Scandinavian Cardiovascular Journal最新文献

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Hemodynamic gain index and risk of ventricular arrhythmias: a prospective cohort study. 血液动力学增益指数与室性心律失常的风险:一项前瞻性队列研究。
IF 2.2 4区 医学
Scandinavian Cardiovascular Journal Pub Date : 2024-12-01 Epub Date: 2024-04-29 DOI: 10.1080/14017431.2024.2347289
Setor K Kunutsor, Sae Young Jae, Sudhir Kurl, Jari A Laukkanen
{"title":"Hemodynamic gain index and risk of ventricular arrhythmias: a prospective cohort study.","authors":"Setor K Kunutsor, Sae Young Jae, Sudhir Kurl, Jari A Laukkanen","doi":"10.1080/14017431.2024.2347289","DOIUrl":"https://doi.org/10.1080/14017431.2024.2347289","url":null,"abstract":"<p><p><i>Objectives:</i> Hemodynamic gain index (HGI), a novel hemodynamic index obtained from cardiopulmonary exercise testing (CPX), is associated with adverse cardiovascular outcomes. However, its specific relationship with ventricular arrhythmias (VAs) is unknown. We aimed to assess the association of HGI with risk of VAs in a prospective study. <i>Design:</i> Hemodynamic gain index was estimated using heart rate and systolic blood pressure (SBP) responses ascertained in 1945 men aged 42-61 years during CPX from rest to maximum exercise, using the formula: [(Heart rate<sub>max</sub> x SBP<sub>max</sub>) - (Heart rate<sub>rest</sub> x SBP<sub>rest</sub>)]/(Heart rate<sub>rest</sub> x SBP<sub>rest</sub>). Cardiorespiratory fitness (CRF) was measured using respiratory gas exchange analysis. Hazard ratios (HRs) (95% confidence intervals, CIs) were estimated for VAs. <i>Results:</i> Over a median follow-up duration of 28.2 years, 75 cases of VA were recorded. In analysis adjusted for established risk factors, a unit (bpm/mmHg) higher HGI was associated with a decreased risk of VA (HR 0.72, 95% CI: 0.55-0.95). The results remained consistent on adjustment for lifestyle factors and comorbidities (HR 0.72, 95% CI: 0.55-0.93). Comparing the top versus bottom tertiles of HGI, the corresponding adjusted HRs (95% CIs) were 0.51 (0.27-0.96) and 0.52 (0.28-0.94), respectively. The associations were attenuated on addition of CRF to the model. HGI improved risk discrimination beyond established risk factors but not CRF. <i>Conclusions:</i> Higher HGI is associated with a reduced risk of VAs in middle-aged and older Caucasian men, but dependent on CRF levels. Furthermore, HGI improves the prediction of the long-term risk for VAs beyond established risk factors but not CRF.</p>","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140866240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Jailed high-pressure balloon technique is superior to jailed wire technique in protecting side branch of coronary bifurcation lesions. 在保护冠状动脉分叉病变侧支方面,栓塞高压球囊技术优于栓塞钢丝技术。
IF 2.2 4区 医学
Scandinavian Cardiovascular Journal Pub Date : 2024-12-01 Epub Date: 2024-05-06 DOI: 10.1080/14017431.2024.2347295
Jiuchun Qiu, Longyan Li, Weiding Wang, Xinjian Li, Zizhao Zhang, Shuai Shao, Gary Tse, Guangping Li, Tong Liu
{"title":"Jailed high-pressure balloon technique is superior to jailed wire technique in protecting side branch of coronary bifurcation lesions.","authors":"Jiuchun Qiu, Longyan Li, Weiding Wang, Xinjian Li, Zizhao Zhang, Shuai Shao, Gary Tse, Guangping Li, Tong Liu","doi":"10.1080/14017431.2024.2347295","DOIUrl":"https://doi.org/10.1080/14017431.2024.2347295","url":null,"abstract":"<p><p><i>Objectives.</i> This study investigated the influence of higher pressure protection with a small diameter balloon of side branch (SB) on bifurcation lesions. <i>Background.</i> Of the different coronary stent implantation techniques, the modified jailed balloon technique has become a viable option for bifurcation lesions. However, there was no detailed study on the relationship between the balloon inflation pressure of the main vessel (MV) and SB. <i>Methods.