{"title":"It must be mono: An atypical case of splenic rupture.","authors":"Ujunwa Eze, Amith Jagannath, Rahul Kashyap, Sukhjeet Kamboj","doi":"10.1177/2050313X261476140","DOIUrl":"10.1177/2050313X261476140","url":null,"abstract":"<p><p>Splenic rupture is a rare but life-threatening complication of infectious mononucleosis, typically associated with Epstein-Barr virus. Early diagnosis of infectious mononucleosis is essential for appropriate management but may be delayed by false-negative early testing and atypical presentations. We report an atypical case of infectious mononucleosis in a 17-year-old male who presented with an acute abdomen secondary to atraumatic splenic rupture confirmed on CT. Initial mononucleosis testing was negative, delaying diagnosis, but repeat testing and subsequent laboratory findings strongly supported the diagnosis of infectious mononucleosis. Despite initial conservative management, worsening symptoms and progression of the splenic hematoma necessitated partial splenectomy. This case highlights the importance of maintaining a high index of suspicion for infectious mononucleosis in young patients with atraumatic splenic rupture despite negative initial testing, as early diagnosis may help guide appropriate management.</p>","PeriodicalId":21418,"journal":{"name":"SAGE Open Medical Case Reports","volume":"14 ","pages":"2050313X261476140"},"PeriodicalIF":0.6,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13583286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148991248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Rapidly progressive calcinosis cutis in adult-onset dermatomyositis: A case report.","authors":"Elona Bebla, Attiya Haroon","doi":"10.1177/2050313X261463982","DOIUrl":"10.1177/2050313X261463982","url":null,"abstract":"<p><p>Calcinosis cutis is an uncommon but clinically significant complication of dermatomyositis, occurring in approximately 11%-20% of adult patients. We report a case of rapidly progressive, extensive calcinosis cutis in a 52-year-old woman with adult-onset dermatomyositis. Despite ongoing systemic immunosuppressive therapy, she developed biopsy-confirmed calcinosis within 3 months of initial presentation, with subsequent extension to the bilateral axillae, anterior chest wall, and proximal thighs causing functional impairment. Myositis-specific antibody panel results are pending. This case illustrates the aggressive potential of calcinosis in adult dermatomyositis, the limited therapeutic options once calcification is established, and the importance of early aggressive disease control.</p>","PeriodicalId":21418,"journal":{"name":"SAGE Open Medical Case Reports","volume":"14 ","pages":"2050313X261463982"},"PeriodicalIF":0.6,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13583267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148991189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alan R Rheaume, Thomas R Marotta, Jeremy L Rempel, Michael M Chow
{"title":"Successful obliteration of a wide-necked carotid terminus aneurysm with an eCLIPs flow diverting device: A case report and review of literature.","authors":"Alan R Rheaume, Thomas R Marotta, Jeremy L Rempel, Michael M Chow","doi":"10.1177/2050313X261461633","DOIUrl":"10.1177/2050313X261461633","url":null,"abstract":"<p><p>Intracranial wide-neck bifurcation aneurysms are challenging to treat with conventional endovascular coiling and stenting techniques. Flow diverting devices can provide adequate neck coverage but risk branch vessel ischemia or stroke. We report the case of a 49-year-old man with an incidental wide-neck internal carotid artery terminus aneurysm, treated successfully with a stand-alone eCLIPs implant-a novel hybrid stent-like device that preserves flow across the parent arteries. At 5 months of follow-up, diagnostic angiography demonstrated complete aneurysm occlusion, and the patient remained neurologically intact. In carefully selected cases of shallow wide-neck bifurcation aneurysms, stand-alone eCLIPs device treatment may be considered as an alternative to standard flow diversion, particularly when the patency of branch or perforating vessels is paramount.</p>","PeriodicalId":21418,"journal":{"name":"SAGE Open Medical Case Reports","volume":"14 ","pages":"2050313X261461633"},"PeriodicalIF":0.6,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13583283/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148991191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nour Kassab, Alev Gümüs, Livio Solari, Françoise Lefebvre, Grégory Callebaut
