Scandinavian Journal of Rheumatology最新文献_第3页

Macrophage colony-stimulating factor receptor/CD115⁺ non-classical monocytes are expanded in systemic lupus erythematosus and associated with lupus nephritis. 巨噬细胞集落刺激因子受体/CD115+非典型单核细胞在系统性红斑狼疮中扩增并与狼疮肾炎相关。

IF 2.2 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2025-03-01 Epub Date: 2024-08-22 DOI: 10.1080/03009742.2024.2387483

M Zeisbrich, R Rzepka, S Finzel, N Venhoff, R E Voll

{"title":"Macrophage colony-stimulating factor receptor/CD115+ non-classical monocytes are expanded in systemic lupus erythematosus and associated with lupus nephritis.","authors":"M Zeisbrich, R Rzepka, S Finzel, N Venhoff, R E Voll","doi":"10.1080/03009742.2024.2387483","DOIUrl":"10.1080/03009742.2024.2387483","url":null,"abstract":"Objective: In systemic lupus erythematosus (SLE), the non-classical monocyte compartment is expanded, but its phenotype and association with clinical disease manifestations have not been explored.Method: Monocyte subsets from 39 SLE patients, 32 healthy age-matched controls, and 16 patients from a disease control (autoimmune connective tissue disease other than SLE) were determined based on CD14 and CD16 surface expression. Cell surface expression of the receptors for macrophage colony-stimulating factor (M-CSF) (CD115) and granulocyte-macrophage colony-stimulating factor (GM-CSF) (CD116), as well as 6-Sulpho LacNAc (slan), were analysed by flow cytometry. The association of monocyte populations with disease manifestations, disease activity markers, and current medication of each patient was analysed by chart review.Results: Non-classical monocytes displayed a cell-type specific signature of high M-CSF receptor CD115 and low GM-CSF receptor CD116 expression that separated them from the other two monocyte subsets. In healthy individuals, the M-CSF receptor on non-classical monocytes was an age-dependent surface marker, with lower expression in young adults. However, SLE monocytes were characterized by a marked expansion of M-CSF receptor/CD115+ non-classical monocytes in patients of all ages. The expanded population of M-CSF receptor/CD115+ non-classical monocytes was associated with lupus nephritis but not with disease activity, and coexpressed slan.Conclusion: The non-classical monocyte subset in SLE is characterized by an expansion of M-CSF receptor/CD115+ cells that are associated with lupus nephritis and coexpress slan.","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":" ","pages":"125-134"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142018503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

'Pencil-in-cup' deformity in systemic sclerosis-rheumatoid arthritis overlap syndrome. 系统性硬化症-类风湿关节炎重叠综合征的“铅笔杯”畸形。

IF 2.2 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2025-03-01 Epub Date: 2025-02-11 DOI: 10.1080/03009742.2025.2456323

E A Acar, S Uslu, O Soysal Gündüz, T Pirildar

引用次数: 0

Early diagnosis of rheumatoid arthritis: associations between patients' perceptions of initial symptoms and the timing of seeking help from the general practitioner. 类风湿关节炎的早期诊断：患者对初始症状的认知与向全科医生寻求帮助的时机之间的关系

IF 2.2 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2025-02-27 DOI: 10.1080/03009742.2025.2464457

