Scandinavian Journal of Rheumatology最新文献_第10页

Construct validity of the PROMIS PF-10 in patients with inflammatory rheumatic diseases and severe limitations in physical functioning. PROMIS PF-10在炎症性风湿病和身体功能严重受限患者中的构建效度

IF 2.1 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2023-11-01 Epub Date: 2023-03-20 DOI: 10.1080/03009742.2023.2182449

Mat van Wissen, B Straathof, Tpm Vliet Vlieland, Chm van den Ende, Mmh Teuwen, W F Peter, A A den Broeder, W B van den Hout, D van Schaardenburg, A M van Tubergen, Mgj Gademan, Sfe van Weely

{"title":"Construct validity of the PROMIS PF-10 in patients with inflammatory rheumatic diseases and severe limitations in physical functioning.","authors":"Mat van Wissen, B Straathof, Tpm Vliet Vlieland, Chm van den Ende, Mmh Teuwen, W F Peter, A A den Broeder, W B van den Hout, D van Schaardenburg, A M van Tubergen, Mgj Gademan, Sfe van Weely","doi":"10.1080/03009742.2023.2182449","DOIUrl":"10.1080/03009742.2023.2182449","url":null,"abstract":"Objective: Assessing the construct validity of the Patient-Reported Outcomes Measurement Information System Physical Function 10-Item Short Form (PROMIS PF-10) in a subpopulation of rheumatoid arthritis (RA) or axial spondyloarthritis (axSpA) patients with severe limitations in physical functioning (PF).Method: RA/axSpA patients with severe functional limitations completed the PROMIS PF-10, Health Assessment Questionnaire - Disability Index (HAQ-DI for RA) or Bath Ankylosing Spondylitis Functional Index (BASFI for axSpA), 36-item Short Form Health Survey (SF-36), EuroQol 5-dimensions 5-level (index score, EQ-VAS), and performed the Six-Minute Walk Test (6MWT). Construct validity was assessed by computing Spearman rank or Pearson correlation coefficients and testing hypotheses about correlations between the PROMIS PF-10 and measures of PF and quality of life.Results: Data from 316 patients (180 RA/136 axSpA, 91.7%/47.8% female, mean ± sd age 58.6 ± 13.2/54.0 ± 11.3 years) were analysed. The median (IQR) PROMIS PF-10 score was 34.5 (31.4-37.6) in RA and 36.0 (32.8-38.3) in axSpA patients. The PROMIS PF-10 correlated strongly with the HAQ-DI, BASFI, and EQ-5D-5L index score (r > 0.6), moderately with the SF-36 Physical Component Summary score, EQ-VAS, and 6MWT (0.30 ≤ r ≤ 0.60), and weakly with the SF-36 Mental Component Summary score (r < 0.30). Five of six hypotheses (83%) were confirmed in both groups.Conclusion: The overall strong correlation of the PROMIS PF-10 with measures of PF and moderate to weak correlations with outcomes measuring different constructs were confirmed in subpopulations of RA and axSpA patients with severe functional limitations, supporting its construct validity.","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9140284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A rare encounter: Kikuchi-Fujimoto disease presenting atypically after BNT162b2 COVID-19 vaccination: a case report. 罕见遭遇:BNT162b2 COVID-19疫苗接种后出现非典型的菊池-藤本病:病例报告

IF 2.1 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2023-11-01 Epub Date: 2023-08-22 DOI: 10.1080/03009742.2023.2241760

K-H Nam, Y Choi

引用次数: 0

Clinical and preclinical pulmonary disease in newly diagnosed rheumatoid arthritis: a two-year follow-up study. 新诊断的类风湿关节炎的临床和临床前肺部疾病:一项为期两年的随访研究

IF 2.1 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2023-11-01 Epub Date: 2023-04-17 DOI: 10.1080/03009742.2023.2194105

C Hyldgaard, S Harders, J Blegvad, M Herly, D Masic, B K Sofíudóttir, G Urbonaviciene, F D Andersen, C Isaksen, B Løgstrup, T Ellingsen

