SAGE Open Medical Case Reports最新文献_第4页

Rhabdomyolysis caused by severe Legionella pneumonia combined with influenza A. 严重军团菌肺炎合并甲型流感所致横纹肌溶解。

IF 0.6

SAGE Open Medical Case Reports Pub Date : 2026-07-28 eCollection Date: 2026-01-01 DOI: 10.1177/2050313X261467831

Zhang Qi, Zhang Caiping, Wang Wei

{"title":"Rhabdomyolysis caused by severe Legionella pneumonia combined with influenza A.","authors":"Zhang Qi, Zhang Caiping, Wang Wei","doi":"10.1177/2050313X261467831","DOIUrl":"10.1177/2050313X261467831","url":null,"abstract":"Rhabdomyolysis is a clinical syndrome characterized by the destruction and disintegration of striated muscle due to various causes such as compression, intense exercise, high fever, medications, and inflammation. This leads to the release of intracellular contents like creatine kinase and myoglobin into the extracellular fluid and bloodstream, resulting in metabolic disturbances, acute kidney injury, and damage to other tissues and organs. Influenza virus or Legionella infection, after the pathogen invades the human body, it can cause systemic inflammatory response syndrome, toxin-mediated myocyte damage, severe hypoxia, and metabolic derangement and acidosis in the body. Legionella pneumonia combined with influenza A exacerbates the infection and collectively induces rhabdomyolysis. At present, there are no reports on rhabdomyolysis caused by coinfection of Legionella and influenza A virus. In this case, we focus on introducing a case of influenza A combined with severe Legionella pneumonia, which eventually developed into rhabdomyolysis and multiple organ dysfunction, thereby filling the gap in this field.","PeriodicalId":21418,"journal":{"name":"SAGE Open Medical Case Reports","volume":"14 ","pages":"2050313X261467831"},"PeriodicalIF":0.6,"publicationDate":"2026-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13420074/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148631503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coexistence of PYCR1-related cutis laxa and bilateral grade V vesicoureteral reflux with reflux nephropathy: A case report. pycr1相关皮肤松弛和双侧V级膀胱输尿管反流并发反流肾病1例

IF 0.6

SAGE Open Medical Case Reports Pub Date : 2026-07-28 eCollection Date: 2026-01-01 DOI: 10.1177/2050313X261472704

Dorna Derakhshan, Faizan Bashir, Ali Derakhshan

{"title":"Coexistence of PYCR1-related cutis laxa and bilateral grade V vesicoureteral reflux with reflux nephropathy: A case report.","authors":"Dorna Derakhshan, Faizan Bashir, Ali Derakhshan","doi":"10.1177/2050313X261472704","DOIUrl":"10.1177/2050313X261472704","url":null,"abstract":"PYCR1-related cutis laxa (autosomal recessive cutis laxa type IIB) is a rare inherited connective tissue disorder characterized by loose, inelastic skin, and variable multisystem involvement. While systemic and neurological manifestations have been well described in the literature, data on renal and urinary tract findings remain sparse. We report a 6-year-old girl with genetically confirmed PYCR1-related cutis laxa who presented with recurrent febrile urinary tract infections. Workup revealed bilateral grade V vesicoureteral reflux alongside a small, atrophic left kidney with cortical defects on dimercaptosuccinic acid scintigraphy, in keeping with established reflux nephropathy. Differential renal function was markedly asymmetric, with the left kidney contributing 24% and the right kidney 76% of total function. Despite the degree of unilateral parenchymal loss, estimated glomerular filtration rate and blood pressure remained within age-appropriate limits, though mild proteinuria was noted on further evaluation. Given the burden of recurrent febrile infections in the setting of high-grade bilateral reflux, she was initially managed with prophylactic nitrofurantoin. Following urology consultation surgical correction was therefore pursued, and she underwent bilateral antireflux surgery. She remained free of breakthrough urinary tract infections throughout early postoperative follow-up. The concurrence of severe vesicoureteral reflux, reflux nephropathy, and PYCR1-related cutis laxa has rarely been documented. Whether this association reflects a pathophysiological link or represents coincidental findings in a single patient is not yet clear; nonetheless, this case highlights the importance of considering underlying urological pathology in children with complex connective tissue disorders who present with recurrent urinary tract infections.","PeriodicalId":21418,"journal":{"name":"SAGE Open Medical Case Reports","volume":"14 ","pages":"2050313X261472704"},"PeriodicalIF":0.6,"publicationDate":"2026-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13420061/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148631487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of toxic epidermal necrolysis in an elderly female patient. 老年女性中毒性表皮坏死松解1例。

