SAGE Open Medical Case Reports最新文献

{"title":"Dupilumab as a treatment for bullous pemphigoid in a liver transplant recipient: A case report.","authors":"Sarah S Rashid, P Régine Mydlarski, Fatemeh Jafarian","doi":"10.1177/2050313X251350348","DOIUrl":"10.1177/2050313X251350348","url":null,"abstract":"<p><p>Bullous pemphigoid is a common subepidermal autoimmune bullous disease that affects the skin and mucous membranes. It is more prevalent in the elderly, often resulting in significant morbidity and mortality. Bullous pemphigoid is rare in solid organ transplant recipients but presents unique challenges due to their underlying immunosuppression, which increases the risks of infection and adverse drug reactions. Herein, we present the first reported case of dupilumab successfully treating bullous pemphigoid in a liver transplant recipient.</p>","PeriodicalId":21418,"journal":{"name":"SAGE Open Medical Case Reports","volume":"13 ","pages":"2050313X251350348"},"PeriodicalIF":0.6,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12179448/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144476571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prurigo pigmentosa in an African-Canadian patient: Expanding the limited literature on skin of color.","authors":"Ghassan Barnawi, Elen Grigorchuk, Raghad Aldibane, Sarah Kashkari, Lea Saroufim, Osama Roshdy","doi":"10.1177/2050313X251350350","DOIUrl":"10.1177/2050313X251350350","url":null,"abstract":"<p><p>Prurigo pigmentosa is a rare inflammatory dermatosis that predominantly affects East Asian populations, with very few reported cases in individuals with darker skin tones. The condition is characterized by pruritic, erythematous papules that evolve into a distinct, net-like pattern of hyperpigmentation. Due to its rarity in non-Asian populations, prurigo pigmentosa is often underdiagnosed or misclassified as other hyperpigmented dermatoses. We present the case of a 33-year-old African-Canadian woman who developed prurigo pigmentosa following prolonged fasting, contributing to the limited literature on this condition in skin of color. This report aims to raise awareness of prurigo pigmentosa in underrepresented populations.</p>","PeriodicalId":21418,"journal":{"name":"SAGE Open Medical Case Reports","volume":"13 ","pages":"2050313X251350350"},"PeriodicalIF":0.6,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12179438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144476574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Upadacitinib in refractory cutaneous pseudolymphoma: A case report.","authors":"Elisabetta Danese, Tea Curic, Francesco Bellinato, Chiara Colato, Paolo Gisondi, Giampiero Girolomoni","doi":"10.1177/2050313X251350370","DOIUrl":"10.1177/2050313X251350370","url":null,"abstract":"<p><p>Cutaneous pseudolymphoma is a benign condition characterized by a reactive B-cell, T-cell or mixed lymphoproliferative process. Different causative agents (e.g. injected substances, tattoo, drugs and insect bites) have been described, but in many cases no cause can be identified; hence, the term idiopathic cutaneous pseudolymphoma. There are no specific guidelines for the treatment of cutaneous pseudolymphoma, and sometimes a few cases are refractory to conventional treatments. We describe a case of a 41-year-old African woman with refractory facial IgG4 pseudolymphoma successfully treated with upadacitinib.</p>","PeriodicalId":21418,"journal":{"name":"SAGE Open Medical Case Reports","volume":"13 ","pages":"2050313X251350370"},"PeriodicalIF":0.6,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12179454/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144476587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Misdiagnosed groin pain in an elderly: Interdisciplinary network as a tool for cost-effective work-collaboration.","authors":"Oskar Kwaczynski, Michael Klauser, Andrej Nowakowski, Debora Nowakowski, Massimo Ruffo, Christian Frank","doi":"10.1177/2050313X251347462","DOIUrl":"10.1177/2050313X251347462","url":null,"abstract":"<p><p>This case report presents an uncommon case of misdiagnosed groin pain in an elderly individual, highlighting the complexities of diagnosing overlapping symptoms in aging populations. With a growing elderly population, healthcare professionals must navigate complex medical histories to provide accurate diagnoses and effective treatment. This case emphasizes the importance of interdisciplinary collaboration and cost-effective diagnostic tools in delivering patient-centered care. We describe the case of an 87-year-old male with a history of heart disease and coronary angiography, who developed groin pain. After excluding a hernia, the patient was referred to our department for further evaluation. Through a thorough medical history and diagnostic tools, including computed tomography (CT) scan and intraarticular infiltration, the underlying cause of the pain was accurately identified and treated. An 87-year-old male with heart disease and previous coronary angiography presented with groin pain. Initially evaluated elsewhere for a potential