Scandinavian Cardiovascular Journal最新文献

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Value of preparticipation cardiovascular evaluation of master athletes by self-reported symptoms and cardiovascular risk-score. 通过自述症状和心血管风险评分对大师级运动员进行赛前心血管评估的价值。
IF 1.2 4区 医学
Scandinavian Cardiovascular Journal Pub Date : 2024-12-01 Epub Date: 2024-10-23 DOI: 10.1080/14017431.2024.2418089
Jostein Grimsmo, Kristina Hermann Haugaa, Ivan Popovic, Øyvind Haugen Lie, Erik Ekker Solberg
{"title":"Value of preparticipation cardiovascular evaluation of master athletes by self-reported symptoms and cardiovascular risk-score.","authors":"Jostein Grimsmo, Kristina Hermann Haugaa, Ivan Popovic, Øyvind Haugen Lie, Erik Ekker Solberg","doi":"10.1080/14017431.2024.2418089","DOIUrl":"https://doi.org/10.1080/14017431.2024.2418089","url":null,"abstract":"<p><p>The risk of sudden cardiac death (SCD) is increased during endurance competitive sports. Coronary artery disease (CAD) is the most common cause of SCD in master athletes ≥ 35 years old (MAs). To reduce the risk of SCD self-assessment of symptoms by questionnaire, and evaluation of cardiovascular risk-score, are recommended as pre-participation cardiovascular evaluation (PCVE). We aimed to examine whether PCVE predicts CVD in MAs with or without increased risk as measured by validated score instruments.</p><p><p>We performed a single-site observational cohort study of healthy MAs based on findings at PCVE. They were allocated in two different groups: those MAs with reported symptoms on the questionnaire and/or with elevated cardiovascular risk score were allocated to a symptom group (SG), while MAs with no symptoms, nor raised risk score were defined as control group (CG). Thereafter, all were examined with extended examinations: resting-ECG, cardiorespiratory exercise testing and echocardiography.</p><p><p>Total, 81 (18 women) MAs participated in the study. There were no differences at baseline between SG (<i>n</i> = 39) and CG (<i>n</i> = 42); sex (<i>p</i> = 0.11), age (55.0 ± 9.8 vs. 51.9 ± 11.1 years; <i>p</i> = 0.18), maximal oxygen uptake (49.8 ± 7.6 vs. 51.6 ± 7.0 ml/kg/min; <i>p</i> = 0.26), resting heart rate (61.4 ± 12.8 vs. 60.2 ± 11.0/min; <i>p</i> = 0.66), training hours/week (7.0 ± 3.2 vs. 7.1 ± 3.1; <i>p</i> = 0.88). After further examination, sixteen (20%) MAs were found with CVD: 12 in SG, 4 in CG (<i>p</i> = 0.024). The negative predictive value and specificity of the PCVE were 90% and 58%, respectively.</p><p><p>Negative findings on PCVE by questionnaire and cardiovascular risk-score may be a strategy to exclude subjects from preparticipation screening, thus saving resources.</p>","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142507002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of stress-induced hyperglycemia on long-term mortality in non-diabetic patients with acute type A aortic dissection: a retrospective analysis. 应激性高血糖对急性 A 型主动脉夹层非糖尿病患者长期死亡率的影响:回顾性分析。
IF 1.2 4区 医学
Scandinavian Cardiovascular Journal Pub Date : 2024-12-01 Epub Date: 2024-07-01 DOI: 10.1080/14017431.2024.2373099
Zhang Liu, Weiqin Huang
{"title":"Effect of stress-induced hyperglycemia on long-term mortality in non-diabetic patients with acute type A aortic dissection: a retrospective analysis.","authors":"Zhang Liu, Weiqin Huang","doi":"10.1080/14017431.2024.2373099","DOIUrl":"https://doi.org/10.1080/14017431.2024.2373099","url":null,"abstract":"<p><strong>Background: </strong>Acute Type A Aortic Dissection (AAAD) is one of the most life-threatening diseases, often associated with transient hyperglycemia induced by acute physiological stress. The impact of stress-induced hyperglycemia on the prognosis of ST-segment elevation myocardial infarction has been reported. However, the relationship between stress-induced hyperglycemia and the prognosis of AAAD patients remains uncertain.