Scandinavian Journal of Rheumatology最新文献_第6页

Von Willebrand factor: a possible biomarker for disease activity in vasculitis. 冯-威廉因子：脉管炎疾病活动的可能生物标志物。

IF 2.2 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2024-11-01 Epub Date: 2024-02-05 DOI: 10.1080/03009742.2024.2302679

S Keret, J Mazareeb, A Snir, A Shouval, A Awisat, L Kaly, I Rosner, M Rozenbaum, N Boulman, E Hardak, G Slobodin, D Rimar

{"title":"Von Willebrand factor: a possible biomarker for disease activity in vasculitis.","authors":"S Keret, J Mazareeb, A Snir, A Shouval, A Awisat, L Kaly, I Rosner, M Rozenbaum, N Boulman, E Hardak, G Slobodin, D Rimar","doi":"10.1080/03009742.2024.2302679","DOIUrl":"10.1080/03009742.2024.2302679","url":null,"abstract":"Objective: Inflammation markers, e.g. C- reactive protein (CRP) and sedimentation rate, can be normal despite active vasculitis. Von Willebrand factor (vWF) is secreted from endothelial cells in response to vascular damage. Some reports suggest increased vWF levels in vasculitis. This study aimed to evaluate vWF serum concentration in vasculitis patients as a possible biomarker of disease activity and to review the current literature.Method: Adult patients with systemic vasculitis were prospectively enrolled. Disease activity was recorded using the Birmingham Vasculitis Activity Score (BVAS) version 3. Blood group-adjusted vWF antigen serum level was evaluated at diagnosis and, when available, after treatment.Results: Twenty-five vasculitis patients were compared to 15 healthy controls. The mean age of patients was 56 ± 17 years and 56% were women. Forty percent had anti-neutrophil cytoplasmic autoantibody-associated vasculitis, 20% giant cell arteritis, 16% polyarteritis nodosa, 8% Takayasu arteritis, and the rest had other vasculitides. The mean disease duration was 3.4 ± 4.8 years. Mean vWF was higher in patients with active vasculitis than in healthy controls (212 ± 81% vs 106 ± 26%, p < 0.001). vWF levels directly correlated with BVAS. In 13 patients with active vasculitis who reached remission or low disease activity after treatment, vWF level at follow-up decreased significantly. In three out of five patients who were treated with interleukin-6 inhibitors, vWF was elevated despite normal CRP levels, while vasculitis was clinically active.Conclusion: vWF antigen serum level is increased in active vasculitis and could potentially serve as a biomarker for active disease.","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":" ","pages":"433-441"},"PeriodicalIF":2.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139692817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cohort study of serological biomarkers for interstitial lung disease in patients with rheumatoid arthritis. 类风湿性关节炎患者间质性肺病血清学生物标志物队列研究。

IF 2.2 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2024-11-01 Epub Date: 2024-10-25 DOI: 10.1080/03009742.2024.2413238

V Colmenares, A Hedman, A Hesslow, B Wahlin, A Södergren

{"title":"Cohort study of serological biomarkers for interstitial lung disease in patients with rheumatoid arthritis.","authors":"V Colmenares, A Hedman, A Hesslow, B Wahlin, A Södergren","doi":"10.1080/03009742.2024.2413238","DOIUrl":"10.1080/03009742.2024.2413238","url":null,"abstract":"Objective: Interstitial lung disease (ILD) is an important cause of mortality in patients with rheumatoid arthritis (RA). Early RA-ILD detection is essential to improve prognosis. Here, we investigated eight serological biomarkers that may contribute to RA-ILD detection.Method: Fifty-five patients from the Early Rheumatoid Arthritis Program were evaluated for ILD with high-resolution computed tomography (HRCT) and pulmonary function tests (PFTs) using the SCAPIS protocol. Blood samples were obtained for biomarker analysis, and patients' clinical records were reviewed. We defined ILD using five different models based on the measurements used to confirm ILD: Model A = HRCT; B = PFTs; C = A plus B; D = C plus symptoms; and E = D plus inhalations.Results: Among 55 patients, two had an ILD diagnosis before the study, but over one-third fulfilled the ILD criteria. Cancer antigen 15-3 (CA15-3) and matrix metalloproteinase-7 (MMP-7) differentiated between RA with and without ILD (all p < 0.05). Surfactant protein D (SP-D) showed similar trends, as did macrophage inflammatory protein-1β (MIP-1β) and chitinase 3-like protein-1 (YKL-40). Based on Pearson's correlation coefficients, MIP-1β and YKL-40 were significantly correlated with DAS28 (MIP-1β: 0.3; YKL-40: 0.4), ESR (MIP-1β: 0.3; YKL-40: 0.4), and CRP (only MIP-1β: 0.4) (all p < 0.05). CA15-3 was correlated with rheumatoid factor and anti-citrullinated peptide antibodies (Pearson's correlation 0.3; both p = 0.03).Conclusions: CA15-3 was the most significant biomarker for ILD detection in RA patients with stable low disease activity, closely followed by MMP-7. SP-D, MIP-1β, and YKL-40 may also contribute to RA-ILD diagnosis.","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":" ","pages":"386-395"},"PeriodicalIF":2.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142507027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk profiles for rheumatoid arthritis-associated interstitial lung disease in a cohort of patients with five-year follow-up. 随访五年的一组类风湿性关节炎相关间质性肺病患者的风险概况。

