Scandinavian Journal of Rheumatology最新文献

Correction.

IF 2.2 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2025-01-24 DOI: 10.1080/03009742.2025.2454755

引用次数: 0

Elevated neutrophil-to-lymphocyte and monocyte-to-lymphocyte ratios are associated with increased flares and elevated cardiovascular disease risk in gout. 中性粒细胞与淋巴细胞比率和单核细胞与淋巴细胞比率升高与痛风中耀斑增加和心血管疾病风险升高有关。

IF 2.2 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2025-01-17 DOI: 10.1080/03009742.2024.2421622

R D Stultz, L Dai, E van Geel, M Gerritsen, M T Nurmohamed, C Lood

{"title":"Elevated neutrophil-to-lymphocyte and monocyte-to-lymphocyte ratios are associated with increased flares and elevated cardiovascular disease risk in gout.","authors":"R D Stultz, L Dai, E van Geel, M Gerritsen, M T Nurmohamed, C Lood","doi":"10.1080/03009742.2024.2421622","DOIUrl":"https://doi.org/10.1080/03009742.2024.2421622","url":null,"abstract":"Objective: Although gout is the most common inflammatory arthritis, there are few tools to monitor disease activity and predict complications in gout patients. The neutrophil-to-lymphocyte ratio (NLR) and monocyte-to-lymphocyte ratio (MLR) are associated with disease activity in various diseases and the NLR has been shown to predict coronary artery disease severity, a common comorbid condition with gout. Thus, we evaluated the use of NLR and MLR as novel biomarkers to measure disease activity and predict cardiovascular disease (CVD) risk in gout patients.Method: Data were collected from 38 gout patients. Disease activity, including total number of acute gout attacks, and 10 year risk of cardiovascular morbidity, were assessed at the patient's visit. Calprotectin, cell counts, and uric acid levels were measured from patients' blood.Results: Levels of the neutrophil activation marker calprotectin correlated with NLR (r = 0.56, p = 0.0004). MLR correlated with total number of gout attacks as well (r = 0.39, p = 0.02). NLR and MLR, but not absolute monocyte or neutrophil counts, were significantly correlated with body mass index and significantly increased in gout patients with high CVD risk (p < 0.05). Using logistic regression analysis, patients with high NLR or MLR (defined as the upper quartile of patients) had increased odds of developing high CVD risk (odds ratio 7.5, 95% confidence interval 1.7-33.0).Conclusion: NLR and MLR are potential biomarkers to predict gout flare risk. An increase in either may indicate an increased risk of CVD morbidity.","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":" ","pages":"1-5"},"PeriodicalIF":2.2,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143010950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Highlighting individual patient data related to chimeric antigen receptor T-cell therapy in refractory autoimmune rheumatic diseases. 强调与嵌合抗原受体t细胞治疗难治性自身免疫性风湿病相关的个体患者数据。

IF 2.2 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2025-01-13 DOI: 10.1080/03009742.2024.2421621

M L Larsen, A Voss, C Tandrup Holst Nielsen, E-M Hauge, M Faurschou, A Troldborg

引用次数: 0

Reviewer acknowledgement December 2023 - November 2024. 评审确认2023年12月- 2024年11月。

IF 2.2 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2025-01-01 Epub Date: 2025-01-22 DOI: 10.1080/03009742.2025.2434411

引用次数: 0

Ultrasonographic findings in diabetic cheiroarthropathy: a pilot study. 糖尿病螯状关节病的超声波检查结果：一项试验性研究。

IF 2.2 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2025-01-01 Epub Date: 2024-07-12 DOI: 10.1080/03009742.2024.2374106

