Scandinavian Journal of Rheumatology最新文献_第2页

Bicaudal D2 autoantibodies are highly specific for systemic sclerosis. 双核 D2 自身抗体对系统硬化症具有高度特异性。

IF 2.2 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2024-09-01 Epub Date: 2024-06-24 DOI: 10.1080/03009742.2024.2335718

L V Iversen, C Tandrup Nielsen, S Jacobsen, M-Lf Hermansen, L P Diederichsen, T Friis

{"title":"Bicaudal D2 autoantibodies are highly specific for systemic sclerosis.","authors":"L V Iversen, C Tandrup Nielsen, S Jacobsen, M-Lf Hermansen, L P Diederichsen, T Friis","doi":"10.1080/03009742.2024.2335718","DOIUrl":"10.1080/03009742.2024.2335718","url":null,"abstract":"Objective: Autoantibodies directed against the intracellular protein bicaudal D2 (BICD2) have been identified as a specific marker of systemic sclerosis (SSc). Since autoantibodies are of value in predicting disease onset and identifying meaningful clinical subsets, as well as having prognostic value, this study aimed to establish the prevalence of BICD2 autoantibodies (anti-BICD2) in a cohort of patients with connective tissue disease and healthy controls.Method: In this cross-sectional study, 363 patients with connective tissue disease (121 SSc, 141 systemic lupus erythematosus, 101 myositis, and 100 blood donors) were tested for the presence of anti-BICD2. All SSc patients were tested for specific anti-nuclear antibodies (ANAs), and clinical and laboratory associations were evaluated in the SSc patients, stratified by anti-BICD2 status.Results: In the SSc cohort, 35 patients had autoantibodies directed against BICD2. The specificity of anti-BICD2 in SSc patients was 96.5%; however, the sensitivity was only 28.9%. Anti-BICD2 and centromere autoantibodies were present together in 91% of the anti-BICD2-positive SSc patients, and in none of the cases was anti-BICD2 the only antibody present. Anti-BICD2-positive patients had lower forced expiratory volume in 1 s (FEV1) (p = 0.01) and lower carbon monoxide transfer coefficient (KCO) (p = 0.01) than anti-BICD2-negative SSc patients, but they had higher forced vital capacity (p = 0.03).Conclusion: Autoantibodies against BICD2 were highly specific for SSc patients. Reduced FEV1 and KCO in anti-BICD2-positive patients may indicate that the presence of anti-BICD2 is associated with altered lung function in an unknown pathophysiological manner, which awaits further elucidation.","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141446917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction. 更正。

IF 2.2 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2024-09-01 Epub Date: 2024-07-18 DOI: 10.1080/03009742.2024.2377498

引用次数: 0

Inferior vena cava occlusion in patients with retroperitoneal fibrosis. 腹膜后纤维化患者的下腔静脉闭塞。

IF 2.2 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2024-09-01 Epub Date: 2024-08-06 DOI: 10.1080/03009742.2024.2381919

M B Krogh, B Jespersen, L C Gormsen, J Budtz-Lilly, K K Keller, H Birn

引用次数: 0

Incidence of seropositive and seronegative rheumatoid arthritis in Denmark: a nationwide population-based study. 丹麦血清阳性和血清阴性类风湿性关节炎的发病率：一项基于全国人口的研究。

IF 2.2 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2024-09-01 Epub Date: 2024-07-08 DOI: 10.1080/03009742.2024.2365540

B G Soussi, R L Cordtz, K Duch, S Kristensen, D Prieto-Alhambra, A Linauskas, C S Bork, E B Schmidt, L Dreyer

