Scandinavian Cardiovascular Journal最新文献

Shrunken pore syndrome in heart transplantation: a pore ready to close? 心脏移植中的萎缩孔综合征；毛孔准备好闭合了吗？

IF 1.2 4区医学

Scandinavian Cardiovascular Journal Pub Date : 2025-12-01 Epub Date: 2025-03-20 DOI: 10.1080/14017431.2025.2481173

Erik Herou, Emilie Mörtsell, Anders Grubb, Shahab Nozohoor, Igor Zindovic, Per Ederoth, Alain Dardashti, Henrik Bjursten

{"title":"Shrunken pore syndrome in heart transplantation: a pore ready to close?","authors":"Erik Herou, Emilie Mörtsell, Anders Grubb, Shahab Nozohoor, Igor Zindovic, Per Ederoth, Alain Dardashti, Henrik Bjursten","doi":"10.1080/14017431.2025.2481173","DOIUrl":"10.1080/14017431.2025.2481173","url":null,"abstract":"Background: A newly discovered renal syndrome, shrunken pore syndrome (SPS), has been shown to increase mortality regardless of renal function. SPS is defined as an estimated glomerular filtration rate (eGFR) of cystatin C ≤ 60% than eGFRcreatinine. We set out to study SPS in relation to the survival of heart transplantation patients with a follow-up of up to 12 years. Methods. This was a single-center cohort study including 253 consecutive patients undergoing heart transplantation. The prevalence of SPS at different time points post-transplantation and its effect on survival was evaluated using Kaplan-Meier's analysis and multivariable Cox proportional hazards regression. Results. The prevalence of SPS was 7.5% the day after transplantation (D1), which rose to 71% week 4 after surgery. There was no difference in survival for patients with SPS D1 compared to patients without SPS D1. Patients with SPS 4 weeks compared to patients without SPS 4 weeks after transplantation showed a 5- and 10-year survival of 73% vs. 93% (p = .02) and 63% vs. 90% (p = .005), respectively. SPS developed during the postoperative period was also found to be an independent predictor of mortality (HR 4.65; 95% CI 1.36-15.8). Discussion. SPS that developed in the postoperative course after heart transplantation was found to be an independent predictor of mortality with a severe negative impact on 5- and 10-year survival.","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":" ","pages":"2481173"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aortic valve phenotype and distal aortic outcome after ascending aortic surgery. 升主动脉手术后主动脉瓣表型与主动脉远端预后。

IF 1.2 4区医学

Scandinavian Cardiovascular Journal Pub Date : 2025-12-01 Epub Date: 2025-06-06 DOI: 10.1080/14017431.2025.2513874

Carl Granath, Michael Dismorr, Hanna M Björck, Emelie Carlestål, Christian Olsson, Fredrik Bredin

{"title":"Aortic valve phenotype and distal aortic outcome after ascending aortic surgery.","authors":"Carl Granath, Michael Dismorr, Hanna M Björck, Emelie Carlestål, Christian Olsson, Fredrik Bredin","doi":"10.1080/14017431.2025.2513874","DOIUrl":"10.1080/14017431.2025.2513874","url":null,"abstract":"Objectives: Recent guidelines advocate postoperative aortic surveillance without clear distinction between aortic valve phenotypes. We sought to determine the long-term occurrence and location of distal aortic complications and aortic growth rates postoperatively in patients with bicuspid and tricuspid aortic valves, respectively.Design: Patients underwent elective ascending aorta replacement, with or without concomitant aortic valve surgery, and computed tomography of the aorta preoperatively. Repeat imaging was performed 10 years after surgery and medical records were reviewed to identify aortic events.Results: Overall, 127 patients (bicuspid n = 85 [66.9%], tricuspid n = 42 [33.1%]; male n = 88 [69.3%]) were included at baseline. Ten patients (23.8%) in the tricuspid group developed an acute aortic event, indication for surgery at a distal segment, or underwent aortic intervention, compared with two (2.4%) in the bicuspid group (p < 0.001). 96 patients (75.6%, bicuspid n = 67, tricuspid n = 29) returned for repeat aortic imaging, with a median follow-up of 10.8 years. The frequency of arch complications was significantly higher in the tricuspid group (n = 4 vs. n = 0, p = 0.007). Multivariable logistic regression identified tricuspid aortic valve (OR 8.52, p = 0.012) and baseline distal aortic diameter (OR 1.27 per mm increment, p < 0.001) as risk factors for a distal aortic complication.Conclusions: Patients with a tricuspid aortic valve are at high risk of a distal aortic complication, whereas patients with a bicuspid aortic valve are at low risk. Long-term surveillance should be individualized accordingly.","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":" ","pages":"2513874"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictors of permanent pacemaker implantation after transcatheter aortic valve implantation. 经导管主动脉瓣置入术后永久起搏器植入的预测因素。