IF 2.2 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2024-11-01 Epub Date: 2024-10-24 DOI: 10.1080/03009742.2024.2408867

C Hyldgaard, J Blegvad, B K Sofiudóttir, F D Andersen, C Isaksen, G Urbonaviciene, L Brix, T W Kragstrup, B B Løgstrup, T Ellingsen

{"title":"Risk profiles for rheumatoid arthritis-associated interstitial lung disease in a cohort of patients with five-year follow-up.","authors":"C Hyldgaard, J Blegvad, B K Sofiudóttir, F D Andersen, C Isaksen, G Urbonaviciene, L Brix, T W Kragstrup, B B Løgstrup, T Ellingsen","doi":"10.1080/03009742.2024.2408867","DOIUrl":"10.1080/03009742.2024.2408867","url":null,"abstract":"Objectives: Early identification of interstitial lung disease (ILD) among patients with rheumatoid arthritis (RA) is a challenge for clinicians. The aim of this study was to evaluate screening algorithms for ILD by comparing the proportion of patients assigned a high-risk profile by three recently proposed models.Method: We used the four-factor risk score, categorizing patients into high and low risk; the ILD screening criteria, categorizing patients into high, intermediate, and low risk; and the risk score for detection of subclinical RA-ILD, with four different risk categories, on patients with RA followed for 5 years after the RA diagnosis with pulmonary function tests, dyspnoea score, and pulmonary imaging.Results: The four-factor risk score identified 22% of the cohort (25/115) as eligible for further ILD investigations, while the ILD screening criteria identified 37% as high risk (43/115) and 34% as intermediate risk (39/115). The risk score for detection of subclinical RA-ILD identified 44% of the cohort as being at increased risk, with 7% in the highest risk group. The agreement between high-risk groups in the two clinical ILD screening models was moderate (kappa 0.43). Three patients in the cohort had clinical or subclinical ILD, and they were identified as high risk in the two clinical models.Conclusion: The three algorithms identified approximately one-third of the cohort as being at increased risk of ILD. Further development and validation of these algorithms are needed to reduce false positives and balance the potential benefit of earlier ILD diagnosis and healthcare resources used for respiratory assessment.","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":" ","pages":"380-385"},"PeriodicalIF":2.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142507028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Keep a closer eye on 'seronegative rheumatoid arthritis'. 密切关注 "血清阴性类风湿性关节炎"。

IF 2.1 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2024-09-17 DOI: 10.1080/03009742.2024.2386756

T Sokka-Isler,K Paalanen,K Puolakka

引用次数: 0

Plasma haem oxygenase-1 may represent a first-in-class biomarker of oxidative stress in rheumatoid arthritis 血浆血氧合酶-1 可能是类风湿性关节炎氧化应激的第一类生物标志物

IF 2.1 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2024-09-17 DOI: 10.1080/03009742.2024.2392364

BB Andersen, S Greisen, K Stengaard-Pedersen, P Junker, K Hørslev-Petersen, M Lund Hetland, M Østergaard, L Midtbøll Ørnbjerg, M Hvid, B Deleuran, MA Nielsen

引用次数: 0

Spontaneous fracture of the distal radius in a middle-aged woman with osseous sarcoidosis. 一名患有骨肉瘤病的中年女性桡骨远端自发性骨折。

IF 2.1 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2024-09-17 DOI: 10.1080/03009742.2024.2395682

C Marin-Huertas,A Roman-Pascual,E Calvo-Aranda

引用次数: 0

Immunoglobulin G4-related breast disease: two cases treated successfully with rituximab 免疫球蛋白 G4 相关乳腺疾病：两例利妥昔单抗治疗成功病例

IF 2.1 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2024-09-16 DOI: 10.1080/03009742.2024.2372899

H Jeries, Y Braun-Moscovici, Y Zohar, A Balbir-Gurman

引用次数: 0

Van Neck-Odelberg disease in an elderly patient. 一名老年患者的范内克-奥德尔伯格病。

IF 2.2 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2024-09-01 Epub Date: 2024-04-02 DOI: 10.1080/03009742.2024.2330248