{"title":"Clinical and preclinical pulmonary disease in newly diagnosed rheumatoid arthritis: a two-year follow-up study.","authors":"C Hyldgaard, S Harders, J Blegvad, M Herly, D Masic, B K Sofíudóttir, G Urbonaviciene, F D Andersen, C Isaksen, B Løgstrup, T Ellingsen","doi":"10.1080/03009742.2023.2194105","DOIUrl":"10.1080/03009742.2023.2194105","url":null,"abstract":"Objective: Pulmonary disease is a major cause of excess mortality among patients with rheumatoid arthritis (RA). Interstitial lung disease (ILD) is a feared complication, but the benefit of screening is unknown. The aim of this study was to assess the frequency of pulmonary disease, including ILD, in early RA.Method: Patients with newly diagnosed RA were recruited prospectively at a single centre and underwent systematic pulmonary function tests (PFTs) and computed tomography (CT) scans at inclusion and after two years.Results: The study included 150 patients (mean age 57 years, 63% female; 59% current or former smokers). Of these, 136 underwent baseline PFTs and 137 CT. Mean forced expiratory volume in one second was 99% predicted and forced vital capacity 106%. Mean diffusing capacity of the lungs for carbon monoxide (DLCO) was 84% predicted. Frequently detected CT abnormalities were pulmonary nodules (42%), bronchiectasis (29%), and emphysema (20%). Two patients had clinically significant ILD and six had mild reticulation suggestive of preclinical ILD. No ILD progression was identified at two-year follow-up. Smoking was associated with DLCO<80% (p=0.004), combined hyperinflation and diffusion impairment (residual volume>120% and DLCO<80%) (p=0.004), and visual emphysema on CT (p<0.001).Conclusion: Emphysema and bronchiectasis were common, but most patients had mild disease with preserved lung function. Preclinical or clinical ILD was seen in a minority in this early phase of RA. These findings suggest symptom-based screening and primary intervention focusing on smoking cessation rather than screening for ILD at the time of RA diagnosis.","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9364777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Angioedema: hereditary or C1-inhibitor deficiency associated with systemic lupus erythematosus? 血管性水肿:遗传性或c1抑制剂缺乏与系统性红斑狼疮相关?

IF 2.1 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2023-11-01 Epub Date: 2023-07-13 DOI: 10.1080/03009742.2023.2230737

Michihiro Kono, Michihito Kono, T Atsumi

{"title":"Angioedema: hereditary or C1-inhibitor deficiency associated with systemic lupus erythematosus?","authors":"Michihiro Kono, Michihito Kono, T Atsumi","doi":"10.1080/03009742.2023.2230737","DOIUrl":"10.1080/03009742.2023.2230737","url":null,"abstract":"Angioedema (AE) manifests as transient localized subcutaneous and mucosal swelling due to increased vascular permeability caused by the release of vasoactive mediators. Although most cases of AE are self-limiting, AE can result in life-threatening asphyxiation due to laryngeal swelling. Acquired angioedema due to C1-inhibitor (C1-INH) deficiency (AAE-C1-INH) is a type of bradykinin-induced AE characterized by the acquired deficiency of C1-INH due to the consumption or the production of neutralizing autoantibodies against C1-INH (anti-C1-INH antibodies), despite normal C1-INH protein synthesis. AAE-C1-INH is much more often associated with lymphoma or monoclonal gam-mopathy of undetermined significance than with autoimmune diseases, including systemic lupus erythematosus (SLE), also in cases where anti-C1-INH antibodies are present. AAE-C1-INH occurs less frequently than hereditary angioedema (HAE) due to C1-INH deficiency (HAE-1) and dysfunction (HAE-2). However, the symptoms and basic diagnostic laboratory profile, including C1-INH function, protein, and C4 levels, are indistinguishable between AAE-C1-INH and HAE-1 (1, 2). Moreover, previous reports showed the increased prevalence of autoimmune diseases, especially SLE, among patients with HAE-1/2 through the chronic consumption of early components of the classical pathway (3).","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10150710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differential diagnostics of polymyalgia rheumatica in a university hospital in Finland. 芬兰大学医院风湿病多肌痛的鉴别诊断。

IF 2.1 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2023-11-01 Epub Date: 2023-06-19 DOI: 10.1080/03009742.2023.2215044