IF 1.2 4区医学

Scandinavian Cardiovascular Journal Pub Date : 2025-12-01 Epub Date: 2025-03-19 DOI: 10.1080/14017431.2025.2481175

Martin Petter Høydahl, Didrik Kjønås, Assami Rösner, Bendik Trones Antonsen, Signe Helene Forsdahl, Rolf Busund

{"title":"Predictors of permanent pacemaker implantation after transcatheter aortic valve implantation.","authors":"Martin Petter Høydahl, Didrik Kjønås, Assami Rösner, Bendik Trones Antonsen, Signe Helene Forsdahl, Rolf Busund","doi":"10.1080/14017431.2025.2481175","DOIUrl":"10.1080/14017431.2025.2481175","url":null,"abstract":"Purpose. Transcatheter aortic valve implantation (TAVI) is increasingly performed in patients with longer life expectancies. The need for permanent pacemaker implantation (PPI) following TAVI has been associated with increased all-cause mortality and morbidity. This study aimed to identify ECG, CT, and procedural predictors of PPI following TAVI. Methods. We conducted a retrospective observational study at the University Hospital of North Norway. Patients who underwent TAVI with SAPIEN 3 or SAPIEN 3 Ultra valves were included, while those with prior pacemakers, self-expanding valves, or valve-in-valve procedures were excluded. Data were collected from medical records, pre-operative CT scans, and procedural angiography. Results. A total of 416 low- to intermediate-risk patients with a median age of 82 years were included. Of these, 64 patients (15.4%) required PPI within ≤30 days following the index procedure. Multivariable regression analysis identified the following predictors for PPI: pre-existing right bundle branch block (odds ratio (OR), 10.7; 95% CI, 4.74-24.3), first-degree atrioventricular block (OR, 2.62; 95% CI, 1.08-6.32), membranous septum length (OR, 0.77; 95% CI, 0.65-0.90), left ventricular outflow tract calcification (OR, 2.18; 95% CI, 1.12-4.27), and the use of 29 mm valves (OR, 2.33; 95% CI, 1.09-4.97). Conclusions. Our study found the following predictors of PPI following TAVI: pre-existing right bundle branch block, first-degree atrioventricular block, the use of 29 mm valves and the presence of left ventricular outflow tract calcification. Additionally, a short MS was found to increase the chance of PPI; therefore, MS measurements should be included in pre-operative assessments to identify at-risk patients.","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":" ","pages":"2481175"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of centrifugal and roller pumps on blood and myocardial structure in a normothermic machine-perfused ex vivo porcine heart model. 离心泵和滚轴泵对恒温机器灌注离体猪心脏模型血液和心肌结构的影响。

IF 1.2 4区医学

Scandinavian Cardiovascular Journal Pub Date : 2025-12-01 Epub Date: 2025-06-30 DOI: 10.1080/14017431.2025.2525115

Chunhua Wang, Shijie Yin, Xiao Yue, Qiangxin Huang, Wei Wu, Guanbin Qin, Lan Luo, Huabei Wu