{"title":"Complete non-anastomotic rupture of an axillobifemoral PTFE bypass following blunt chest trauma: A case report.","authors":"Nour Kassab, Alev Gümüs, Livio Solari, Françoise Lefebvre, Grégory Callebaut","doi":"10.1177/2050313X261489336","DOIUrl":"10.1177/2050313X261489336","url":null,"abstract":"<p><strong>Background: </strong>Non-anastomotic disruption of an axillofemoral bypass graft is an exceedingly rare but potentially life-threatening complication. Most reported cases present with a delayed pseudoaneurysm, whereas acute complete graft disruption with active hemorrhage is exceptional.</p><p><strong>Case presentation: </strong>A man in his late 50s with a history of a left axillobifemoral PTFE bypass performed in 2022 for chronic aorto-iliac occlusive disease presented to the emergency department with acute left thoracic and upper-limb pain and a rapidly developing pulsatile thoracic swelling following blunt chest trauma against the edge of a table. Computed tomography angiography demonstrated a large left anterior chest-wall hematoma communicating with the axillobifemoral graft and associated active bleeding. Emergency surgical exploration was undertaken. A complete transverse rupture of the graft was identified in the non-anastomotic portion, with no disruption of either the proximal or distal arterial anastomosis. The graft was repaired by direct end-to-end prosthesis-to-prosthesis anastomosis. The postoperative course was uneventful with preserved graft patency and good clinical outcome. A distal clavicular fracture was subsequently identified.</p><p><strong>Conclusion: </strong>Complete non-anastomotic rupture of an axillobifemoral PTFE graft following blunt trauma is extremely uncommon but should be considered in patients with a previous axillofemoral bypass who develop acute chest-wall pain, swelling, or hemorrhage after trauma. Prompt CTA and emergency surgical management are essential because delayed diagnosis may result in life-threatening hemorrhage.</p>","PeriodicalId":21418,"journal":{"name":"SAGE Open Medical Case Reports","volume":"14 ","pages":"2050313X261489336"},"PeriodicalIF":0.6,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13558926/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148930603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mutasim Binidris, Menatalla Shehata, Ahmed Mahfouz, Omar Abousaad, Willington Francis, Muhammed Rafeeq
{"title":"Disseminated meningococcal infection presenting with constrictive pericarditis and bilateral septic arthritis without meningitis: A case report.","authors":"Mutasim Binidris, Menatalla Shehata, Ahmed Mahfouz, Omar Abousaad, Willington Francis, Muhammed Rafeeq","doi":"10.1177/2050313X261488253","DOIUrl":"10.1177/2050313X261488253","url":null,"abstract":"<p><p>Invasive meningococcal disease is a life-threatening infection that classically presents as meningitis or meningococcemia. Extra-meningeal manifestations, including pericarditis and septic arthritis, are uncommon and may complicate diagnosis, particularly in the absence of meningeal involvement. A previously healthy vaccinated man in his 50s presented with acute bilateral knee pain and swelling following a short history of fever, productive cough, fatigue, and dyspnea. Blood cultures grew <i>Neisseria meningitidis</i> serogroup W, whereas cerebrospinal fluid, synovial fluid, and pericardial fluid cultures remained negative. Cardiac magnetic resonance imaging demonstrated constrictive pericarditis with circumferential pericardial enhancement and pericardial effusion. The patient was successfully treated with intravenous ceftriaxone, colchicine, ibuprofen, pericardiocentesis, and bilateral knee washout, followed by oral ciprofloxacin. This case adds to the limited literature describing concurrent cardiac and musculoskeletal manifestations of invasive meningococcal disease without meningitis and shows the importance of early recognition, comprehensive investigation and multidisciplinary management of these uncommon presentations.</p>","PeriodicalId":21418,"journal":{"name":"SAGE Open Medical Case Reports","volume":"14 ","pages":"2050313X261488253"},"PeriodicalIF":0.6,"publicationDate":"2026-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13554543/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148920913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Imaging manifestations of Bouveret's syndrome: A rare case report of gallstone-induced ileus.","authors":"Ting Wang, Xiaolong Ma, Jun Chai","doi":"10.1177/2050313X261480880","DOIUrl":"10.1177/2050313X261480880","url":null,"abstract":"<p><p>Bouveret's syndrome, a rare cholelithiasis complication (gallstone impaction via cholecystoduodenal fistula causing gastric outlet obstruction), is reported in an 81-year-old male with chronic cholecystitis, coronary heart disease, and left nephrectomy. He presented with spasmodic epigastric pain, nausea, and vomiting of coffee-ground-like gastric contents. Multimodal imaging confirmed the diagnosis, and laparoscopic gallstone extraction was successful.