J Paltta, S Suuronen, L Pirilä, A Palomäki

{"title":"Differential diagnostics of polymyalgia rheumatica in a university hospital in Finland.","authors":"J Paltta, S Suuronen, L Pirilä, A Palomäki","doi":"10.1080/03009742.2023.2215044","DOIUrl":"10.1080/03009742.2023.2215044","url":null,"abstract":"Objectives: Diagnosing polymyalgia rheumatica (PMR) can be difficult as many conditions present with similar symptoms and findings. This study aimed to analyse how often the diagnosis of PMR changes during follow-up in a university hospital setting and to determine the most common clinical conditions initially misdiagnosed as PMR.Method: All patients with a new primary diagnosis of PMR on at least one visit during the years 2016-2019 were identified from the hospital discharge register of Turku University Hospital, Finland. A diagnosis of PMR was confirmed if the patient met at least one of the five classification criteria, complete clinical follow-up (median 34 months) was compatible with PMR, and no other diagnosis better explained their condition.Results: Of the patients initially diagnosed with PMR, 65.5% were considered to have PMR after further evaluation and clinical follow-up. The most common conditions initially diagnosed as PMR were inflammatory arthritides (34.9%), degenerative or stress-related musculoskeletal disorders (13.2%), infection (9.3%), malignancy (9.3%), giant cell vasculitis (6.2%) and other vasculitis (6.2%), and a wide range of other less common diseases. The diagnosis of PMR remained in 81.3% of patients who fulfilled the 2012 American College of Rheumatology/European League Against Rheumatism PMR classification criteria and in 45.5% of patients who did not.Conclusions: Diagnosing PMR is challenging, even in a university hospital. One-third of the initial diagnoses of PMR changed during further evaluation and follow-up. There is a substantial risk of misdiagnosis, especially in patients with atypical presentation, and the differential diagnoses of PMR must be considered carefully.","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10019479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Physical therapy in patients with rheumatoid arthritis and axial spondyloarthritis: the patients' perspective. 类风湿关节炎和轴型脊柱炎患者的物理治疗:患者的观点。

IF 2.1 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2023-11-01 Epub Date: 2023-05-04 DOI: 10.1080/03009742.2023.2195726

Mat van Wissen, Mgj Gademan, Tpm Vliet Vlieland, B Straathof, Mmh Teuwen, W F Peter, Chm van den Ende, Sfe van Weely

{"title":"Physical therapy in patients with rheumatoid arthritis and axial spondyloarthritis: the patients' perspective.","authors":"Mat van Wissen, Mgj Gademan, Tpm Vliet Vlieland, B Straathof, Mmh Teuwen, W F Peter, Chm van den Ende, Sfe van Weely","doi":"10.1080/03009742.2023.2195726","DOIUrl":"10.1080/03009742.2023.2195726","url":null,"abstract":"Objective: To assess the duration, frequency, and content of individual physical therapy (PT) in patients with rheumatoid arthritis (RA) or axial spondyloarthritis (axSpA).Method: In this cross-sectional study, an electronic questionnaire aimed at people with RA and axSpA was distributed through various communication channels of the Dutch Arthritis Foundation. It comprised questions on sociodemographic and health characteristics, received PT (currently and/or in the past year) and, if applicable, its duration, frequency, and content (active exercises, manual treatment, physical modalities, and/or counselling/education).Results: The study included 257 and 94 patients with self-reported diagnoses of RA and axSpA, of whom 163 (63%) and 77 (82%) currently or had recently received individual PT. The duration of individual PT was long-term (> 3 months) in 79% of RA and 83% of axSpA patients, with an average frequency of once per week in most. Although active exercises and counselling/education were each reported by ≥ 73% of the patients with RA and axSpA who received long-term individual PT, passive treatment modalities were also often offered (≥ 89%), in particular massage, kinesiotaping, and/or passive mobilization. The same pattern was seen in patients receiving short-term PT.Conclusion: The majority of patients with RA and axSpA received PT currently or in the past year, usually individually, long-term, and at a frequency of once a week. Although active exercises and education are recommended in guidelines, passive treatment options that are not advised were relatively often reported. An implementation study to identify barriers and facilitators regarding adherence to clinical practice guidelines seems warranted.","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9774787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pyridostigmine ameliorates pristane-induced arthritis symptoms in Dark Agouti rats. 吡地斯的明改善黑鼠前列腺素诱导的关节炎症状。

IF 2.1 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2023-11-01 Epub Date: 2023-06-20 DOI: 10.1080/03009742.2023.2196783

M Zeng, A Issotina Zibrila, X Li, X Liu, X Wang, Z Zeng, Z Wang, Y He, L Meng, J Liu