{"title":"Effect of centrifugal and roller pumps on blood and myocardial structure in a normothermic machine-perfused ex vivo porcine heart model.","authors":"Chunhua Wang, Shijie Yin, Xiao Yue, Qiangxin Huang, Wei Wu, Guanbin Qin, Lan Luo, Huabei Wu","doi":"10.1080/14017431.2025.2525115","DOIUrl":"10.1080/14017431.2025.2525115","url":null,"abstract":"Objective. In this study, we investigated the different effects of roller and centrifugal pumps on blood and myocardial tissue structure in a normothermic machine-perfused ex vivo porcine heart model. Methods. We selected 16 healthy Guangxi Bama miniature pigs weighing 25-30 kg and randomly divided them into two groups, one perfused by a roller pump and the other perfused by a centrifugal pump. We recorded hemodynamic parameters, measured blood gases to test for erythrocyte destruction, coagulation, myocardial injury markers, and inflammatory factors, and observed pathological and ultrastructural changes in the left ventricular wall myocardial tissue. Results. There were no differences in perfusion, heart rate, blood gases, hemolysis, or cardiac enzyme levels between the two groups (p > .05). The centrifugal pump group had a higher platelet count, fibrinogen level, and prothrombin time and lower levels of D-dimer (p < .05). In the centrifugal pump group, compared to the roller pump group, the pro-inflammatory factor levels were significantly higher and interleukin-10 levels were significantly lower (p < .05). Hematoxylin-eosin staining and transmission electron microscopy results showed no difference in the degree of myocardial tissue damage between the two groups. Conclusion. The results of this study suggested that the centrifugal pump model reduced platelet destruction, prolonged prothrombin time, avoided excessive fibrinogen activation, and attenuated elevated D-dimer levels. However, the centrifugal pump induced a greater inflammatory response compared to roller pump.","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":" ","pages":"2525115"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144497937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physical activity levels and associated biopsychosocial characteristics among attendees to exercise-based cardiac rehabilitation. 以运动为基础的心脏康复参与者的身体活动水平和相关的生物心理社会特征

IF 1.2 4区医学

Scandinavian Cardiovascular Journal Pub Date : 2025-12-01 Epub Date: 2025-03-13 DOI: 10.1080/14017431.2025.2472763

Hedvig Zetterberg, Annika Bring, Emil Hagström, Marie Breidenskog, Henrik Johansson, Charlotte Urell

{"title":"Physical activity levels and associated biopsychosocial characteristics among attendees to exercise-based cardiac rehabilitation.","authors":"Hedvig Zetterberg, Annika Bring, Emil Hagström, Marie Breidenskog, Henrik Johansson, Charlotte Urell","doi":"10.1080/14017431.2025.2472763","DOIUrl":"10.1080/14017431.2025.2472763","url":null,"abstract":"Aim. Exercise-based cardiac rehabilitation (exCR) reduces morbidity and mortality after acute coronary syndrome (ACS). Little is known about physical activity (PA) levels at exCR program completion and associated demographic, medical, and psychosocial factors. Methods. Cross-sectional data from the ongoing Keep-Up-Going study were used, including 100 participants with recent ACS and ≥80% attendance to 3 months supervised exCR program. Physical activity was assessed by an accelerometer and self-reported psychosocial characteristics were collected at the end of the exCR. Associations between achieving the PA target (>150 min of moderate-to-vigorous-intensity PA/week) and biopsychosocial characteristics were assessed using univariable logistic regression analyses. Results. Mean age was 67 years and 24% were women. Participants achieving the PA target (76%) were more likely to have higher levels of social support, higher outcome expectations for PA, and higher intrinsic regulation (motivation, p < .05 for all). Those not achieving the PA target (24%) had a higher proportion of sedentary time, fewer steps/day, and were more likely to be older, retired, and have reduced left ventricular ejection fraction (LVEF) (p < .05 for all). Conclusions. Although exCR participation provides exercise routines, one-fourth of individuals did not reach the guideline-directed PA targets after an ACS. In addition to higher age and reduced LVEF, lower levels of social support, outcome expectations, and motivation were associated with low levels of PA. Exploring these factors could be of importance to support individuals' behavior change toward increased PA during the exCR period.","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":" ","pages":"2472763"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143606014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The use of antiarrhythmic drugs for atrial fibrillation in Finland 2007-2018. 2007 - 2018年芬兰房颤抗心律失常药物的使用