</p>","PeriodicalId":21418,"journal":{"name":"SAGE Open Medical Case Reports","volume":"14 ","pages":"2050313X261480880"},"PeriodicalIF":0.6,"publicationDate":"2026-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13546460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148901009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sivakajani Balakumar, Kelum Priyadarshana, Sandawana William Majoni
{"title":"Severe calciphylaxis in a post-kidney transplant patient with chronic allograft dysfunction and unmodifiable anticoagulation.","authors":"Sivakajani Balakumar, Kelum Priyadarshana, Sandawana William Majoni","doi":"10.1177/2050313X261479200","DOIUrl":"10.1177/2050313X261479200","url":null,"abstract":"<p><p>Calciphylaxis is a rare but life-threatening disorder characterised by progressive vascular calcification, thrombosis, and painful skin necrosis, with high morbidity and mortality. Although most cases are reported in patients with end-stage kidney disease receiving dialysis, it can also occur in kidney transplant recipients, particularly in the setting of chronic allograft dysfunction and persistent disturbances in mineral metabolism. We report the case of a 70-year-old man who developed biopsy-confirmed calciphylaxis during chronic allograft failure secondary to chronic T-cell-mediated rejection and BK virus nephropathy following deceased-donor kidney transplantation. Additional risk factors included hyperphosphataemia, secondary hyperparathyroidism, long-term warfarin therapy for a mechanical aortic valve, and ongoing immunosuppression. Management involved multidisciplinary care, including cessation of warfarin with bridging intravenous unfractionated heparin, initiation of maintenance haemodialysis, optimisation of chronic kidney disease-mineral and bone disorder, intravenous sodium thiosulfate administered after each haemodialysis session, intensive wound care, pain management, and planned hyperbaric oxygen therapy. Despite these interventions, the patient developed varicella-zoster virus encephalitis and disseminated <i>Trichosporon</i> infection, resulting in progressive multisystem illness and death. This case highlights the multifactorial pathogenesis, diagnostic challenges, and poor prognosis of calciphylaxis in kidney transplant recipients with advanced allograft failure, particularly when anticoagulation cannot be safely discontinued because of a mechanical heart valve. Early recognition, histopathological confirmation, and prompt multidisciplinary management are essential; however, outcomes remain poor in patients with advanced graft dysfunction and ongoing immunosuppression.</p>","PeriodicalId":21418,"journal":{"name":"SAGE Open Medical Case Reports","volume":"14 ","pages":"2050313X261479200"},"PeriodicalIF":0.6,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13547796/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148906923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohamed A Youssef, Zahra Sarrafan Chaharsoughi, Celeste E Wagner, Hafiz Ghani, Sreeram Parupudi, Ranjana Nawgiri
{"title":"Gastric adenosquamous carcinoma with an apparently pure squamous phenotype on limited biopsy in a patient with HIV: A case report.","authors":"Mohamed A Youssef, Zahra Sarrafan Chaharsoughi, Celeste E Wagner, Hafiz Ghani, Sreeram Parupudi, Ranjana Nawgiri","doi":"10.1177/2050313X261486169","DOIUrl":"10.1177/2050313X261486169","url":null,"abstract":"<p><p>Gastric carcinomas with squamous differentiation are exceptionally rare and diagnostically difficult, particularly on limited biopsy material. We report a case of an HIV-positive man in his mid-60s who presented with abdominal pain, melena, and unintentional weight loss. Initial upper endoscopy revealed a large, ulcerated mass involving the gastric fundus and cardia; superficial endoscopic biopsies were non-diagnostic. Endoscopic ultrasound-guided biopsy demonstrated invasive squamous cell carcinoma without a glandular component, and the tumor was staged cT4b cN1 cM0 (clinical Stage IVA, AJCC/UICC eighth edition). The biopsy interpretation was treated as provisional, since sampling of this extent cannot exclude a glandular component. After neoadjuvant FLOT chemotherapy, total gastrectomy with multivisceral resection yielded gastric adenosquamous carcinoma with hepatic metastatic adenocarcinoma, establishing M1 disease and Stage IV. A pure squamous phenotype in a gastric biopsy is therefore not sufficient to diagnose primary gastric squamous cell carcinoma; the distinction rests on the resection specimen. The patient's HIV infection is relevant background rather than a demonstrated cause.