{"title":"Pyridostigmine ameliorates pristane-induced arthritis symptoms in Dark Agouti rats.","authors":"M Zeng, A Issotina Zibrila, X Li, X Liu, X Wang, Z Zeng, Z Wang, Y He, L Meng, J Liu","doi":"10.1080/03009742.2023.2196783","DOIUrl":"10.1080/03009742.2023.2196783","url":null,"abstract":"Objective: Rheumatoid arthritis (RA) is a chronic inflammatory disorder. Pyridostigmine (PYR), an acetylcholinesterase (AChE) inhibitor, has been shown to reduce inflammation and oxidative stress in several animal models for inflammation-associated conditions. The present study aimed to investigate the effects of PYR on pristane-induced (PIA) in Dark Agouti (DA) rats.Method: DA rats were intradermally infused with pristane to establish the PIA model, which was treated with PYR (10 mg/kg/day) for 27 days. The effects of PYR on synovial inflammation, oxidative stress, and gut microbiota were evaluated by determining arthritis scores, H&E staining, quantitative polymerase chain reaction, and biochemical assays, as well as 16S rDNA sequencing.Results: Pristane induced arthritis, with swollen paws and body weight loss, increased arthritis scores, synovium hyperplasia, and bone or cartilage erosion. The expression of pro-inflammatory cytokines in synovium was higher in the PIA group than in the control group. PIA rats also displayed elevated levels of malondialdehyde, nitric oxide, superoxide dismutase, and catalase in plasma. Moreover, sequencing results showed that the richness, diversity, and composition of the gut microbiota dramatically changed in PIA rats. PYR abolished pristane-induced inflammation and oxidative stress, and corrected the gut microbiota dysbiosis.Conclusion: The results of this study support the protective role of PYR in PIA in DA rats, associated with the attenuation of inflammation and correction of gut microbiota dysbiosis. These findings open new perspectives for pharmacological interventions in animal models of RA.","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9723017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 2.1 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2023-11-01 Epub Date: 2023-11-16 DOI: 10.1080/03009742.2023.2240596

A J Landgren, Lth Jacobsson, E Klingberg, R Mirzaev, M Dehlin

{"title":"Health-related quality of life by gout severity in women and men with gout in primary care: results from a questionnaire study in Western Sweden.","authors":"A J Landgren, Lth Jacobsson, E Klingberg, R Mirzaev, M Dehlin","doi":"10.1080/03009742.2023.2240596","DOIUrl":"10.1080/03009742.2023.2240596","url":null,"abstract":"Objective: We aimed to compare health-related quality of life (HRQoL) by gout severity, overall and by sex.Method: A questionnaire was sent to patients with gout (n = 1444) identified at 12 primary care centres in Western Sweden. The questionnaire asked about comorbidities, gout-specific aspects, and HRQoL, using the RAND 36-Item Health Survey. Responders were divided into 'mild', 'moderate', or 'severe' gout based on the number of self-reported flares (0, 1-2, ≥ 3) during the past 12 months.Results: Out of 1444 gout patients, 784 (54.3%) responded to the questionnaire. Among the respondents, 673 [560 (83.2%) men and 113 (16.8%) women] provided answers regarding the number of gout flares in the past year. Of these, 322 (47.8%), 218 (32.4%), and 133 (19.8%) were classified as having mild, moderate, and severe gout, respectively. Allopurinol use was more frequent in those with mild disease. In more severe gout, HRQoL was reduced compared to less severe gout [severe vs mild gout, mean values for physical component summary (PCS) score 39.5 vs 43.6, p = 0.002, and mental component summary (MCS) score 46.6 vs 51.1, p < 0.001]. When excluding those with a flare in the past month, the HRQoL was still worse in severe gout (vs mild), although differences were attenuated and not statistically significant for the PCS and for women.Conclusion: Gout severity, defined as the number of flares during the past year, was associated with significant reductions in HRQoL.","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41126855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of patient education as a stand-alone intervention for patients with chronic widespread pain and fibromyalgia: a systematic review and meta-analysis of randomized trials. 患者教育作为慢性广泛性疼痛和纤维肌痛患者独立干预的有效性:随机试验的系统回顾和荟萃分析。

IF 2.2 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2023-11-01 Epub Date: 2023-05-10 DOI: 10.1080/03009742.2023.2192450

P H Duhn, E E Wæhrens, M B Pedersen, S M Nielsen, H Locht, H Bliddal, R Christensen, K Amris