C Löffler, J Leipe, B Hellmich

{"title":"Ultrasonographic findings in diabetic cheiroarthropathy: a pilot study.","authors":"C Löffler, J Leipe, B Hellmich","doi":"10.1080/03009742.2024.2374106","DOIUrl":"10.1080/03009742.2024.2374106","url":null,"abstract":"Objective: Diabetic cheiroarthropathy (DCA) is one of the musculoskeletal manifestations of diabetes mellitus. It is clinically diagnosed using the prayer and tabletop signs. The clinical appearance, however, mimics autoimmune-mediated polyarthritis of the hands and fingers. It is therefore crucial to positively identify DCA patients.Method: We used high-frequency B-mode ultrasound to investigate 14 patients with DCA and seven non-DCA diabetics with anti-cyclic citrullinated peptide antibody-positive rheumatoid arthritis (RA). We recorded the frequency of synovitis in radiocarpal, metacarpophalangeal, and proximal interphalangeal joints, the presence of tenosynovitis of the finger flexor tendons, echogenicity of the synovia and the flexor tendon sheaths, and soft tissue alterations in the digits. We compared our findings between groups to determine sonographic characteristics of DCA.Results: A low rate of small finger joint involvement in the presence of a high rate of finger flexor tendinopathy showed a high association with DCA in correlation (p = 0.002) and regression analysis (p < 0.001). Tendon sheaths were significantly more often hyperechoic and proliferative in DCA compared to RA (p = 0.008), and hypoechoic soft tissue alterations were almost exclusively seen in DCA patients (p = 0.003). Radiocarpal joint involvement and its echogenicity did not differ between groups.Conclusion: Ultrasonography shows typical features in DCA, and is capable of discriminating DCA from non-DCA patients with RA and diabetes.","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":" ","pages":"41-48"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141591248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term association between physical activity and global functioning in patients with axial spondyloarthritis: results of a two-year prospective study. 轴性脊柱关节炎患者体育锻炼与整体功能之间的长期关系：一项为期两年的前瞻性研究结果。

IF 2.2 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2025-01-01 Epub Date: 2024-07-24 DOI: 10.1080/03009742.2024.2376810

K Y Kang, S Y Park, T H Chung

{"title":"Long-term association between physical activity and global functioning in patients with axial spondyloarthritis: results of a two-year prospective study.","authors":"K Y Kang, S Y Park, T H Chung","doi":"10.1080/03009742.2024.2376810","DOIUrl":"10.1080/03009742.2024.2376810","url":null,"abstract":"Objectives: To assess the longitudinal association between physical activity and global functioning in patients with axial spondyloarthritis (axSpA), and to identify the subtype of physical activity that is longitudinally related to global functioning.Method: Physical activity was measured using Global Physical Activity Questionnaire. Global functioning was assessed using the Assessment of SpondyloArthritis international Society Health Index (ASAS HI). The amount and subtype (work, transport, and recreation) of physical activity, disease activity, and ASAS HI were assessed at baseline, and at 1 and 2 year follow-up. Physical activity levels were categorized as low, moderate, or high. The longitudinal association between physical activity and ASAS HI scores was analysed using a generalized estimating equation.Results: The study evaluated 160 patients. Univariate analysis identified physical activity at moderate level and higher, Ankylosing Spondylitis Disease Activity Score (ASDAS), and syndesmophyte number as being longitudinally associated with ASAS HI over 2 years. Multivariate analysis identified physical activity at moderate level and higher as being longitudinally associated with ASAS HI. Physical activity above moderate levels was associated independently with good global functioning. In the analysis stratified by radiographic axSpA and non-radiographic axSpA, a positive association between physical activity and global functioning was observed in both groups. Only recreational activity, but not work- and transport-related activity, showed an independent longitudinal relationship with the ASAS HI score.Conclusions: Physical activity at moderate level and higher was associated independently with global functioning in axSpA. Therefore, patients should maintain physical activity above moderate levels to preserve global function.","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":" ","pages":"8-15"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141752615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Methotrexate prolonged the shedding of replicable SARS-CoV-2 with re-increased antigens in a rheumatoid arthritis patient. 甲氨蝶呤延长了一名类风湿性关节炎患者体内可复制的 SARS-CoV-2 的脱落时间，并重新增加了抗原。

IF 2.2 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2025-01-01 Epub Date: 2024-09-04 DOI: 10.1080/03009742.2024.2361994

A Takatani, T Kobayashi, N Iwamoto, T Aramaki, K Terada, K Izumikawa, M M Ngwe Tun, K Morita, Y Ueki, A Kawakami, K Eguchi

引用次数: 0

Correction. 修正。

IF 2.2 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2025-01-01 Epub Date: 2025-01-22 DOI: 10.1080/03009742.2025.2434417

引用次数: 0

Retention rate of a novel autoinjector e-Device introduced to patients with chronic arthritis treated with certolizumab pegol in clinical practice: an observational implementation study. 在临床实践中为接受曲妥珠单抗 pegol 治疗的慢性关节炎患者引入新型自动注射器电子设备的保留率：一项观察性实施研究。

IF 2.2 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2025-01-01 Epub Date: 2024-07-08 DOI: 10.1080/03009742.2024.2365508