X Wang, W Feng

引用次数: 0

Role of physical therapy in adult chronic non-bacterial osteitis: patients' and therapists' perspectives. 物理治疗在成人慢性非细菌性骨炎中的作用：患者和治疗师的观点。

IF 2.2 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2024-09-01 Epub Date: 2024-06-04 DOI: 10.1080/03009742.2024.2352965

A T Leerling, D A Ueckert, F J Van der Giesen, Tpm Vliet-Vlieland, E M Winter

{"title":"Role of physical therapy in adult chronic non-bacterial osteitis: patients' and therapists' perspectives.","authors":"A T Leerling, D A Ueckert, F J Van der Giesen, Tpm Vliet-Vlieland, E M Winter","doi":"10.1080/03009742.2024.2352965","DOIUrl":"10.1080/03009742.2024.2352965","url":null,"abstract":"Objectives: Chronic nonbacterial osteitis (CNO) is a rare bone disease causing pain and functional impairment. We aimed to explore the application of physical therapy (PT) for adult CNO from the patients' and primary care therapists' perspective.Method: Cross-sectional study among the Dutch adult CNO cohort (1992-present). A survey on PT-use for axial spondylarthritis was adapted for CNO. Patients using PT in the past 2 years (recent PT-users) were asked about modalities, perceived effects, satisfaction, and preferences for provision. Their current physical therapists were invited to complete a self-developed survey covering therapy details and educational preferences.Results: 80/199 invited patients and 14/16 invited therapists completed the survey respectively. 41 (51%) patients used PT for CNO in the preceding 2 years, 14 (18%) used PT >2 years back, and 25 (31%) never used PT. Recent PT-users (n=41) reported diverse treatment modalities, involving massage (61%), joint mobilizations (44%), breathing exercises (49%), muscle strengthening (32%) and counselling through of home-exercises (46%) and pain education (32%). 64% of all patients desired greater emphasis from physicians regarding the role of PT. Most therapists would appreciate referral letters with CNO-specific information (93%), and consultations with specialized therapists (86%).Conclusions: In this study, two-third of adult CNO patients had -ever or recently- used PT, which involved variable therapeutic modalities. Most patients were receptive to a larger role of PT in CNO-management and most therapists preferred CNO-specific information to optimize their care. These findings provide a foundation for the development and systematic evaluation of CNO-specific PT.","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":" ","pages":"335-344"},"PeriodicalIF":2.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141238223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tumour necrosis factor inhibitors and serious infections in reproductive-age women and their offspring: a narrative review. 肿瘤坏死因子抑制剂与育龄妇女及其后代的严重感染：叙述性综述。

IF 2.2 4区医学

Scandinavian Journal of Rheumatology Pub Date : 2024-09-01 Epub Date: 2024-02-05 DOI: 10.1080/03009742.2024.2303832

L K Flatman, I Malhamé, I Colmegna, A Bérard, S Bernatsky, É Vinet

{"title":"Tumour necrosis factor inhibitors and serious infections in reproductive-age women and their offspring: a narrative review.","authors":"L K Flatman, I Malhamé, I Colmegna, A Bérard, S Bernatsky, É Vinet","doi":"10.1080/03009742.2024.2303832","DOIUrl":"10.1080/03009742.2024.2303832","url":null,"abstract":"Tumour necrosis factor inhibitors (TNFi) are commonly used to treat patients with chronic inflammatory diseases, and function by inhibiting the pro-inflammatory cytokine tumour necrosis factor-α (TNF-α). Although beneficial in reducing disease activity, they are associated with an increased risk of serious infections. Data on the risk of serious infections associated with TNFi use during the reproductive years, particularly in pregnancy, are limited. For pregnant women, there is an additional risk of immunosuppression in the offspring as TNFi can be actively transported across the placenta, which increases in the second and third trimesters. Several studies have explored the risk of serious infections with TNFi exposure in non-pregnant and pregnant patients and offspring exposed in utero, indicating an increased risk in non-pregnant patients and a potentially increased risk in pregnant patients. The studies on TNFi-exposed offspring showed conflicting results between in utero TNFi exposure and serious infections during the offspring's first year. Further research is needed to understand differential risks based on TNFi subtypes. Guidelines conditionally recommend the rotavirus vaccine before 6 months of age for offspring exposed to TNFi in utero, but more data are needed to support these recommendations because of limited evidence. This narrative review provides an overview of the risk in non-pregnant patients and summarizes evidence on how pregnancy can increase vulnerability to certain infections and how TNFi may influence this susceptibility. This review focuses on the evidence regarding the risk of serious infections in pregnant patients exposed to TNFi and the risk of infections in their offspring.","PeriodicalId":21424,"journal":{"name":"Scandinavian Journal of Rheumatology","volume":" ","pages":"295-306"},"PeriodicalIF":2.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139692816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0