IF 0.6

SAGE Open Medical Case Reports Pub Date : 2026-07-28 eCollection Date: 2026-01-01 DOI: 10.1177/2050313X261454197

Esenia Bechir, Ganna Isayeva, Simeon Troesch, Mairi Ziaka

{"title":"A case of toxic epidermal necrolysis in an elderly female patient.","authors":"Esenia Bechir, Ganna Isayeva, Simeon Troesch, Mairi Ziaka","doi":"10.1177/2050313X261454197","DOIUrl":"10.1177/2050313X261454197","url":null,"abstract":"Toxic epidermal necrolysis is a rare, potentially fatal, and mainly drug-induced dermatological emergency that requires immediate medical intervention. It is characterized by extensive erythema, widespread sloughing of the epidermis and mucous membranes, and tissue necrosis. The condition can result in significant skin loss and serious complications such as sepsis and shock. With a mortality rate of 30%-50%, early recognition and prompt treatment are critical to improving outcomes. Here we report the case of an 85-year-old woman who presented to our emergency department with confluent erythematous maculopapular eruptions affecting more than 60% of her body surface area, accompanied by a positive Nikolsky sign and widespread areas of denuded skin, including involvement of the oral, vaginal, and anal mucosa following self-administered trimethoprim-sulfamethoxazole for a urinary tract infection. A skin biopsy revealed transepidermal necrosis with minimal active inflammation in the upper dermis. We initiated systemic glucocorticoid therapy along with fluid resuscitation. The patient remained stable throughout hospitalization. By the time of discharge, dermatological findings had significantly improved, and the skin was in the re-epithelialization phase. In conclusion, a high index of clinical suspicion for toxic epidermal necrolysis is necessary when a patient receiving trimethoprim-sulfamethoxazole presents with blistering and/or skin sloughing. Prompt treatment with immunosuppressive agents and supportive care is essential to improve outcomes.","PeriodicalId":21418,"journal":{"name":"SAGE Open Medical Case Reports","volume":"14 ","pages":"2050313X261454197"},"PeriodicalIF":0.6,"publicationDate":"2026-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13420068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148631520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pyoderma gangrenosum presenting to an infectious diseases clinic: A 2024 case series. 呈递到传染病诊所的坏疽性脓皮病：2024年病例系列。

IF 0.6

SAGE Open Medical Case Reports Pub Date : 2026-07-26 eCollection Date: 2026-01-01 DOI: 10.1177/2050313X261463941

Fabiana Kellen, Michael Silverman, Esfandiar Shojaei, MohammadReza Rahimi Shahmirzadi, Lili Ataie

{"title":"Pyoderma gangrenosum presenting to an infectious diseases clinic: A 2024 case series.","authors":"Fabiana Kellen, Michael Silverman, Esfandiar Shojaei, MohammadReza Rahimi Shahmirzadi, Lili Ataie","doi":"10.1177/2050313X261463941","DOIUrl":"10.1177/2050313X261463941","url":null,"abstract":"Pyoderma gangrenosum is a rare neutrophilic dermatosis characterized by painful ulcerative skin lesions and a lack of definitive diagnostic tests. It is frequently mistaken for infectious conditions, often resulting in inappropriate antibiotic use and delayed immunosuppressive therapy. To describe the clinical and demographic characteristics of patients with pyoderma gangrenosum initially assessed in an infectious diseases setting and identify patterns that may aid in earlier diagnosis and management. A retrospective case series was conducted at a Cellulitis Clinic. Patients with a PARACELSUS score ⩾10 were included. Ten patients met inclusion criteria. Median age was 61.5 years; 60% were female and 90% Caucasian. Autoimmune diseases were present in 90%, mental health disorders in 50%, and endocrine abnormalities in 60%. Notably, 20% developed pyoderma gangrenosum at sites of healed scars-a rare presentation. Early recognition and multidisciplinary management are essential for timely treatment and improved outcomes.","PeriodicalId":21418,"journal":{"name":"SAGE Open Medical Case Reports","volume":"14 ","pages":"2050313X261463941"},"PeriodicalIF":0.6,"publicationDate":"2026-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13402762/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148607192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polymicrobial orbital apex syndrome in an immunocompromised patient: A multidisciplinary diagnostic challenge. 免疫功能低下患者的多微生物眶尖综合征：多学科诊断挑战。

IF 0.6

SAGE Open Medical Case Reports Pub Date : 2026-07-24 eCollection Date: 2026-01-01 DOI: 10.1177/2050313X261465145

