Scandinavian Cardiovascular Journal最新文献_第2页

The use of antiarrhythmic drugs for atrial fibrillation in Finland 2007-2018. 2007 - 2018年芬兰房颤抗心律失常药物的使用

IF 1 4区医学

Scandinavian Cardiovascular Journal Pub Date : 2025-12-01 Epub Date: 2025-02-20 DOI: 10.1080/14017431.2025.2467735

Rasmus Siponen, Juha Hartikainen, Janne Virrankorpi, Antti Lappalainen, Konsta Teppo, Olli Halminen, Aapo Aro, Annukka Marjamaa, Birgitta Salmela, Jari Haukka, Jukka Putaala, Miika Linna, Pirjo Mustonen, Juhani Airaksinen, Mika Lehto

{"title":"The use of antiarrhythmic drugs for atrial fibrillation in Finland 2007-2018.","authors":"Rasmus Siponen, Juha Hartikainen, Janne Virrankorpi, Antti Lappalainen, Konsta Teppo, Olli Halminen, Aapo Aro, Annukka Marjamaa, Birgitta Salmela, Jari Haukka, Jukka Putaala, Miika Linna, Pirjo Mustonen, Juhani Airaksinen, Mika Lehto","doi":"10.1080/14017431.2025.2467735","DOIUrl":"10.1080/14017431.2025.2467735","url":null,"abstract":"Background: Patients with atrial fibrillation (AF) are often treated with antiarrhythmic drugs (AADs) to maintain sinus rhythm and with heart rate-lowering drugs to achieve the optimal rate control. In this study, we investigated trends in the use of AADs and rate control drugs in Finnish patients with AF.Methods and results: The Finnish AntiCoagulation in Atrial Fibrillation (FinACAF) study is a nationwide study including all patients with AF in Finland from 2007 to 2018. The number of AAD purchases and the proportions of all prevalent AF patients in a certain year of interest were calculated. In total, 391030 AF patients were identified between 2007 and 2018, and 39,816 (10.2%) of them had purchased either class I or III AADs. The proportion of patients using classes I and III AADs decreased from 8.6% to 6.3%. Flecainide and amiodarone were the most often used AADs. The use of flecainide and amiodarone decreased from 4.9% to 3.9% and 1.9% to 1.5%, respectively. The proportion of patients on beta-blockers remained stable at 75%. Dronedarone became available in 2011 when it also was the most used (0.8% of patients), but the use decreased thereafter. The use of sotalol and digoxin decreased from 1.5% to 0.6% and 24.6% to 11.0% over the study period.Conclusion: The number of AAD purchases increased alongside with the increasing prevalence of AF, whereas the proportion of AF patients on classes I and III AADs and digoxin decreased between 2007 and 2018. Flecainide remained the most used AAD followed by amiodarone.","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":" ","pages":"2467735"},"PeriodicalIF":1.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143415088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vasomotor and fibrinolytic effects of leptin in man. 瘦素在人体内的血管舒缩和纤溶作用。

IF 1 4区医学

Scandinavian Cardiovascular Journal Pub Date : 2025-12-01 Epub Date: 2025-03-19 DOI: 10.1080/14017431.2025.2478867

Manuel Gonzalez, Simon Robinson, Nicholas L Mills, Marie Eriksson, Thomas Sandström, David E Newby, Tommy Olsson, Anders Blomberg, Stefan Söderberg

{"title":"Vasomotor and fibrinolytic effects of leptin in man.","authors":"Manuel Gonzalez, Simon Robinson, Nicholas L Mills, Marie Eriksson, Thomas Sandström, David E Newby, Tommy Olsson, Anders Blomberg, Stefan Söderberg","doi":"10.1080/14017431.2025.2478867","DOIUrl":"10.1080/14017431.2025.2478867","url":null,"abstract":"Objectives: The adipocyte-derived hormone leptin has been associated with the pathogenesis of cardiovascular disease. The mechanisms underlying this association are unclear but may relate to effects on the vascular endothelium. Our aim was to explore the effects of leptin on endothelial vasomotor and fibrinolytic function in healthy volunteers and patients with coronary artery disease.Design: The vascular effects of leptin were assessed infusing recombinant human leptin in healthy volunteers during measuring vasomotor response by venous occlusion plethysmography. Additionally, circulating levels of leptin were analysed in relation to endothelial dysfunction in patients with established coronary artery disease.Results: In healthy male volunteers, intra-arterial infusion of recombinant human leptin (80, 800 and 8,000 ng/min; n = 10) did not affect basal forearm blood flow, plasma tissue plasminogen activator (tPA) or plasminogen activator inhibitor type 1 concentrations (all p > 0.05). However, during concomitant co-infusion with leptin (800 ng/min; n = 10), drug-induced vasodilatation was reduced (p = 0.001), and tPA activity increased (p = 0.002). In patients with coronary artery disease, those with the high plasma leptin levels had reduced drug-induced vasodilatation (p < 0.001), and increased net release of tPA antigen and activity (p < 0.001 and p = 0.03, respectively) compared to those with low levels. The study has been registered retrospectively at Clinical Trials with number NCT04374500.Conclusion: Intrabrachial leptin infusion did not affect the basal vascular tone, whereas acute and chronic hyperleptinemia was associated with blunted vasoreactivity in healthy volunteers, and in patients with coronary artery disease.","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":" ","pages":"2478867"},"PeriodicalIF":1.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143606096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiogenic shock and extracorporeal membrane oxygenation: etiology and 1-year survival. 心源性休克和体外膜氧合：病因和1年生存率。