T S Jørgensen, R L Hansen, B Pouls, B Van den Bemt, C Sjöwall, L E Kristensen

{"title":"Retention rate of a novel autoinjector e-Device introduced to patients with chronic arthritis treated with certolizumab pegol in clinical practice: an observational implementation study.","authors":"T S Jørgensen, R L Hansen, B Pouls, B Van den Bemt, C Sjöwall, L E Kristensen","doi":"10.1080/03009742.2024.2365508","DOIUrl":"10.1080/03009742.2024.2365508","url":null,"abstract":"Objectives: The objectives were to explore the clinical retention rate of an e-Device aimed at empowering chronic arthritis patients using certolizumab pegol (CZP) and to analyse beliefs about medication in the Danish population.Method: Patients treated with CZP were recruited from the Netherlands, Denmark, and Sweden through rheumatology clinics at initiation of, or switching to, the e-Device. Patients were adults (aged 18-85 years) diagnosed with rheumatoid arthritis, axial spondyloarthritis, or psoriatic arthritis. Patients administered three consecutive self-injections at home. Descriptive statistics regarding baseline characteristics, retention rates, and reasons for withdrawal were assessed, along with the Beliefs about Medicines Questionnaire.Results: In total, 59 patients participated (Netherlands 25, Denmark 15, Sweden 19). Most subjects (71%) were women, with a mean ± sd age of 55 ± 16.2 years and mean disease duration 12 ± 8.8 years. Six patients (10%) started CZP de novo and the remaining patients switched device. The overall retention rate was 42% after 52 weeks, declining to 38% after 104 weeks. A sharp decline, 34%, was seen at week 8. Between weeks 32 and 112, only four patients (6.8%) withdrew from the study. The primary reason for withdrawal was the patient's request. Stratification by country showed significant differences for some outcomes.Conclusion: An initial large dropout was evident within the first 8 weeks, with almost no dropouts thereafter. The reasons for withdrawal were primarily patient requests. Thus, the injection experience must be tailored carefully when selecting patients for new autoinjector e-Devices to enhance retention rates and patient satisfaction.","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":" ","pages":"25-32"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141555427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Participation in a digital self-management intervention for osteoarthritis and socioeconomic inequalities in patient-related outcomes. 参与骨关节炎数字化自我管理干预与患者相关结果的社会经济不平等。

IF 2.2 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2025-01-01 Epub Date: 2024-06-20 DOI: 10.1080/03009742.2024.2361542

A Mahmoudian, L S Lohmander, L E Dahlberg, A Kiadaliri

{"title":"Participation in a digital self-management intervention for osteoarthritis and socioeconomic inequalities in patient-related outcomes.","authors":"A Mahmoudian, L S Lohmander, L E Dahlberg, A Kiadaliri","doi":"10.1080/03009742.2024.2361542","DOIUrl":"10.1080/03009742.2024.2361542","url":null,"abstract":"Objective: To investigate changes in socioeconomic inequalities in patient-related outcomes and pain medication use, following participation in a digital self-management intervention for osteoarthritis (OA) in Sweden.Method: Participants with hip/knee OA enrolled in the digital intervention were included. Self-reported outcomes collected were the numerical rating scale (NRS) pain, activity impairment, general health, Knee/Hip injury and Osteoarthritis Outcome Score (KOOS-12, HOOS-12) Pain, Function, and Quality of Life subscales, 5-level EuroQol 5 Dimensions (EQ-5D-5L), Patient Acceptable Symptom State (PASS) for function, walking difficulties, fear of movement, wish for surgery, pain medication use, physical function measured by the 30s chair-stand test, and level of physical activity. Educational attainment was used as a socioeconomic measure and the concentration index was used to assess the magnitude of inequalities at baseline and 3 month follow-up.Results: The study included 21,688 participants (mean ± sd age 64.1 ± 9.1 years, 74.4% females). All outcomes except for PASS demonstrated inequalities in favour of highly educated participants at both time-points, with highly educated participants reporting better outcomes. At 3 month follow-up, the magnitude of inequality widened for activity impairment, but narrowed for NRS pain, EQ-5D-5L, KOOS-12/HOOS-12 Pain and Function, physical function, and wish for surgery. There were no statistically conclusive changes in the magnitude of inequalities for the remaining outcomes.Conclusions: There were inequalities in patient-related outcomes in favour of those with higher education among participants of a digital self-management intervention for OA, although the magnitude of these pre-existing inequalities generally narrowed after the 3 month intervention.","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":" ","pages":"33-40"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141427448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0