Scandinavian Journal of Rheumatology最新文献

{"title":"On the interpretation of validation in register-based identification of polymyalgia rheumatica.","authors":"F Shahid Tanveer, R Irfan","doi":"10.1080/03009742.2026.2666974","DOIUrl":"10.1080/03009742.2026.2666974","url":null,"abstract":"","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":" ","pages":"386-387"},"PeriodicalIF":1.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148259270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Giant mass-like ankle pannus in rheumatoid arthritis.","authors":"D Bulut Gökten, R Mercan","doi":"10.1080/03009742.2026.2647538","DOIUrl":"10.1080/03009742.2026.2647538","url":null,"abstract":"","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":" ","pages":"378-379"},"PeriodicalIF":1.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147676363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Avacopan in a compassionate use programme for severe anti-neutrophil cytoplasmic antibody-associated vasculitis in Sweden.","authors":"I Gunnarsson, A Lindholm, M Petkovic, S Brolin, O Börjesson, I Al Azzawi, R Andraos, C Sjöwall, K Palmblad, A Horne, J Rofors, M Weiner, S Ohlsson, A Antovic, A Bruchfeld","doi":"10.1080/03009742.2026.2640767","DOIUrl":"10.1080/03009742.2026.2640767","url":null,"abstract":"<p><strong>Objective: </strong>Avacopan (AVAC), an oral selective C5a receptor inhibitor, has been approved for treatment in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Outside randomized controlled studies, real-world data are scarce. The aim of this study was to provide further insight into the clinical experience of AVAC.</p><p><strong>Method: </strong>We analysed data from 16 patients with severe AAV included in an AVAC compassionate use programme. Disease activity was estimated with the Birmingham Vasculitis Activity Score (BVAS). Fatigue was assessed using the Multidimensional Assessment of Fatigue (MAF).</p><p><strong>Results: </strong>Thirteen patients (81%) were diagnosed with granulomatosis with polyangiitis (GPA) and three (19%) with microscopic polyangiitis. The mean age at AVAC initiation was 51 (range 16-74) years. The median [interquartile range (IQR)] BVAS score was 10 (3.25-13.25) at baseline and 0 (0-0) at 6 months (p < 0.0001). All but one reached clinical remission. Prednisolone was tapered from a median (IQR) dose of 25 (20-60) to 2.5 (0-5) mg/day at 6 months (p = 0.0001). Eight patients discontinued prednisolone [median time 2.5 month1 week to 10 months)]. The median (IQR) estimated glomerular filtration rate in patients with renal AAV (n = 10) increased from 50 (13-75) to 58 (15.5-88) mL/min/1.73 m² at 6 months (p = 0.055). One patient progressed to end-stage kidney disease, while another was able to discontinue haemodialysis. Serious adverse events were seen in five of the 16 patients (31.3%). The MAF score decreased, with a mean difference of 6.65 (p = 0.05) at 6 months.</p><p><strong>Conclusion: </strong>The use of AVAC in a case series with mainly GPA patients led to rapid clinical improvement, reduction of corticosteroid doses, and improvement in fatigue. The findings demonstrate beneficial effects of AVAC as add-on therapy in severe AAV.</p>","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":" ","pages":"337-343"},"PeriodicalIF":1.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147988259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Caplan syndrome presenting as tumour-like pulmonary nodules in a patient with rheumatoid arthritis: a diagnostic challenge.","authors":"Z Zhang, L Kang, Z Zhang","doi":"10.1080/03009742.2026.2650906","DOIUrl":"10.1080/03009742.2026.2650906","url":null,"abstract":"","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":" ","pages":"383-385"},"PeriodicalIF":1.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147699652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cough as a clinical manifestation of giant cell arteritis.","authors":"L Moreel, A Van Gelder, A Betrains, L Boeckxstaens, K Van Laere, E De Langhe, D Blockmans, S Vanderschueren","doi":"10.1080/03009742.2026.2644011","DOIUrl":"10.1080/03009742.2026.2644011","url":null,"abstract":"<p><strong>Objectives: </strong>Cough is an underrecognized and atypical manifestation of giant cell arteritis (GCA), which may lead to diagnostic delay. Literature on cough in GCA is limited and lacks comprehensive data on clinical relevance. The aim of this study was to assess the frequency of cough at diagnosis in GCA patients and to compare clinical characteristics between those with and without cough.</p><p><strong>Method: </strong>Consecutive patients diagnosed with GCA between 2000 and 2020 and followed for ≥ 12 months at the University Hospitals Leuven (Belgium) were included retrospectively.