IF 1 4区医学

Scandinavian Cardiovascular Journal Pub Date : 2025-12-01 Epub Date: 2025-03-25 DOI: 10.1080/14017431.2025.2481179

Inga L Ingvarsdottir, Andreas Westerlind, Isabella Lepore, Tomas Gudbjartsson, Bengt Redfors, Göran Dellgren

{"title":"Cardiogenic shock and extracorporeal membrane oxygenation: etiology and 1-year survival.","authors":"Inga L Ingvarsdottir, Andreas Westerlind, Isabella Lepore, Tomas Gudbjartsson, Bengt Redfors, Göran Dellgren","doi":"10.1080/14017431.2025.2481179","DOIUrl":"10.1080/14017431.2025.2481179","url":null,"abstract":"Objectives. Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is used to provide cardiorespiratory support in cardiogenic shock (CS), but selection of patients and timing of ECMO-start remain a challenge. This study aims to describe the 1 year outcome of VA-ECMO for CS with focus on etiology and severity of shock. Methods. VA-ECMO was used on 371 occasions between 2004 and 2019 at our center. Of these, 177 patients received VA-ECMO for CS and were included in this retrospective single-center study. Univariable and multivariable logistic regression models were used to determine predictors of all-cause mortality at 1 year. Results. Patients were grouped according to underlying etiology: non-ischemic heart failure (NIHF, N = 49), ischemic heart disease (IHD, N = 83) and miscellaneous diagnoses (Misc, N = 45). Markers of disease severity were lower for patients with NIHF. One year survival was 40% for all patients, 57%, 36% and 27% for the NIHF-, IHD and Misc-groups, respectively (p < .01). Univariable logistic regression analysis identified several variables associated with 1-year mortality, such as underlying etiology, pH and lactate, while biventricular failure was associated with a better prognosis. However, in the multivariable analysis, only ECPR remained significantly associated with increased mortality (OR 3.67, (CI 1.66-8.31), p < .01) Conclusions. In this retrospective study of VA-ECMO for CS, we found an acceptable one-year survival rate of 40%, with a more favorable outcome for NIHF-patients. The negative association of ECPR with a higher 1 year mortality suggests the importance of patient selection as well as timing of the VA-ECMO before deterioration to cardiac arrest.","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":" ","pages":"2481179"},"PeriodicalIF":1.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of atrial fibrillation among Swedish adults participating in the general population study EpiHealth. 参与EpiHealth一般人群研究的瑞典成年人房颤患病率

IF 1 4区医学

Scandinavian Cardiovascular Journal Pub Date : 2025-12-01 Epub Date: 2025-07-02 DOI: 10.1080/14017431.2025.2526044

