Scandinavian Journal of Rheumatology最新文献_第2页

Pristimerin inhibits the progression of antibody-induced autoimmune arthritis. Pristimerin 可抑制抗体诱导的自身免疫性关节炎的发展。

IF 2.2 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2025-05-01 Epub Date: 2024-11-12 DOI: 10.1080/03009742.2024.2421618

H Nanjaiah, K D Moudgil

{"title":"Pristimerin inhibits the progression of antibody-induced autoimmune arthritis.","authors":"H Nanjaiah, K D Moudgil","doi":"10.1080/03009742.2024.2421618","DOIUrl":"10.1080/03009742.2024.2421618","url":null,"abstract":"Objectives: Rheumatoid arthritis (RA) is an autoimmune disease of the synovial joints. Pro-inflammatory cytokines produced by various immune cells drive the chronic inflammatory processes that lead to joint damage. Many drugs are available for the treatment of RA, but a significant proportion of patients do not respond adequately to them and/or have severe adverse effects. Accordingly, there is an urgent need for new therapeutics for RA. Therefore, we tested pristimerin, a natural triterpenoid, for its anti-arthritic activity in experimental RA.Method: Collagen antibody-induced arthritis (CAIA) was induced in DBA/1 mice. After the onset of arthritis, mice were injected daily intraperitoneally with pristimerin or vehicle for 9 days. The severity of clinical arthritis was graded and further validated by micro-computed tomography and histological examination of the hind paws. Defined mediators of arthritogenic processes were quantified by gene expression in the spleen and further validated by immunohistochemistry of paws.Results: We observed that pristimerin can effectively control arthritis progression in CAIA mice. A preliminary exploration of the mechanisms showed that pristimerin targeted key pro-inflammatory cytokines and chemokines, along with specific mediators of angiogenesis, bone remodelling, and cellular signalling, including the Notch signalling pathway.Conclusions: This is the first report on pristimerin for its use in the treatment of antibody-induced arthritis and for the targeting of Notch pathway in arthritis by this triterpenoid. As pristimerin can control the effector phase of arthritis, our results are promising for the translation of this experimental therapy to RA patients.","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":" ","pages":"198-203"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142627227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex distribution in psoriatic arthritis: a systematic literature review. 银屑病关节炎的性别分布：系统文献综述。

IF 2.2 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2025-05-01 Epub Date: 2025-02-26 DOI: 10.1080/03009742.2025.2465014

B Firlatan, G S Kart Bayram, G Ayan, E Karabulut, U Kalyoncu

{"title":"Sex distribution in psoriatic arthritis: a systematic literature review.","authors":"B Firlatan, G S Kart Bayram, G Ayan, E Karabulut, U Kalyoncu","doi":"10.1080/03009742.2025.2465014","DOIUrl":"10.1080/03009742.2025.2465014","url":null,"abstract":"Objective: Although the prevalence of psoriatic arthritis (PsA) is considered equal between the sexes, recent PsA studies have reported a female predominance, with female-to-male ratios between 1.2:1 and 2:1. It is not clear whether this is related to a change in the epidemiology of the disease or to different patterns of patients attending outpatient clinics. We aimed to assess the female-to-male ratios in recent PsA studies.Method: A systematic review of the literature (January 2020 to September 2022) was performed using the PubMed database with keywords and MeSH terms referring to 'psoriatic arthritis'. Randomized controlled trials (RCTs), and cross-sectional, prospective, and retrospective cohort studies involving at least 20 patients and specifying the number of males and females were considered eligible.Results: From 2800 initially identified articles, 481 eligible studies with 871 144 participants were analysed, revealing a female majority (54.1%). When we evaluated the studies based on their design, we found that female sex was more predominant in each type of design, with retrospective cohort studies having the highest prevalence. According to the number of centres involved, multi-centre studies demonstrated a greater representation of female participants than single-centre studies (54% vs 50%). Regarding the geographical locations, studies conducted in America, Europe, and multinational contexts displayed a female predominance.Conclusion: In our assessment, RCTs had the closest sex equality, with a slight preponderance of females. The real-life and multi-centre studies had more pronounced female rates, with several differences observed in different geographical locations.","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":" ","pages":"192-197"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143503669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and validation of a patient knowledge questionnaire for rheumatoid arthritis (PKQ-RA-11) in Danish and German. 丹麦语和德语类风湿性关节炎患者知识问卷（PKQ-RA-11）的开发和验证。