hernia, the patient believed a foreign body in his muscles was the source of his pain. However, a planning X-ray failed to reveal this. Upon referral, a thorough medical history was taken, and a CT scan was performed to locate the foreign body and assess its proximity to the femoral nerve. The CT scan confirmed a broken angiography catheter (3-40 mm) near the femoral nerve. Additionally, severe fourth-grade coxarthrosis was identified. Despite the patient's belief that the foreign body caused his pain, we determined coxarthrosis was the main issue. An intraarticular infiltration provided pain relief, confirming the diagnosis, and a total hip arthroplasty with catheter removal was performed, resulting in complete pain relief. This case underscores the need for thorough evaluation and interdisciplinary collaboration in diagnosing complex conditions in elderly patients. Intraarticular infiltration remains a valuable diagnostic tool, even alongside advanced imaging, helping prevent unnecessary procedures and improving patient outcomes.</p>","PeriodicalId":21418,"journal":{"name":"SAGE Open Medical Case Reports","volume":"13 ","pages":"2050313X251347462"},"PeriodicalIF":0.6,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12177233/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bolus doses of insulin versus a continuous insulin infusion for treating hyperkalaemia in adults: A case series.","authors":"Nicole King, Neil Martinson, Mmakwata Lesudi, Ebrahim Variava","doi":"10.1177/2050313X251348368","DOIUrl":"10.1177/2050313X251348368","url":null,"abstract":"<p><p>Hyperkalaemia is a medical emergency that may manifest with a spectrum of cardiac conduction abnormalities and, if not promptly managed, can progress to cardiac arrest. While standard management typically involves stat doses of insulin to lower serum potassium, the optimal dosing regimen remains controversial. Patients whose serum potassium exceeds the upper normal limit by more than 1 mmol/L often require repeated conventional management to shift potassium intracellularly - usually every 2 to 4 h. Although dialysis is indicated in patients with concomitant renal dysfunction, its availability in resource-constrained settings is limited. We present three cases of symptomatic hyperkalaemia successfully managed with continuous insulin infusions, thereby obviating the need for dialysis. These cases underscore the potential role of continuous insulin infusions as an alternative strategy for correcting hyperkalaemia in settings where dialysis is not immediately available.</p>","PeriodicalId":21418,"journal":{"name":"SAGE Open Medical Case Reports","volume":"13 ","pages":"2050313X251348368"},"PeriodicalIF":0.6,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12177256/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thoracic SMARCA4-deficient undifferentiated tumor: A case report in a 40-year-old male without a smoking history.","authors":"Karnik Soghomonian, Ahmad Ibrahim","doi":"10.1177/2050313X251342982","DOIUrl":"10.1177/2050313X251342982","url":null,"abstract":"<p><p>Thoracic SMARCA4-deficient undifferentiated tumor is a recently identified aggressive malignancy characterized by inactivating mutations leading to the loss of SMARCA4 protein expression. First classified in the 2021 World Health Organization Classification of Thoracic Tumors, thoracic SMARCA4-deficient undifferentiated tumor typically presents in men in their fourth to sixth decade of life, often with a history of smoking, though a subset of cases occurs in nonsmokers. We present a rare case of stage IV thoracic SMARCA4-deficient undifferentiated tumor in a 40-year-old male without a smoking history, presenting with spinal metastases. The patient experienced right upper back pain, chest pain, and dyspnea. Imaging revealed a right lung mass, multiple hilar and supraclavicular lymph nodes, and spinal metastases. A computed tomography-guided biopsy of the right lung mass initially suggested small cell carcinoma, but subsequent lymph node excision and expert pathologic review confirmed thoracic SMARCA4-deficient undifferentiated tumor, characterized by rhabdoid morphology and loss of SMARCA4 expression. Treatment included concurrent chemoradiotherapy with cisplatin and etoposide, followed by a regimen of carboplatin, etoposide, and atezolizumab, with maintenance therapy using atezolizumab. Despite complications such as a femoral neck fracture and pancytopenia, imaging showed a reduction in tumor size. This case highlights the diagnostic complexity and treatment approaches for thoracic SMARCA4-deficient undifferentiated tumors.