S D Pedersen, B D Nielsen, M L Assmann, E M Hauge, A de Thurah

{"title":"Early diagnosis of rheumatoid arthritis: associations between patients' perceptions of initial symptoms and the timing of seeking help from the general practitioner.","authors":"S D Pedersen, B D Nielsen, M L Assmann, E M Hauge, A de Thurah","doi":"10.1080/03009742.2025.2464457","DOIUrl":"https://doi.org/10.1080/03009742.2025.2464457","url":null,"abstract":"Objectives: Early diagnosis is essential to the prognosis of rheumatoid arthritis (RA), but little is known about patients' perceptions of the first symptoms. Illness representations shape patients' help-seeking behaviour. The Illness Perception Questionnaire - Revised (IPQ-R) can measure these, allowing us to understand the patients' role in diagnostic delays. The aim of this study was to explore the connection between RA patients' perceptions of initial symptoms and the time taken to seek help from a general practitioner (GP).Method: 1163 recently diagnosed individuals with RA, identified from the Danish Rheumatology Database, DANBIO, filled out a questionnaire. We used adjusted multivariable linear regression to calculate the median ratio (MR) for those with the highest scores within each IPQ-R subscale compared to the lowest scores.Results: Altogether, 404 patients answered the questionnaire. The overall median patient delay was 63 [interquartile range (IQR) 17-214] days. Younger patients experienced longer delays than older [84 (IQR 30-361) vs 54 (14-162) days]. High expectations of treatment control led to 54% lower median time to first GP contact compared to low expectations [adjusted median ratio (MR) 0.54, 95% confidence interval (CI) 0.29-0.99]. High perceptions of symptom variability at disease onset led to a higher median time to first GP contact (adjusted MR 1.61, 95% CI 0.93-2.78).Conclusion: People with RA symptoms may delay seeing their GP due to low expectations of treatment effectiveness and significant symptom variability. Information campaigns could educate patients on recognizing warning signs and encourage them to seek medical attention.","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":" ","pages":"1-10"},"PeriodicalIF":2.2,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex distribution in psoriatic arthritis: a systematic literature review. 银屑病关节炎的性别分布：系统文献综述。

IF 2.2 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2025-02-26 DOI: 10.1080/03009742.2025.2465014

B Firlatan, G S Kart Bayram, G Ayan, E Karabulut, U Kalyoncu

{"title":"Sex distribution in psoriatic arthritis: a systematic literature review.","authors":"B Firlatan, G S Kart Bayram, G Ayan, E Karabulut, U Kalyoncu","doi":"10.1080/03009742.2025.2465014","DOIUrl":"https://doi.org/10.1080/03009742.2025.2465014","url":null,"abstract":"Objective: Although the prevalence of psoriatic arthritis (PsA) is considered equal between the sexes, recent PsA studies have reported a female predominance, with female-to-male ratios between 1.2:1 and 2:1. It is not clear whether this is related to a change in the epidemiology of the disease or to different patterns of patients attending outpatient clinics. We aimed to assess the female-to-male ratios in recent PsA studies.Method: A systematic review of the literature (January 2020 to September 2022) was performed using the PubMed database with keywords and MeSH terms referring to 'psoriatic arthritis'. Randomized controlled trials (RCTs), and cross-sectional, prospective, and retrospective cohort studies involving at least 20 patients and specifying the number of males and females were considered eligible.Results: From 2800 initially identified articles, 481 eligible studies with 871 144 participants were analysed, revealing a female majority (54.1%). When we evaluated the studies based on their design, we found that female sex was more predominant in each type of design, with retrospective cohort studies having the highest prevalence. According to the number of centres involved, multi-centre studies demonstrated a greater representation of female participants than single-centre studies (54% vs 50%). Regarding the geographical locations, studies conducted in America, Europe, and multinational contexts displayed a female predominance.Conclusion: In our assessment, RCTs had the closest sex equality, with a slight preponderance of females. The real-life and multi-centre studies had more pronounced female rates, with several differences observed in different geographical locations.","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":" ","pages":"1-6"},"PeriodicalIF":2.2,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143503669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and validation of a patient knowledge questionnaire for rheumatoid arthritis (PKQ-RA-11) in Danish and German. 丹麦语和德语类风湿性关节炎患者知识问卷（PKQ-RA-11）的开发和验证。

IF 2.2 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2025-02-24 DOI: 10.1080/03009742.2025.2463734

