SAGE Open Medical Case Reports最新文献_第5页

Marked discrepancy of platelet counts between in-hospital and external laboratory testing due to pre-analytical factors: A case highlighting pseudothrombocytopenia. 由于分析前因素，院内血小板计数与外部实验室检测的显著差异：一例突出的假性血小板减少症。

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SAGE Open Medical Case Reports Pub Date : 2026-07-14 eCollection Date: 2026-01-01 DOI: 10.1177/2050313X261468918

Masami Nita

引用次数: 0

Right atrial mass after cardiac arrest: A case report and brief literature review. 心脏骤停后右心房肿块1例报告及简要文献复习。

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SAGE Open Medical Case Reports Pub Date : 2026-07-13 eCollection Date: 2026-01-01 DOI: 10.1177/2050313X261462285

Zhenghong Chen, Qixuan Li, Zhongzhao Yuan, Tian Wang, Chengwei Yin, Peihua Geng

引用次数: 0

Endophthalmitis in XEN45 Gel Stent: Case report and review of the literature. XEN45凝胶支架内眼内炎一例报告及文献复习。

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SAGE Open Medical Case Reports Pub Date : 2026-07-13 eCollection Date: 2026-01-01 DOI: 10.1177/2050313X261465147

William Xu, Anjay Shah, Kristin Ates Hicks, Lauren Jeang, Jinghua Chen

{"title":"Endophthalmitis in XEN45 Gel Stent: Case report and review of the literature.","authors":"William Xu, Anjay Shah, Kristin Ates Hicks, Lauren Jeang, Jinghua Chen","doi":"10.1177/2050313X261465147","DOIUrl":"10.1177/2050313X261465147","url":null,"abstract":"This is a care of endophthalmitis following XEN45 Gel Stent implantation managed with combined corneal transplant and pars plana vitrectomy, and to review reported cases of endophthalmitis after minimally invasive glaucoma surgery. A 67-year-old male with primary open-angle glaucoma developed endophthalmitis 2 months after XEN45 implantation. Upon referral to our tertiary care center, he underwent urgent implant removal, penetrating keratoplasty with temporary keratoprosthesis, and pars plana vitrectomy with intravitreal antibiotics. Cultures grew Streptococcus gordonii. A second corneal transplant with fresh donor tissue was performed 4 months later. Despite vision limited to light perception, the infection resolved and the eye was preserved. This is the first reported case of XEN45 Gel Stent-associated endophthalmitis which was successfully controlled with combined keratoplasty and vitrectomy. Our review of published cases identified 45 minimally invasive glaucoma surgery-related endophthalmitis cases, with XEN45 accounting for 58%. Potential risk factors included the XEN45 stent's susceptibility to exposure after conjunctival erosion, pool water exposure, and ab externo insertion during implantation. In cases of XEN45 Gel Stent-associated endophthalmitis, corneal transplant with pars plana vitrectomy could be a successful strategy to control infection and spare the globe.","PeriodicalId":21418,"journal":{"name":"SAGE Open Medical Case Reports","volume":"14 ","pages":"2050313X261465147"},"PeriodicalIF":0.6,"publicationDate":"2026-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13365692/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148448954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rhupus syndrome presenting with anterior scleritis and lupus nephritis: A case report. 以前巩膜炎和狼疮性肾炎为表现的狼疮综合征1例。

IF 0.6

SAGE Open Medical Case Reports Pub Date : 2026-07-11 eCollection Date: 2026-01-01 DOI: 10.1177/2050313X261467123

Myrah Sheriff, Veena Patel

引用次数: 0

Ten-year progression of Caroli's disease with portal hypertension despite endoscopic and pharmacological therapy: Implications for liver transplantation-A case report. 经内窥镜和药物治疗，Caroli病合并门静脉高压症10年进展：对肝移植的影响- 1例报告。

IF 0.6

SAGE Open Medical Case Reports Pub Date : 2026-07-11 eCollection Date: 2026-01-01 DOI: 10.1177/2050313X261467162

Han Meng, Ruiyu Xie, Chuanjie Yang

{"title":"Ten-year progression of Caroli's disease with portal hypertension despite endoscopic and pharmacological therapy: Implications for liver transplantation-A case report.","authors":"Han Meng, Ruiyu Xie, Chuanjie Yang","doi":"10.1177/2050313X261467162","DOIUrl":"10.1177/2050313X261467162","url":null,"abstract":"Caroli's disease is a rare congenital disorder of the intrahepatic bile ducts that may be complicated by congenital hepatic fibrosis, portal hypertension, and recurrent variceal bleeding. We report the 10-year clinical course of a 29-year-old woman with Caroli's disease and portal hypertension who was managed in the Department of Gastroenterology. At initial presentation in 2015, she had splenomegaly, severe esophagogastric fundal varices, preserved liver biochemistry, Child-Pugh class A disease, and a low model for end-stage liver disease score. Symptoms improved after nonselective beta-blocker therapy; however, longitudinal follow-up showed persistent portal hypertension, recurrent gastrointestinal bleeding, and progressive impairment of hepatic reserve. From 2023 onward, she experienced recurrent hematemesis and melena despite sequential endoscopic variceal ligation and beta-blocker therapy, including conversion from propranolol to carvedilol. During the most recent admission on May 25, 2024, laboratory and imaging findings indicated progressive cholestasis, portal hypertension, Child-Pugh class B disease, and a model for end-stage liver disease score of 9.9. After multidisciplinary team evaluation, liver transplantation was considered clinically indicated, and the patient was activated on the transplant waiting list. This case demonstrates the limitations of long-term endoscopic and pharmacological therapy in Caroli's disease complicated by portal hypertension and supports timely transplant referral before advanced hepatic decompensation occurs.","PeriodicalId":21418,"journal":{"name":"SAGE Open Medical Case Reports","volume":"14 ","pages":"2050313X261467162"},"PeriodicalIF":0.6,"publicationDate":"2026-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13356321/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148431103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erosive vulvar lichen planus improved with topical ruxolitinib: A case report. 外用鲁索利替尼改善糜烂性外阴扁平苔藓1例。

