SAGE Open Medical Case Reports最新文献_第2页

A clinical case and pharmacokinetic analysis of an inadvertent overdose of dipyrone (metamizole) without clinical toxicity: A case report. 无意中过量使用双吡隆（甲氨唑）无临床毒性的临床病例和药代动力学分析：1例报告。

IF 0.6

SAGE Open Medical Case Reports Pub Date : 2026-04-15 eCollection Date: 2026-01-01 DOI: 10.1177/2050313X261439208

Andreas Wehrfritz, Stefanie Schmidt, Harald Ihmsen, Steffen Fiedler, Felix Volleth, Roland C E Francis, Ixchel Castellanos

{"title":"A clinical case and pharmacokinetic analysis of an inadvertent overdose of dipyrone (metamizole) without clinical toxicity: A case report.","authors":"Andreas Wehrfritz, Stefanie Schmidt, Harald Ihmsen, Steffen Fiedler, Felix Volleth, Roland C E Francis, Ixchel Castellanos","doi":"10.1177/2050313X261439208","DOIUrl":"10.1177/2050313X261439208","url":null,"abstract":"Dipyrone (metamizole) is a widely used non-opioid analgesic. Its use is restricted due to the risk of side effects such as liver toxicity. We report the case of a patient who accidentally received an oral dose of 12.5 g (132 mg/kg) dipyrone. The patient was monitored for the next 62 days and remained asymptomatic, showing no signs of gastrointestinal, hepatic, or other toxicity. Dipyrone was not detectable in the plasma, while the plasma concentrations of its active metabolites 4-methylaminoantipyrine and 4-aminoantipyrine were elevated. The pharmacokinetics were best described by nonlinear one-compartment models with Michaelis-Menten elimination. The terminal half-life of both metabolites was 2.9 h. These results demonstrate the rapid absorption of dipyrone and the extremely short window for effective gastric decontamination. Due to its specific pharmacokinetic profile, the high systemic exposure to active dipyrone metabolites did not result in acute organ toxicity in this case. Therefore, intensive medical monitoring may not always be mandatory after dipyrone overdose in otherwise clinically stable patients, although agranulocytosis remains as idiosyncratic long-term risk.","PeriodicalId":21418,"journal":{"name":"SAGE Open Medical Case Reports","volume":"14 ","pages":"2050313X261439208"},"PeriodicalIF":0.6,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13087337/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147723571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Occult capsular injury in suspected traumatic and iatrogenic cataracts: a case report with imaging and pearls for surgical management. 疑似外伤性和医源性白内障的隐蔽性囊损伤：影像学和珍珠手术治疗1例报告。

IF 0.6

SAGE Open Medical Case Reports Pub Date : 2026-04-11 eCollection Date: 2026-01-01 DOI: 10.1177/2050313X261438378

Ikesinachi Osuorah, Mubarik Mohamed, Mohammad Soleimani

{"title":"Occult capsular injury in suspected traumatic and iatrogenic cataracts: a case report with imaging and pearls for surgical management.","authors":"Ikesinachi Osuorah, Mubarik Mohamed, Mohammad Soleimani","doi":"10.1177/2050313X261438378","DOIUrl":"https://doi.org/10.1177/2050313X261438378","url":null,"abstract":"Traumatic and iatrogenic cataracts may conceal occult capsular injury that routine slit-lamp examination and biometry fail to detect, increasing the risk of intraoperative complications. We present a mechanism-aware, imaging-guided approach to cataract surgery in an eye with suspected capsular compromise. An elderly man with a dense cataract and limited fundus view underwent preoperative imaging, which revealed a focal anterior capsular defect on ultrasound biomicroscopy, while posterior capsule integrity remained uncertain. His history included multiple intravitreal injections and prior anterior chamber paracentesis, raising suspicion for iatrogenic capsular injury. Given possible posterior fragility, surgery was performed using a noncontinuous curvilinear capsulotomy with radial relaxing incisions, low-vacuum and low-flow phacoemulsification, and contingency planning for capsular support and anterior vitrectomy. A monofocal intraocular lens was successfully implanted in the capsular bag without complication. This case highlights the importance of linking mechanism, targeted imaging (swept-source OCT or ultrasound biomicroscopy depending on media clarity), and a modified surgical strategy to reduce the risk of posterior capsule rupture and improve intraoperative preparedness.","PeriodicalId":21418,"journal":{"name":"SAGE Open Medical Case Reports","volume":"14 ","pages":"2050313X261438378"},"PeriodicalIF":0.6,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13077139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147692012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Atypical hemolytic uremic syndrome in infant with solitary kidney. 孤立肾婴儿的不典型溶血性尿毒症综合征。