L R Knudsen, J Knitza, F Mühlensiepen, A Hueber, J Henes, M Ndosi, A de Thurah

{"title":"Development and validation of a patient knowledge questionnaire for rheumatoid arthritis (PKQ-RA-11) in Danish and German.","authors":"L R Knudsen, J Knitza, F Mühlensiepen, A Hueber, J Henes, M Ndosi, A de Thurah","doi":"10.1080/03009742.2025.2463734","DOIUrl":"https://doi.org/10.1080/03009742.2025.2463734","url":null,"abstract":"Objective: Patient education is a cornerstone of rheumatology care, enabling patients to effectively and safely manage their condition. Standardized patient knowledge assessments are essential for benchmarking care quality and tailoring education to individual needs. This study aimed to develop and validate Danish and German versions of a patient knowledge questionnaire (PKQ) for rheumatoid arthritis (RA).Method: Danish and German adaptations from the English version involved a forward-and-backward translation process. Face validity was assessed with patients with RA in Denmark and Germany. Subsequently, the generated PKQ-RA-11 versions were tested in Danish and German RA patients.Results: The face-validity assessment included 20 patients (10 Danish, 10 German). Adjustments in the Danish version included rephrasing options and aligning with digital patient education content. The German version followed the refined Danish version with necessary cultural adjustments. PKQ-RA-11 comprises 11 multiple-choice questions with a scoring system to minimize guessing. The final PKQ-RA-11 was completed by 175 Danish and 174 German patients; mean completion time was 7.5 and 7.4 minutes, respectively. Mean ± sd baseline PKQ-RA-11 scores were 7.9 ± 1.6 for Danish and 6.2 ± 2.5 for German participants. Longitudinal data from Denmark indicated an increase in knowledge scores following patient education, shown by a mean score of 8.6 ± 1.5, demonstrating the tool's responsiveness to changes in patient understanding of RA.Conclusion: PKQ-RA-11 is a standardized tool for assessing disease-related knowledge in individuals with RA. It can be used to provide objective and transparent measures of patient understanding in educational programmes, clinical practice, or research.","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":" ","pages":"1-9"},"PeriodicalIF":2.2,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rapid improvement of rheumatoid arthritis symptoms with ozoralizumab: a case of progress monitored by musculoskeletal ultrasonography. 用ozoralizumab快速改善类风湿性关节炎症状：一个由肌肉骨骼超声监测进展的病例。

IF 2.2 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2025-02-19 DOI: 10.1080/03009742.2025.2464451

D Nakagomi, S Hanai

引用次数: 0

Association of clinical variables with methotrexate response in patients with psoriatic arthritis. 银屑病关节炎患者甲氨蝶呤反应与临床变量的关系。

IF 2.2 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2025-02-14 DOI: 10.1080/03009742.2025.2455885

F R Kasiem, L J Tucker, L C Coates, J J Luime, I Tchetverikov, M Vis, Jmw Hazes, M R Kok

{"title":"Association of clinical variables with methotrexate response in patients with psoriatic arthritis.","authors":"F R Kasiem, L J Tucker, L C Coates, J J Luime, I Tchetverikov, M Vis, Jmw Hazes, M R Kok","doi":"10.1080/03009742.2025.2455885","DOIUrl":"https://doi.org/10.1080/03009742.2025.2455885","url":null,"abstract":"Objective: Methotrexate (MTX) is widely used as first-line treatment in psoriatic arthritis (PsA). Despite the variable efficacy of MTX in PsA compared to newer therapeutic agents, its affordability and availability make it crucial, especially in resource-limited healthcare settings. Identification of factors associated with MTX non-response could facilitate early redirection to more effective therapy. This study aimed to identify baseline clinical, demographic, and psychosocial variables associated with non-response 3 months after MTX initiation in a real-world, treatment-naïve PsA patient cohort.Method: Recently diagnosed, disease-modifying anti-rheumatic drug-naïve PsA patients were included. Treatment response was defined by attaining minimal disease activity 3 months after initiation of MTX monotherapy. A multivariate logistic regression analysis was performed, including sensitivity analysis. Missing variables were imputed through multiple imputations.Results: In total, 287 patients were included, of whom 199 (69%) were non-responders. The median dose of MTX was 19.5 (interquartile range 15-25) mg/week. Worse baseline functioning (Health Assessment Questionnaire) [odds ratio (OR) 0.28, 95% confidence interval (CI) 0.13-0.60], higher tender joint count in 68 joints (OR 0.91, 95% CI 0.84-0.97), and higher depression scores (Hospital Anxiety and Depression Scale) (OR 0.88, 95% CI 0.78-0.99) were associated with a lower response rate to MTX at 3 months.Conclusion: Our findings highlight the need for a comprehensive approach to managing patients with PsA. This involves addressing modifiable risk factors, such as depression, alongside controlling PsA disease activity. Further research is warranted to evaluate whether this integrated strategy could improve treatment efficacy and overall patient outcomes.","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":" ","pages":"1-8"},"PeriodicalIF":2.2,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143415091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

