Movement Disorders最新文献

{"title":"Education, History, Disparities, Other Topics","authors":"","doi":"10.1002/mds.30315","DOIUrl":"https://doi.org/10.1002/mds.30315","url":null,"abstract":"","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"40 S1","pages":"S229-S245"},"PeriodicalIF":7.6,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://movementdisorders.onlinelibrary.wiley.com/doi/epdf/10.1002/mds.30315","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145228239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric, Paroxysmal, and Rare Neurometabolic Diseases","authors":"","doi":"10.1002/mds.30319","DOIUrl":"https://doi.org/10.1002/mds.30319","url":null,"abstract":"","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"40 S1","pages":"S382-S412"},"PeriodicalIF":7.6,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://movementdisorders.onlinelibrary.wiley.com/doi/epdf/10.1002/mds.30319","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145228186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI, Technology, Telemedicine","authors":"","doi":"10.1002/mds.30311","DOIUrl":"https://doi.org/10.1002/mds.30311","url":null,"abstract":"","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"40 S1","pages":"S1-S60"},"PeriodicalIF":7.6,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://movementdisorders.onlinelibrary.wiley.com/doi/epdf/10.1002/mds.30311","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145228238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measuring Dopamine Transporter Availability and Synaptic Density in Parkinson's Disease: A Dual-Tracer Positron Emission Tomography Imaging Study.","authors":"Faranak Ebrahimian Sadabad,Tommaso Volpi,Praveen Honhar,Sule Tinaz,Mark Dias,Takuya Toyonaga,Mika Naganawa,Jean-Dominique Gallezot,Yanghong Yang,Waleed Ibrahim,Brian Pittman,Salih Cayir,Rajiv Radhakrishnan,Gustavo A Angarita,Sophie E Holmes,Robert Comley,Richard E Carson,Sjoerd J Finnema,David Matuskey","doi":"10.1002/mds.70041","DOIUrl":"https://doi.org/10.1002/mds.70041","url":null,"abstract":"BACKGROUND18F-FE-PE2I is a highly selective dopamine transporter (DAT) positron emission tomography (PET) radioligand, whereas 11C-UCB-J targets synaptic vesicle glycoprotein 2A (SV2A), enabling the assessment of synaptic density. Both tracers show significant alterations in Parkinson's disease (PD) in nigrostriatal regions. However, the extent of overlap between overall synaptic loss and dopaminergic denervation across different disease stages remains unclear.OBJECTIVETo evaluate similarities and differences between patterns of DAT and SV2A binding in healthy controls (HC) and PD patients at different disease stages.METHODSThirty patients with PD (12 women, age: 65.8 ± 7.1 years) and thirteen HCs (7 women, age: 57.8 ± 5.4 years) underwent PET imaging with 18F-FE-PE2I and 11C-UCB-J on separate days. Patients with PD were also stratified by disease duration into two subgroups (<3 years, n = 10; >6 years, n = 11). Binding potentials (BPND) were quantified in four regions of interest (ROIs): caudate, putamen, ventral striatum (VS), and substantia nigra (SN). Between-group differences in BPND were evaluated against HCs for each tracer, and correlations between 18F-FE-PE2I and 11C-UCB-J BPND were evaluated.RESULTSIn HCs, significant correlations were observed between caudate 18F-FE-PE2I and striatal 11C-UCB-J BPND (caudate, putamen, VS). In PD (full cohort and longer-duration subgroup), significant correlations emerged between SN 11C-UCB-J and striatal 18F-FE-PE2I. Percent differences between patients with PD and HCs with 18F-FE-PE2I and 11C-UCB-J were similar only in the SN.CONCLUSIONSThis study examined the relationship between DAT and overall synaptic density in nigrostriatal ROIs in PD using dual-tracer PET imaging, and there were distinct patterns that vary across disease stages. Understanding the interplay between dopaminergic and presynaptic degeneration in PD could enhance our knowledge of its pathophysiology and contribute to improve diagnosis. © 2025 International Parkinson and Movement Disorder Society.","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"114 1","pages":""},"PeriodicalIF":8.6,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145209096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphological Changes in Direct Pathway Striatal Neurons in a Rat Model of Tardive Dyskinesia","authors":"Hiroki Hikichi, Haruo Nishijima, Fumiaki Mori, Iku Kinoshita, Chieko Suzuki, Koichi Wakabayashi, Masahiko Tomiyama","doi":"10.1002/mds.70068","DOIUrl":"https://doi.org/10.1002/mds.70068","url":null,"abstract":"BackgroundTardive dyskinesia (TD) and drug‐induced parkinsonism (DIP) arise from prolonged dopamine antagonist use. Although D2 receptor hypersensitivity in the indirect pathway is a proposed mechanism, the role of the direct pathway remains unclear.ObjectivesTo investigate morphological changes in the direct pathway striatal neurons' axon terminals in a rat model of haloperidol‐induced TD and DIP.MethodsMale Wistar rats received haloperidol decanoate or placebo over 6 months. Behavioral tests assessed TD‐ and DIP‐like symptoms. Axon terminals forming synapses on dendrites in the internal (GPi) and external (GPe) segments of the globus pallidus were analyzed using electron and immunoelectron microscopy.ResultsHaloperidol‐treated rats exhibited both TD‐ and DIP‐like behaviors. Vesicular