SAGE Open Medical Case Reports最新文献_第2页

Hodgkin lymphoma presenting as paraneoplastic cerebellar degeneration: A case report.

IF 0.6

SAGE Open Medical Case Reports Pub Date : 2025-03-20 eCollection Date: 2025-01-01 DOI: 10.1177/2050313X251328391

Anisha Kadubandi, Madhu Midathada, Lakshman Arcot Jayagopal

{"title":"Hodgkin lymphoma presenting as paraneoplastic cerebellar degeneration: A case report.","authors":"Anisha Kadubandi, Madhu Midathada, Lakshman Arcot Jayagopal","doi":"10.1177/2050313X251328391","DOIUrl":"10.1177/2050313X251328391","url":null,"abstract":"A 49-year-old male presented with subacute onset of ataxia, dizziness, and dysarthria over a 4-week period. Laboratory workup and magnetic resonance imaging brain imaging were unremarkable, and no neurological etiology was identified. Anti-Tr antibodies were detected in serum and cerebrospinal fluid. A positron-emission tomography scan showed small nonspecific periaortic and aortocaval lymph nodes, which were not amenable for biopsy. He was treated with immunosuppressive treatment, and a CT scan showed resolution of the previous activity. A repeat positron-emission tomography scan 6 months after the original presentation showed reappearance with increased size and activity of the lymph nodes. An abdominal lymph node biopsy showed classical Hodgkin's lymphoma. The bone marrow biopsy was negative, placing him at Ann Arbor stage IIA. He was treated with two cycles of Adriamycin, Bleomycin, Vinblastine, and Dacarbazine followed by two cycles of Adriamycin, Brentuximab Vedotin, Vinblastine, and Dacarbazine due to a drop in diffusion capacity of the lungs for carbon monoxide from Bleomycin. He remains in remission from the lymphoma but with residual neurological symptoms. This case report suggests that patients with Hodgkin's and paraneoplastic neurological syndrome may demonstrate radiological improvement related to immunosuppressive treatment which can delay diagnosis and accurate treatment in patients with paraneoplastic cerebellar degeneration and underlying malignancy. The presence of anti-Tr antibody supports the diagnosis of Hodgkin lymphoma in the setting of paraneoplastic cerebellar symptoms.","PeriodicalId":21418,"journal":{"name":"SAGE Open Medical Case Reports","volume":"13 ","pages":"2050313X251328391"},"PeriodicalIF":0.6,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924092/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Myoepithelioma of the upper lip: A rare case report with a literature review of diagnostic approaches.

IF 0.6

SAGE Open Medical Case Reports Pub Date : 2025-03-17 eCollection Date: 2025-01-01 DOI: 10.1177/2050313X241305185

Farid Ghadyani, Samira Behrad

{"title":"Myoepithelioma of the upper lip: A rare case report with a literature review of diagnostic approaches.","authors":"Farid Ghadyani, Samira Behrad","doi":"10.1177/2050313X241305185","DOIUrl":"10.1177/2050313X241305185","url":null,"abstract":"Myoepithelioma is an extremely rare salivary gland neoplasm with diverse histological variants. Understanding myoepithelioma's clinical, radiological, and molecular features is crucial for accurate diagnosis and management. We present a case of a 40-year-old Iranian male with a painless, firm, solitary exophytic mass on the upper lip. Surgical excision was curative, with no recurrence at 36 months. Histopathological analysis confirmed myoepithelioma with spindle and plasmacytoid cell variants. Myoepithelioma's rarity is reflected in epidemiologic studies and its features are mainly recognized by the information in the case reports. Majorly it appears at the site of major salivary glands and occasionally the palate. The occurrence at the site of the upper lip is extremely rare and only appeared in a few case reports. Seeking the history of previous exposures to possible etiologic factors might not be a facilitator. Differential diagnosis includes pleomorphic adenoma, myoepithelial carcinoma, and basal cell adenoma. The main diagnostic approach is histopathological analysis. Following that, the tumor's nature, cell variants, and possible transformation could be evaluated. While molecular studies supplement diagnosis, their routine clinical use is limited and their necessity is debated. The application of artificial intelligence could be helpful when uncertainty arises, or for analyzing microscopic images. Surgical excision with healthy margins is curative, and follow-up is essential.","PeriodicalId":21418,"journal":{"name":"SAGE Open Medical Case Reports","volume":"13 ","pages":"2050313X241305185"},"PeriodicalIF":0.6,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11915260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Management of inhalational injury secondary to prolonged anhydrous ammonia exposure with venovenous ECMO: A case report.