</p><p><strong>Results: </strong>We included 398 GCA patients, of whom 72 (18%) reported cough. Patients with cough were slightly younger (69.8 vs 72.3 years, p = 0.019), more frequently had constitutional symptoms (94% vs 73%, p < 0.001), and less often had polymyalgia rheumatica (26% vs 50%, p < 0.001) or permanent visual loss (3% vs 19%, p < 0.001). They had higher C-reactive protein (86 vs 68 mg/L, p = 0.003) and erythrocyte sedimentation rate (80 vs 67 mm/h, p = 0.036), and lower haemoglobin (11.3 vs 11.8 g/dL, p = 0.008) and albumin (36.7 vs 38.4 g/L, p = 0.013). Positron emission tomography total vascular score (10 vs 5, p = 0.009) was higher in GCA patients with cough. Although time to first relapse was shorter (10 vs 13 months, p = 0.018), relapse probability [hazard ratio (HR) 1.15, 95% confidence interval (CI) 0.82-1.61, p = 0.420] and the probability of discontinuing glucocorticoids were similar (HR 1.10, 95% CI 0.80-1.50, p = 0.563).</p><p><strong>Conclusion: </strong>GCA patients with cough may represent a distinct phenotype associated with systemic inflammation and large-vessel involvement. Further prospective studies with standardized cough assessment are needed to clarify the role of cough in GCA.</p>","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":" ","pages":"329-336"},"PeriodicalIF":1.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147628339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does lacrimal gland ultrasound discriminate between Sjögren's disease and non-Sjögren's sicca patients?","authors":"Nrf Sluijpers, T Yang, A J Stel, J F van Nimwegen, L Olie, J Vehof, Ksm van der Geest, H Bootsma, S Arends, A D Coumou, S Pringle, K Delli","doi":"10.1080/03009742.2026.2644006","DOIUrl":"10.1080/03009742.2026.2644006","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the performance of colour Doppler lacrimal gland ultrasound (LGUS CD) for discriminating Sjögren's disease (SjD) from non-SjD sicca patients under routine clinical practice conditions.</p><p><strong>Method: </strong>Forty patients with clinically suspected SjD underwent ocular function tests [Schirmer's test, ocular staining score (OSS)] and LGUS CD evaluation. Ultrasound images and videos were scored for both lacrimal glands using the Outcome Measures in Rheumatology (OMERACT) CD scoring system (range 0-3). Subsequently, a total score (range 0-6) was calculated for each patient. Sensitivity and specificity of LGUS CD and ocular function tests were calculated to predict SjD classification according to 2016 American College of Rheumatology/European Alliance of Associations for Rheumatology (ACR/EULAR) classification criteria. Construct validity of LGUS CD was assessed by determining Spearman's correlation coefficients between LGUS CD, Schirmer's test, and OSS.</p><p><strong>Results: </strong>Twenty-three patients were classified with SjD and 17 as non-SjD sicca patients. LGUS CD sensitivity was 57% and specificity was 53% for prediction of classification according to 2016 ACR/EULAR classification criteria for SjD. Total LGUS CD score of both eyes and the individual LGUS CD score of the left and right eye did not differ significantly between SjD and non-SjD sicca patients. None of the ACR/EULAR classification criteria differed significantly between the groups with high and low LGUS CD scores. Poor correlations were determined between LGUS CD and ocular function tests (ρ = 0.028-0.187).</p><p><strong>Conclusion: </strong>LGUS CD demonstrated similar characteristics in SjD and non-SjD sicca patients, suggesting limited discriminatory value. Refined ultrasonographic scoring systems are needed to improve differentiation between these patient groups.</p>","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":" ","pages":"358-365"},"PeriodicalIF":1.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147699619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and radiological distinctiveness of anti-cyclic citrullinated peptide antibody-negative rheumatoid arthritis-associated interstitial lung disease: a retrospective cohort study.","authors":"Y Han, F Jiang, Q Zhu, C Li, X Chen, J Xu, Z An, J Zhao","doi":"10.1080/03009742.2026.2650907","DOIUrl":"10.1080/03009742.2026.2650907","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the differences in clinical manifestations, serological profiles, pulmonary function, and high-resolution computed tomography (HRCT) findings between patients with anti-cyclic citrullinated peptide (CCP) antibody-negative and anti-CCP-positive rheumatoid arthritis-associated interstitial lung disease (RA-ILD).</p><p><strong>Method: </strong>A retrospective cohort of 214 RA-ILD patients admitted to Peking University Third Hospital between December 2009 and May 2025 was analysed. Comprehensive clinical data, laboratory parameters, pulmonary function tests, and HRCT features were systematically compared between anti-CCP-negative and anti-CCP-positive groups.