No association between vascular inflammation and estimated glomerular filtration rate in patients with rheumatoid arthritis: secondary analysis of the TARGET trial. 类风湿关节炎患者血管炎症和肾小球滤过率之间无关联：TARGET试验的二次分析

IF 2.2 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2025-02-05 DOI: 10.1080/03009742.2025.2455878

S Fukui, A Tawakol, W C Winkelmayer, L M Santacroce, J T Giles, K P Liao, J M Bathon, D H Solomon

引用次数: 0

Work in the picture? The reporting of and effects on work outcomes in exercise therapy trials in people with rheumatoid arthritis or axial spondyloarthritis: a systematic review. 画中的工作？类风湿关节炎或轴性脊柱炎患者运动治疗试验的报告及其对工作结果的影响：系统综述。

IF 2.2 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2025-02-04 DOI: 10.1080/03009742.2024.2445940

N F Bakker, J Knoop, J W Schoones, Tpm Vliet Vlieland, Sfe van Weely

{"title":"Work in the picture? The reporting of and effects on work outcomes in exercise therapy trials in people with rheumatoid arthritis or axial spondyloarthritis: a systematic review.","authors":"N F Bakker, J Knoop, J W Schoones, Tpm Vliet Vlieland, Sfe van Weely","doi":"10.1080/03009742.2024.2445940","DOIUrl":"https://doi.org/10.1080/03009742.2024.2445940","url":null,"abstract":"Objective: Many people with rheumatoid arthritis (RA) or axial spondyloarthritis (axSpA) face limitations in societal participation, including work. Supervised exercise therapy improves symptoms and physical functioning, but its impact on work outcomes is unclear. This systematic review aims to examine the reporting of and effects on work outcomes in exercise therapy trials.Method: Eight databases were searched up to February 2024 for randomized controlled trials (RCTs) evaluating the (cost-)effectiveness of supervised exercise therapy interventions in adults with RA/axSpA. The reporting of work and other social participation outcomes, the content of the exercise therapy intervention, and their effects on work outcomes were extracted. Within- and between-group results on work outcomes were summarized.Results: In total, 41 (22 RA, 19 axSpA) RCTs on supervised exercise therapy were included, none of which was specifically targeted at work. Two RCTs in people with RA included work outcomes (absenteeism and employment hours). None of the RCTs in axSpA reported work outcomes. A work-related item or subscale was reported in 6/22 of the RA and 7/19 of the axSpA trials. Outcomes on societal participation (including work) were reported in 13/22 of the RA and 18/19 of the axSpA trials. Effects on work were reported on different outcomes and results were inconclusive.Conclusion: Work outcomes are rarely reported in exercise therapy trials in people with RA/axSpA. To determine the effects of supervised exercise therapy on work, future studies should include work outcomes. International consensus on which outcome to use could increase the comparability of results.","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":" ","pages":"1-17"},"PeriodicalIF":2.2,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Highlighting individual patient data related to chimeric antigen receptor T-cell therapy in refractory autoimmune rheumatic diseases. 强调与嵌合抗原受体t细胞治疗难治性自身免疫性风湿病相关的个体患者数据。

IF 2.2 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2025-01-13 DOI: 10.1080/03009742.2024.2421621

M L Larsen, A Voss, C Tandrup Holst Nielsen, E-M Hauge, M Faurschou, A Troldborg

引用次数: 0