Movement Disorders最新文献

{"title":"Neuropsychiatric and Cognitive Symptom Evolution over the First Decade of Biomarker‐Positive, Sporadic Parkinson's Disease","authors":"Izabelle Schoen,Jing Wang,Sharon X. Xie,Chelsea Caspell‐Garcia,Eugenia Mamikonyan,Melanie Stark,Nabila Dahodwala,Andrew D. Siderowf,Roseanne Dobkin,Michele K. York,Daniel Weintraub","doi":"10.1002/mds.70557","DOIUrl":"https://doi.org/10.1002/mds.70557","url":null,"abstract":"Abstract Background Parkinson's disease (PD) is frequently accompanied by neuropsychiatric symptoms (NPS), including cognitive impairment, which often emerge early and co‐occur. Their long‐term evolution remains incompletely characterized, particularly in biomarker‐positive cohorts. Objective The aim was to examine the evolution of NPS in biomarker‐positive PD over the first decade following diagnosis. Methods Parkinson's Precision Medicine Initiative data were used to evaluate nine NPS in dual biomarker‐positive PD (positive cerebrospinal fluid ⍺‐synuclein seed amplification assay and abnormal dopamine transporter single‐photon emission computed tomography; n = 846) and healthy controls (HCs; n = 282). Analyses included generalized estimating equations (GEEs), principal components analysis (PCA), and cluster analysis. Results In PD, absolute prevalence of eight NPS increased over 10 years (6.6%–23.5%), while anxiety declined slightly. Prevalence in HCs remained low and stable. GEE models demonstrated increasing odds of all NPS in PD except anxiety, with notable increases in psychosis (odds ratio [OR], 1.21; 95% confidence interval [CI], 1.17–1.25) and apathy (OR, 1.17; 95% CI, 1.13–1.22). PD participants had higher rates of depression, psychosis, apathy, rapid eye movement sleep behavior disorder, excessive daytime sleepiness, impulse control disorders, and impaired cognition than HCs over time. Mean NPS count increased in PD (1.39 to 2.39), but remained stable in HCs (0.60 to 0.58). PCA identified a stable affective domain, a perceptual domain that included cognitive and sleep symptoms, and a time‐varying motivational‐behavioral domain. Cluster analysis at diagnosis identified low‐ and high‐burden NPS subgroups that remained applicable at 5‐ and 10‐year timepoints. Conclusions NPS increase in prevalence and co‐occurrence over 10 years in biomarker‐positive, sporadic PD. Time‐varying symptom groupings and persistent low‐ and high‐NPS burden phenotypes further highlight the progressive and heterogeneous nature of NPS evolution in PD. © 2026 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"5 1","pages":""},"PeriodicalIF":8.6,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149088998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Directional Adaptive Deep Brain Stimulation: An Initial Report of Safety, Tolerability, and Effectiveness","authors":"Martijn Beudel,Todd M. Herrington,Simon Little,Jill L. Ostrem,Leonardo Almeida,Adolfo Ramirez‐Zamora,Alfonso Fasano,Travis Hassell,Kyle T. Mitchell,Elena Moro,Michal Gostkowski,Scott Stanslaski,Rebekah L.S. Summers,Tim J. Goble,Robert S. Raike,Lisa Tonder,Ye Tan,Helen Bronte‐Stewart,the ADAPT‐PD Trial Investigators","doi":"10.1002/mds.70556","DOIUrl":"https://doi.org/10.1002/mds.70556","url":null,"abstract":"Abstract Background Adaptive deep brain stimulation (aDBS) is a safe and effective therapy for people with Parkinson's disease (PWP). Utilization of directional aDBS has not been specifically evaluated. Objectives The goal is to report the first data on the safety, tolerability, and preliminary effectiveness of chronic, directional aDBS in PWP. Methods A supplemental cohort from the Adaptive DBS Algorithm for Personalized Therapy in Parkinson's Disease Trial received directional aDBS. Participants who were previously receiving stable continuous directional DBS (dDBS) completed an open‐label evaluation of two aDBS modes. Results Seventeen participants were enrolled, with 15 completing directional aDBS evaluation. The prespecified primary endpoint and post hoc success criterion was met for both directional aDBS modes. On‐time without troublesome dyskinesia was increased, with a median of 1.2 hours/day in directional dual threshold aDBS mode. Stimulation‐related events were similar between dDBS and directional aDBS. All 15 participants chose to continue with directional aDBS chronically. Conclusions Preliminary data indicates chronic directional aDBS is feasible, tolerable, effective, and safe in PWP. © 2026 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"57 1","pages":""},"PeriodicalIF":8.6,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149092434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional, Drug-Induced, Autoimmune Movement Disorders","authors":"","doi":"10.1002/mds.70475","DOIUrl":"10.1002/mds.70475","url":null,"abstract":"","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"41 S1","pages":"S351-S381"},"PeriodicalIF":7.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mds.70475","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149085977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allied Healthcare, Quality of Life, Palliative Care, Patient Perspectives","authors":"","doi":"10.1002/mds.70483","DOIUrl":"10.1002/mds.70483","url":null,"abstract":"","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"41 S1","pages":"S69-S88"},"PeriodicalIF":7.