Movement Disorders最新文献

{"title":"Dystonia","authors":"","doi":"10.1002/mds.70481","DOIUrl":"10.1002/mds.70481","url":null,"abstract":"","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"41 S1","pages":"S251-S328"},"PeriodicalIF":7.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mds.70481","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149085972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperkinetic Movement Disorders (Non-Dystonia)","authors":"","doi":"10.1002/mds.70477","DOIUrl":"10.1002/mds.70477","url":null,"abstract":"","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"41 S1","pages":"S382-S510"},"PeriodicalIF":7.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mds.70477","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149085975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gray Matter Microstructure Measured Using Diffusion Imaging as a Biomarker of Severity in Lewy Body Diseases","authors":"Angeliki Zarkali,&nbsp;Ivelina Dobreva,&nbsp;Naomi Hannaway,&nbsp;Rohan Bhome,&nbsp;George E.C. Thomas,&nbsp;Steffani Carrera,&nbsp;Amanda J. Heslegrave,&nbsp;Elena Veleva,&nbsp;Henrik Zetterberg,&nbsp;Rimona S. Weil","doi":"10.1002/mds.70355","DOIUrl":"10.1002/mds.70355","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Despite widespread cortical involvement in Lewy body diseases, conventional gray matter magnetic resonance imaging (MRI) shows limited sensitivity. Diffusion-weighted MRI-derived microstructural measures have shown utility in Alzheimer's disease, but their application across the Lewy body disease spectrum remains limited.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The goal was to examine gray matter microstructure in 197 participants across the Lewy body disease spectrum (88 Lewy body dementia [LBD], 109 Parkinson's disease, and normal cognition [PD-NC]) and 46 controls.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Tissue-weighted neurite density index, tissue-weighted orientation dispersion index, and free water fraction were examined across 200 cortical and 32 subcortical regions. We compared these cross-sectionally between LBD, PD-NC and controls, and longitudinally over 3 years in a subset of 100 patients with Parkinson's disease cognitively intact at baseline. We assess associations with disease severity and plasma p-tau217 levels.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>LBD showed widespread cortical and subcortical increases in free water fraction and, to lesser extent, orientation dispersion compared to controls and PD-NC, despite minimal atrophy and no neurite density differences. In temporoparietal regions, increases in free water fraction and orientation dispersion correlated with cognitive, but not motor, severity, and with plasma p-tau217. Longitudinally, Parkinson's disease patients who developed cognitive impairment showed greater free water fraction increases within bilateral temporal regions, right thalamus, and right caudate.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Diffusion-derived microstructural measures, particularly free water fraction are sensitive to early and progressive gray matter changes associated with cognitive decline in Lewy body diseases. Findings suggest microstructural disruption without overt neuronal loss and support free water fraction as a potential biomarker for disease staging and progression. © 2026 The Author(s). <i>Movement Disorders</i> published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.</p>\u0000 </section>\u0000 </div>","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"41 9","pages":"2310-2324"},"PeriodicalIF":7.7,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mds.70355","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148020559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Teaching Deep Brain Stimulation to Walk","authors":"Rubens Gisbert Cury MD, PhD,&nbsp;Camila Aquino MD, MSc, PhD","doi":"10.1002/mds.70458","DOIUrl":"10.1002/mds.70458","url":null,"abstract":"","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"41 9","pages":"2289-2290"},"PeriodicalIF":7.7,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148582268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding Hereditary Ataxias: A Historical Quest for Definition and Classification","authors":"Léo Coutinho MD,&nbsp;Carlos Henrique Ferreira Camargo MD, MSc, PhD, FAAN,&nbsp;Hélio Afonso Ghizoni Teive MD, MSc, PhD, FAAN","doi":"10.1002/mds.70448","DOIUrl":"10.1002/mds.70448","url":null,"abstract":"<p>The classification of hereditary ataxias has evolved over two centuries, from anatomical descriptions to genetically informed frameworks. Initially grounded in clinicopathological observation, early models emphasized familial patterns and structural lesions. Key figures, including Gordon Holmes, Joseph Greenfield, and Anita Harding, shaped the nosology, culminating in Harding's inheritance-based classification in the 1980s. This model enabled significant genetic discoveries, including the identification of spinocerebellar ataxia type 1 (SCA1) and the emergence of the SCA nomenclature. However, despite advances in molecular genetics, current classifications remain limited in clinical practice. They offer little guidance for diagnosis or therapy and often function as expanding gene catalogues rather than coherent clinical tools. Recent efforts to standardize nomenclature for autosomal recessive cerebellar ataxias have improved clarity but have not resolved broader challenges. The overlap between hereditary and secondary forms, phenotypic variability, and inconsistent terminology continue to complicate classification. This review retraces the historical trajectory of hereditary ataxia classification to provide insights for future developments. © 2026 International Parkinson and Movement Disorder Society.