</p><p><strong>Methods: </strong>The clinical data of 456 patients with acute type A aortic dissection were retrospectively reviewed. Patients were divided into two groups based on their admission blood glucose. Cox model regression analysis was performed to assess the relationship between stress-induced hyperglycemia and the 30-day and 1-year mortality rates of these patients.</p><p><strong>Results: </strong>Among the 456 patients, 149 cases (32.7%) had AAAD combined with stress-induced hyperglycemia (SIH). The results of the multifactor regression analysis of the Cox model indicated that hyperglycemia (RR = 1.505, 95% CI: 1.046-2.165, <i>p</i> = 0.028), aortic coarctation involving renal arteries (RR = 3.330, 95% CI: 2.237-4.957, <i>p</i> < 0.001), aortic coarctation involving superior mesenteric arteries (RR = 1.611, 95% CI: 1.056-2.455, <i>p</i> = 0.027), and aortic coarctation involving iliac arteries (RR = 2.034, 95% CI: 1.364-3.035, <i>p</i> = 0.001) were independent influences on 1-year postoperative mortality in AAAD patients.</p><p><strong>Conclusion: </strong>The current findings indicate that stress-induced hyperglycemia measured on admission is strongly associated with 1-year mortality in patients with AAAD. Furthermore, stress-induced hyperglycemia may be related to the severity of the condition in patients with AAAD.</p>","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141470582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Management of bifurcation lesions with active side branch protection strategies. 采用主动侧枝保护策略管理分叉病变。
IF 1.2 4区 医学
Scandinavian Cardiovascular Journal Pub Date : 2024-12-01 Epub Date: 2024-08-08 DOI: 10.1080/14017431.2024.2389897
Berkay Serter, Cemalettin Akman, Abdullah Doğan, Ahmet Güner, Fatih Uzun
{"title":"Management of bifurcation lesions with active side branch protection strategies.","authors":"Berkay Serter, Cemalettin Akman, Abdullah Doğan, Ahmet Güner, Fatih Uzun","doi":"10.1080/14017431.2024.2389897","DOIUrl":"https://doi.org/10.1080/14017431.2024.2389897","url":null,"abstract":"","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141907613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Symptoms during pregnancy in primiparous women with congenital heart disease. 患有先天性心脏病的初产妇在怀孕期间的症状。
IF 2.2 4区 医学
Scandinavian Cardiovascular Journal Pub Date : 2024-12-01 Epub Date: 2024-01-08 DOI: 10.1080/14017431.2024.2302135
Annika Bay, Malin Berghammer, Åsa Burström, Ylva Holstad, Christina Christersson, Mikael Dellborg, Aleksandra Trzebiatowska-Krzynska, Peder Sörensson, Ulf Thilén, Bengt Johansson
{"title":"Symptoms during pregnancy in primiparous women with congenital heart disease.","authors":"Annika Bay, Malin Berghammer, Åsa Burström, Ylva Holstad, Christina Christersson, Mikael Dellborg, Aleksandra Trzebiatowska-Krzynska, Peder Sörensson, Ulf Thilén, Bengt Johansson","doi":"10.1080/14017431.2024.2302135","DOIUrl":"https://doi.org/10.1080/14017431.2024.2302135","url":null,"abstract":"<p><p><i>Background:</i> As more women with congenital heart disease (CHD) are reaching childbearing age, it becomes more common for their symptoms to be evaluated during pregnancy. However, pregnancy-related symptoms are similar to those caused by heart disease. This study investigated the prevalence of factors associated with symptoms during pregnancy in women with CHD. <i>Methods:</i> The national birth register was searched for primiparous women with CHD who were registered in the national