</i> In this study, we collected information of patients who underwent percutaneous coronary intervention (PCI) for bifurcated lesions between March 2019 and December 2022. They were divided into two groups according to the operation way: active jailed balloon technique (A-JBT) group and jailed wire technique (JWT) group. <i>Results.</i> A total of 216 patients were enrolled. The A-JBT group had a larger SB stenosis diameter (1.53 ± 0.69 vs. 0.95 ± 0.52, <i>p</i> < .001), the lower degree of stenosis (44.34 ± 18.30 vs. 63.69 ± 17.34, <i>p</i> < .001) compared to the JWT group. However, the JWT group had a higher incidence of SB occlusion (18.0% vs. 1.9%, <i>p</i> < .001) compared to the A-JBT group. Nevertheless, the success rate for both groups was 100%. <i>Conclusions.</i> This novel high inflation pressure and small diameter balloon approach we propose has significant advantages. There is a lower rate of SB occlusion and SB dissection, which is more cost-effective and provides better clinical outcomes for the patient. This method should be considered in the future for treating bifurcation lesions.</p>","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140851175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular mechanism of triptolide in myocardial fibrosis through the Wnt/β-catenin signaling pathway. 三苯氧胺通过 Wnt/β-catenin 信号通路促进心肌纤维化的分子机制
IF 2.2 4区 医学
Scandinavian Cardiovascular Journal Pub Date : 2024-12-01 Epub Date: 2024-01-02 DOI: 10.1080/14017431.2023.2295785
Yiwen Zhang, Feng Lu
{"title":"Molecular mechanism of triptolide in myocardial fibrosis through the Wnt/β-catenin signaling pathway.","authors":"Yiwen Zhang, Feng Lu","doi":"10.1080/14017431.2023.2295785","DOIUrl":"10.1080/14017431.2023.2295785","url":null,"abstract":"<p><p><i>Objective.</i> Myocardial fibrosis (MF) is a common manifestation of end-stage cardiovascular diseases. Triptolide (TP) provides protection against cardiovascular diseases. This study was to explore the functional mechanism of TP in MF rats <i>via</i> the Wnt/β-catenin pathway. <i>Methods.</i> The MF rat model was established <i>via</i> subcutaneous injection of isoproterenol (ISO) and treated with low/medium/high doses of TP (L-TP/M-TP/H-TP) or Wnt agonist BML-284. Cardiac function was examined by echocardiography. Pathological changes of myocardial tissues were observed by HE and Masson staining. Col-I/Col-III/Vimentin/α-SMA levels were detected by immunohistochemistry, RT-qPCR, and Western blot. Collagen volume fraction content was measured. Expression levels of the Wnt/β-catenin pathway-related proteins (β-catenin/c-myc/Cyclin D1) were detected by Western blot. Rat cardiac fibroblasts were utilized for <i>in vitro</i> validation experiments. <i>Results.</i> MF rats had enlarged left ventricle, decreased systolic and diastolic function and cardiac dysfunction, elevated collagen fiber distribution, collagen volume fraction and hydroxyproline content. Levels of Col-I/Col-III/Vimentin/α-SMA, and protein levels of β-catenin/c-myc/Cyclin D1 were increased in MF rats. The Wnt/β-catenin pathway was activated in the myocardial tissues of MF rats. TP treatment alleviated impairments of cardiac function and myocardial tissuepathological injury, decreased collagen fibers, collagen volume fraction, Col-I, Col-III, α-SMA and Vimentin levels, HYP content, inhibited Wnt/β-catenin pathway, with H-TP showing the most significant effects. Wnt agonist BML-284 antagonized the inhibitive effect of TP on MF. TP inhibited the Wnt/β-catenin pathway to repress the proliferation and differentiation of mouse cardiac fibroblasts <i>in vitro. Conclusions</i>. TP was found to ameliorate ISO-induced MF in rats by inhibiting the Wnt/β-catenin pathway.</p>","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139074899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Atrial fibrillation incidence after coronary artery bypass graft surgery and percutaneous coronary intervention: the prospective AFAF cohort study. 冠状动脉旁路移植手术和经皮冠状动脉介入治疗术后的心房颤动发生率:前瞻性 AFAF 队列研究。