IF 2.2 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2025-05-01 Epub Date: 2025-02-24 DOI: 10.1080/03009742.2025.2463734

L R Knudsen, J Knitza, F Mühlensiepen, A Hueber, J Henes, M Ndosi, A de Thurah

{"title":"Development and validation of a patient knowledge questionnaire for rheumatoid arthritis (PKQ-RA-11) in Danish and German.","authors":"L R Knudsen, J Knitza, F Mühlensiepen, A Hueber, J Henes, M Ndosi, A de Thurah","doi":"10.1080/03009742.2025.2463734","DOIUrl":"10.1080/03009742.2025.2463734","url":null,"abstract":"Objective: Patient education is a cornerstone of rheumatology care, enabling patients to effectively and safely manage their condition. Standardized patient knowledge assessments are essential for benchmarking care quality and tailoring education to individual needs. This study aimed to develop and validate Danish and German versions of a patient knowledge questionnaire (PKQ) for rheumatoid arthritis (RA).Method: Danish and German adaptations from the English version involved a forward-and-backward translation process. Face validity was assessed with patients with RA in Denmark and Germany. Subsequently, the generated PKQ-RA-11 versions were tested in Danish and German RA patients.Results: The face-validity assessment included 20 patients (10 Danish, 10 German). Adjustments in the Danish version included rephrasing options and aligning with digital patient education content. The German version followed the refined Danish version with necessary cultural adjustments. PKQ-RA-11 comprises 11 multiple-choice questions with a scoring system to minimize guessing. The final PKQ-RA-11 was completed by 175 Danish and 174 German patients; mean completion time was 7.5 and 7.4 minutes, respectively. Mean ± sd baseline PKQ-RA-11 scores were 7.9 ± 1.6 for Danish and 6.2 ± 2.5 for German participants. Longitudinal data from Denmark indicated an increase in knowledge scores following patient education, shown by a mean score of 8.6 ± 1.5, demonstrating the tool's responsiveness to changes in patient understanding of RA.Conclusion: PKQ-RA-11 is a standardized tool for assessing disease-related knowledge in individuals with RA. It can be used to provide objective and transparent measures of patient understanding in educational programmes, clinical practice, or research.","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":" ","pages":"166-174"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Highlighting individual patient data related to chimeric antigen receptor T-cell therapy in refractory autoimmune rheumatic diseases. 强调与嵌合抗原受体t细胞治疗难治性自身免疫性风湿病相关的个体患者数据。

IF 2.2 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2025-05-01 Epub Date: 2025-01-13 DOI: 10.1080/03009742.2024.2421621

M L Larsen, A Voss, C Tandrup Holst Nielsen, E-M Hauge, M Faurschou, A Troldborg

引用次数: 0

Incident rheumatoid arthritis in patients living in Turkey and in Denmark: a comparative clinical, genetic, and serological study. 生活在土耳其和丹麦的类风湿关节炎患者的发病情况：临床、遗传和血清学比较研究。

IF 2.2 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2025-05-01 Epub Date: 2024-11-25 DOI: 10.1080/03009742.2024.2424083

C Rasmussen, G Can, R Steffensen, G Kenar Artin, H Y Tuğsal, D Solmaz, N Inanc, B N Coşkun, Y Pehlivan, S Akar, F Onen, K B Lauridsen, N S Krogh, N Akkoc

