Scandinavian Journal of Rheumatology最新文献_第6页

Clinical features, anti-neutrophil cytoplasmic antibody (ANCA) status, and human leucocyte antigen (HLA) phenotypes of patients diagnosed with both rheumatoid arthritis and granulomatosis with polyangiitis: a case series of six patients with predominant myeloperoxidase (MPO)-ANCA positivity and HLA-DR4/DQ8/DPB1*04:01 phenotype. 类风湿性关节炎和肉芽肿病合并多血管炎患者的临床特征、抗中性粒细胞胞浆抗体（ANCA）状态及人白细胞抗原（HLA）表型：6例髓过氧化物酶(MPO)-ANCA阳性、HLA- dr4 /DQ8/DPB1*04:01表型的患者。

IF 2.1 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2026-06-09 DOI: 10.1080/03009742.2026.2666986

O Abrahamsen, M Faurschou, H Bruunsgaard, B Baslund

{"title":"Clinical features, anti-neutrophil cytoplasmic antibody (ANCA) status, and human leucocyte antigen (HLA) phenotypes of patients diagnosed with both rheumatoid arthritis and granulomatosis with polyangiitis: a case series of six patients with predominant myeloperoxidase (MPO)-ANCA positivity and HLA-DR4/DQ8/DPB1*04:01 phenotype.","authors":"O Abrahamsen, M Faurschou, H Bruunsgaard, B Baslund","doi":"10.1080/03009742.2026.2666986","DOIUrl":"https://doi.org/10.1080/03009742.2026.2666986","url":null,"abstract":"Objective: To describe the clinical features of six patients diagnosed with both rheumatoid arthritis (RA) and granulomatosis with polyangiitis (GPA), as well as their anti-neutrophil cytoplasmic antibody (ANCA) status and human leucocyte antigen (HLA) phenotypes.Method: Patients diagnosed with both RA and GPA were identified among people followed at our department for ANCA-associated vasculitis. Genomic HLA typing was performed using routine methods.Results: We identified six patients diagnosed with both RA and GPA. All patients were women, five were myeloperoxidase (MPO)-ANCA positive, one was proteinase 3 (PR3)-ANCA positive, five had erosive joint disease, and all patients were immunoglobulin M-rheumatoid factor and/or anti-cyclic citrullinated peptide antibody positive. Five had localized GPA, one had systemic GPA, four had subglottic stenosis, and three had saddle nose deformity. The median time between the two diagnoses was 13 (range 7-17) years. Four patients had RA before GPA, while two had GPA before RA. The MPO-ANCA-positive patients all had an HLA-DR4/DQ8/DPB1*04:01 phenotype.Conclusion: In this case series of patients diagnosed with both RA and GPA, a long latency period between the two diagnoses was observed in all cases. All patients were women, the majority had erosive arthritis, and many patients were affected by saddle nose deformity and/or subglottic stenosis. MPO-ANCA was present in the majority of patients, which has not been described before. All patients were HLA-DR4/DQ8/DPB1*04:01 positive. These findings may contribute to our understanding of the underlying pathogenesis and the clinical recognition of this rare disease overlap.","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":" ","pages":"1-4"},"PeriodicalIF":2.1,"publicationDate":"2026-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148205928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Longitudinal patterns of C-reactive protein values in calcium pyrophosphate deposition disease. 焦磷酸钙沉积病中c反应蛋白值的纵向模式。

IF 2.1 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2026-05-22 DOI: 10.1080/03009742.2026.2666987