quality register for patients with CHD. <i>Results:</i> Symptoms during the third trimester were reported in 104 of 465 evaluated women. The most common symptom was palpitations followed by dyspnea. Factors associated with symptoms were tested in a univariable model; higher NYHA classification (>1) (OR 11.3, 95%CI 5.5-23.2), low physical activity (≤3 h/week) (OR 2.1 95%CI 1.3-3.6) and educational level ≤ 12 years (OR 1.9 95%CI 1.2-3.0) were associated with having symptoms. In multivariable analysis, low physical activity level (OR 2.4 95%CI 1.2-5.0) and higher NYHA class (OR 11.3 95%CI 5.0-25.6) remained associated with symptoms during pregnancy. There were no cases with new onset of impaired systemic ventricular function during pregnancy. <i>Conclusion:</i> Symptoms during pregnancy are common in women with CHD but are often already present before pregnancy. Because ordinary symptoms during pregnancy often overlap with symptoms of heart disease, it is important to know if symptoms were present before pregnancy and if they became worse during pregnancy. These results should be included in pre-pregnancy counselling and considered in the monitoring during pregnancy.</p>","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139404189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Growth, survival and events in patients with aortic arch pathology. 主动脉弓病变患者的生长、存活和事件。
IF 1.2 4区 医学
Scandinavian Cardiovascular Journal Pub Date : 2024-12-01 Epub Date: 2024-09-25 DOI: 10.1080/14017431.2024.2406790
Emelie Carlestål, Anders Franco-Cereceda, Christian Olsson
{"title":"Growth, survival and events in patients with aortic arch pathology.","authors":"Emelie Carlestål, Anders Franco-Cereceda, Christian Olsson","doi":"10.1080/14017431.2024.2406790","DOIUrl":"https://doi.org/10.1080/14017431.2024.2406790","url":null,"abstract":"<p><strong>Objectives: </strong>This study describes aortic growth, survival and events in patients with aortic arch pathology.</p><p><strong>Methods: </strong>Patients with an index diameter ≥4.5 cm or other pathology of the native aortic arch, were followed with longitudinal computed tomography and clinical data collected retrospectively. Aortic growth was estimated using a linear mixed model. Survival and event rates were estimated using Kaplan-Meier methods. Cox analysis assessed clinical and radiological predictors with outcomes (death, local or remote aortic events (acute aortic syndromes or intervention)). <i>Results.</i> 186 patients underwent 683 CT scans during 638 of patient years. The estimated annual growth was 0.28 (mm/year). 47 (25%) patients had an event and a 66% five-year event-free survival. 29 patients died, of whom 11 suffered an aortic death. 19 events were local and 25 events were remote, mostly primary events were interventions. In Cox analysis, increasing descending aortic diameter was an independent predictor of all cause of death (hazard ratio [HR], 2.16), aortic death (HR 4.81), and local event (HR 1.71). <i>Conclusions.</i> In patients with aortic arch pathology, growth, and aortic events should be expected. Increasing descending aortic diameter could presage an added risk, but other variables appear needed to identify patients at risk, select them for intervention or surveillance.</p>","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142353032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Non-invasive pressure-volume loops show high arterial elastance in children with repaired tetralogy of Fallot. 无创压力-容积环路显示法洛氏四联症修复患儿的动脉弹性较高。
IF 1.2 4区 医学
Scandinavian Cardiovascular Journal Pub Date : 2024-12-01 Epub Date: 2024-10-24 DOI: 10.1080/14017431.2024.2418085