IF 0.6

SAGE Open Medical Case Reports Pub Date : 2026-07-10 eCollection Date: 2026-01-01 DOI: 10.1177/2050313X261463898

Rahila Shaikh, Carly Kirshen

{"title":"Erosive vulvar lichen planus improved with topical ruxolitinib: A case report.","authors":"Rahila Shaikh, Carly Kirshen","doi":"10.1177/2050313X261463898","DOIUrl":"10.1177/2050313X261463898","url":null,"abstract":"Lichen planus is a chronic immune-mediated inflammatory disorder, and vulvar lichen planus (VLP) is a debilitating subtype often refractory to standard therapy. Emerging evidence on Janus kinase-signal transducer and activator of transcription pathway dysregulation in the pathogenesis of VLP supports Janus kinase inhibition as a potential therapeutic strategy. We report a 71-year-old woman with chronic VLP, including severe pruritus, pain, erosive erythema, and progressive vulvar scarring, who failed multiple topical and systemic therapies. These therapies included topical and oral corticosteroids, mycophenolate mofetil, acitretin, tacrolimus, and roflumilast, which were discontinued due to inadequate response or intolerance. Following the initiation of topical ruxolitinib 1.5% cream twice daily, she achieved complete resolution of erythema, pruritus, and burning after 3 months, without local or systemic adverse effects. This is the first reported case of VLP treated with a topical Janus kinase inhibitor, supporting topical Janus kinase inhibition as a steroid-sparing therapeutic option for refractory disease; however, cost and access may limit its use.","PeriodicalId":21418,"journal":{"name":"SAGE Open Medical Case Reports","volume":"14 ","pages":"2050313X261463898"},"PeriodicalIF":0.6,"publicationDate":"2026-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13356331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148431082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pulmonary infection due to emerging Lophomonas pathogen in immunocompetent patients: Two case reports. 免疫功能正常患者因新发Lophomonas病原体引起的肺部感染：2例报告。

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SAGE Open Medical Case Reports Pub Date : 2026-07-09 eCollection Date: 2026-01-01 DOI: 10.1177/2050313X261464741

Zakaria Zakariaei, Eissa Soleymani, Hossein Mehravaran, Mahdi Fakhar, Elham Sadat Banimostafavi, Majidreza Adelani, Ali Sharifpour

{"title":"Pulmonary infection due to emerging Lophomonas pathogen in immunocompetent patients: Two case reports.","authors":"Zakaria Zakariaei, Eissa Soleymani, Hossein Mehravaran, Mahdi Fakhar, Elham Sadat Banimostafavi, Majidreza Adelani, Ali Sharifpour","doi":"10.1177/2050313X261464741","DOIUrl":"10.1177/2050313X261464741","url":null,"abstract":"Lophomoniasis is a new emerging parasitic disease caused by Lophomonas spp., a protozoan that predominantly resides in a commensal relationship within the hindgut of cockroaches. This pathogen is known to affect the lower respiratory tract in humans, resulting in clinical manifestations such as cough, sputum production, and shortness of breath. We present two case studies involving a 54-year-old- and a 38-year-old male, both with a history of cigarette smoking but no known underlying medical conditions. These individuals presented at the emergency room with respiratory symptoms and were subsequently evaluated. No significant abnormalities were shown on the lung computed tomography scan in Case 1, whereas empyema was observed in the right lung in Case 2. Analysis of bronchoalveolar lavage fluid from each patient revealed Lophomonas spp., an emerging protozoan pathogen, by microscopic examination. Based on these findings, metronidazole was administered to both patients, resulting in successful treatment of the infection. These cases highlight that Lophomonas spp. is a significant respiratory pathogen capable of causing a spectrum of disease in immunocompetent individuals, from mild bronchitis to severe pneumonia with complications. They emphasize the critical importance of including lophomoniasis in the differential diagnosis for persistent or atypical respiratory infections. Timely treatment with metronidazole was effective, resulting in clinical resolution.","PeriodicalId":21418,"journal":{"name":"SAGE Open Medical Case Reports","volume":"14 ","pages":"2050313X261464741"},"PeriodicalIF":0.6,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13351216/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148423639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case report and literature review: Cerebral spinal fluid leak after COVID nasopharyngeal swab testing. 1例病例报告及文献复习：新冠肺炎鼻咽拭子检测后脑脊液泄漏。