M Gill, H Guan, J E Collins, S K Tedeschi

{"title":"Longitudinal patterns of C-reactive protein values in calcium pyrophosphate deposition disease.","authors":"M Gill, H Guan, J E Collins, S K Tedeschi","doi":"10.1080/03009742.2026.2666987","DOIUrl":"https://doi.org/10.1080/03009742.2026.2666987","url":null,"abstract":"Objective: Calcium pyrophosphate deposition (CPPD) disease is a crystalline arthritis with inflammatory and non-inflammatory manifestations. We investigated longitudinal patterns of C-reactive protein (CRP) in patients with different inflammatory CPPD phenotypes.Method: Participants in a single-centre CPPD registry were categorized as having acute calcium pyrophosphate (CPP) crystal arthritis only (acute CPP), chronic CPP inflammatory arthritis only (chronic CPP), or both acute & chronic CPP. We included patients with one CRP (mg/L) value from the date of CPPD diagnosis to March 2024. We used generalized estimating equation (GEE) linear regression to compare log-transformed CRP values by inflammatory CPPD phenotype, accounting for within-subject correlation. Longitudinal CRP was plotted with cubic splines for each phenotype. A mixed-effects model adjusted for age and sex estimated the effect of CPPD phenotype on log-transformed CRP over time.Results: Among 54 patients with 264 CRP values, mean ± sd age was 68.2 ± 8.8 years, 63% were female, and median (interquartile range) follow-up was 4.7 (2.7-7.9) years. Longitudinal CRP values fluctuated most widely in the acute CPP group. CRP was significantly higher in the acute & chronic CPP than in the chronic CPP group in a GEE model (p = 0.01). CRP was non-significantly higher over time in the acute & chronic CPP group (p = 0.15) and the acute CPP group (p = 0.12) compared with the chronic CPP group in the mixed-effects model.Conclusion: We identified distinct patterns of CRP according to CPPD clinical phenotype. CRP was higher over time in patients with acute CPP crystal arthritis compared with chronic CPP inflammatory arthritis only.","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":" ","pages":"1-7"},"PeriodicalIF":2.1,"publicationDate":"2026-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147988275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Organ-specific autoimmunity in primary Sjögren's disease. 原发性Sjögren疾病的器官特异性自身免疫

IF 1.5 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2026-05-01 Epub Date: 2026-01-23 DOI: 10.1080/03009742.2025.2598989

A Garcia-Torralba, G Hernández-Molina

{"title":"Organ-specific autoimmunity in primary Sjögren's disease.","authors":"A Garcia-Torralba, G Hernández-Molina","doi":"10.1080/03009742.2025.2598989","DOIUrl":"10.1080/03009742.2025.2598989","url":null,"abstract":"Objective: To assess the prevalence of organ-specific autoimmunity (OSA) among patients with primary Sjögren's disease (SjD), and its association with clinical and serological variables and disease activity.Method: We included 328 patients with SjD according to ACR/EULAR criteria. We recorded the following types of OSA: gastrointestinal [primary biliary cholangitis (PBC), autoimmune hepatitis (AH), coeliac disease], haematological (pernicious anaemia, haemolytic anaemia, idiopathic thrombocytopenia purpura), neurological (myasthenia gravis), dermatological (vitiligo, alopecia areata), and endocrinological (autoimmune thyroid disease and type 1 diabetes). We also registered demographics, basal Schirmer I test, non-stimulated whole salivary flow, serological variables, treatment (ever), and basal and cumulative EULAR Sjögren's Syndrome Disease Activity Index (ESSDAI) score at last follow-up.Results: We found OSA in 122 patients (37.9%), the most frequent being autoimmune hypothyroidism (n = 56), PBC (n = 28), and AH (n = 8). OSA preceded SjD in 37 patients (30.3%), followed it in 62 (50.8%), and was concomitant in 23 (18.8%). In logistic regression analysis comparing patients with OSA (concomitant/post-SjD diagnosis) versus those without OSA, the variables associated with OSA were anti-Ro/SSA [odds ratio (OR) 0.44, 95% confidence interval (CI) 0.20-0.97, p = 0.04], disease duration (OR 1.03, 95% CI 1.005-1.06, p = 0.01), and use of methotrexate (OR 0.32, 95% CI 0.55-0.73, p = 0.007) and azathioprine (OR 2.12, 95% CI 1.14-3.84, p = 0.01).Conclusion: One-third of patients with primary SjD had OSA, with endocrine involvement being the most common. OSA may precede, follow, or accompany the diagnosis of SjD, and is not associated with higher disease activity. Monitoring for OSA is important as it contributes to comorbidity in these patients.","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":" ","pages":"203-207"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146030499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sensitive detection of plasma interferon regulatory factor-5 (IRF5) by solid-phase proximity ligation assay validates IRF5 high and low subgroups in patients with systemic lupus erythematosus. 血浆干扰素调节因子-5 （IRF5）在系统性红斑狼疮患者血浆干扰素调节因子-5 （IRF5）高亚群和低亚群检测中的敏感性

IF 2.1 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2026-05-01 Epub Date: 2025-12-09 DOI: 10.1080/03009742.2025.2582936