IF 0.6

SAGE Open Medical Case Reports Pub Date : 2026-04-05 eCollection Date: 2026-01-01 DOI: 10.1177/2050313X261422088

Claire Collins, Nisha Singh

引用次数: 0

Persistent troponin elevation in the heart of Fabry disease due to coronary microvascular dysfunction. 冠状动脉微血管功能障碍引起的法布里病心脏持续肌钙蛋白升高

IF 0.6

SAGE Open Medical Case Reports Pub Date : 2026-04-03 eCollection Date: 2026-01-01 DOI: 10.1177/2050313X261438242

Clement Tan, Mark Daniel Higgins, Zhihua Zhang, Matthew Hiskens

引用次数: 0

Imaging cystoid macular oedema secondary to branch retinal vein occlusion with spectral domain optical coherence tomography: A case report. 光谱域光学相干断层成像视网膜分支静脉闭塞继发的囊样黄斑水肿1例报告。

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SAGE Open Medical Case Reports Pub Date : 2026-04-03 eCollection Date: 2026-01-01 DOI: 10.1177/2050313X261436550

Samuel Livingstone Kumaran, Gokulakrishnan Kannaki Renuga Sri, Beena Esther Thomas, Shiju Monickaraj Selvister

{"title":"Imaging cystoid macular oedema secondary to branch retinal vein occlusion with spectral domain optical coherence tomography: A case report.","authors":"Samuel Livingstone Kumaran, Gokulakrishnan Kannaki Renuga Sri, Beena Esther Thomas, Shiju Monickaraj Selvister","doi":"10.1177/2050313X261436550","DOIUrl":"https://doi.org/10.1177/2050313X261436550","url":null,"abstract":"Spectral domain optical coherence tomography has changed the way we view retinal diseases by providing us with high-resolution, cross-sectional images. It is very important for diagnosing and keeping a track of cystoid macular oedema, especially when it is caused by vascular conditions such as branch retinal vein occlusion. A 47-year-old man with poorly controlled type 2 diabetes mellitus presented with reduced visual acuity in his left eye. Amsler grid testing showed that the patient had metamorphopsia. The fundus examination indicated inferotemporal branch retinal vein occlusion, necessitating additional assessment. Spectral domain optical coherence tomography confirmed cystoid macular oedema with increased macula thickness and disruption of the external limiting membrane and ellipsoid zone, indicating disorganization of the outer retinal layers with photoreceptor involvement. There was also a partial posterior vitreous detachment. The changes in the outer retinal layers are important optical coherence tomography biomarkers that are linked to reduced visual acuity. The patient received an intravitreal injection of ranibizumab along with an adjunctive course of topical nepafenac (a nonsteroidal anti-inflammatory drug). During follow-up, spectral domain optical coherence tomography showed resolution of macular oedema, and the best-corrected visual acuity improved from 20/80 to 20/40, and the metamorphopsia was diminished. A small intraretinal cyst close to the fovea, hard exudates, and progressing posterior vitreous detachment were, however, seen. This case underscores the significance of systemic metabolic dysfunction, the prognostic utility of optical coherence tomography biomarkers, and the necessity of therapeutic strategies in the management of branch retinal vein occlusion.","PeriodicalId":21418,"journal":{"name":"SAGE Open Medical Case Reports","volume":"14 ","pages":"2050313X261436550"},"PeriodicalIF":0.6,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13051151/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147634153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Postmortem artefacts in sudden cardiac death: A forensic case report. 心源性猝死的死后伪影：一个法医案例报告。

IF 0.6

SAGE Open Medical Case Reports Pub Date : 2026-04-02 eCollection Date: 2026-01-01 DOI: 10.1177/2050313X261436147

Treasa James, Deep Rattan Mittal, Akhilesh Pathak

引用次数: 0

Rare case of recurrent respiratory papillomatosis with malignant transformation. 复发性呼吸道乳头状瘤病伴恶性转化1例。

IF 0.6

SAGE Open Medical Case Reports Pub Date : 2026-04-02 eCollection Date: 2026-01-01 DOI: 10.1177/2050313X261436099

