SAGE Open Medical Case Reports最新文献_第2页

Advanced anaplastic thyroid carcinoma with positive expression of PD-L1 response to immune checkpoint inhibitors: A case report.

IF 0.6

SAGE Open Medical Case Reports Pub Date : 2025-01-27 eCollection Date: 2025-01-01 DOI: 10.1177/2050313X241313084

Shanmin Fan, Yang Yuan, Yanfang Su, Die Sang

{"title":"Advanced anaplastic thyroid carcinoma with positive expression of PD-L1 response to immune checkpoint inhibitors: A case report.","authors":"Shanmin Fan, Yang Yuan, Yanfang Su, Die Sang","doi":"10.1177/2050313X241313084","DOIUrl":"10.1177/2050313X241313084","url":null,"abstract":"Anaplastic thyroid carcinoma (ATC) is one rare type of thyroid carcinoma without standard systemic treatment for advanced disease. Recent evidence has demonstrated promising efficacy of immune checkpoint inhibitors, particularly those targeting programmed death-1 (PD-1)/programmed death ligand 1 (PD-L1), in a variety of solid tumors. However, there have been no research of immune checkpoint inhibitors plus chemotherapy in ATC. Here, we present the case of a 37-year-old man with metastatic ATC with positive PD-L1 expression, who achieved long-term remission of 34 months after later-line treatment with zimberelimab (a PD-1 inhibitor) and nab-paclitaxel, followed by single-agent zimberelimab maintenance therapy. After three cycles of the combination treatment, the thyroid lesion and the liver metastases shrank dramatically, leading to the best overall response of partial remission. PD-L1 expression may serve as a potential biomarker for tumor response to immune checkpoint inhibitors in ATC. Our review highlights the need for further studies investigating the role of PD-L1 status as biomarker to predict the prognosis of immunotherapy in the treatment of ATC.","PeriodicalId":21418,"journal":{"name":"SAGE Open Medical Case Reports","volume":"13 ","pages":"2050313X241313084"},"PeriodicalIF":0.6,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11773542/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143060510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Seminoma Diagnosed by Multicancer Detection Testing: A Case Report.

IF 0.6

SAGE Open Medical Case Reports Pub Date : 2025-01-26 eCollection Date: 2025-01-01 DOI: 10.1177/2050313X251316987

Elizabeth A Gilman, Aditya K Ghosh, Sara Seegmiller, Ivana T Croghan, Ryan T Hurt

引用次数: 0

A giant degenerative uterine leiomyoma mimicking an ovarian neoplasm: Case report.

IF 0.6

SAGE Open Medical Case Reports Pub Date : 2025-01-23 eCollection Date: 2025-01-01 DOI: 10.1177/2050313X251315066

Van Trung Hoang, The Huan Hoang, Hoang Anh Thi Van, Ngoc Trinh Thi Pham, Vichit Chansomphou, Thanh Tam Thi Nguyen, Cong Thao Trinh, Duc Thanh Hoang

{"title":"A giant degenerative uterine leiomyoma mimicking an ovarian neoplasm: Case report.","authors":"Van Trung Hoang, The Huan Hoang, Hoang Anh Thi Van, Ngoc Trinh Thi Pham, Vichit Chansomphou, Thanh Tam Thi Nguyen, Cong Thao Trinh, Duc Thanh Hoang","doi":"10.1177/2050313X251315066","DOIUrl":"10.1177/2050313X251315066","url":null,"abstract":"Uterine leiomyoma, also referred to as fibroid or myoma, is a prevalent benign tumor that can present with a range of clinical manifestations. The symptoms, which vary based on the tumor's location, size, and number, include pain, constipation, urinary disturbances, and abnormal menstrual bleeding. Certain types of uterine leiomyomas, such as pedunculated subserosal myomas or large degenerating cystic myomas, may closely mimic ovarian tumors, leading to significant diagnostic and management challenges. In this report, we present the case of a 47-year-old woman who experienced severe dyspnea and abdominal distension. Comprehensive radiological evaluation revealed a massive lesion, with both solid and cystic components, occupying the entire abdominopelvic cavity. Histological analysis confirmed the diagnosis of cellular leiomyoma. This case underscores the importance of considering degenerative cystic myoma in the differential diagnosis of large, cystic intra-abdominal tumors of unknown origin, to avoid misdiagnosis and ensure appropriate management.","PeriodicalId":21418,"journal":{"name":"SAGE Open Medical Case Reports","volume":"13 ","pages":"2050313X251315066"},"PeriodicalIF":0.6,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758534/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dental rehabilitation of cleft palate patients using zygomatic implants: A case report.

IF 0.6

SAGE Open Medical Case Reports Pub Date : 2025-01-23 eCollection Date: 2025-01-01 DOI: 10.1177/2050313X241305171

Teresa Creo-Martinez, Maitena Canivell-Zabaleta, Alba Sanjuan-Sanjuan, Manuel Caro

引用次数: 0

Successful treatment of severe acrodermatitis continua of hallopeau with Bimekizumab: A case report.