IF 2.2 4区 医学
Scandinavian Cardiovascular Journal Pub Date : 2024-12-01 Epub Date: 2024-05-02 DOI: 10.1080/14017431.2024.2347297
Anders Wickbom, Espen Fengsrud, Joakim Alfredsson, Johan Engdahl, Torbjörn Kalm, Anders Ahlsson
{"title":"Atrial fibrillation incidence after coronary artery bypass graft surgery and percutaneous coronary intervention: the prospective AFAF cohort study.","authors":"Anders Wickbom, Espen Fengsrud, Joakim Alfredsson, Johan Engdahl, Torbjörn Kalm, Anders Ahlsson","doi":"10.1080/14017431.2024.2347297","DOIUrl":"10.1080/14017431.2024.2347297","url":null,"abstract":"<p><p><i>Objectives.</i> Atrial fibrillation is a common arrhythmia in patients with ischemic heart disease. This study aimed to determine the cumulative incidence of new-onset atrial fibrillation after percutaneous coronary intervention or coronary artery bypass grafting surgery during 30 days of follow-up. <i>Design.</i> This was a prospective multi-center cohort study on atrial fibrillation incidence following percutaneous coronary intervention or coronary artery bypass grafting for stable angina or non-ST-elevation acute coronary syndrome. Heart rhythm was monitored for 30 days postoperatively by in-hospital telemetry and handheld thumb ECG recordings after discharge were performed. The primary endpoint was the cumulative incidence of atrial fibrillation 30 days after the index procedure. <i>Results.</i> In-hospital atrial fibrillation occurred in 60/123 (49%) coronary artery bypass graft and 0/123 percutaneous coronary intervention patients (<i>p</i> < .001). The cumulative incidence of atrial fibrillation after 30 days was 56% (69/123) of patients undergoing coronary artery bypass grafting and 2% (3/123) of patients undergoing percutaneous coronary intervention (<i>p</i> < .001). CABG was a strong predictor for atrial fibrillation compared to PCI (OR 80.2, 95% CI 18.1-354.9, <i>p</i> < .001). Thromboembolic stroke occurred in-hospital in one coronary artery bypass graft patient unrelated to atrial fibrillation, and at 30 days in two additional patients, one in each group. There was no mortality. <i>Conclusion.</i> New-onset atrial fibrillation during 30 days of follow-up was rare after percutaneous coronary intervention but common after coronary artery bypass grafting. A prolonged uninterrupted heart rhythm monitoring strategy identified additional patients in both groups with new-onset atrial fibrillation after discharge.</p>","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140852641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Five-year outcomes of mitral valve repair for leaflet prolapse at a medium-sized Norwegian university hospital. 挪威一所中型大学医院二尖瓣修复术治疗瓣叶脱垂的五年疗效。
IF 1.2 4区 医学
Scandinavian Cardiovascular Journal Pub Date : 2024-12-01 Epub Date: 2024-07-25 DOI: 10.1080/14017431.2024.2379336
Trym Løvseth Kavlie, Henrik Agerup Kildahl, Håvard Dalen, Dag Ole Nordhaug, Katrine Hordnes Slagsvold, Bjørnar Leangen Grenne, Espen Holte