</p>","PeriodicalId":21418,"journal":{"name":"SAGE Open Medical Case Reports","volume":"13 ","pages":"2050313X251342982"},"PeriodicalIF":0.6,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12177234/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurological Behcet's disease with transverse myelitis in an adolescent: A case report.","authors":"Jeanine McColl, Teresa Liang, Dax G Rumsey","doi":"10.1177/2050313X251346246","DOIUrl":"10.1177/2050313X251346246","url":null,"abstract":"<p><p>Neurological Behcet's disease is a rare systemic vasculitis marked by recurrent oral or genital ulcers, eye manifestations of uveitis or retinal vasculitis, and skin lesions. This report details a case of neurological Behcet's disease in a 14-year-old Somali male who presented with bilateral pan uveitis, genital ulcers, altered level of consciousness, and seizure. The patient met 2014 International Criteria for Behcet Disease. Magnetic resonance imaging demonstrated abnormal hyperintensity to bilateral hippocampi and mesial temporal lobes. Spine magnetic resonance imaging revealed patchy long segment T2 signal abnormality of the central spinal cord and patchy enhancement at T6. He received IV methylprednisolone, IV infliximab, and then oral prednisone. This case demonstrates children with neurological Behcet's disease can present with hippocampus involvement and transverse myelitis. Physicians should consider neurological Behcet's disease in pediatric patients presenting with altered level of consciousness or seizure. It illustrates the importance of timely intervention in mitigating the neurological complications associated with neurological Behcet's disease.</p>","PeriodicalId":21418,"journal":{"name":"SAGE Open Medical Case Reports","volume":"13 ","pages":"2050313X251346246"},"PeriodicalIF":0.6,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174670/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postoperative death investigation using a modified en bloc dissection of the kidney-ureter-bladder apparatus with postmortem contrast imaging: A case report on autopsy.","authors":"Pradip Rana, Darshan Galoria, Srushti Shukla, William A Cox, Prashant Verma, Shridhar Dave, Arijit Datta","doi":"10.1177/2050313X251346388","DOIUrl":"10.1177/2050313X251346388","url":null,"abstract":"<p><p>Medicolegal autopsies should be performed for sudden, unexpected, and suspicious deaths. Such autopsies should be performed by a knowledgeable Forensic Pathologist who has experience in performing traditional autopsy techniques, as well as having an understanding of how to supplement these techniques with more scientifically advanced techniques such as magnetic resonance imaging and postmortem computed tomography. In this case, we utilized the traditional Ghon technique to remove the urogenital system, combined with postmortem computed tomography of the coronary arteries and contrast imaging of the ureters. By combining a traditional autopsy technique with more advanced imaging techniques, we were able to definitively establish the cause of death as coronary artery occlusion and, by doing so, remove any suspicion of medical negligence committed by the treating physicians during ureteroscopic bilateral stone removal.</p>","PeriodicalId":21418,"journal":{"name":"SAGE Open Medical Case Reports","volume":"13 ","pages":"2050313X251346388"},"PeriodicalIF":0.6,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174715/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic non-healing ulcer reveals pyoderma gangrenosum: A case report.","authors":"Orhan Yilmaz, Philip Doiron, Robyn Evans","doi":"10.1177/2050313X251350372","DOIUrl":"10.1177/2050313X251350372","url":null,"abstract":"<p><p>Pyoderma gangrenosum is a rare, ulcerative skin condition with complex diagnostic and therapeutic challenges, particularly in cases without associated systemic conditions. We present the case of a 71-year-old female with a chronic, non-healing ulcer, initially unresponsive to conventional topical treatments. After a thorough evaluation and biopsy, a diagnosis of pyoderma gangrenosum was made. Treatment efforts included both intralesional and topical therapies, with varying responses observed. This case highlights the challenges in diagnosing and managing pyoderma gangrenosum, emphasizing the need for individualized care and a multidisciplinary approach to treat chronic, non-healing ulcers.</p>","PeriodicalId":21418,"journal":{"name":"SAGE Open Medical Case Reports","volume":"13 ","pages":"2050313X251350372"},"PeriodicalIF":0.6,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174731/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case report and review of an unusual congenital follicular melanocytic nevus in a child.","authors":"Moolla Siddiq, Liy-Wong Carmen","doi":"10.1177/2050313X251350364","DOIUrl":"10.1177/2050313X251350364","url":null,"abstract":"<p><p>We present a case of a 7-year-old girl with a congenital melanocytic nevus exhibiting a unique follicular pigmentation pattern. The lesion was present since birth and was largely asymptomatic. Regular dermatological follow-ups and patient education on self-screening and sun protection were recommended. This case highlights the wide-ranging morphological appearance of congenital melanocytic nevus and underscores the recommendations of monitoring for potential malignancy and addressing psychosocial impacts.</p>","PeriodicalId":21418,"journal":{"name":"SAGE Open Medical Case Reports","volume":"13 ","pages":"2050313X251350364"},"PeriodicalIF":0.6,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}