{"title":"Incidence of seropositive and seronegative rheumatoid arthritis in Denmark: a nationwide population-based study.","authors":"B G Soussi, R L Cordtz, K Duch, S Kristensen, D Prieto-Alhambra, A Linauskas, C S Bork, E B Schmidt, L Dreyer","doi":"10.1080/03009742.2024.2365540","DOIUrl":"10.1080/03009742.2024.2365540","url":null,"abstract":"Objective: To investigate and compare trends in incidence rates (IRs) of seropositive and seronegative rheumatoid arthritis (RA) in Denmark using various data sources for serostatus definition.Method: This nationwide population-based cohort study was based on data from Danish healthcare and clinical quality registries between 2000 and 2018. Information on anti-cyclic citrullinated peptide and immunoglobulin M rheumatoid factor was obtained, and definitions of seropositivity according to the number of applied data sources were prespecified. Annual age- and sex-standardized IRs were calculated as the number of incident seropositive and seronegative cases, divided by the number of person-years (PY) in the general population in that given year.Results: An increasing temporal trend in IR of seropositive RA and a decreasing trend in seronegative RA were observed. The IRs were higher for seropositive RA than for seronegative RA from 2009 onwards, with a widening of the IR gap between 2009 and 2016 regardless of the definition of seropositivity. When combining laboratory- and physician-reported autoantibody information and ICD-10 codes, the IR of seropositive RA in 2018 was approximately twice that of seronegative RA, at 19.0 and 9.0 per 100 000 PY, respectively. The level of antibody testing increased significantly during the study period.Conclusions: The IR of seropositive RA increased over time, whereas the IR of seronegative RA decreased. Temporal IR changes may be caused by a real change in the RA serology subtypes, an increase in autoantibody testing and availability, changes in registration practice over time, or a combination of these factors.","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141555426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New onset of guttate psoriasis, Hallopeau's continuous acrodermatitis, and psoriatic arthritis after COVID-19 vaccine. 接种COVID-19疫苗后，新发肠套叠型银屑病、哈罗波氏持续性皮炎和银屑病关节炎。

IF 2.2 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2024-09-01 Epub Date: 2024-02-26 DOI: 10.1080/03009742.2024.2316998

A Zoli, G Peluso, M Grimaldi, C De Simone, M A D'Agostino, A Ortolan

引用次数: 0

Tomographic ultrasound for three-dimensional visualization of temporal arteries. 用于颞动脉三维可视化的断层超声。

IF 2.2 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2024-09-01 Epub Date: 2024-03-04 DOI: 10.1080/03009742.2024.2320585

M Naumovska, U Dahlstrand, L Engqvist, M Cinthio, J Albinsson, R Sheikh, A Merdasa, M Malmsjo

{"title":"Tomographic ultrasound for three-dimensional visualization of temporal arteries.","authors":"M Naumovska, U Dahlstrand, L Engqvist, M Cinthio, J Albinsson, R Sheikh, A Merdasa, M Malmsjo","doi":"10.1080/03009742.2024.2320585","DOIUrl":"10.1080/03009742.2024.2320585","url":null,"abstract":"Objective: Conventional two-dimensional ultrasound has been assessed for the non-invasive diagnosis of giant cell arteritis (GCA), but the results are operator dependent, resulting in low sensitivity. Tomographic three-dimensional (3D) ultrasound is a novel technique that enables the objective documentation of vessel geometry. Here, for the first time, its utility is assessed for visualizing temporal arteries.Method: The temporal artery of 14 healthy subjects and three subjects with suspected GCA was examined using tomographic 3D ultrasound.Results: This technique enabled 3D mapping of the architecture of the temporal artery. The inner and outer vessel diameters showed considerable interindividual variability. However, calculation of the vessel wall fraction revealed the combination of vessel wall thickening and lumen narrowing, which may be indicative of GCA.Conclusions: This proof-of-concept study indicates that tomographic 3D ultrasound can be used for objective mapping of the temporal artery. The technique must be evaluated regarding its diagnostic sensitivity in GCA before it can be introduced in clinical practice.","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140022497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-determined motivation and physical activity in patients with rheumatoid arthritis: a cross-sectional study. 类风湿性关节炎患者的自决动机和体育锻炼：一项横断面研究。

IF 2.2 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2024-09-01 Epub Date: 2024-01-26 DOI: 10.1080/03009742.2023.2300576