{"title":"Five-year outcomes of mitral valve repair for leaflet prolapse at a medium-sized Norwegian university hospital.","authors":"Trym Løvseth Kavlie, Henrik Agerup Kildahl, Håvard Dalen, Dag Ole Nordhaug, Katrine Hordnes Slagsvold, Bjørnar Leangen Grenne, Espen Holte","doi":"10.1080/14017431.2024.2379336","DOIUrl":"https://doi.org/10.1080/14017431.2024.2379336","url":null,"abstract":"<p><p><i>Objective</i>. To evaluate patient characteristics and 5-year outcomes after surgical mitral valve (MV) repair for leaflet prolapse at a medium-sized cardiothoracic center. <i>Background</i>. Contemporary reports on the outcome of MV repair at medium-sized cardiothoracic centers are sparse. <i>Methods</i>. Patients receiving open-heart surgery with MV repair due to primary mitral regurgitation caused by leaflet prolapse between 2015 and 2021, without active endocarditis, were included. Clinical data, complications, re-interventions, mortality, and echocardiographic data were retrospectively registered from electronical patient charts, both pre-operatively and from post-operative follow-ups. <i>Results</i>. One hundred and three patients were included, 83% male, with a mean age of 62 years. All-cause mortality was 9% during a median follow-up time of 4.9 years. Re-intervention rate on the MV was 4%. Post-operative complications before last available follow-up visit at median 3.0 years were infrequent, with new-onset atrial fibrillation/flutter in 16%, post-operative MV regurgitation grade II or above in 17% and post-operative tricuspid regurgitation grade II or above in 14%. <i>Conclusions</i>. These data demonstrate that surgical MV repair for leaflet prolapse at a medium-sized cardiothoracic center was associated with low re-intervention rate and few severe complications. The presented results are comparable to data from surgical high-volume centers, indicating that surgical MV repair can be safely performed at selected medium-sized cardiothoracic centers.</p>","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141760723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lower heart rate in patients with acute heart failure: the role of left ventricular ejection fraction. 降低急性心力衰竭患者的心率:左心室射血分数的作用。
IF 1.2 4区 医学
Scandinavian Cardiovascular Journal Pub Date : 2024-12-01 Epub Date: 2024-08-08 DOI: 10.1080/14017431.2024.2386977
Miguel Lorenzo, Gema Miñana, Patricia Palau, Gonzalo Núñez, Rafael de la Espriella, Enrique Santas, Sandra Villar, Victor Donoso, Eduardo Núñez, Juan Sanchis, Antoni Bayés-Genis, Julio Núñez
{"title":"Lower heart rate in patients with acute heart failure: the role of left ventricular ejection fraction.","authors":"Miguel Lorenzo, Gema Miñana, Patricia Palau, Gonzalo Núñez, Rafael de la Espriella, Enrique Santas, Sandra Villar, Victor Donoso, Eduardo Núñez, Juan Sanchis, Antoni Bayés-Genis, Julio Núñez","doi":"10.1080/14017431.2024.2386977","DOIUrl":"https://doi.org/10.1080/14017431.2024.2386977","url":null,"abstract":"<p><strong>Background: </strong>The clinical impact of heart rate (HR) in heart failure with preserved ejection fraction (HFpEF) is a matter of debate. Among those with HFpEF, chronotropic incompetence (CI) has emerged as a pathophysiological mechanism linked to the severity of the disease. In this study, we sought to evaluate whether admission heart rate in acute heart failure differs along left ventricular ejection fraction (LVEF).</p><p><strong>Methods: </strong>We included retrospectively 3,712 consecutive patients admitted for acute heart failure (AHF) in the Cardiology department of a third level center. HR values were assessed at presentation. LVEF was assessed by transthoracic echocardiogram during the index admission and stratified into four categories: reduced ejection fraction (<math><mrow><mo>≤</mo></mrow></math>40%), mildly reduced ejection fraction (41-49%), preserved ejection fraction (50-64%) and supranormal ejection fraction (<math><mrow><mo>≥</mo></mrow></math>65%). The association between HR and LVEF was assessed by multivariate linear and multinomial regression analyses.