IF 0.6

SAGE Open Medical Case Reports Pub Date : 2025-03-17 eCollection Date: 2025-01-01 DOI: 10.1177/2050313X251327670

Paul J Fletcher, Brent Kidd, James T Zorn, John Costello

引用次数: 0

Beyond "buzzwords"-updated recommendations for evaluating patients presenting without la belle indifference and diagnosing functional neurological symptom disorder: A case report.

IF 0.6

SAGE Open Medical Case Reports Pub Date : 2025-03-12 eCollection Date: 2025-01-01 DOI: 10.1177/2050313X251325367

Jessica L Bennett, Elizabeth A Keene, Anisha Chinthalapally

{"title":"Beyond \"buzzwords\"-updated recommendations for evaluating patients presenting without la belle indifference and diagnosing functional neurological symptom disorder: A case report.","authors":"Jessica L Bennett, Elizabeth A Keene, Anisha Chinthalapally","doi":"10.1177/2050313X251325367","DOIUrl":"10.1177/2050313X251325367","url":null,"abstract":"La belle indifference-absence of psychological distress despite presence of significant neurological symptoms-is often highlighted in current literature as a key diagnostic criterion for functional neurological symptom disorder. However, as exemplified with this case, functional neurological symptom disorder may present without la belle indifference more commonly than previously believed. A distressed 60-year-old female presented with abdominal pain, then suddenly lost ability to speak and developed rapid, rhythmic mandible movements. Multidisciplinary examination including diagnostic evaluation of the heart, head, and neck was largely unremarkable. Following her extensive evaluation, it was revealed that she had experienced similar symptoms previously, during times of high psychological stress. A diagnosis of functional neurological symptom disorder was established, and her symptoms resolved with minimal intervention. To best serve our patients, clinicians are encouraged to perform thorough history collection and physical examination prior to obtaining costly and time-consuming diagnostic studies whenever possible. By asking about risk factors of functional neurological symptom disorder early in the patient encounter, clinicians may be able to reduce unnecessary diagnostic testing, thus minimizing patient exposure to potential risks associated with extensive diagnostic evaluation and decreasing healthcare costs.","PeriodicalId":21418,"journal":{"name":"SAGE Open Medical Case Reports","volume":"13 ","pages":"2050313X251325367"},"PeriodicalIF":0.6,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11905022/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Uncomplicated full-term birth after laparoscopical salpingotomy as organ-preserving therapy of naturally conceived heterotopic pregnancy: A case report.

IF 0.6

SAGE Open Medical Case Reports Pub Date : 2025-03-12 eCollection Date: 2025-01-01 DOI: 10.1177/2050313X251325121

Roland Csorba, Antonella Iannaccone, Panagiotis Tsikouras, Saed Almasarweh

{"title":"Uncomplicated full-term birth after laparoscopical salpingotomy as organ-preserving therapy of naturally conceived heterotopic pregnancy: A case report.","authors":"Roland Csorba, Antonella Iannaccone, Panagiotis Tsikouras, Saed Almasarweh","doi":"10.1177/2050313X251325121","DOIUrl":"10.1177/2050313X251325121","url":null,"abstract":"Heterotopic pregnancy, the simultaneous occurrence of intrauterine and extrauterine gestations, is a rare phenomenon, especially without a history of assisted reproduction. This case report describes a 33-year-old woman presenting with severe abdominal pain at 7 weeks of pregnancy. Transvaginal ultrasound revealed an intrauterine singleton pregnancy and an adnexal mass, highly suspicious of an ectopic pregnancy, along with significant intraperitoneal fluid. Emergency laparoscopy confirmed intra-abdominal hemorrhage and a near rupture of the left fallopian tube. A laparoscopic salpingotomy successfully resolved the ectopic pregnancy while preserving the intrauterine pregnancy. Postoperative course was uneventful. The patient later delivered a healthy infant at term. This case highlights the importance of considering heterotopic pregnancy in patients with confirmed intrauterine pregnancy, even in the absence of assisted reproductive technologies and other risk factors.","PeriodicalId":21418,"journal":{"name":"SAGE Open Medical Case Reports","volume":"13 ","pages":"2050313X251325121"},"PeriodicalIF":0.6,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11905025/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Melano-erythrodermic folliculotropic mycosis fungoides misdiagnosed as a case of recalcitrant atopic dermatitis: A case report.

IF 0.6

SAGE Open Medical Case Reports Pub Date : 2025-03-12 eCollection Date: 2025-01-01 DOI: 10.1177/2050313X251320468

Nada Alghamdi, Haya Alzammami, Maryam Mohammed Alfaraj

引用次数: 0

Combined autologous hematopoietic stem cell transplantation and CD19 CAR T-cell therapy for relapsed/refractory diffuse large B-cell lymphoma with TP53 mutation: A case report.