Viggo Klementsson, Misha Bhat, Katarina Steding-Ehrenborg, Erik Hedström, Petru Liuba, Pia Sjöberg
{"title":"Non-invasive pressure-volume loops show high arterial elastance in children with repaired tetralogy of Fallot.","authors":"Viggo Klementsson, Misha Bhat, Katarina Steding-Ehrenborg, Erik Hedström, Petru Liuba, Pia Sjöberg","doi":"10.1080/14017431.2024.2418085","DOIUrl":"https://doi.org/10.1080/14017431.2024.2418085","url":null,"abstract":"<p><strong>Background: </strong>Children with repaired tetralogy of Fallot (rToF) often have pulmonary regurgitation with right ventricular (RV) dilatation and dysfunction, whereas less is known about the effect on the left ventricle (LV). The aim was to investigate LV haemodynamic variables derived from non-invasive pressure-volume loops in children with rToF and how they compare to controls and previous research on adults.</p><p><strong>Materials and methods: </strong>Ten children with rToF and pulmonary regurgitation (12 years [10-13], 6 males) and 10 age- and sex-matched healthy controls (12 years [10-14], 6 males) underwent brachial blood pressure in conjunction with cardiac magnetic resonance imaging. Pressure-volume loops were derived by brachial blood pressure together with LV volumes throughout the cardiac cycle in short-axis cine images yielding several haemodynamic variables, including arterial elastance. The RV endocardial border was delineated in end-diastole and end-systole.</p><p><strong>Results: </strong>Children with rToF and pulmonary regurgitation had larger RV end-diastolic volume (136 [114-156]) than controls (100 [94-112] ml/m<sup>2</sup>; <i>p</i> = 0.0015) and smaller LV end-diastolic volume (83 [58-91] ml/m<sup>2</sup>) than controls (101 [92-110] ml/m<sup>2</sup>; <i>p</i> = 0.002). Arterial elastance was higher in children with rToF (1.5 [1.3-2.7] mmHg/ml) than in controls (1.1 [1.0-1.5] mmHg/ml; <i>p</i> = 0.02). Heart rate was higher in children with rToF (77 [74-81] bpm) than in controls (69 [65-75] bpm; <i>p</i> = 0.027).</p><p><strong>Conclusion: </strong>Children with rToF had higher arterial elastance and heart rate than controls, likely due to increased sympathetic tone to compensate for impaired LV filling following pulmonary regurgitation. If this contributes to increased risk of adverse cardiovascular and cerebrovascular events remains to be studied.</p>","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142507001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of normal body mass index and weight loss with long-term major cardiovascular events after PCI for myocardial infarction. 正常体重指数和体重减轻与 PCI 治疗心肌梗死后长期主要心血管事件的关系。
IF 1.2 4区 医学
Scandinavian Cardiovascular Journal Pub Date : 2024-12-01 Epub Date: 2024-08-06 DOI: 10.1080/14017431.2024.2386984
Jan Erik Otterstad, John Munkhaugen, Vidar Ruddox, Thor Edvardsen, Jøran Hjelmesæth
{"title":"Association of normal body mass index and weight loss with long-term major cardiovascular events after PCI for myocardial infarction.","authors":"Jan Erik Otterstad, John Munkhaugen, Vidar Ruddox, Thor Edvardsen, Jøran Hjelmesæth","doi":"10.1080/14017431.2024.2386984","DOIUrl":"https://doi.org/10.1080/14017431.2024.2386984","url":null,"abstract":"<p><p><i>Objectives:</i> To investigate whether normal body mass index (BMI) shortly after percutaneous coronary intervention (PCI) for myocardial infarction is associated with increased risk of long-term major cardiovascular events (MACE), and to explore potential clinical determinants of long-term weight loss (WL) after PCI. <i>Methods:</i> Single-center cohort study with 5-year follow-up of patients treated with PCI for myocardial infarction between 2016 and 2018. Categorical WL