{"title":"Incident rheumatoid arthritis in patients living in Turkey and in Denmark: a comparative clinical, genetic, and serological study.","authors":"C Rasmussen, G Can, R Steffensen, G Kenar Artin, H Y Tuğsal, D Solmaz, N Inanc, B N Coşkun, Y Pehlivan, S Akar, F Onen, K B Lauridsen, N S Krogh, N Akkoc","doi":"10.1080/03009742.2024.2424083","DOIUrl":"10.1080/03009742.2024.2424083","url":null,"abstract":"Objective: The north-south gradient hypothesis proposes that individuals with rheumatoid arthritis (RA) residing in southern regions manifest a younger age of onset and milder disease compared to their northern counterparts. This study aimed to compare treatment-naïve, new-onset RA patients in Denmark and Turkey, examining demographic, clinical, laboratory, and genetic parameters.Method: Prospective data collection was conducted, with all patients meeting the 2010 American College of Rheumatology/European League Against Rheumatism criteria. Shared epitope (SE) allele carrier frequencies were examined for genetic comparisons between patients and normal controls.Results: Out of 223 RA patients, 109 were Danish and 114 Turkish. Danish patients exhibited a median age at onset of 60 years, whereas Turkish patients were younger at 51 years (p = 0.0007). The Danish cohort displayed significantly more swollen and tender joints, resulting in higher Disease Activity Score based on 28-joint count-C-reactive protein (DAS28-CRP). Danish RA patients and controls possessed more RA risk-enhancing alleles (S2 + S3P) and fewer risk-protective (S1 + S3D) alleles than Turkish patients and controls.Conclusion: This study substantiates the north-south gradient hypothesis, highlighting that new-onset RA patients in Denmark tend to experience an older age of onset and more severe disease activity than their Turkish counterparts. Variations in risk-enhancing alleles and fewer risk-protective alleles in Danish patients and controls are associated with these distinctions. Future research should investigate the genetic and environmental factors underlying these regional disparities, exploring their persistence in the long-term course of the disease through follow-up studies.","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":" ","pages":"158-165"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rapid improvement of rheumatoid arthritis symptoms with ozoralizumab: a case of progress monitored by musculoskeletal ultrasonography. 用ozoralizumab快速改善类风湿性关节炎症状：一个由肌肉骨骼超声监测进展的病例。

IF 2.2 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2025-05-01 Epub Date: 2025-02-19 DOI: 10.1080/03009742.2025.2464451

D Nakagomi, S Hanai

引用次数: 0

Baricitinib for skin vasculitis in primary Sjögren's disease: report of two cases. 巴西替尼治疗原发性Sjögren病皮肤血管炎2例报告。

IF 2.2 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2025-04-25 DOI: 10.1080/03009742.2025.2488098

G Hernández-Molina

引用次数: 0

Exploratory study of predictors of decreased ability to perform activities of daily living in people living with hand osteoarthritis. 手骨关节炎患者日常生活能力下降预测因素的探索性研究。

IF 2.2 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2025-04-24 DOI: 10.1080/03009742.2025.2484127

U Andersen, A Døssing, H Gudbergsen, V Hagelskjaer, H Bliddal, E E Wæhrens

{"title":"Exploratory study of predictors of decreased ability to perform activities of daily living in people living with hand osteoarthritis.","authors":"U Andersen, A Døssing, H Gudbergsen, V Hagelskjaer, H Bliddal, E E Wæhrens","doi":"10.1080/03009742.2025.2484127","DOIUrl":"https://doi.org/10.1080/03009742.2025.2484127","url":null,"abstract":"Objective: People with hand osteoarthritis (OA) report decreased ability to perform activities of daily living (ADL). However, few are referred to occupational therapy by their general practitioner. This study aimed to identify clinical predictors of decreased ADL ability in people with hand OA as markers of the need for referral to occupational therapy.Method: A cross-sectional study was conducted as an independent add-on to a randomized controlled trial of adults with hand OA (the COLOR trial). Measures of self-reported (ADL Interview) and observed (Assessment of Motor and Process Skills) ADL ability were collected. Data representing potential predictors identified by stakeholders were extracted from the COLOR trial: age, sex, symptom duration, hand OA type, grip strength, pain, stiffness, function, illness perception, and health-related quality of life. Correlational analyses and prediction models were used.Results: Correlations between ADL ability and potential predictors in the 62 participants were low to negligible (r < 0.5). Based on root mean square error (RMSE) estimates, prediction models for observed ADL motor (RMSE = 0.3) and ADL process (RMSE = 0.2) ability were more accurate than for self-reported ADL ability (RMSE = 0.6). However, these variables only predicted observed ADL motor and ADL process ability with 16% (adjusted Rs = 0.163) and 12% (adjusted Rs = 0.120) accuracy, respectively.Conclusion: The findings suggest that variables representing body functions, perceived health, and quality of life do not predict ADL ability among people living with hand OA. An adequately powered study is recommended to explore this topic further.","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":" ","pages":"1-9"},"PeriodicalIF":2.2,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Translation, cross-cultural adaptation, and reliability of the EULAR Systemic Sclerosis Impact of Disease (ScleroID) questionnaire in a Danish population. 丹麦人群中EULAR系统性硬化症影响（ScleroID）问卷的翻译、跨文化适应和可靠性

IF 2.2 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2025-04-03 DOI: 10.1080/03009742.2025.2480910