{"title":"Effectiveness of patient education as a stand-alone intervention for patients with chronic widespread pain and fibromyalgia: a systematic review and meta-analysis of randomized trials.","authors":"P H Duhn, E E Wæhrens, M B Pedersen, S M Nielsen, H Locht, H Bliddal, R Christensen, K Amris","doi":"10.1080/03009742.2023.2192450","DOIUrl":"10.1080/03009742.2023.2192450","url":null,"abstract":"Objective: Patient education is recommended as an integral component of the therapeutic plan for the management of chronic widespread pain (CWP) and fibromyalgia (FM). The key purpose of patient education is to increase the patient's competence to manage his or her own health requirements, encouraging self-management and a return to desired everyday activities and lifestyle. The aim of this systematic review was to evaluate the evidence for the benefits and potential harms associated with the use of patient education as a stand-alone intervention for individuals with CWP and FM through randomized controlled trials (RCTs).Method: On 24 November 2021 a systematic search of PubMed, MEDLINE, Embase, CENTRAL, PsycINFO, CINAHL, ClinicalTrials.gov, American College of Rheumatology, European League Against Rheumatism, and the World Health Organization International Clinical Trials Registry Platform identified 2069 studies. After full-text screening, five RCT studies were found to be eligible for the qualitative evidence synthesis.Results: Patient education as a stand-alone intervention presented an improvement in patients' global assessment (standardized mean difference 0.79, 95% confidence interval 0.13 to 1.46). When comparing patient education with usual care, no intervention, or waiting list, no differences were found for functioning, level of pain, emotional distress in regard to anxiety and depression, or pain cognition.Conclusion: This review reveals the need for RCTs investigating patient education as a stand-alone intervention for patients with FM, measuring outcomes such as disease acceptance, health-related quality of life, enhancement of patients' knowledge of pain, pain coping skills, and evaluation of prioritized learning outcomes.","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9439006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-thrombotics and major adverse cardiovascular events in anti-phospholipid syndrome: a cross-sectional study using the 2016-2018 National Inpatient Sample database. 抗磷脂综合征的抗血栓和主要不良心血管事件:使用2016-2018年全国住院患者样本数据库的横断面研究

IF 2.1 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2023-11-01 Epub Date: 2023-08-16 DOI: 10.1080/03009742.2023.2238402

R Grovu, A Nguyen, K Sangaraju, C Wei, A Mustafa, A Slobodnick

{"title":"Anti-thrombotics and major adverse cardiovascular events in anti-phospholipid syndrome: a cross-sectional study using the 2016-2018 National Inpatient Sample database.","authors":"R Grovu, A Nguyen, K Sangaraju, C Wei, A Mustafa, A Slobodnick","doi":"10.1080/03009742.2023.2238402","DOIUrl":"10.1080/03009742.2023.2238402","url":null,"abstract":"Objective: This study assessed the relationship between anti-thrombotics and major adverse cardiovascular events (MACE) in patients with anti-phospholipid syndrome (APS).Method: We included 13 947 subjects with APS from the National (Nationwide) Inpatient Sample (NIS) database for 2016-2018, and collected relevant covariates and demographic data using ICD-10 codes. Our two primary outcomes were MACE and death. We performed multivariate logistic regression analysis to assess the impact of various anti-thrombotic regimens on MACE/death in our primary cohort and high-risk subgroups.Results: Patients on anti-coagulants had significantly reduced odds of MACE [odds ratio (OR) 0.68, 95% confidence interval (CI) 0.62-0.76, p < 0.001] as well as each of its subcomponents. Those not on any anti-coagulants had significantly increased odds of MACE (OR 1.47, 95% CI 1.24-1.72, p < 0.001). No significant association was found between anti-platelet use and the odds of MACE (p > 0.05). Patients on anti-coagulants were the only class that appeared to have a mortality benefit with reduced odds for death (OR 0.64, 95% CI 0.49-0.84, p = 0.001). In the subgroups at higher risk for MACE (those with atrial fibrillation and thrombocytopenia), full anti-coagulation therapy was also the only anti-thrombotic class that significantly affected the odds of MACE, with a protective effect on MACE, but had no mortality benefit.Conclusion: Patients with APS are most likely to benefit from anti-coagulant therapy in reducing MACE. Furthermore, anti-platelets alone or in combination with anti-coagulants are probably not beneficial in MACE reduction and may even increase risk.","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10062149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0