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mds.70483","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149085971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Education, History, Disparities, Other Topics","authors":"","doi":"10.1002/mds.70476","DOIUrl":"10.1002/mds.70476","url":null,"abstract":"","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"41 S1","pages":"S329-S350"},"PeriodicalIF":7.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mds.70476","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149085976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Timing of Deep Brain Stimulation and Cognitive Trajectories in\u0000 \u0000 GBA1\u0000 \u0000 ‐Associated Parkinson's Disease","authors":"Evridiki Asimakidou,Micol Avenali,Jan O. Aasly,Mitra Afshari,Roy N. Alcalay,Sharlet Anderson,Carlo Alberto Artusi,Bryan Bernard,Marco Bozzali,Susan Bressman,Giovanna Calandra‐Buonaura,Francesco Cavallieri,Roberto Cilia,Jean‐Christoph Corvol,Antoniangela Cocco,Rob M.A. de Bie,Debra Ehrlich,Roberto Eleopra,Thomas Foltynie,Alessio Di Fonzo,Giulia Giannini,Christopher Goetz,Deborah Hall,Joohi Jimenez‐Shahed,Leonardo Lopiano,Vanessa Lythe,Maria Chiara Malaguti,Francesca Mameli,Graziella Mangone,Karen Marder,M. Maral Mouradian,Augusto Rini,Luisa Sambati,Rachel Saunders‐Pullman,Vicki Lynn Shanker,Francesca Spagnolo,Marie‐Laure Welter,Roberta Zangaglia,Gian Pal,Enza Maria Valente,PARKNET Study Group","doi":"10.1002/mds.70520","DOIUrl":"https://doi.org/10.1002/mds.70520","url":null,"abstract":"Abstract Background Individuals with Parkinson's disease (PD) carrying GBA1 variants often develop advanced motor complications that prompt evaluation for deep brain stimulation (DBS). However, concerns about accelerated cognitive decline after DBS in GBA1 carriers complicate clinical decision making. A critical aspect that is increasingly gaining attention is the time at which DBS is performed. Objective The objective is to determine how the timing of DBS in relation to PD onset impacts cognitive trajectories across different GBA1 variant classes and in individuals without GBA1 variants. Methods A multicenter cohort study across 10 study sites in Europe and the USA was conducted. The study population comprised subjects with ( GBA1 ‐Associated Parkinson's Disease [GBA‐PD]) and without GBA1 variants (nonGBA‐PD), who were subjected to bilateral subthalamic nucleus (STN)‐DBS. The main outcome measure was the Mattis Dementia Rating Scale (MDRS). Results A total of 343 individuals (91 GBA‐PD and 252 nonGBA‐PD) were included in this study. Percentile‐based stratification into early and late STN‐DBS treatment groups and linear mixed model analyses revealed that GBA‐PD patients in the late DBS group had a significantly faster rate of cognitive decline independent of age, with sensitivity analyses identifying the 7‐ and 8‐year cutoffs as the time points with a significant difference between early and late STN‐DBS groups in GBA‐PD. A negative correlation between MDRS scores and time from disease onset to STN‐DBS was observed in GBA‐PD, and was not present in nonGBA‐PD. Cognitive trajectories were markedly worse in GBA‐PD compared to nonGBA‐PD, and this pattern was not influenced by the variant type. Conclusions In GBA‐PD, STN‐DBS treatment at later stages is associated with greater risk of cognitive decline. Earlier STN‐DBS intervention in GBA‐PD may extend the period of improved motor function before the onset of significant cognitive decline. These findings highlight the potential importance of early genetic testing and disease duration when considering STN‐DBS in genetically defined PD populations. © 2026 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"26 1","pages":""},"PeriodicalIF":8.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149088361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical and Other Parkinsonisms","authors":"","doi":"10.1002/mds.70482","DOIUrl":"10.1002/mds.70482","url":null,"abstract":"","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"41 S1","pages":"S89-S250"},"PeriodicalIF":7.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mds.70482","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149085973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric, Rare Neurometabolic, and Paroxysmal Movement Disorders","authors":"","doi":"10.1002/mds.70480","DOIUrl":"10.1002/mds.70480","url":null,"abstract":"","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"41 S1","pages":"S1421-S1453"},"PeriodicalIF":7.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mds.70480","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149086242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI, Technology, Telemedicine","authors":"","doi":"10.1002/mds.70484","DOIUrl":"10.1002/mds.70484","url":null,"abstract":"","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"41 S1","pages":"S1-S68"},"PeriodicalIF":7.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mds.70484","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149086240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parkinson's Disease","authors":"","doi":"10.1002/mds.70479","DOIUrl":"10.1002/mds.70479","url":null,"abstract":"","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"41 S1","pages":"S511-S1420"},"PeriodicalIF":7.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mds.70479","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149085974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}