted from the COLOR trial: age, sex, symptom duration, hand OA type, grip strength, pain, stiffness, function, illness perception, and health-related quality of life. Correlational analyses and prediction models were used.Results: Correlations between ADL ability and potential predictors in the 62 participants were low to negligible (r < 0.5). Based on root mean square error (RMSE) estimates, prediction models for observed ADL motor (RMSE = 0.3) and ADL process (RMSE = 0.2) ability were more accurate than for self-reported ADL ability (RMSE = 0.6). However, these variables only predicted observed ADL motor and ADL process ability with 16% (adjusted Rs = 0.163) and 12% (adjusted Rs = 0.120) accuracy, respectively.Conclusion: The findings suggest that variables representing body functions, perceived health, and quality of life do not predict ADL ability among people living with hand OA. An adequately powered study is recommended to explore this topic further.","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":" ","pages":"263-271"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0