I S Houge, M Hoff, V Videm

{"title":"Self-determined motivation and physical activity in patients with rheumatoid arthritis: a cross-sectional study.","authors":"I S Houge, M Hoff, V Videm","doi":"10.1080/03009742.2023.2300576","DOIUrl":"10.1080/03009742.2023.2300576","url":null,"abstract":"Objective: To identify factors associated with two self-reported measures of physical activity (PA) in patients with rheumatoid arthritis (RA).Method: Hospital outpatients with RA from central Norway filled in questionnaires about symptoms, psychological factors, and PA. Outcomes were two alternative self-reported measures of PA: (i) fulfilling the aerobic PA recommendations of ≥ 150 min/week at moderate intensity or ≥ 75 min/week at vigorous intensity; or (ii) being in the PA maintenance stage of the Stages of Exercise Behaviour Change framework. Logistic regression was applied to identify factors associated with PA. Step 1 included the independent variables sex, age, and smoking habits. Step 2a added self-reported function, joint pain during the past 6 months, and fatigue to Step 1. Step 2b added Exercise Self-Efficacy and the Relative Autonomy Index (RAI), calculated from the Behavioural Regulation in Exercise Questionnaire-2, to Step 1. Step 3 included all the mentioned independent variables. Steps 1-3 were analysed for each PA measure.Results: In total, 227 patients participated. The RAI had a statistically significant positive association with being physically active according to both PA definitions. Joint pain had a significant negative association with meeting the aerobic PA recommendations but was not associated with being in the PA maintenance stage.Conclusion: The degree of self-determined motivation was the most consistent variable associated with self-reported PA behaviour. Joint pain was associated with one of the two PA measures. Motivation and joint pain may be useful targets for intervention in clinical practice to improve PA engagement among patients with RA.","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139564169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phenotypic characteristics of patients with chronic widespread pain and fibromyalgia: a cross-sectional cluster analysis. 慢性广泛性疼痛和纤维肌痛患者的表型特征：横断面聚类分析。

IF 2.2 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2024-09-01 Epub Date: 2024-01-26 DOI: 10.1080/03009742.2023.2297514

P H Duhn, R Christensen, H Locht, M Henriksen, E Ginnerup-Nielsen, H Bliddal, E E Wæhrens, K Thielen, K Amris

{"title":"Phenotypic characteristics of patients with chronic widespread pain and fibromyalgia: a cross-sectional cluster analysis.","authors":"P H Duhn, R Christensen, H Locht, M Henriksen, E Ginnerup-Nielsen, H Bliddal, E E Wæhrens, K Thielen, K Amris","doi":"10.1080/03009742.2023.2297514","DOIUrl":"10.1080/03009742.2023.2297514","url":null,"abstract":"Objective: This study aimed to explore whether phenotypic characteristics of patients with chronic widespread pain (CWP) and fibromyalgia (FM) can be aggregated into definable clusters that may help to tailor treatments.Method: Baseline variables (sex, age, education, marital/employment status, pain duration, prior CWP/FM diagnosis, concomitant rheumatic disease, analgesics, tender point count, and disease variables derived from standardized questionnaires) collected from 1099 patients (93.4% females, mean age 44.6 years) with a confirmed CWP or FM diagnosis were evaluated by hierarchical cluster analysis. The number of clusters was based on coefficients in the agglomeration schedule, supported by dendrograms and silhouette plots. Simple and multiple regression analyses using all variables as independent predictors were used to assess the likelihood of cluster assignment, reported as odds ratios (ORs) with 95% confidence intervals (CIs).Results: Only one cluster emerged (Cluster 1: 455 patients). Participants in this cluster were characterized as working (OR 66.67, 95% CI 7.14 to 500.00), with a medium-term/higher education (OR 16.80, 95% CI 1.94 to 145.41), married/cohabiting (OR 14.29, 95% CI 1.26 to 166.67), and using mild analgesics (OR 25.64, 95% CI 0.58 to > 999.99). The odds of being an individual in Cluster 1 were lower when having a worse score on the PDQ (score ≥ 18) (OR < 0.001, 95% CI < 0.001 to 0.02).Conclusion: We identified one cluster, where participants were characterized by a potentially favourable clinical profile. More studies are needed to evaluate whether these characteristics could be used to guide the management of patients with CWP and FM.","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139564158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Macrophage colony-stimulating factor receptor/CD115⁺ non-classical monocytes are expanded in systemic lupus erythematosus and associated with lupus nephritis. 巨噬细胞集落刺激因子受体/CD115+非典型单核细胞在系统性红斑狼疮中扩增并与狼疮肾炎相关。

IF 2.2 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2024-08-22 DOI: 10.1080/03009742.2024.2387483