gamma‐aminobutyric acid (GABA) transporter (VGAT)‐positive terminals were selectively enlarged in the GPi, and substance <jats:italic>P</jats:italic> colocalization indicated a direct pathway origin.ConclusionsStructural alterations in direct pathway nerve terminals may contribute to TD, challenging conventional models that focus solely on the indirect pathway. © 2025 The Author(s). <jats:italic>Movement Disorders</jats:italic> published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"94 7 1","pages":""},"PeriodicalIF":8.6,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145203251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"September Infographic","authors":"","doi":"10.1002/mds.29857","DOIUrl":"https://doi.org/10.1002/mds.29857","url":null,"abstract":"<p>\u0000 \u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 Low/high multi-frequency stimulation of the subthalamic nucleus improves verbal fluency maintaining motor control in Parkinson's Disease</p>","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"40 9","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145196360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Movement Disorders: Volume 40, Number 9, September 2025","authors":"","doi":"10.1002/mds.70038","DOIUrl":"https://doi.org/10.1002/mds.70038","url":null,"abstract":"","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"40 9","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://movementdisorders.onlinelibrary.wiley.com/doi/epdf/10.1002/mds.70038","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145196272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to: \"Microglia Replacement in CSF1R-RD: Current Evidence and Future Priorities\".","authors":"Hemmo A F Yska,Stéphanie Nguyen,Marianne Golse,Fanny Mochel,Violetta Zujovic","doi":"10.1002/mds.70054","DOIUrl":"https://doi.org/10.1002/mds.70054","url":null,"abstract":"","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"4 1","pages":""},"PeriodicalIF":8.6,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145189317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to: \"Early Indian Age at Onset of Parkinson's: A Case for a Gene-Environment Lens\".","authors":"Asha Kishore,Rupam Borgohain,Divya Kalikavil Puthenveedu,Roopa Rajan,Pramod Kumar Pal,Rukmini-Mridula Kandadai,Ravi Yadav,Sahil Mehta,Hrishikesh Kumar,Niraj Kumar,Prashanth Lingappa Kukkle,Soaham Desai,Kuldeep Shetty,Pettarusp Murzban Wadia,Annu Aggarwal,Pankaj Ashok Agarwal,Mirza Masoom Abbas,Syam Krishnan,Divya M Radhakrishnan,Gurusidheswar Mahadevappa Wali,Achal Srivastava,Nitish Kamble,Teresa Maria D'Costa Ferreira,Vivek Lal,Ashwin Ashok Kumar Sreelatha,Luis-Giraldo Gonzalez-Ricardo,Manas Chacko,Manu Sharma","doi":"10.1002/mds.70053","DOIUrl":"https://doi.org/10.1002/mds.70053","url":null,"abstract":"","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"69 1","pages":""},"PeriodicalIF":8.6,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145189475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vagus Nerve Stimulation in Movement Disorders, from Principles to a Systematic Review of Evidence.","authors":"Francesca Proietti,Matteo Maria Ottaviani,Elisabetta Burchi,Giorgio Vivacqua,Gaia Anzini,Riccardo Antonio Ricciuti,Fioravante Capone,Vaughan G Macefield,Vincenzo Di Lazzaro,Massimo Marano","doi":"10.1002/mds.70044","DOIUrl":"https://doi.org/10.1002/mds.70044","url":null,"abstract":"BACKGROUNDThe vagus nerve (VN), the principal component of the parasympathetic branch of the autonomic nervous system (ANS), mediates bidirec communication between the central nervous system (CNS) and peripheral organs. Vagus nerve stimulation (VNS), delivered through invasive (iVNS) or non-invasive (transcutaneous cervical [tcVNS] and transcutaneous auricular [taVNS]), exerts multimodal effects on multiple circuits and neurotransmitters, and is currently under investigation in movement disorders.OBJECTIVESThis systematic review evaluates the therapeutic potential of VNS in movement disorders (MDs), with a focus on Parkinson's disease (PD), parkinsonism, tremor and essential tremor (ET), cervical dystonia (CD), and Tourette's syndrome (TS).METHODSA systematic search of PubMed, Web of Science, and Scopus was conducted for studies published between 2020 and 2025, following Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines.RESULTSThirty-two studies met the inclusion criteria: 22 on PD or parkinsonism (14 clinical and 8 preclinical on PD, 1 clinical on multisystem atrophy), 6 on tremor and ET (4 clinical, 2 preclinical), 2 clinical studies on CD, and 1 clinical study on TS. Across conditions, VNS was reported to improve motor and non-motor, enhance synaptic plasticity, modulate neurotransmitter activity relevant to MDs (GABA, norepinephrine, dopamine, and acetylcholine), and reduce neuroinflammation.CONCLUSIONSCurrent evidence supports the multimodal effect of VNS in MDs, particularly in PD, where the most consistent benefits were observed. Non-invasive taVNS represents a promising, safer alternative to iVNS. Larger randomized controlled trials with standardized protocols are needed to validate efficacy, optimize stimulation parameters, and determine long-term clinical and biological impact. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"65 1","pages":""},"PeriodicalIF":8.6,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145189260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}