</p>","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"41 9","pages":"2293-2298"},"PeriodicalIF":7.7,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148623866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Greater Motor and Nonmotor Burden at Diagnosis Is Associated With Amyloid Copathology in Parkinson's Disease","authors":"Han Kyu Na MD,&nbsp;Yeeun Sun MD,&nbsp;Chan Wook Park MD, PhD,&nbsp;Jung Hyun Lee MD,&nbsp;Yun Young Choi MD,&nbsp;Quynh Phuong Vo MD,&nbsp;Seok Jong Chung MD, PhD,&nbsp;Han Soo Yoo MD, PhD,&nbsp;Chul Hyoung Lyoo MD, PhD,&nbsp;Young H. Sohn MD, PhD,&nbsp;Jin Yong Hong MD, PhD,&nbsp;Phil Hyu Lee MD, PhD","doi":"10.1002/mds.70446","DOIUrl":"10.1002/mds.70446","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Concurrent Alzheimer's disease pathology is increasingly recognized as a poor prognostic factor in Parkinson's disease (PD), yet reliable clinical indicators for early identification of AD copathology remain poorly established.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Objective&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;To investigate baseline motor and nonmotor symptom profiles associated with amyloid-β (Aβ) copathology in newly diagnosed PD.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Among patients with PD who underwent Aβ imaging, we retrospectively identified 152 patients who completed the Cross-Cultural Smell Identification Test (CC-SIT), autonomic function tests, neuropsychological assessment, and Neuropsychiatric Inventory Questionnaire (NPI-Q) at drug-naive state. Predictors of Aβ positivity were identified using stepwise multivariable logistic regression and validated with Random Forest classifiers employing Boruta feature selection.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Compared with Aβ-negative counterparts (n = 93), Aβ-positive (Aβ + PD, n = 59) patients demonstrated greater olfactory dysfunction (CC-SIT, &lt;i&gt;P&lt;/i&gt; = 0.002), dysautonomia (Composite Autonomic Severity Scale [CASS], &lt;i&gt;P&lt;/i&gt; &lt; 0.001), and mood disturbance (NPI-Q-mood, &lt;i&gt;P&lt;/i&gt; &lt; 0.001) and higher prevalence of probable rapid eye movement sleep behavior disorder (&lt;i&gt;P&lt;/i&gt; = 0.009) and neurogenic orthostatic hypotension (&lt;i&gt;P&lt;/i&gt; = 0.006). Aβ + PD patients showed greater motor disability (Unified Parkinson's Disease Rating Scale Part III [UPDRS-III], &lt;i&gt;P&lt;/i&gt; &lt; 0.001) despite comparable striatal dopamine transporter uptake. Logistic regression identified lower CC-SIT scores (odds ratio [OR] = 0.821, 95% confidence interval [CI&lt;sub&gt;95%&lt;/sub&gt;]: 0.703–0.959), higher CASS scores (OR = 1.380, CI&lt;sub&gt;95%&lt;/sub&gt;: 1.144–1.666), higher NPI-Q-mood scores (OR = 1.057, CI&lt;sub&gt;95%&lt;/sub&gt;: 1.005–1.111), higher UPDRS-III (OR = 1.080, CI&lt;sub&gt;95%&lt;/sub&gt;: 1.030–1.132), and APOE ε4 carrier status (OR = 3.643, CI&lt;sub&gt;95%&lt;/sub&gt;: 1.479–8.969) as independent predictors of Aβ positivity, which were also confirmed as important variables by Boruta feature selection.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Our findings suggest that greater motor and nonmotor symptom burden at diagnosis, characterized by olfactory/autonomic dysfunction, mood disturbance, and motor deficits disproportionate to dopaminergic denervation, was associated with Aβ positivity in PD. © 2026 The Author(s). &lt;","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"41 9","pages":"2299-2309"},"PeriodicalIF":7.7,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mds.70446","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148612112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Alzheimer's Disease Co-Pathology on Shunt Outcomes in Idiopathic Normal Pressure Hydrocephalus: A Systematic Review and Meta-Analysis","authors":"Ameya Patwardhan MD,&nbsp;Mojtaba Sharafkhah MD,&nbsp;Michael Borrie MD,&nbsp;Jaspreet Bhangu MD","doi":"10.1002/mds.70333","DOIUrl":"10.1002/mds.70333","url":null,"abstract":"<p>Idiopathic normal pressure hydrocephalus (iNPH) is a potentially reversible condition characterized by gait, cognitive, and urinary impairment and treated with cerebrospinal fluid shunting, yet post-shunt outcomes vary. Coexisting Alzheimer's disease (AD) pathology may contribute to this variability. This systematic review and meta-analysis investigated whether pre-shunt AD co-pathology influences post-shunt outcomes across distinct clinical domains and follow-up durations. Following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, PubMed, Embase, Scopus, and Web of Science were searched for studies assessing the impact of pre-shunt AD co-pathology on post-shunt outcomes in iNPH. Studies were included in the meta-analysis if they stratified patients by pre-shunt AD status (iNPH-AD vs. iNPH-nAD) and reported at least