</p><p><strong>Results: </strong>The mean age of the sample was 73,9 ± 11.3 years, 1,734 (47,4%) were women, and 1,214 (33,2%), 570 (15,6%), 1,229 (33,6%) and 648 (17,7%) patients showed LVEF <math><mrow><mo>≤</mo></mrow></math>40%, 41-49%, 50-64%, and ≥65% respectively. The median HR at admission was 95 (IQR 78-120) beats per minute and 1,653 were on atrial fibrillation (45.2%). There was an inverse relationship between HR at admission and LVEF. Lower HR was significantly associated with a higher LVEF in the whole sample (<i>p</i> < 0,001). This inverse relationship was found in sinus rhythm but not in patients with atrial fibrillation.</p><p><strong>Conclusion: </strong>HR at admission for AHF is a predictor of LVEF but only in patients with sinus rhythm.</p>","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141902789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Accuracy of subtraction fractional flow reserve with computed tomography in identifying early revascularization in patients with coronary artery disease. 计算机断层扫描减影分数血流储备在识别冠心病患者早期血管再通方面的准确性。
IF 1.2 4区 医学
Scandinavian Cardiovascular Journal Pub Date : 2024-12-01 Epub Date: 2024-07-04 DOI: 10.1080/14017431.2024.2373082
Tingting Zhu, Defu Li, Jinhan Qiao, Qian Li, Yinghao Xu, Bing Ge, Liming Xia
{"title":"Accuracy of subtraction fractional flow reserve with computed tomography in identifying early revascularization in patients with coronary artery disease.","authors":"Tingting Zhu, Defu Li, Jinhan Qiao, Qian Li, Yinghao Xu, Bing Ge, Liming Xia","doi":"10.1080/14017431.2024.2373082","DOIUrl":"https://doi.org/10.1080/14017431.2024.2373082","url":null,"abstract":"<p><strong>Objectives: </strong>The diagnostic performance of fractional flow reserve with computed tomography (FFR-CT) is affected by the presence of calcified plaque. Subtraction can remove the influence of calcification in coronary computed tomography angiography (CCTA) to increase confidence in the diagnosis of coronary artery stenosis. Our purpose is to investigate the accuracy of post-subtraction FFR-CT in predicting early revascularization.</p><p><strong>Design: </strong>Based on CCTA data of 237 vessels from 79 patients with coronary artery disease, subtraction CCTA images were obtained at a local post-processing workstation, and the conventional and post-subtraction FFR-CT measurements and the difference in proximal and distal FFR-CT values of the narrowest segment of the vessel (ΔFFR-CT) were analyzed for their accuracy in predicting early coronary artery hemodynamic reconstruction.</p><p><strong>Results: </strong>With FFR-CT ≤ 0.8 as the criterion, the accuracy of conventional and post-subtraction FFR-CT measurements in predicting early revascularization was 73.4% and 77.2% at the patient level, and 64.6% and 72.2% at the vessel level, respectively. The specificity of post-subtraction FFR-CT measurements was significantly higher than that of conventional FFR-CT at both the patient and vessel levels (P of 0.013 and 0.015, respectively). At the vessel level, the area under the curve of receiver operating characteristic was 0.712 and 0.797 for conventional and post-subtraction ΔFFR-CT, respectively, showing a difference (P = 0.047), with optimal cutoff values of 0.07 and 0.11, respectively.</p><p><strong>Conclusion: </strong>The post-subtraction FFR-CT measurements enhance the specificity in predicting early revascularization. The post-subtraction ΔFFR-CT value of the stenosis segment > 0.11 may be an important indicator for early revascularization.</p>","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141498878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Electrocardiographic abnormalities and NT-proBNP levels at long-term follow-up of patients with dyspnea after pulmonary embolism. 肺栓塞后呼吸困难患者长期随访时的心电图异常和 NT-proBNP 水平。
IF 1.2 4区 医学
Scandinavian Cardiovascular Journal Pub Date : 2024-06-27 Epub Date: 2024-07-03 DOI: 10.1080/14017431.2024.2373090