was defined as > 0 kg body weight reduction from baseline to end of follow-up. <i>Results:</i> Of 236 patients (24% women), mean age was 64.9 ± 10.2 years and mean BMI within 4 days after PCI was 27.1 ± 4.3 kg/m<sup>2</sup>. Seventy-five patients (32%) had at least one MACE, equally distributed between those with normal weight (31%), overweight (32%), and obesity (31%). Patients with overweight or obesity had a lower crude mortality rate than their normal weight counterparts (7.4% vs 16.4%, <i>p</i> = 0.049), but the relative hazard of death did not differ from those with normal weight, HR 0.50, 95% CI 0.22-1.15. Patients with either a long-term WL (<i>n</i> = 112) or no WL (<i>n</i> = 95) had a comparable incidence of non-fatal MACE (27% vs 22%, <i>p</i> = 0.518). The proportion of patients reporting unintentional weight loss was significantly higher in the normal weight group (82%) compared with those with overweight (41%) or obesity (28%), <i>p</i> < 0.001. <i>Conclusion:</i> Our results did not confirm any association between normal BMI after PCI and long-term MACE. However, patients with normal BMI at baseline had a higher incidence of unintentional WL than those with elevated BMI. Trial registration: Current research information system in Norway (CRISTIN): ID 542528.</p>","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141898128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Single center outcomes after temporary mechanical circulatory assist device prior to Heartmate 3 implantation - a retrospective cohort study. 在植入 Heartmate 3 之前使用临时机械循环辅助装置后的单中心结果 - 一项回顾性队列研究。
IF 1.2 4区 医学
Scandinavian Cardiovascular Journal Pub Date : 2024-12-01 Epub Date: 2024-07-04 DOI: 10.1080/14017431.2024.2353066
Imran Jamal Iversen, Finn Gustafsson, Kasper Rossing, Peter Hasse Møller-Sørensen, Peter Skov Olsen, Christian Holdflod Møller
{"title":"Single center outcomes after temporary mechanical circulatory assist device prior to Heartmate 3 implantation - a retrospective cohort study.","authors":"Imran Jamal Iversen, Finn Gustafsson, Kasper Rossing, Peter Hasse Møller-Sørensen, Peter Skov Olsen, Christian Holdflod Møller","doi":"10.1080/14017431.2024.2353066","DOIUrl":"https://doi.org/10.1080/14017431.2024.2353066","url":null,"abstract":"<p><p><i>Objectives</i>. Temporary mechanical circulatory support (TMCS) has become a component in the therapeutic strategy for treatment of cardiogenic shock as a bridge-to-decision. TMCS can facilitate recovery of cardiopulmonary function, end-organ function, and potentially reduce the surgical risk of left ventricular assist device (LVAD) implantation. Despite the improvements of hemodynamics and end-organ function, post-LVAD operative morbidity might be increased in these high-risk patients. The aim of the study was to compare outcomes after Heartmate 3 (HM3) implantation in patients with and without TMCS prior to HM3 implant. <i>Methods.</i> In this retrospective cohort study of all HM3 patients in the period between November 2015 and October 2021, patients with and without prior TMCS were compared. Patients' demographics, baseline clinical characteristics, laboratory tests, intraoperative variables, postoperative outcomes, and adverse events were collected from patient records. <i>Results.</i> The TMCS group showed an improvement in hemodynamics prior to LVAD implantation. Median TMCS duration was 19.5 (14-26) days. However, the TMCS group were more coagulopathic, had more wound infections, neurological complications, and more patients were on dialysis compared with patient without TMCS prior to HM3 implantation. Survival four years after HM3 implantation was 80 and 82% in the TMCS (<i>N</i> = 22) and non-TMCS group (<i>N</i> = 41), respectively. <i>Conclusion</i>. Patients on TMCS had an acceptable short and long-term survival and comparable to patients receiving HM3 without prior TMCS. However, they had a more complicated postoperative course.