Elizabeth Y X Leong, Alex J Y Cheong, Jianbin Ding, Maryanne Romero Chew, Terese Huiying Low, Blanche X H Lim

{"title":"Polymicrobial orbital apex syndrome in an immunocompromised patient: A multidisciplinary diagnostic challenge.","authors":"Elizabeth Y X Leong, Alex J Y Cheong, Jianbin Ding, Maryanne Romero Chew, Terese Huiying Low, Blanche X H Lim","doi":"10.1177/2050313X261465145","DOIUrl":"10.1177/2050313X261465145","url":null,"abstract":"We report a diagnostically challenging case of polymicrobial orbital apex syndrome in an immunocompromised patient, emphasizing the importance of early multidisciplinary intervention and consideration of fungal aetiologies in high-risk individuals. A 70-year-old woman with multiple comorbidities presented with subacute left orbital pain and frontotemporal headache, with early signs of cranial nerve VI palsy. Despite initial stability, the patient deteriorated over 2 weeks, developing complete left ophthalmoplegia, proptosis, and vision loss. Further investigation demonstrated a polymicrobial skull base osteomyelitis with orbital apex and cavernous sinus involvement. Histopathology revealed necrotic material with chronic inflammation, and cultures identified Aspergillus flavus, Pseudomonas aeruginosa, Staphylococcus aureus, and Candida parapsilosis. The patient was treated with intravenous vancomycin, oral ciprofloxacin, and voriconazole for 6-8 weeks. Diagnosing orbital apex syndrome in immunocompromised individuals is complex and early imaging is critical. A high clinical suspicion for fungal infection should be maintained, with a strong role for timely tissue diagnosis. Coordinated multidisciplinary care and targeted antimicrobial therapy can prevent further morbidity from intracranial extension.","PeriodicalId":21418,"journal":{"name":"SAGE Open Medical Case Reports","volume":"14 ","pages":"2050313X261465145"},"PeriodicalIF":0.6,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13400923/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148593258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiple mucosal Schwann cell hamartomas of the gallbladder in a patient with pancreaticobiliary maljunction and chronic pancreatitis: A case report. 胆囊多发粘膜雪旺细胞错构瘤合并胰胆管畸形合并慢性胰腺炎1例报告。

IF 0.6

SAGE Open Medical Case Reports Pub Date : 2026-07-24 eCollection Date: 2026-01-01 DOI: 10.1177/2050313X261453780

Omar Aljuboori, Saif Rahman, Sarag Boukhar

引用次数: 0

Metastatic mucinous tubular and spindle cell carcinoma of the kidney: Case report and literature review. 肾转移性粘液管状细胞癌和梭形细胞癌：病例报告和文献复习。

IF 0.6

SAGE Open Medical Case Reports Pub Date : 2026-07-21 eCollection Date: 2026-01-01 DOI: 10.1177/2050313X261472016

Raghad Bokhari, Amal Al-Garni, Hala Adnan Bokhari

引用次数: 0

Salt-associated angina bullosa haemorrhagica in a child: A case report with literature review. 儿童盐相关性大疱性出血心绞痛1例并文献复习。

IF 0.6

SAGE Open Medical Case Reports Pub Date : 2026-07-19 eCollection Date: 2026-01-01 DOI: 10.1177/2050313X261467133

Khlood A Alkurdi, Jihad A Alokaily, Sara D Alzanbaqi, Hassan H Alamer, Jawaher M Alotaibi, Abdullah F Alshammari

{"title":"Salt-associated angina bullosa haemorrhagica in a child: A case report with literature review.","authors":"Khlood A Alkurdi, Jihad A Alokaily, Sara D Alzanbaqi, Hassan H Alamer, Jawaher M Alotaibi, Abdullah F Alshammari","doi":"10.1177/2050313X261467133","DOIUrl":"10.1177/2050313X261467133","url":null,"abstract":"Angina bullosa haemorrhagica is a rare, benign, self-limiting oral mucosal disorder characterised by the sudden appearance of blood-filled bullae in the absence of systemic or haematological abnormalities. Paediatric cases remain exceptionally uncommon. This report describes a 5-year-old Saudi Arabian boy who presented with multiple painless haemorrhagic oral bullae after ingesting natural salt crystals during a visit to a salt lake in Al-Qassim, Saudi Arabia. Clinical examination revealed 18 haemorrhagic bullae involving the buccal mucosa, labial mucosa, and tongue, without systemic symptoms or signs of trauma. Laboratory investigations were unremarkable, and a probable clinical diagnosis of angina bullosa haemorrhagica temporally associated with salt ingestion was established. The lesions ruptured spontaneously within 24 h and healed completely without scarring within 7 days. A literature review identified 40 reported cases from 26 studies, with idiopathic causes and local traumatic or dietary factors being the most commonly associated findings. This report highlights the importance of recognising angina bullosa haemorrhagica in children and considering possible environmental or dietary contributing factors while avoiding unnecessary investigations and interventions.","PeriodicalId":21418,"journal":{"name":"SAGE Open Medical Case Reports","volume":"14 ","pages":"2050313X261467133"},"PeriodicalIF":0.6,"publicationDate":"2026-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13385603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148550053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Continuation of sedative infusions during palliative extubation for refractory status epilepticus in hepatic encephalopathy: A case report. 肝性脑病难治性癫痫持续状态患者姑息拔管期间持续镇静输注：1例报告。