IF 0.6

SAGE Open Medical Case Reports Pub Date : 2026-07-08 eCollection Date: 2026-01-01 DOI: 10.1177/2050313X261456987

Jeremy Shi, Ya Xu, Chinyere Mbagwu

{"title":"A case report and literature review: Cerebral spinal fluid leak after COVID nasopharyngeal swab testing.","authors":"Jeremy Shi, Ya Xu, Chinyere Mbagwu","doi":"10.1177/2050313X261456987","DOIUrl":"10.1177/2050313X261456987","url":null,"abstract":"Coronavirus disease 2019 (COVID-19) swab testing has been commonplace since the onset of the pandemic, with few reported adverse effects beyond general discomfort. We report a rare clinical presentation of a cerebrospinal fluid leak following a nasopharyngeal COVID-19 swab. The patient, a 49-year-old female with a history of migraines, idiopathic intracranial hypertension (pseudotumor cerebri), fibromyalgia, depression, and prior traumatic brain injury, presented to the emergency department with a headache. The patient underwent nasopharyngeal swab testing 10 days before her visit. She experienced the immediate postprocedure onset of a global headache and clear nasal discharge that persisted until presentation. Physical examination revealed continuous clear rhinorrhea from the left nostril. Associated symptoms included blurry vision, nausea, vomiting, and postural instability. The patient was managed conservatively; the leak and associated symptoms resolved within 24 h. Computed tomography of the head and paranasal sinuses showed no overt skull base defect but revealed subtle dehiscence along the right optic canal and right foramen rotundum, as well as dilation of the optic nerve sheaths. These findings suggest elevated intracranial pressure, which may have predisposed the patient to a cerebrospinal fluid leak. Given the clinical history and temporal relationship, this is a presumptive cerebrospinal fluid leak secondary to the COVID-19 swab; however, no confirmatory testing was performed. Increased awareness of this adverse effect, particularly in patients with pre-existing risk factors, is essential for early diagnosis. Anterior nasal or mid-turbinate swabs may be safer for vulnerable patients, as nasopharyngeal swabs are more frequently linked to iatrogenic skull base injuries according to reported cases. To our knowledge, this represents the 15th reported instance of a post-swab cerebrospinal fluid leak and includes a comprehensive literature review.","PeriodicalId":21418,"journal":{"name":"SAGE Open Medical Case Reports","volume":"14 ","pages":"2050313X261456987"},"PeriodicalIF":0.6,"publicationDate":"2026-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13351236/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148423659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A rare case of galactocele in a patient with macroprolactinoma. The hypothetical role of poor compliance with dopamine agonist therapy. 巨催乳素瘤罕见半乳膨出1例。多巴胺激动剂治疗依从性差的假设作用。

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SAGE Open Medical Case Reports Pub Date : 2026-07-08 eCollection Date: 2026-01-01 DOI: 10.1177/2050313X261456979

Elabbass A Abdelmahmuod, Haidar Bustanji, Tarik Elhadd

{"title":"A rare case of galactocele in a patient with macroprolactinoma. The hypothetical role of poor compliance with dopamine agonist therapy.","authors":"Elabbass A Abdelmahmuod, Haidar Bustanji, Tarik Elhadd","doi":"10.1177/2050313X261456979","DOIUrl":"10.1177/2050313X261456979","url":null,"abstract":"Galactocele is a rare clinical finding in males and is even more uncommon in the context of prolactin-secreting pituitary adenomas. Its occurrence raises important questions about the effects of hyperprolactinemia in men, especially when there is poor treatment adherence. We describe a 34-year-old man with type 2 diabetes who presented with erectile dysfunction, gynecomastia, and galactorrhea. Investigations confirmed hyperprolactinemia secondary to a pituitary macroadenoma. He was started on cabergoline, which improved his symptoms. However, after discontinuing therapy for several months, he developed a painful breast mass. Ultrasound and aspiration confirmed a galactocele-a finding rarely reported in adult males. The mass resolved after aspiration, and dopamine agonist therapy was resumed. This case highlights the importance of recognizing galactocele as a potential complication of untreated or poorly managed hyperprolactinemia in men. It underscores the need for sustained adherence to dopamine agonists and vigilance in evaluating male patients with gynecomastia and galactorrhea.","PeriodicalId":21418,"journal":{"name":"SAGE Open Medical Case Reports","volume":"14 ","pages":"2050313X261456979"},"PeriodicalIF":0.6,"publicationDate":"2026-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13346722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148423693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Radiation-induced morphoea in the setting of previous breast cancer: A case report. 既往乳腺癌放射诱导的形态学：1例报告。

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SAGE Open Medical Case Reports Pub Date : 2026-07-08 eCollection Date: 2026-01-01 DOI: 10.1177/2050313X261463846

Sydney A Yee, David M Langelier, Kyla Taylor, Lynne H Robertson

引用次数: 0