IF 0.6

SAGE Open Medical Case Reports Pub Date : 2025-03-11 eCollection Date: 2025-01-01 DOI: 10.1177/2050313X241306236

Ziyi Cai, Dongmei Zou, Qiang Ma, Wanling Sun, Yixian Guo

引用次数: 0

Successful treatment of pediatric patient with Dravet syndrome with cenobamate: Case report.

IF 0.6

SAGE Open Medical Case Reports Pub Date : 2025-02-27 eCollection Date: 2025-01-01 DOI: 10.1177/2050313X251324079

Oleg V Lobanov, Mary Bertrand

{"title":"Successful treatment of pediatric patient with Dravet syndrome with cenobamate: Case report.","authors":"Oleg V Lobanov, Mary Bertrand","doi":"10.1177/2050313X251324079","DOIUrl":"https://doi.org/10.1177/2050313X251324079","url":null,"abstract":"Dravet syndrome, also known as severe myoclonic epilepsy of infancy, is an epileptic encephalopathy characterized by severe epilepsy accompanied by impaired psychomotor and neurologic development. Onset is in the first year of life in apparently healthy infants. Seizures in Dravet syndrome are highly pharmacoresistant, and the SUDEP mortality rate is high. Here, we present the first case of the successful use of cenobamate in a pediatric patient (9-year-old female) with Dravet syndrome and pharmacoresistant epilepsy despite the prior use and failure of typical medications for Dravet syndrome, including fenfluramine, valproate, and clobazam, among others. At 6-month follow-up, the frequency of generalized tonic-clonic seizures decreased from 8 per month to 1 per month upon reaching a daily dose of 50 mg (1.9 mg/kg/day), which represents an 87.5% reduction. No side effects were reported. Given the single-patient case report nature of this study, further investigations are needed to extrapolate the usefulness of cenobamate across different age groups and genetic variants.","PeriodicalId":21418,"journal":{"name":"SAGE Open Medical Case Reports","volume":"13 ","pages":"2050313X251324079"},"PeriodicalIF":0.6,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11869260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Atypical giant proliferating cystic pilomatrixoma: A case review. 非典型巨大增生性囊性皮瘤：病例回顾

IF 0.6

SAGE Open Medical Case Reports Pub Date : 2025-02-27 eCollection Date: 2025-01-01 DOI: 10.1177/2050313X251320195

Kerman Sekhon, Yvette Miller-Monthrope, Christian Murray, Michael Weinberg

{"title":"Atypical giant proliferating cystic pilomatrixoma: A case review.","authors":"Kerman Sekhon, Yvette Miller-Monthrope, Christian Murray, Michael Weinberg","doi":"10.1177/2050313X251320195","DOIUrl":"10.1177/2050313X251320195","url":null,"abstract":"Pilomatrixoma, or calcifying epithelioma of Malherbe, is a rare and benign tumour. Typical presentation of pilomatrixoma is solitary, firm lesions found in the head and neck regions. Pilomatrixoma are often misdiagnosed due to their clinical presentation, which is synonymous with other cutaneous pathology. The reported and true incidence of pilomatrixoma are 1% and 16%, respectively. Cystic pilomatrixoma is a unique variant that presents without the pathognomonic feature of a firm lesion. This study presents the case of a 52-year-old man with a post-auricular pilomatrixoma. It is erythematous, soft, mobile, and 4 cm in diameter. Its size categorizes the lesion as a giant pilomatrixoma. These pilomatrixoma pose a diagnostic challenge as they mimic malignant lesions. It was highly erythematous and mimicked Merkel cell carcinoma in on initial presentation. It was a sebum-filled lesion, which is quite atypical for pilomatrixoma. A previous study finds that only three cases of cystic pilomatrixoma have been reported in the literature previously. This case study presents the case of an atypical variant of a rare tumour. There is a paucity in the literature on cystic pilomatrixoma. Giant proliferating cystic pilomatrixoma has not previously been described in a case report in the literature, as to our knowledge. This study highlights the diversity in the clinical presentations of pilomatrixoma to improve our clinical sensitivity to pilomatrixoma.","PeriodicalId":21418,"journal":{"name":"SAGE Open Medical Case Reports","volume":"13 ","pages":"2050313X251320195"},"PeriodicalIF":0.6,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11866365/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143524276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of altruistic suicide by severe carbon monoxide poisoning. 一例严重一氧化碳中毒的利他自杀。

IF 0.6

SAGE Open Medical Case Reports Pub Date : 2025-02-27 eCollection Date: 2025-01-01 DOI: 10.1177/2050313X251321064

Aanchal Amit Shah, Jorge Salazar, Prabhava Bagla, Aparna Das

引用次数: 0