IF 0.6

SAGE Open Medical Case Reports Pub Date : 2026-07-18 eCollection Date: 2026-01-01 DOI: 10.1177/2050313X261468910

Liam D Ferreira, Shailaja Hayden

{"title":"Continuation of sedative infusions during palliative extubation for refractory status epilepticus in hepatic encephalopathy: A case report.","authors":"Liam D Ferreira, Shailaja Hayden","doi":"10.1177/2050313X261468910","DOIUrl":"10.1177/2050313X261468910","url":null,"abstract":"Refractory status epilepticus complicating hepatic encephalopathy poses unique palliative challenges as standard extubation protocols typically reduce or discontinue sedative infusions, risking immediate seizure recurrence and distress. We report a 53-year-old man with end-stage cirrhosis and hepatocellular carcinoma who developed hepatic encephalopathy and refractory status epilepticus precipitated by small bowel obstruction. Despite ammonia-lowering therapy and multiple antiseizure medications, seizures remained refractory. Electroencephalography confirmed status epilepticus despite escalating therapy. Given prohibitive surgical risk and poor prognosis, the multidisciplinary team and patient's family elected to withdraw life-sustaining treatments, requesting he not die with an endotracheal tube in place. He underwent palliative extubation while continuing propofol and midazolam infusions to suppress seizure activity and ensure comfort. He died peacefully without visible seizure activity. Although limited by a single patient, this case provides a practical example of a rarely described palliative strategy: continuing sedative infusions during palliative extubation to prevent agonal seizures in refractory status epilepticus.","PeriodicalId":21418,"journal":{"name":"SAGE Open Medical Case Reports","volume":"14 ","pages":"2050313X261468910"},"PeriodicalIF":0.6,"publicationDate":"2026-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13380675/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148520876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Carcinoma en cuirasse mimicking dermatomal herpes zoster: A case report. 模拟皮肤带状疱疹的胸腺癌1例。

IF 0.6

SAGE Open Medical Case Reports Pub Date : 2026-07-17 eCollection Date: 2026-01-01 DOI: 10.1177/2050313X261461686

Dylan Hollman, Brian D Rankin, Astrid de Boeck, Susan M Poelman

{"title":"Carcinoma en cuirasse mimicking dermatomal herpes zoster: A case report.","authors":"Dylan Hollman, Brian D Rankin, Astrid de Boeck, Susan M Poelman","doi":"10.1177/2050313X261461686","DOIUrl":"10.1177/2050313X261461686","url":null,"abstract":"Carcinoma en cuirasse is a rare form of cutaneous metastasis, typically presenting with a sclerodermoid, infiltrated plaque, most commonly associated with breast cancer. In rare circumstances, carcinoma en cuirasse can mimic alternate etiologies including infectious, inflammatory or treatment-related dermatoses. We present the case of a 58-year-old woman with a 2-year history of stage IV metastatic estrogen receptor positive, progesterone receptor negative, HER2 negative breast carcinoma who developed a pruritic dermatomal eruption of her right flank that was initially empirically treated as herpes zoster without success prior to dermatology consultation. Subsequent skin biopsy revealed a \"single file\" dermal infiltration of epithelial cells, while immunohistochemistry for estrogen receptor demonstrated strong nuclear positivity, confirming the diagnosis of cutaneous metastasis. This case underscores the importance of considering carcinoma en cuirasse in patients with dermatomal eruptions in the context of known malignancy to ensure timely dermatology evaluation, prevent diagnostic delay and allow treatment escalation when necessary.","PeriodicalId":21418,"journal":{"name":"SAGE Open Medical Case Reports","volume":"14 ","pages":"2050313X261461686"},"PeriodicalIF":0.6,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13379675/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148497995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0