</p><p><strong>Results: </strong>Among the 214 RA-ILD patients, 41 (19.2%) were anti-CCP negative and 173 (80.8%) were anti-CCP positive. Compared with the anti-CCP-positive group, the anti-CCP-negative group had a lower proportion of males (17.1% vs 36.4%, p < 0.05) and smokers (12.2% vs 28.3%, p < 0.05), but a higher prevalence of anti-SSB antibody positivity (10.8% vs 2.5%, p < 0.05). HRCT revealed fewer fibrotic features, including reticulation, honeycombing, and traction bronchiectasis (36.6% vs 67.1%, p < 0.05), and a lower prevalence of the usual interstitial pneumonia pattern (22.0% vs 43.4%, p < 0.05) in the anti-CCP-negative group. No significant intergroup differences were observed in age at RA onset, comorbidities, disease activity scores, velcro rales, or pulmonary function parameters.</p><p><strong>Conclusion: </strong>While anti-CCP-negative and anti-CCP-positive RA-ILD patients share many clinical similarities, the anti-CCP-negative subgroup is characterized by a distinct profile including lower frequencies of males and smoking, higher anti-SSB antibody positivity, and less severe fibrotic lesions on HRCT.</p>","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":" ","pages":"315-322"},"PeriodicalIF":1.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147699578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral colonization of <i>Pneumocystis jirovecii</i> in patients with rheumatoid arthritis and respiratory symptoms: a substudy of the AURORA cohort.","authors":"B K Sofíudóttir, M S Kragsnæs, C B Laursen, U S Justesen, S Harders, J R Davidsen, T Ellingsen","doi":"10.1080/03009742.2026.2644022","DOIUrl":"10.1080/03009742.2026.2644022","url":null,"abstract":"<p><strong>Objectives: </strong>Pneumocystis pneumonia (PCP) is a serious fungal infection in immunocompromised patients. We investigated the prevalence of <i>Pneumocystis jirovecii</i> (PJ) colonization using oral wash polymerase chain reaction (PCR) in Danish rheumatoid arthritis (RA) patients with respiratory symptoms or recurrent pneumonia, and assessed its diagnostic utility for PCP.</p><p><strong>Method: </strong>This secondary analysis of the AURORA study included 76 consenting adults (aged ≥ 18 years) with RA and respiratory symptoms or recurrent pneumonia. Oral wash samples were tested for PJ using a validated PCR assay. All patients underwent pulmonary assessment, including high-resolution computed tomography (HRCT). Medical records were audited for PCP diagnoses after 2 years.</p><p><strong>Results: </strong>The mean age was 65.6 years, 63% were female, 24% received biological disease-modifying anti-rheumatic drug treatment, and 8% had received biological treatment of >3 years' duration. Only one patient (1%), treated with methotrexate and rituximab and presenting with recurrent pneumonia, cough, and dyspnoea, tested positive for PJ. HRCT showed pneumonia, interstitial lung disease (usual interstitial pneumonia pattern), bronchiectasis, and emphysema. PCP was confirmed by a respiratory physician based on clinical presentation. No other patients developed PCP during follow-up.</p><p><strong>Conclusion: </strong>Oral colonization with PJ was rare in this cohort of Danish RA patients with respiratory symptoms. The low prevalence of colonization and the absence of PCP in PJ-negative patients suggest that routine screening for oral PJ colonization is not warranted in this population.</p>","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":" ","pages":"323-328"},"PeriodicalIF":1.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147841971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Answer to: 'On the interpretation of validation in register-based identification of polymyalgia rheumatica' by Tanveer and Irfan.","authors":"A O Donskov, T Gaster, E M Hauge, A De Thurah, M Nørgaard, K K Keller","doi":"10.1080/03009742.2026.2666984","DOIUrl":"10.1080/03009742.2026.2666984","url":null,"abstract":"","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":" ","pages":"388-389"},"PeriodicalIF":1.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148259299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful treatment of rheumatoid arthritis-associated pure red cell aplasia with rituximab: a case report.","authors":"Y Wada, K Ninagawa, Y Fujieda, Y Shimizu","doi":"10.1080/03009742.2026.2647537","DOIUrl":"10.1080/03009742.2026.2647537","url":null,"abstract":"","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":" ","pages":"375-377"},"PeriodicalIF":1.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147699589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}