IF 1.2 4区医学

Scandinavian Cardiovascular Journal Pub Date : 2025-12-01 Epub Date: 2025-02-20 DOI: 10.1080/14017431.2025.2467735

Rasmus Siponen, Juha Hartikainen, Janne Virrankorpi, Antti Lappalainen, Konsta Teppo, Olli Halminen, Aapo Aro, Annukka Marjamaa, Birgitta Salmela, Jari Haukka, Jukka Putaala, Miika Linna, Pirjo Mustonen, Juhani Airaksinen, Mika Lehto

{"title":"The use of antiarrhythmic drugs for atrial fibrillation in Finland 2007-2018.","authors":"Rasmus Siponen, Juha Hartikainen, Janne Virrankorpi, Antti Lappalainen, Konsta Teppo, Olli Halminen, Aapo Aro, Annukka Marjamaa, Birgitta Salmela, Jari Haukka, Jukka Putaala, Miika Linna, Pirjo Mustonen, Juhani Airaksinen, Mika Lehto","doi":"10.1080/14017431.2025.2467735","DOIUrl":"10.1080/14017431.2025.2467735","url":null,"abstract":"Background: Patients with atrial fibrillation (AF) are often treated with antiarrhythmic drugs (AADs) to maintain sinus rhythm and with heart rate-lowering drugs to achieve the optimal rate control. In this study, we investigated trends in the use of AADs and rate control drugs in Finnish patients with AF.Methods and results: The Finnish AntiCoagulation in Atrial Fibrillation (FinACAF) study is a nationwide study including all patients with AF in Finland from 2007 to 2018. The number of AAD purchases and the proportions of all prevalent AF patients in a certain year of interest were calculated. In total, 391030 AF patients were identified between 2007 and 2018, and 39,816 (10.2%) of them had purchased either class I or III AADs. The proportion of patients using classes I and III AADs decreased from 8.6% to 6.3%. Flecainide and amiodarone were the most often used AADs. The use of flecainide and amiodarone decreased from 4.9% to 3.9% and 1.9% to 1.5%, respectively. The proportion of patients on beta-blockers remained stable at 75%. Dronedarone became available in 2011 when it also was the most used (0.8% of patients), but the use decreased thereafter. The use of sotalol and digoxin decreased from 1.5% to 0.6% and 24.6% to 11.0% over the study period.Conclusion: The number of AAD purchases increased alongside with the increasing prevalence of AF, whereas the proportion of AF patients on classes I and III AADs and digoxin decreased between 2007 and 2018. Flecainide remained the most used AAD followed by amiodarone.","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":" ","pages":"2467735"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143415088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiogenic shock and extracorporeal membrane oxygenation: etiology and 1-year survival. 心源性休克和体外膜氧合：病因和1年生存率。

IF 1.2 4区医学

Scandinavian Cardiovascular Journal Pub Date : 2025-12-01 Epub Date: 2025-03-25 DOI: 10.1080/14017431.2025.2481179

Inga L Ingvarsdottir, Andreas Westerlind, Isabella Lepore, Tomas Gudbjartsson, Bengt Redfors, Göran Dellgren