F N Foldager, J Beck Larsen, A Christensen, J Laursen, S Egsgaard, J Brincks, M Godt Hansen, M Pilegaard, M Ladefoged Assmann, A de Thurah, K Søndergaard, I Mechlenburg

{"title":"Translation, cross-cultural adaptation, and reliability of the EULAR Systemic Sclerosis Impact of Disease (ScleroID) questionnaire in a Danish population.","authors":"F N Foldager, J Beck Larsen, A Christensen, J Laursen, S Egsgaard, J Brincks, M Godt Hansen, M Pilegaard, M Ladefoged Assmann, A de Thurah, K Søndergaard, I Mechlenburg","doi":"10.1080/03009742.2025.2480910","DOIUrl":"https://doi.org/10.1080/03009742.2025.2480910","url":null,"abstract":"Objectives: This study aims to translate and cross-culturally adapt the European Alliance of Associations for Rheumatology (EULAR) Systemic Sclerosis Impact of Disease (ScleroID) questionnaire to Danish; and to assess its reliability in patients with systemic sclerosis (SSc).Method: The translation and cross-cultural adaptation of the ScleroID questionnaire were conducted according to COnsensus-based Standard for the selection of health Measurement INstruments (COSMIN) guidelines. The test-retest reliability was assessed in 50 Danish patients with SSc.Results: All steps for the translation process were followed and approved by the developers of ScleroID. The translation process resulted in changes to the wording of 'aspects' to 'symptoms', 'phenomenon' to 'syndrome', and 'social life' to 'social relations and leisure activities' to create a more meaningful translation in a Danish context. For the Danish version of the ScleroID, the intraclass correlation coefficient (ICC) was 0.90 [95% confidence interval (CI) 0.83; 0.94]. The ICC for each of the 10 individual health domains in ScleroID ranged from 0.52 (95% CI 0.29; 0.70) (digital ulcers) to 0.87 (0.78; 0.92) (lower gastrointestinal symptoms and fatigue).Conclusion: The overall ICC for the Danish version of the ScleroID was excellent, which indicates that it can be implemented as a reliable patient-reported outcome measure in patients with SSc in Denmark.","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":" ","pages":"1-8"},"PeriodicalIF":2.2,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A preceptorship programme to learn ultrasonography for diagnosis of giant cell arteritis. 学习超声诊断巨细胞动脉炎的实习计划。

IF 2.2 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2025-04-02 DOI: 10.1080/03009742.2025.2480871

C B Mukhtyar, A Ather, G Ducker, T Ecclestone, S Fordham, H Naeem, F L Coath

{"title":"A preceptorship programme to learn ultrasonography for diagnosis of giant cell arteritis.","authors":"C B Mukhtyar, A Ather, G Ducker, T Ecclestone, S Fordham, H Naeem, F L Coath","doi":"10.1080/03009742.2025.2480871","DOIUrl":"https://doi.org/10.1080/03009742.2025.2480871","url":null,"abstract":"Objective: Ultrasonography has been proposed as the initial diagnostic modality in suspected giant cell arteritis. Proposed quality standards advocate for a certified sonographer. Currently, there are no formal training programmes, and single educational events do not suffice as certification. We developed a preceptorship programme for diagnostic ultrasonography. Here, we describe its contents and test its efficacy.Method: The programme comprises three stages. The preclinical stage includes machine setting and surface anatomy. Second stage includes supervised assessment, passed via a directly observed procedure form. In the final validation stage, the trainee and trainer perform an ultrasonography examination in succession, with a comparison of the results. For this programme, a scan included all three segments of the superficial temporal artery and all three parts of the axillary arteries. Comparison of the intima-media thickness (IMT) and categorical judgements for the halo sign and final diagnosis were made.Results: Six trainees have been through this programme so far. A median of 16 ultrasonography examinations was required to reach the validation stage. The mean ± SD IMT in 360 segments, as measured by the trainee and trainer, was 0.45 ± 0.34 and 0.46 ± 0.35, respectively (p = 0.26). The agreement between trainee and trainer for the presence or absence of halo was excellent in 403 segments (κ = 0.91, 95% confidence interval 0.86, 0.96). There was 100% agreement on the final diagnosis.Conclusion: The integration of technical knowledge with practical skills results in a robust training programme, validating trainees to continue scanning independently.","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":" ","pages":"1-6"},"PeriodicalIF":2.2,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0