鼻腔原发性间变性淋巴瘤激酶阴性间变性大细胞淋巴瘤并发真菌感染1例。

IF 0.6 Q3 MEDICINE, GENERAL & INTERNAL

SAGE Open Medical Case Reports Pub Date : 2025-05-17 eCollection Date: 2025-01-01 DOI:10.1177/2050313X251342938

Yun Huang, Liang Luo, Yi-Bin Liu, Xin-Tao Wang, Long-Gui You, Huan Li

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引用次数: 0

摘要

本文报告一例合并真菌感染的鼻腔原发性间变性淋巴瘤激酶阴性间变性大细胞淋巴瘤。患者66岁，女性，左侧面部疼痛1个月。病理检查显示：(1)原发性全身性间变性淋巴瘤激酶阴性间变性大细胞淋巴瘤。免疫组织化学结果显示CD21(-)表征,CD20(克隆L26) (-), CD3 (-), CD30 (+), Ki67 (+ 60%), CD5 (+), CD7(-)、CD56 (-), granzyme B (+), CK (-), CK5/6 (-), CD99 (+), Syn (-), s - 100 (-), CD2(+)、CD4 (+), CD8 (-), CD43 (+), EMA(+),间变性淋巴瘤激酶(5 a4)(-)。原位杂交结果显示为EBER（-）。(2)镜下发现大量真菌菌丝呈簇状或片状排列，PAS（+）和Grocott's甲基苯丙胺银染色（+）证实真菌感染的存在。

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Nasal primary anaplastic lymphoma kinase-negative anaplastic large cell lymphoma with fungal infection: A case report.

This report pertains to a case of nasal primary anaplastic lymphoma kinase-negative anaplastic large cell lymphoma, which was complicated by a fungal infection. The patient, a 66-year-old female, experienced pain in the left side of her face for 1 month. Pathological examination revealed the following: (1) primary systemic anaplastic lymphoma kinase-negative anaplastic large cell lymphoma. Immunohistochemical findings showed CD21(-), CD20 (clone L26) (-), CD3 (-), CD30 (+), Ki67 (60% +), CD5 (+), CD7 (-), CD56 (-), granzyme B (+), CK (-), CK5/6 (-), CD99 (+), Syn (-), S-100 (-), CD2 (+), CD4 (+), CD8 (-), CD43 (+), EMA (+), and anaplastic lymphoma kinase (5A4) (-). In situ hybridization results indicated EBER (-). (2) Microscopic findings suggested numerous fungal hyphae arranged in clusters or sheets, with PAS (+) and Grocott's methenamine silver stain (+) staining confirming the presence of a fungal infection.

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来源期刊

SAGE Open Medical Case Reports MEDICINE, GENERAL & INTERNAL-

CiteScore

0.60

自引率

0.00%

发文量

320

审稿时长

8 weeks

期刊介绍： SAGE Open Medical Case Reports (indexed in PubMed Central) is a peer reviewed, open access journal. It aims to provide a publication home for short case reports and case series, which often do not find a place in traditional primary research journals, but provide key insights into real medical cases that are essential for physicians, and may ultimately help to improve patient outcomes. SAGE Open Medical Case Reports does not limit content due to page budgets or thematic significance. Papers are subject to rigorous peer review and are selected on the basis of whether the research is sound and deserves publication. By virtue of not restricting papers to a narrow discipline, SAGE Open Medical Case Reports facilitates the discovery of the connections between papers, whether within or between disciplines. Case reports can span the full spectrum of medicine across the health sciences in the broadest sense, including: Allergy/Immunology Anaesthesia/Pain Cardiovascular Critical Care/ Emergency Medicine Dentistry Dermatology Diabetes/Endocrinology Epidemiology/Public Health Gastroenterology/Hepatology Geriatrics/Gerontology Haematology Infectious Diseases Mental Health/Psychiatry Nephrology Neurology Nursing Obstetrics/Gynaecology Oncology Ophthalmology Orthopaedics/Rehabilitation/Occupational Therapy Otolaryngology Palliative Medicine Pathology Pharmacoeconomics/health economics Pharmacoepidemiology/Drug safety Psychopharmacology Radiology Respiratory Medicine Rheumatology/ Clinical Immunology Sports Medicine Surgery Toxicology Urology Women''s Health.