{"title":"Cardiogenic shock and extracorporeal membrane oxygenation: etiology and 1-year survival.","authors":"Inga L Ingvarsdottir, Andreas Westerlind, Isabella Lepore, Tomas Gudbjartsson, Bengt Redfors, Göran Dellgren","doi":"10.1080/14017431.2025.2481179","DOIUrl":"10.1080/14017431.2025.2481179","url":null,"abstract":"Objectives. Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is used to provide cardiorespiratory support in cardiogenic shock (CS), but selection of patients and timing of ECMO-start remain a challenge. This study aims to describe the 1 year outcome of VA-ECMO for CS with focus on etiology and severity of shock. Methods. VA-ECMO was used on 371 occasions between 2004 and 2019 at our center. Of these, 177 patients received VA-ECMO for CS and were included in this retrospective single-center study. Univariable and multivariable logistic regression models were used to determine predictors of all-cause mortality at 1 year. Results. Patients were grouped according to underlying etiology: non-ischemic heart failure (NIHF, N = 49), ischemic heart disease (IHD, N = 83) and miscellaneous diagnoses (Misc, N = 45). Markers of disease severity were lower for patients with NIHF. One year survival was 40% for all patients, 57%, 36% and 27% for the NIHF-, IHD and Misc-groups, respectively (p < .01). Univariable logistic regression analysis identified several variables associated with 1-year mortality, such as underlying etiology, pH and lactate, while biventricular failure was associated with a better prognosis. However, in the multivariable analysis, only ECPR remained significantly associated with increased mortality (OR 3.67, (CI 1.66-8.31), p < .01) Conclusions. In this retrospective study of VA-ECMO for CS, we found an acceptable one-year survival rate of 40%, with a more favorable outcome for NIHF-patients. The negative association of ECPR with a higher 1 year mortality suggests the importance of patient selection as well as timing of the VA-ECMO before deterioration to cardiac arrest.","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":" ","pages":"2481179"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vasomotor and fibrinolytic effects of leptin in man. 瘦素在人体内的血管舒缩和纤溶作用。

IF 1.2 4区医学

Scandinavian Cardiovascular Journal Pub Date : 2025-12-01 Epub Date: 2025-03-19 DOI: 10.1080/14017431.2025.2478867

Manuel Gonzalez, Simon Robinson, Nicholas L Mills, Marie Eriksson, Thomas Sandström, David E Newby, Tommy Olsson, Anders Blomberg, Stefan Söderberg

{"title":"Vasomotor and fibrinolytic effects of leptin in man.","authors":"Manuel Gonzalez, Simon Robinson, Nicholas L Mills, Marie Eriksson, Thomas Sandström, David E Newby, Tommy Olsson, Anders Blomberg, Stefan Söderberg","doi":"10.1080/14017431.2025.2478867","DOIUrl":"10.1080/14017431.2025.2478867","url":null,"abstract":"Objectives: The adipocyte-derived hormone leptin has been associated with the pathogenesis of cardiovascular disease. The mechanisms underlying this association are unclear but may relate to effects on the vascular endothelium. Our aim was to explore the effects of leptin on endothelial vasomotor and fibrinolytic function in healthy volunteers and patients with coronary artery disease.Design: The vascular effects of leptin were assessed infusing recombinant human leptin in healthy volunteers during measuring vasomotor response by venous occlusion plethysmography. Additionally, circulating levels of leptin were analysed in relation to endothelial dysfunction in patients with established coronary artery disease.Results: In healthy male volunteers, intra-arterial infusion of recombinant human leptin (80, 800 and 8,000 ng/min; n = 10) did not affect basal forearm blood flow, plasma tissue plasminogen activator (tPA) or plasminogen activator inhibitor type 1 concentrations (all p > 0.05). However, during concomitant co-infusion with leptin (800 ng/min; n = 10), drug-induced vasodilatation was reduced (p = 0.001), and tPA activity increased (p = 0.002). In patients with coronary artery disease, those with the high plasma leptin levels had reduced drug-induced vasodilatation (p < 0.001), and increased net release of tPA antigen and activity (p < 0.001 and p = 0.03, respectively) compared to those with low levels. The study has been registered retrospectively at Clinical Trials with number NCT04374500.Conclusion: Intrabrachial leptin infusion did not affect the basal vascular tone, whereas acute and chronic hyperleptinemia was associated with blunted vasoreactivity in healthy volunteers, and in patients with coronary artery disease.","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":" ","pages":"2478867"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143606096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of atrial fibrillation among Swedish adults participating in the general population study EpiHealth. 参与EpiHealth一般人群研究的瑞典成年人房颤患病率

IF 1.2 4区医学

Scandinavian Cardiovascular Journal Pub Date : 2025-12-01 Epub Date: 2025-07-02 DOI: 10.1080/14017431.2025.2526044