N Karami, E Wigren, C Preger, R Gallini, I Gunnarsson, E Svenungson, S Gräslund, H Idborg

{"title":"Sensitive detection of plasma interferon regulatory factor-5 (IRF5) by solid-phase proximity ligation assay validates IRF5 high and low subgroups in patients with systemic lupus erythematosus.","authors":"N Karami, E Wigren, C Preger, R Gallini, I Gunnarsson, E Svenungson, S Gräslund, H Idborg","doi":"10.1080/03009742.2025.2582936","DOIUrl":"10.1080/03009742.2025.2582936","url":null,"abstract":"Objectives: Interferon regulatory factor 5 (IRF5) plays a central role in interferon-mediated inflammation and is implicated in autoimmune diseases, including systemic lupus erythematosus (SLE). Detecting IRF5 in plasma is challenging due to its low circulating levels, highlighting the need for a highly sensitive and quantitative assay. This study aimed to develop such an assay, validate the existence of previously identified IRF5 high and low subgroups in SLE, and support the potential of IRF5 as a biomarker in precision medicine.Method: We established a solid-phase proximity ligation assay (SP-PLA) for IRF5 detection using a commercially available polyclonal antibody, which was benchmarked against two in-house recombinant antibodies. A linear calibration curve was generated using recombinant IRF5 protein (range 0.01-100 pg/µL), with a limit of detection between 0.01 and 0.05 pg/µL. EDTA-plasma samples from three SLE subgroups (n = 25 per group) were analysed.Results: IRF5 was detectable in all SLE plasma samples using SP-PLA (mean 0.63 pg/µL; sd 1.92 pg/µL; maximum 13.54 pg/µL). The IRF5 high SLE subgroup showed significantly higher IRF5 plasma levels than the IRF5 low SLE subgroup (Dunn's post-hoc test, adjusted p < 0.05).Conclusion: The SP-PLA enabled sensitive and specific detection of low-level IRF5 in plasma and confirmed the presence of IRF5 high and low subgroups in SLE using a quantitative method. These findings support the potential of IRF5 as a biomarker, but validation in independent cohorts is required. The assay may facilitate patient stratification in future research and precision medicine approaches targeting the interferon pathway.","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":" ","pages":"184-190"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145715743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multidimensional factors affecting mortality and causes of death in patients with systemic lupus erythematosus: a Finnish cohort study with more than 20 years of follow-up. 影响系统性红斑狼疮患者死亡率和死亡原因的多维因素：一项芬兰队列研究，随访超过20年。

IF 1.5 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2026-05-01 Epub Date: 2026-02-02 DOI: 10.1080/03009742.2025.2607899

M-L Ojakäär, H Kautiainen, S Ekblom-Kullberg, H Relas, H Julkunen

{"title":"Multidimensional factors affecting mortality and causes of death in patients with systemic lupus erythematosus: a Finnish cohort study with more than 20 years of follow-up.","authors":"M-L Ojakäär, H Kautiainen, S Ekblom-Kullberg, H Relas, H Julkunen","doi":"10.1080/03009742.2025.2607899","DOIUrl":"10.1080/03009742.2025.2607899","url":null,"abstract":"Objective: To study multidimensional factors affecting long-term mortality and causes of death in patients with systemic lupus erythematosus (SLE).Method: A cohort of 224 SLE patients from the Helsinki University Hospital was established in the early 2000s. Personal interviews, examinations, and chart reviews followed a protocol that included demographics, clinical data, education, socioeconomic factors, lifestyle, and laboratory tests. Causes of death were obtained from the official death certificate statistics of Statistics Finland.Results: The mean age of the patients was 47.4 years, and the median follow-up duration was 20.5 years. Eighty-two patients (36.6%) had died. Survival rates at 5, 10, and 20 years were 94.8%, 85.3%, and 63.1%, respectively. The overall standardized mortality ratio was 2.73 (95% confidence interval 2.20-3.39). In univariate analyses, baseline factors associated with mortality included age, disease duration, body mass index (BMI), education, income, damage score, comorbidities, renal failure, and smoking history. In multivariable analyses, independent predictors of mortality were age, damage score, and renal failure, and a trend was observed for BMI and smoking history. Common primary causes of death included cardiovascular diseases (CVDs) (29 patients, 35%), malignancies (22, 27%), and SLE (10, 12%). Infections were the immediate cause of death in 16 cases (20%).Conclusion: Multidimensional factors are associated with increased long-term mortality in SLE, and independent predictors include age, damage score, and renal failure. To improve the outcome of SLE, our results emphasize active treatment of CVDs and their risk factors, major organ manifestations of the disease and infections, and targeted cancer screening.","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":" ","pages":"208-216"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146106851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pregnancy outcomes in women with idiopathic inflammatory myopathies: a single-centre study from Sweden. 特发性炎性肌病妇女的妊娠结局：来自瑞典的一项单中心研究