</p>","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141498879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In Nordic countries 30-day mortality rate is half that estimated with EuroSCORE II in high-risk adult patients given aprotinin and undergoing mainly complex cardiac procedures. 在北欧国家,主要接受复杂心脏手术的高危成人患者服用阿普罗宁后,30 天的死亡率仅为 EuroSCORE II 估计死亡率的一半。
IF 2.2 4区 医学
Scandinavian Cardiovascular Journal Pub Date : 2024-12-01 Epub Date: 2024-03-31 DOI: 10.1080/14017431.2024.2330347
Jan van der Linden, Thomas Fux, Timo Kaakinen, Juha Rutanen, Jenni M Toivonen, Fredrik Nyström, Alexander Wahba, Bengt Hammas, Maria Parviainen, Doris Cunha-Goncalves, Seppo Hiippala
{"title":"In Nordic countries 30-day mortality rate is half that estimated with EuroSCORE II in high-risk adult patients given aprotinin and undergoing mainly complex cardiac procedures.","authors":"Jan van der Linden, Thomas Fux, Timo Kaakinen, Juha Rutanen, Jenni M Toivonen, Fredrik Nyström, Alexander Wahba, Bengt Hammas, Maria Parviainen, Doris Cunha-Goncalves, Seppo Hiippala","doi":"10.1080/14017431.2024.2330347","DOIUrl":"10.1080/14017431.2024.2330347","url":null,"abstract":"<p><p><i>Objectives.</i> To describe current on- (isolated coronary arterty bypass grafting, iCABG) and off-label (non-iCABG) use of aprotinin and associated safety endpoints in adult patients undergoing high-risk cardiac surgery in Nordic countries. <i>Design.</i> Data come from 10 cardiac surgery centres in Finland, Norway and Sweden participating in the European Nordic aprotinin patient registry (NAPaR). <i>Results.</i> 486 patients were given aprotinin between 2016 and 2020. 59 patients (12.1%) underwent iCABG and 427 (87.9%) non-iCABG, including surgery for aortic dissection (16.7%) and endocarditis (36.0%). 89.9% were administered a full aprotinin dosage and 37.0% were re-sternotomies. Dual antiplatelet treatment affected 72.9% of iCABG and 7.0% of non-iCABG patients. 0.6% of patients had anaphylactic reactions associated with aprotinin. 6.4% (95 CI% 4.2%-8.6%) of patients were reoperated for bleeding. Rate of postoperative thromboembolic events, day 1 rise in creatinine >44μmol/L and new dialysis for any reason was 4.7% (95%CI 2.8%-6.6%), 16.7% (95%CI 13.4%-20.0%) and 14.0% (95%CI 10.9%-17.1%), respectively. In-hospital mortality and 30-day mortality was 4.9% (95%CI 2.8%-6.9%) and 6.3% (95%CI 3.7%-7.8%) in all patients versus mean EuroSCORE II 11.4% (95%CI 8.4%-14.0%, <i>p</i> < .01). 30-day mortality in patients undergoing surgery for aortic dissection and endocarditis was 6.2% (95%CI 0.9%-11.4%) and 6.3% (95%CI 2.7%-9.9%) versus mean EuroSCORE II 13.2% (95%CI 6.1%-21.0%, <i>p</i> = .11) and 14.5% (95%CI 12.1%-16.8%, <i>p</i> = .01), respectively. <i>Conclusions.</i> NAPaR data from Nordic countries suggest a favourable safety profile of aprotinin in adult cardiac surgery.</p>","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140332019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A reply to the letter to the editor "Management of bifurcation lesions with active side branch protection strategies". 回复致编辑的信 "采用主动侧支保护策略管理分叉病变"。
IF 1.2 4区 医学
Scandinavian Cardiovascular Journal Pub Date : 2024-12-01 Epub Date: 2024-08-09 DOI: 10.1080/14017431.2024.2389901
Jiuchun Qiu, Longyan Li, Weiding Wang, Xinjian Li, Zizhao Zhang, Shuai Shao, Gary Tse, Guangping Li, Tong Liu
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