Pernilla Höiby, Moncef Zarrouk, Lars Lind, Johan Sundström, Sölve Elmståhl

{"title":"Prevalence of atrial fibrillation among Swedish adults participating in the general population study EpiHealth.","authors":"Pernilla Höiby, Moncef Zarrouk, Lars Lind, Johan Sundström, Sölve Elmståhl","doi":"10.1080/14017431.2025.2526044","DOIUrl":"10.1080/14017431.2025.2526044","url":null,"abstract":"Objectives. This study aimed to estimate the prevalence of atrial fibrillation (AF) and identify its associated comorbidities in adults aged 45 years and older, using data from the Swedish general population study EpiHealth. Design. In a cross-sectional design, data of health history, lifestyle factors, anthropometric measurement, and 1-lead ECG recordings from participants in the EpiHealth study were linked to data from the Swedish Patient Registry. Results. Among the 22,616 participants (56.2% women), the overall prevalence of AF was 3.9%, of which 0.3% were newly diagnosed cases identified by single 1-lead ECG at cohort examination. AF prevalence was higher in men than in women across all age groups and increased with age, reaching 17.2% among men aged 75 years and older. Participants with AF had a higher prevalence of cardiovascular comorbidities compared to those without AF. Conclusions. The findings highlight the increasing prevalence of AF with advancing age and its higher occurrence in men compared to women. The screening-detected prevalence of AF of 0.3% among participants in this general population study suggests that simple 1-lead ECG could be a manageable approach to screen for AF. The strong association between AF and cardiovascular comorbidities emphasizes the need for management strategies to address this condition, particularly in older adults.","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":" ","pages":"2526044"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144529502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CircFNDC3B inhibits vascular smooth muscle cells proliferation in abdominal aortic aneurysms by targeting the miR-1270/PDCD10 axis. CircFNDC3B通过靶向miR-1270/PDCD10轴抑制腹主动脉瘤血管平滑肌细胞增殖。

IF 1.2 4区医学

Scandinavian Cardiovascular Journal Pub Date : 2025-12-01 Epub Date: 2024-12-21 DOI: 10.1080/14017431.2024.2441114

Baoping Deng, Jing Xu, Yue Wei, Jinfeng Zhang, Na Zeng, Yulan He, Qiaoli Zeng, Dehua Zou, Runmin Guo

{"title":"CircFNDC3B inhibits vascular smooth muscle cells proliferation in abdominal aortic aneurysms by targeting the miR-1270/PDCD10 axis.","authors":"Baoping Deng, Jing Xu, Yue Wei, Jinfeng Zhang, Na Zeng, Yulan He, Qiaoli Zeng, Dehua Zou, Runmin Guo","doi":"10.1080/14017431.2024.2441114","DOIUrl":"10.1080/14017431.2024.2441114","url":null,"abstract":"Objectives. This study investigated the role and underlying regulatory mechanisms of circular RNA fibronectin type III domain containing 3B (circFNDC3B) in abdominal aortic aneurysm (AAA). Methods. The expression of circFNDC3B in AAA and normal tissues was assessed by quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR). To evaluate the biological functions of circFNDC3B, assays were employed including 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT), flow cytometry, and Caspase-3 activity assays. Additionally, RNA immunoprecipitation (RIP), dual-luciferase reporter assay, Western blotting, and rescue experiments were utilized to elucidate the molecular mechanism of circFNDC3B. Results. Our findings revealed a significant upregulation of circFNDC3B expression in AAA clinical specimens compared to normal tissues. Functionally, overexpression of circFNDC3B inhibited vascular smooth muscle cells (VSMCs) proliferation and induced apoptosis, contributing to AAA formation in the Ang II-induced AAA model. Mechanistically, circFNDC3B acted as a molecular sponge for miR-1270, leading to the upregulation of programmed cell death 10 (PDCD10). Decreased expression of PDCD10 abrogated the -promoting effects of circFNDC3B overexpression on AAA development. Conclusions. This study demonstrates that circFNDC3B promotes the progression of AAA by targeting the miR-1270/PDCD10 pathway. Our findings suggest that circFNDC3B as well as miR-1270/PDCD10 pathway may serve as a potential therapeutic target for AAA treatment.","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":" ","pages":"2441114"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0