one post-shunt outcome compared between groups. Random-effects meta-analyses pooled standardized mean differences across short- (&lt;12 months) and long-term (≥12 months) follow-up. Sixteen studies (n = 1825 patients) were included in the systematic review, with nine (n = 428) eligible for meta-analysis. Pre-shunt AD co-pathology prevalence ranged from 23.9% to 67.6%, and post-shunt follow-up duration ranged from 3 to 60 months. No short-term group differences were observed for cognitive outcomes; however, a significant long-term group effect indicated poorer cognitive recovery in the iNPH-AD group. Gait measures showed short-term group differences favoring the iNPH-nAD group, with no group effects at long-term follow-up, whereas urinary outcomes showed no group differences at any follow-up. AD pathology is not a contraindication to shunting; rather, AD biomarker assessment should be incorporated into the pre-shunt workup, as it can enhance outcome prediction and support tailored postoperative management. © 2026 International Parkinson and Movement Disorder Society.</p>","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"41 9","pages":"2254-2266"},"PeriodicalIF":7.7,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147826260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations Between Cumulative Head Trauma and Self-Reported Parkinsonism and Parkinson's Disease in Former Soccer Players","authors":"Annalise E. Miner BS,&nbsp;Matthew J. Kmiecik PhD,&nbsp;Niharika Namburi MHA,&nbsp;Nathaniel Dunckley,&nbsp;Charles H. Adler MD, PhD,&nbsp;Erika D. Driver-Dunckley MD,&nbsp;Christopher J. Nowinski PhD,&nbsp;Joshua Gottesman MD,&nbsp;Yorghos Tripodis PhD,&nbsp;Robert A. Stern PhD,&nbsp;Ann C. McKee MD,&nbsp;Thor D. Stein MD, PhD,&nbsp;Jesse Mez MD,&nbsp;Farren B.S. Briggs PhD,&nbsp;Michael L. Alosco PhD","doi":"10.1002/mds.70380","DOIUrl":"10.1002/mds.70380","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Cumulative head trauma, encompassing repetitive head impacts (RHI) and traumatic brain injury (TBI), has been associated with later-life neurodegenerative disease. Studies on parkinsonism/Parkinson's disease (PD) have evaluated RHI and TBI in isolation, yielding mixed results. Cumulative head trauma may better predict PD risk.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To examine independent and cumulative effects of RHI through soccer participation and TBI history on PD diagnosis and age at diagnosis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We used a cross-sectional cohort design with data from the Fox Insight study. Participants completed self-report questionnaires on PD diagnosis, TBI (no TBI, TBI with loss of consciousness [LOC], TBI without LOC), and sport participation. Multivariable logistic regressions examined the effects of soccer, TBI group, and their interaction on PD diagnosis. Cox proportional hazards examined associations with time to PD diagnosis. Covariates included age, sex, race, education, income, body mass index, heart disease/diabetes, and family PD history.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among 1231 participants (mean[SD] age = 66.12[10.60]), 278 played soccer (953 non–contact and collision sport [CCS] athletes). Participants reported no TBI (390[33%]), TBI without LOC (495[43%]), or TBI with LOC (258[23%]). Overall, 768(62%) reported a PD diagnosis (mean[SD] age at diagnosis = 59.02[9.86]). A significant soccer × TBI interaction indicated that soccer players with TBI with LOC had 2.6× higher odds of PD compared to non-CCS athletes without TBI (OR [95% CI] = 2.600[1.085–6.305], <i>P</i> = 0.033). Former soccer players with TBI with LOC had a 15.6% higher hazard of early PD diagnosis (HR = 1.469, <i>P</i> = 0.027) compared to non-CCS athletes with no TBI.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Cumulative head trauma (RHI + TBI) increased PD risk and lowered age at onset. © 2026 The Author(s). <i>Movement Disorders</i> published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.</p>\u0000 </section>\u0000 </div>","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"41 9","pages":"2325-2337"},"PeriodicalIF":7.7,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mds.70380","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148201936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging LysoPD and MitoPD: Lysosomal pH Links Two Hallmarks of Parkinson's Disease","authors":"Hari Prasad MBBS, MMST, PhD","doi":"10.1002/mds.70492","DOIUrl":"10.1002/mds.70492","url":null,"abstract":"","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"41 9","pages":"2291-2292"},"PeriodicalIF":7.7,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148754401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safeguarding Advanced Therapies—The Dangers of Therapeutic Neuroabandonment: How Should We Ensure Patient Safety and Scientific Integrity When a Commercial Clinical Trial Sponsor Becomes Insolvent?","authors":"Saeed Kayhanian MB, BChir,&nbsp;Simon Rowe MBBS,&nbsp;Roger A. Barker PhD","doi":"10.1002/mds.70379","DOIUrl":"10.1002/mds.70379","url":null,"abstract":"","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":"41 9","pages":"2278-2279"},"PeriodicalIF":7.7,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148059290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}