</p>","PeriodicalId":21418,"journal":{"name":"SAGE Open Medical Case Reports","volume":"14 ","pages":"2050313X261486169"},"PeriodicalIF":0.6,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13538990/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148888468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
James R Burmeister, Malik Jawad, Ismail Zazay, Aaron Kobernick
{"title":"Patulous Eustachian tube dysfunction following rapid weight loss associated with semaglutide use: A case report.","authors":"James R Burmeister, Malik Jawad, Ismail Zazay, Aaron Kobernick","doi":"10.1177/2050313X261486164","DOIUrl":"10.1177/2050313X261486164","url":null,"abstract":"<p><p>Patulous Eustachian tube dysfunction (PETD) is an uncommon condition characterized by an abnormally patent Eustachian tube, leading to symptoms such as aural fullness and autophony. Rapid weight loss is a recognized risk factor due to loss of peritubal adipose support. With the increasing use of semaglutide and other glucagon-like peptide-1 receptor agonists for obesity management, substantial and rapid weight reduction has become more common, raising the potential for underrecognized otologic complications. A 79-year-old male presented with intermittent bilateral aural fullness and ear \"popping\" without associated pain, vertigo, or systemic symptoms. His history was notable for intentional weight loss of approximately 200 lb following initiation of semaglutide therapy. Otoscopic examination was unremarkable, and prior tympanometry demonstrated normal middle ear pressure. In the absence of findings suggestive of obstructive Eustachian tube dysfunction, a clinical diagnosis of patulous Eustachian tube dysfunction was made. The patient was managed conservatively with hydration, intranasal saline, and avoidance of decongestants. Rapid, extreme weight loss associated with GLP-1 receptor agonist therapy may precipitate PETD and should be considered in patients presenting with aural fullness and normal middle ear findings. Recognition of this association supports appropriate conservative management and may prevent unnecessary interventions.</p>","PeriodicalId":21418,"journal":{"name":"SAGE Open Medical Case Reports","volume":"14 ","pages":"2050313X261486164"},"PeriodicalIF":0.6,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13538991/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148888397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maab F Elhaj, Elabbass A Abdelmahmuod, Stephen F Beer, Tarik Elhadd
{"title":"The value of adrenal venous sampling in unveiling the conundrum of double unilateral adrenal adenomas in a case of primary hyperaldosteronism.","authors":"Maab F Elhaj, Elabbass A Abdelmahmuod, Stephen F Beer, Tarik Elhadd","doi":"10.1177/2050313X261487243","DOIUrl":"10.1177/2050313X261487243","url":null,"abstract":"<p><p>Primary hyperaldosteronism (PHA) is a cause of secondary hypertension, often due to adrenal adenoma. The diagnosis and management of multiple unilateral adrenal adenomas in PHA represent a unique challenge. Adrenal venous sampling (AVS) has become a pivotal diagnostic tool in these cases, providing critical information for accurate localization of aldosterone production. Here, we describe a rare case of a 52-year-old female with a history of resistant essential hypertension who presented with multiple unilateral adrenal adenomas concomitant with adrenal hyperplasia in a case of primary hyperaldosteronism. The use of AVS in localization of aldosterone production was the determining factor in deciding the ultimate management of the patient, leading to successful follow-up on medical therapy with spironolactone.</p>","PeriodicalId":21418,"journal":{"name":"SAGE Open Medical Case Reports","volume":"14 ","pages":"2050313X261487243"},"PeriodicalIF":0.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13535070/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148881479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}