Lars T Nilsson, Therese Andersson, Bo Carlberg, Lars Å Johansson, Stefan Söderberg
{"title":"Electrocardiographic abnormalities and NT-proBNP levels at long-term follow-up of patients with dyspnea after pulmonary embolism.","authors":"Lars T Nilsson, Therese Andersson, Bo Carlberg, Lars Å Johansson, Stefan Söderberg","doi":"10.1080/14017431.2024.2373090","DOIUrl":"https://doi.org/10.1080/14017431.2024.2373090","url":null,"abstract":"<p><strong>Objectives: </strong>Electrocardiogram (ECG) and measurement of plasma brain natriuretic peptides (BNP) are established markers of right ventricular dysfunction (RVD) in the setting of acute pulmonary embolism (PE) but their value at long-term follow-up is largely unknown. The purpose of this prospective study was to determine the prevalence of ECG abnormalities, describe levels of N-terminal proBNP (NT-proBNP), and establish their association with dyspnea at long-term follow-up after PE.</p><p><strong>Design: </strong>All Swedish patients diagnosed with acute PE in 2005 (<i>n</i> = 5793) were identified through the Swedish National Patient Registry. Surviving patients in 2007 (<i>n</i> = 3510) were invited to participate. Of these, 2105 subjects responded to a questionnaire about dyspnea and comorbidities. Subjects with dyspnea or risk factors for development of chronic thromboembolic pulmonary hypertension were included in the study in a secondary step, which involved collection of blood samples and ECG registration.</p><p><strong>Results: </strong>Altogether 49.3% had a completely normal ECG. The remaining participants had a variety of abnormalities, 7.2% had atrial fibrillation/flutter (AF). ECG with any sign of RVD was found in 7.2% of subjects. Right bundle branch block was the most common RVD sign with a prevalence of 6.4%. An abnormal ECG was associated with dyspnea. AF was associated with dyspnea, whereas ECG signs of RVD were not. 61.2% of subjects had NT-proBNP levels above clinical cut-off (>125 ng/L). The degree of dyspnea did not associate independently with NT-proBNP levels.</p><p><strong>Conclusions: </strong>We conclude that the value of ECG and NT-proBNP in long term follow-up after PE lies mostly in differential diagnostics.</p>","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141493164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A reply to the letter to the editor "Common practice of underreporting and downplaying adverse events and exaggerating benefits in patients undergoing percutaneous coronary intervention of chronic total occlusions". 回复致编辑的信 "对接受经皮冠状动脉介入治疗慢性全闭塞患者少报、淡化不良事件并夸大获益的常见做法"。
IF 1.2 4区 医学
Scandinavian Cardiovascular Journal Pub Date : 2024-06-25 Epub Date: 2024-07-02 DOI: 10.1080/14017431.2024.2373102
Lauri Mansikkaniemi, Hirokazu Miyashita, Juha Sinisalo, Juhani Stewart, Petri Laine
{"title":"A reply to the letter to the editor \"Common practice of underreporting and downplaying adverse events and exaggerating benefits in patients undergoing percutaneous coronary intervention of chronic total occlusions\".","authors":"Lauri Mansikkaniemi, Hirokazu Miyashita, Juha Sinisalo, Juhani Stewart, Petri Laine","doi":"10.1080/14017431.2024.2373102","DOIUrl":"https://doi.org/10.1080/14017431.2024.2373102","url":null,"abstract":"","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141477353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Common practice of underreporting and downplaying adverse events and exaggerating benefits in patients undergoing percutaneous coronary intervention of chronic total occlusions. 在接受经皮冠状动脉介入治疗慢性全闭塞患者中,低报和淡化不良事件、夸大获益的常见做法。
IF 1.2 4区 医学
Scandinavian Cardiovascular Journal Pub Date : 2024-06-25 Epub Date: 2024-07-03 DOI: 10.1080/14017431.2024.2373070
Mohammad Reza Movahed
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