Kae-Feng Yang, Wei-Cheng Lin, Yin-Chun Chang

{"title":"Rare case of recurrent respiratory papillomatosis with malignant transformation.","authors":"Kae-Feng Yang, Wei-Cheng Lin, Yin-Chun Chang","doi":"10.1177/2050313X261436099","DOIUrl":"https://doi.org/10.1177/2050313X261436099","url":null,"abstract":"Recurrent respiratory papillomatosis is a benign neoplastic growth of the respiratory system, often linked to human papillomavirus types 6 and 11. This case report presents a rare progression to severe airway obstruction and potential malignancy in a 59-year-old male with a history of smoking, hepatitis B carrier status, pulmonary tuberculosis, and a tracheal papilloma. Initially hospitalized for right upper lobe pneumonia, a computed tomography scan revealed a bronchial tumor. Bronchial brushing, washing, and biopsy confirmed squamous cell papilloma. Treatment included bronchoscopy with argon plasma coagulation ablation and debulking surgery for the right upper lobe bronchus and airway tumor; however, recurrence was noted on a follow-up computed tomography scan. Repeat bronchoscopy with argon plasma coagulation ablation confirmed squamous cell papilloma with squamous cell carcinoma in situ. The patient was administered human papillomavirus vaccination to mitigate disease progression and remains under active surveillance. This paper highlights a rare malignant transformation of airway recurrent respiratory papillomatosis.","PeriodicalId":21418,"journal":{"name":"SAGE Open Medical Case Reports","volume":"14 ","pages":"2050313X261436099"},"PeriodicalIF":0.6,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13051098/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147634195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acquired platelet dysfunction induced by infection in an older patient: Severe hemorrhage despite normal platelet count. 1例老年患者感染引起的获得性血小板功能障碍：尽管血小板计数正常，但严重出血。

IF 0.6

SAGE Open Medical Case Reports Pub Date : 2026-03-31 eCollection Date: 2026-01-01 DOI: 10.1177/2050313X261436132

Yuanyuan Jiang, Nan Lu, Xinmiao Chang, Yanlan Guo, Jinlong Liu, Yinlian Ru, Wenbin Wu

引用次数: 0

Conservative management of self-induced pneumoparotid in a 46-year-old male: A case report. 46岁男性自发性腮腺炎的保守治疗1例。

IF 0.6

SAGE Open Medical Case Reports Pub Date : 2026-03-31 eCollection Date: 2026-01-01 DOI: 10.1177/2050313X261422078

Samir Alkhouri, Caleb Jolley, Claire Victoria Ong, Kurtis Young, Emily S Sagalow, Everett Young, Harry H Ching

{"title":"Conservative management of self-induced pneumoparotid in a 46-year-old male: A case report.","authors":"Samir Alkhouri, Caleb Jolley, Claire Victoria Ong, Kurtis Young, Emily S Sagalow, Everett Young, Harry H Ching","doi":"10.1177/2050313X261422078","DOIUrl":"https://doi.org/10.1177/2050313X261422078","url":null,"abstract":"Pneumoparotid is a rare cause of parotid gland swelling characterized by the presence of air within Stensen's duct and/or the parotid gland itself. It is often confused with more common causes of parotid enlargement, such as infection, and may be self-induced or associated with increased intraoral pressure. Awareness of this entity is important to avoid misdiagnosis and inappropriate treatment. We report an adult case of self-induced pneumoparotid in a 46-year-old male who developed recurrent bilateral parotid swelling over several months due to intentional oral auto-insufflation performed to relieve temporomandibular joint discomfort and anxiety. On otolaryngology evaluation, he had mild, soft, non-erythematous parotid swelling with subtle crepitus over the left gland. Computed tomography of the head and neck demonstrated air within both Stensen's ducts, the parotid parenchyma, and the overlying facial subcutaneous tissues, with no signs of inflammation or abscess. The patient was afebrile and without leukocytosis, and a diagnosis of self-induced pneumoparotid was established. He was managed conservatively with counseling to discontinue the pressure-generating maneuvers, and no procedural intervention was required. The swelling resolved with behavior modification, and he remained free of recurrence over 3 months. This case highlights pneumoparotid as an important differential diagnosis for recurrent, noninfectious parotid swelling and demonstrates that early recognition combined with targeted history-taking and conservative management can prevent unnecessary invasive treatments and serious complications, even in adult patients.","PeriodicalId":21418,"journal":{"name":"SAGE Open Medical Case Reports","volume":"14 ","pages":"2050313X261422078"},"PeriodicalIF":0.6,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13039627/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147609774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neisseria lactamica as a novel cause of prosthetic valve endocarditis in an intravenous drug user: A case report. 内酰胺奈瑟菌是静脉吸毒者人工瓣膜心内膜炎的新病因：1例报告。

IF 0.6

SAGE Open Medical Case Reports Pub Date : 2026-03-31 eCollection Date: 2026-01-01 DOI: 10.1177/2050313X261430801

Joseph Ragan, Fariha Hasan, Satyajeet Roy, Maher Al-Safadi

引用次数: 0