IF 1.5 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2026-05-01 Epub Date: 2026-01-23 DOI: 10.1080/03009742.2025.2595785

M Willstedt, M Holmqvist, Ä Mantel, I E Lundberg, K Hellgren

{"title":"Pregnancy outcomes in women with idiopathic inflammatory myopathies: a single-centre study from Sweden.","authors":"M Willstedt, M Holmqvist, Ä Mantel, I E Lundberg, K Hellgren","doi":"10.1080/03009742.2025.2595785","DOIUrl":"10.1080/03009742.2025.2595785","url":null,"abstract":"Objective: To assess pregnancy and delivery outcomes in women with idiopathic inflammatory myopathies (IIMs) before and after diagnosis, in relation to maternal and IIM characteristics.Method: We identified women with IIM aged 18-40 years diagnosed at Karolinska University Hospital, and included in the Swedish nationwide myositis register (SweMyoNet) 2006-2022. Clinical data before and during pregnancy, and pregnancy and delivery outcomes were extracted from medical charts, and compared to background data of the Swedish general obstetric population during the same period.Results: We identified 34 births among 21 women during 2006-2021, classified into two groups: births occurring up to 5 years before (pre-IIM, n = 10) and births after IIM diagnosis (post-IIM, n = 24). We observed higher frequencies for all IIM births versus the general obstetric population: caesarean delivery (29% vs 21%), labour induction (27% vs 18%), and instrumental delivery (21% vs 9.1%). These outcomes were similarly frequent in pre- and post-IIM births. Conversely, the proportion of preterm births was lower in IIM births than in the general population (3.0% vs 5.6%). Overall, IIM disease activity was low at time of pregnancy according to Manual Muscle Test-8, creatinine kinase, and glucocorticoid doses.Conclusion: Women with IIM, both before and after diagnosis, had higher proportions of labour induction, caesarean delivery, and instrumental delivery than the general population, regardless of low IIM disease activity at time of pregnancy. The increased proportions of these outcomes also in pre-IIM births may indicate an impact of pro-inflammation and autoimmunity on reproductive health before diagnosis.","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":" ","pages":"197-202"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146030514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral glucocorticoid premedication for preventing infusion-related reactions to rituximab in rheumatoid arthritis. 口服糖皮质激素预用药预防类风湿性关节炎患者利妥昔单抗输注相关反应。

IF 1.5 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2026-05-01 Epub Date: 2026-01-23 DOI: 10.1080/03009742.2025.2599023

Pmet Bovens, L van Esveld, Mhm Wientjes, N van Herwaarden, D F Ten Cate, E J Melis, N Lesuis, B J van den Bemt, A A den Broeder

{"title":"Oral glucocorticoid premedication for preventing infusion-related reactions to rituximab in rheumatoid arthritis.","authors":"Pmet Bovens, L van Esveld, Mhm Wientjes, N van Herwaarden, D F Ten Cate, E J Melis, N Lesuis, B J van den Bemt, A A den Broeder","doi":"10.1080/03009742.2025.2599023","DOIUrl":"10.1080/03009742.2025.2599023","url":null,"abstract":"Objective: In current practice, intravenous prednisolone is administered as pretreatment to rituximab (RTX) to prevent infusion-related reactions (IRRs). This retrospective observational cohort study investigated whether 50 mg oral prednisolone is as effective as 50 mg intravenous methylprednisolone in preventing IRRs in rheumatoid arthritis (RA) patients, as this could potentially be a more practical, patient-friendly, and cost-effective alternative.Method: Since January 2022, the local RTX pretreatment protocol changed from 50 mg methylprednisolone intravenously to 50 mg prednisolone orally. All RTX infusions in RA patients, administered between 31 January 2020 and 30 January 2024, were examined for the occurrence of IRRs. The adjusted odds ratio (OR) for IRRs was calculated for oral versus intravenous prednisolone administration. All IRRs were evaluated for symptoms, severity, type, and outcome of reaction.Results: In total, 2253 RTX infusions in 515 patients were included, 976 with oral and 1277 with intravenous premedication. IRRs were reported after 84 infusions (3.7%). The adjusted OR was non-significantly in favour of oral treatment (OR 0.61, 95% confidence interval 0.30-1.20). IRRs were mostly mild and required little or no intervention, and a trend towards lower IRR risk for lower RTX dosing and when using concomitant disease-modifying anti-rheumatic drugs was observed.Conclusion: Oral prednisolone pretreatment to RTX does not result in more infusion-related reactions in patients with RA, and may therefore, based on other advantages, be preferable to intravenous glucocorticoids.","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":" ","pages":"172-176"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146030575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The relationship between arthritis or rheumatoid arthritis in the elderly and falls: results based on the China Health and Retirement Longitudinal Study (CHARLS). 老年人关节炎或类风湿关节炎与跌倒的关系：基于中国健康与退休纵向研究（CHARLS）的结果