Pernilla Höiby, Moncef Zarrouk, Lars Lind, Johan Sundström, Sölve Elmståhl

{"title":"Prevalence of atrial fibrillation among Swedish adults participating in the general population study EpiHealth.","authors":"Pernilla Höiby, Moncef Zarrouk, Lars Lind, Johan Sundström, Sölve Elmståhl","doi":"10.1080/14017431.2025.2526044","DOIUrl":"10.1080/14017431.2025.2526044","url":null,"abstract":"Objectives. This study aimed to estimate the prevalence of atrial fibrillation (AF) and identify its associated comorbidities in adults aged 45 years and older, using data from the Swedish general population study EpiHealth. Design. In a cross-sectional design, data of health history, lifestyle factors, anthropometric measurement, and 1-lead ECG recordings from participants in the EpiHealth study were linked to data from the Swedish Patient Registry. Results. Among the 22,616 participants (56.2% women), the overall prevalence of AF was 3.9%, of which 0.3% were newly diagnosed cases identified by single 1-lead ECG at cohort examination. AF prevalence was higher in men than in women across all age groups and increased with age, reaching 17.2% among men aged 75 years and older. Participants with AF had a higher prevalence of cardiovascular comorbidities compared to those without AF. Conclusions. The findings highlight the increasing prevalence of AF with advancing age and its higher occurrence in men compared to women. The screening-detected prevalence of AF of 0.3% among participants in this general population study suggests that simple 1-lead ECG could be a manageable approach to screen for AF. The strong association between AF and cardiovascular comorbidities emphasizes the need for management strategies to address this condition, particularly in older adults.","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":" ","pages":"2526044"},"PeriodicalIF":1.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144529502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reply to the letter regarding: Validity of a smartwatch to detect atrial fibrillation in patients after heart valve surgery - a prospective observational study. 关于智能手表在心脏瓣膜手术后检测心房颤动的有效性的回复——一项前瞻性观察研究。

IF 1 4区医学

Scandinavian Cardiovascular Journal Pub Date : 2025-12-01 Epub Date: 2025-09-29 DOI: 10.1080/14017431.2025.2566057

Margrethe Müller, Tove Aminda Hanssen, Gyrd Thrane

引用次数: 0

Smartwatch ECGs in postoperative care: a validated step toward digital rhythm monitoring. 术后护理中的智能手表心电图：迈向数字心律监测的有效一步。

IF 1 4区医学

Scandinavian Cardiovascular Journal Pub Date : 2025-12-01 Epub Date: 2025-09-29 DOI: 10.1080/14017431.2025.2566045

Wahab Khawar Siddiqui

引用次数: 0

CircFNDC3B inhibits vascular smooth muscle cells proliferation in abdominal aortic aneurysms by targeting the miR-1270/PDCD10 axis. CircFNDC3B通过靶向miR-1270/PDCD10轴抑制腹主动脉瘤血管平滑肌细胞增殖。

IF 1.2 4区医学

Scandinavian Cardiovascular Journal Pub Date : 2025-12-01 Epub Date: 2024-12-21 DOI: 10.1080/14017431.2024.2441114

Baoping Deng, Jing Xu, Yue Wei, Jinfeng Zhang, Na Zeng, Yulan He, Qiaoli Zeng, Dehua Zou, Runmin Guo

{"title":"CircFNDC3B inhibits vascular smooth muscle cells proliferation in abdominal aortic aneurysms by targeting the miR-1270/PDCD10 axis.","authors":"Baoping Deng, Jing Xu, Yue Wei, Jinfeng Zhang, Na Zeng, Yulan He, Qiaoli Zeng, Dehua Zou, Runmin Guo","doi":"10.1080/14017431.2024.2441114","DOIUrl":"10.1080/14017431.2024.2441114","url":null,"abstract":"Objectives. This study investigated the role and underlying regulatory mechanisms of circular RNA fibronectin type III domain containing 3B (circFNDC3B) in abdominal aortic aneurysm (AAA). Methods. The expression of circFNDC3B in AAA and normal tissues was assessed by quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR). To evaluate the biological functions of circFNDC3B, assays were employed including 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT), flow cytometry, and Caspase-3 activity assays. Additionally, RNA immunoprecipitation (RIP), dual-luciferase reporter assay, Western blotting, and rescue experiments were utilized to elucidate the molecular mechanism of circFNDC3B. Results. Our findings revealed a significant upregulation of circFNDC3B expression in AAA clinical specimens compared to normal tissues. Functionally, overexpression of circFNDC3B inhibited vascular smooth muscle cells (VSMCs) proliferation and induced apoptosis, contributing to AAA formation in the Ang II-induced AAA model. Mechanistically, circFNDC3B acted as a molecular sponge for miR-1270, leading to the upregulation of programmed cell death 10 (PDCD10). Decreased expression of PDCD10 abrogated the -promoting effects of circFNDC3B overexpression on AAA development. Conclusions. This study demonstrates that circFNDC3B promotes the progression of AAA by targeting the miR-1270/PDCD10 pathway. Our findings suggest that circFNDC3B as well as miR-1270/PDCD10 pathway may serve as a potential therapeutic target for AAA treatment.","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":" ","pages":"2441114"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Minimally invasive mitral valve surgery in a non-high volume center. 微创二尖瓣手术在非高容量中心。