IF 0.6

SAGE Open Medical Case Reports Pub Date : 2025-01-22 eCollection Date: 2025-01-01 DOI: 10.1177/2050313X241311043

Lily Xu, Kaiyang Li, Eric Mutter, Annie Langley

引用次数: 0

Unveiling the mystery of hepatic epithelioid angiomyolipoma: A unique case report with literature review. 揭示肝上皮样血管平滑肌脂肪瘤的奥秘：一个独特的病例报告并文献复习。

IF 0.6

SAGE Open Medical Case Reports Pub Date : 2025-01-19 eCollection Date: 2025-01-01 DOI: 10.1177/2050313X251314072

Da Teng, Yue Xu, Qingtao Meng, Qingsong Yang

{"title":"Unveiling the mystery of hepatic epithelioid angiomyolipoma: A unique case report with literature review.","authors":"Da Teng, Yue Xu, Qingtao Meng, Qingsong Yang","doi":"10.1177/2050313X251314072","DOIUrl":"10.1177/2050313X251314072","url":null,"abstract":"Hepatic epithelioid angiomyolipoma is a rare mesenchymal liver tumor within the perivascular epithelioid cell tumor family, known for its uncertain malignancy and potential for aggressive behavior. Clinical presentation, laboratory findings, and imaging results lack specificity, making pathological examination critical for definitive diagnosis. This case report presents a 61-year-old male patient with a single tumor in the right liver lobe, measuring approximately 101 mm × 99 mm. Initial imaging misdiagnosed the mass as hepatocellular carcinoma. Following multidisciplinary treatment discussions and subsequent tumor resection, histopathology and immunohistochemistry confirmed hepatic epithelioid angiomyolipoma. Accurate diagnosis of hepatic epithelioid angiomyolipoma is challenging, relying on histopathological examination and immunohistochemistry as diagnostic standards. Continuous monitoring of patients with hepatic epithelioid angiomyolipoma over an extended period is deemed essential. This report highlights the positive impact of multidisciplinary treatment in diagnosing and managing hepatic epithelioid angiomyolipoma.","PeriodicalId":21418,"journal":{"name":"SAGE Open Medical Case Reports","volume":"13 ","pages":"2050313X251314072"},"PeriodicalIF":0.6,"publicationDate":"2025-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11744629/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143010949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dias-Logan syndrome with a de novo p.Leu360Profs*212 heterozygous pathogenic variant of BCL11A in a Chinese patient: A case report. Dias-Logan综合征伴BCL11A新发p.Leu360Profs*212杂合致病变异1例

IF 0.6

SAGE Open Medical Case Reports Pub Date : 2025-01-19 eCollection Date: 2025-01-01 DOI: 10.1177/2050313X251314069

Yizhuo Shu, Xiaoling Chen, Zhuoqun Wei, Chunyue Chen

{"title":"Dias-Logan syndrome with a de novo p.Leu360Profs*212 heterozygous pathogenic variant of BCL11A in a Chinese patient: A case report.","authors":"Yizhuo Shu, Xiaoling Chen, Zhuoqun Wei, Chunyue Chen","doi":"10.1177/2050313X251314069","DOIUrl":"10.1177/2050313X251314069","url":null,"abstract":"Dias-Logan syndrome, also known as intellectual developmental disorder with persistence of fetal hemoglobin (HbF), or BCL11A-related intellectual developmental disorder, is an extremely rare neurogenetic disorder characterized by intellectual disability (ID), delayed psychomotor development, variable dysmorphic features, and asymptomatic persistence of fetal hemoglobin. The prevalence and incidence of this condition are currently unknown. We report an 8-year-old Han Chinese male patient with Dias-Logan syndrome who carries a de novo heterozygous pathogenic variant, c.1078dupC (p.Leu360Profs*212), in the BCL11A gene, leading to ID and γ-globin suppression, identified through trio-based whole exome sequencing (trio-WES). All his blood parameters were normal except for an elevated HbF level, which was 19.9% of total hemoglobin. Given the negative family history for ID, epilepsy, and alcohol consumption, de novo inheritance was presumed. Consequently, trio-WES analysis (parents and child) was conducted as it can identify potential new causal variants in the offspring. So far, a comprehensive understanding of the phenotypic spectrum of Dias-Logan syndrome and the impact of genotypic variation on disease severity is still lacking. Therefore, our case report enriches the existing literature on the clinical spectrum and genotype-phenotype correlations of BCL11A-related syndrome and provides some helpful information for diagnosis, management, and genetic counseling.","PeriodicalId":21418,"journal":{"name":"SAGE Open Medical Case Reports","volume":"13 ","pages":"2050313X251314069"},"PeriodicalIF":0.6,"publicationDate":"2025-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11744616/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143010948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case report on acute combined poisoning of Indoxacarb and Novoluron and its management. 茚虫威与诺华龙急性联合中毒1例报告及处理。

IF 0.6

SAGE Open Medical Case Reports Pub Date : 2025-01-11 eCollection Date: 2025-01-01 DOI: 10.1177/2050313X241307682

Rohita Chitithoti, Chopparapu Sai Supraja, Danaboyina Sreelekha, Sri Lakshmi Sai Meghana Adusumilli, Ramireddy Veerareddy, Puppala Santosh

引用次数: 0

Certolizumab pegol in severe hidradenitis suppurativa in pregnancy: A case report. Certolizumab pegol治疗妊娠期严重化脓性汗腺炎1例。

IF 0.6

SAGE Open Medical Case Reports Pub Date : 2025-01-10 eCollection Date: 2025-01-01 DOI: 10.1177/2050313X241311374

Paolo Gisondi, Elena Montalto, Tea Curic, Elisabetta Danese, Francesco Bellinato, Giampiero Girolomoni

引用次数: 0

Case report: Diagnostic challenges of papulonodular mucinosis in a 67-year-old female. 病例报告：一名 67 岁女性乳头状粘液病的诊断难题。

IF 0.6

SAGE Open Medical Case Reports Pub Date : 2025-01-09 eCollection Date: 2025-01-01 DOI: 10.1177/2050313X241311372

Holly E Zahary Loreman, Karen I Holfeld

引用次数: 0