IF 2.1 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2026-05-01 Epub Date: 2025-08-11 DOI: 10.1080/03009742.2025.2518630

J Ren, R Li, H Peng

引用次数: 0

Preventing relapse of cerebral infarction with belimumab in a patient with primary anti-phospholipid syndrome: a case report. 贝利单抗预防原发性抗磷脂综合征患者脑梗死复发：1例报告

IF 2.1 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2026-05-01 Epub Date: 2025-11-04 DOI: 10.1080/03009742.2025.2566537

Y Wada, K Ninagawa, Y Fujieda, Y Shimizu

引用次数: 0

Chronic obstructive pulmonary disease and rheumatoid arthritis: severe exacerbations, pneumonia, and death in a population-based cohort. 慢性阻塞性肺疾病和类风湿关节炎：以人群为基础的队列中的严重恶化、肺炎和死亡

IF 1.5 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2026-05-01 Epub Date: 2026-02-16 DOI: 10.1080/03009742.2025.2603046

C Hyldgaard, B Bonnesen, A K Vognsen, P Sivapalan, J Eklöf, A S Jordan, E Bendstrup, T Ellingsen, J-Us Jensen

{"title":"Chronic obstructive pulmonary disease and rheumatoid arthritis: severe exacerbations, pneumonia, and death in a population-based cohort.","authors":"C Hyldgaard, B Bonnesen, A K Vognsen, P Sivapalan, J Eklöf, A S Jordan, E Bendstrup, T Ellingsen, J-Us Jensen","doi":"10.1080/03009742.2025.2603046","DOIUrl":"10.1080/03009742.2025.2603046","url":null,"abstract":"Objective: Respiratory disease contributes to the excess mortality seen in rheumatoid arthritis (RA), and chronic obstructive pulmonary disease (COPD) is frequently encountered. The aim of this study was to investigate the risk of severe acute exacerbation, pneumonia, and death among patients with RA and COPD compared with patients with COPD alone.Method: The study population was patients with hospital-based, outpatient follow-up for COPD identified from the Danish COPD registry. Diagnoses of RA, information about hospitalizations for acute exacerbations of COPD (AECOPD), pneumonia, and vital status were obtained from National Health Registries. Follow-up was 12 months after first outpatient contact for COPD. Hospitalizations for AECOPD and pneumonia, and risk of death in COPD with or without RA, were compared using Cox proportional hazards regression analysis. Covariates were balanced using inverse probability of treatment (IPT) weighting.Results: The study included 58 655 patients with hospital-based follow-up for COPD, 2033 (3.5%) of whom had RA. More than 25% of the cohort experienced hospitalization with AECOPD and/or pneumonia in the first year after first outpatient COPD hospital contact. IPT-weighted unadjusted Cox regression analysis showed similar risk of hospitalization with AECOPD among patients with RA and COPD [hazard ratio (HR) 1.004, 95% confidence interval (CI) 0.89-1.13] and death (HR 1.13, 95% CI 0.98-1.30), but increased risk of hospitalization for pneumonia (HR 1.26, 95% CI 1.11-1.42).Conclusion: The increased risk of pneumonia associated with RA may be attributed to immunosuppression. The findings should lead to increased focus on optimizing COPD therapies and preventive measures.","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":" ","pages":"163-171"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146202460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0