M Zeisbrich, R Rzepka, S Finzel, N Venhoff, R E Voll

{"title":"Macrophage colony-stimulating factor receptor/CD115+ non-classical monocytes are expanded in systemic lupus erythematosus and associated with lupus nephritis.","authors":"M Zeisbrich, R Rzepka, S Finzel, N Venhoff, R E Voll","doi":"10.1080/03009742.2024.2387483","DOIUrl":"https://doi.org/10.1080/03009742.2024.2387483","url":null,"abstract":"Objective: In systemic lupus erythematosus (SLE), the non-classical monocyte compartment is expanded, but its phenotype and association with clinical disease manifestations have not been explored.Method: Monocyte subsets from 39 SLE patients, 32 healthy age-matched controls, and 16 patients from a disease control (autoimmune connective tissue disease other than SLE) were determined based on CD14 and CD16 surface expression. Cell surface expression of the receptors for macrophage colony-stimulating factor (M-CSF) (CD115) and granulocyte-macrophage colony-stimulating factor (GM-CSF) (CD116), as well as 6-Sulpho LacNAc (slan), were analysed by flow cytometry. The association of monocyte populations with disease manifestations, disease activity markers, and current medication of each patient was analysed by chart review.Results: Non-classical monocytes displayed a cell-type specific signature of high M-CSF receptor CD115 and low GM-CSF receptor CD116 expression that separated them from the other two monocyte subsets. In healthy individuals, the M-CSF receptor on non-classical monocytes was an age-dependent surface marker, with lower expression in young adults. However, SLE monocytes were characterized by a marked expansion of M-CSF receptor/CD115+ non-classical monocytes in patients of all ages. The expanded population of M-CSF receptor/CD115+ non-classical monocytes was associated with lupus nephritis but not with disease activity, and coexpressed slan.Conclusion: The non-classical monocyte subset in SLE is characterized by an expansion of M-CSF receptor/CD115+ cells that are associated with lupus nephritis and coexpress slan.","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142018503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drug survival analysis of etanercept compared with monoclonal antibody tumour necrosis factor-α inhibitors in rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis: a propensity score-matched analysis from the Czech ATTRA registry. 依那西普与单克隆抗体肿瘤坏死因子-α抑制剂在类风湿性关节炎、银屑病关节炎和强直性脊柱炎中的药物存活率分析：来自捷克 ATTRA 登记处的倾向得分匹配分析。

IF 2.2 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2024-08-06 DOI: 10.1080/03009742.2024.2381746

Š Tichý, L Nekvindová, J Baranová, J Vencovský, K Pavelka, P Horák, J Závada

{"title":"Drug survival analysis of etanercept compared with monoclonal antibody tumour necrosis factor-α inhibitors in rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis: a propensity score-matched analysis from the Czech ATTRA registry.","authors":"Š Tichý, L Nekvindová, J Baranová, J Vencovský, K Pavelka, P Horák, J Závada","doi":"10.1080/03009742.2024.2381746","DOIUrl":"https://doi.org/10.1080/03009742.2024.2381746","url":null,"abstract":"Objectives: To compare the drug survival of etanercept to monoclonal tumour necrosis factor-α inhibitors in rheumatoid arthritis, ankylosing spondylitis and psoriatic arthritis.Methods: Patients initiating first line biological therapy with tumour necrosis factor-α were propensity score matched and compared for drug survival with a Kaplan-Meier analysis.Results: We matched 657 to 657 patients in rheumatoid arthritis, the median survival time on etanercept was 44.6 months vs. 36.8 months on monoclonal antibody tumour necrosis factor-α inhibitors, with a hazard ratio of 0.94, p = 0.416 We matched 187 to 356 patients in ankylosing spondylitis, the median survival time on etanercept was 75.1 compared to 68.0 months, hazard ratio of 0.78, p = 0.087 We matched 81 to 160 psoriatic arthritis patients, the median survival time on etanercept was 35.8. compared to 65.7 months, hazard ratio 1.61, p = 0.011. Patients treated with etanercept had significantly worse psoriasis scoring during follow up.Conclusions: We found comparable survival in rheumatoid arthritis and ankylosing spondylitis. In psoriatic arthritis, we found significantly shorter survival on etanercept, possibly due to worse response of skin and nail manifestations.","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141894191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0