IF 1 4区医学

Scandinavian Cardiovascular Journal Pub Date : 2025-12-01 Epub Date: 2025-06-13 DOI: 10.1080/14017431.2025.2514743

Anna Albåge, Hans Granfeldt, Farkas Vánky

{"title":"Minimally invasive mitral valve surgery in a non-high volume center.","authors":"Anna Albåge, Hans Granfeldt, Farkas Vánky","doi":"10.1080/14017431.2025.2514743","DOIUrl":"10.1080/14017431.2025.2514743","url":null,"abstract":"Objectives. In September 2019, the preferred surgical approach shifted for patients undergoing mitral valve (MV) surgery at our institution. The aim of this study was to compare minimally invasive surgery (MIS) with prior conventional sternotomy (CS) approach, to assess quality and safety of MIS in a non-high volume center. Methods. This single-center retrospective observational study comprised 254 patients, 102 CS patients and 152 MIS patients, who underwent MV surgery for mitral regurgitation with or without concomitant procedures (i.e. tricuspid valve surgery, atrial fibrillation ablation, closure of ASD) between January 2015 and October 2023. Results. CS patients were older with a higher preoperative risk profile. Mitral repair was the predominant procedure regardless of surgical approach. MIS had longer intraoperative times, yet were equal to CS in regard to myocardial injury, intensive care unit stay and postoperative complications. MIS had lower rates of permanent pacemaker insertions (4% vs. 13%; p < .014) and a shorter postoperative length of stay (5 vs. 7 days; p < .001). The 30-day mortality was low (1% vs 2%; p > .5). Proposed learning curve of MIS was demonstrated by a tendency of reduced intraoperative times with growing experience. Conclusions. MIS is a feasible alternative to the CS approach for MV surgery even at non-high volume centers. MV surgery with MIS results in a shorter postoperative length of stay, with comparable outcomes in terms of low mortality as well as surgical and postoperative morbidity. We believe that the prolonged intraoperative times will shorten with increased experience of these procedures.","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":" ","pages":"2514743"},"PeriodicalIF":1.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ex vivo resuscitation and evaluation of hearts after 22 minutes of normothermic cardiac arrest. 正常心脏骤停22分钟后的体外复苏和心脏评估。

IF 1 4区医学

Scandinavian Cardiovascular Journal Pub Date : 2025-12-01 Epub Date: 2025-06-27 DOI: 10.1080/14017431.2025.2525098

Stig Steen, Qiuming Liao, Audrius Pascevivius, Mei Li, Erik Steen

{"title":"Ex vivo resuscitation and evaluation of hearts after 22 minutes of normothermic cardiac arrest.","authors":"Stig Steen, Qiuming Liao, Audrius Pascevivius, Mei Li, Erik Steen","doi":"10.1080/14017431.2025.2525098","DOIUrl":"10.1080/14017431.2025.2525098","url":null,"abstract":"Objective: The aim was to resuscitate and evaluate hearts ex vivo after 22 min of cardiac arrest with the goal of increasing the number of usable hearts from controlled donation after circulatory death (cDCD).Design: Eight pigs (39-61 kg) underwent 22 min of ventricular fibrillation, after which the heart was first perfused in vivo for three minutes with an oxygenated, erythrocyte-containing cardioplegic preservation solution. The heart was then explanted and perfused ex vivo with the same solution for three hours at 18 °C in a transportable heart preservation system. Functional evaluation was performed ex vivo (n = 7), while one heart underwent orthotopic transplantation and was monitored for 24 h.Results: The seven hearts evaluated ex vivo easily pumped twice the cardiac output measured in vivo. The transplanted heart maintained normal blood pressure, blood gases, and urine output throughout the 24-hour observation period. At the end of this period the aortic pressure was 104/80 mmHg with a heart rate of 129 beats per minute. Intravenous administration of 20, 40, and 100 µg adrenaline resulted in an aortic pressures of 238/171, 284/196, and 287/201 mmHg with corresponding heart rates of 162, 188, and 223 beats per minute.Conclusion: Hearts exposed to 22 min of cardiac arrest were successfully resuscitated ex vivo and demonstrated adequate function when evaluated.","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":" ","pages":"2525098"},"PeriodicalIF":1.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144476519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Left atrial appendage occlusion: real world observational data on in-hospital results, clinical outcome and hemoglobin level. 左心耳闭塞：住院结果、临床结局和血红蛋白水平的真实世界观察数据。

IF 1 4区医学

Scandinavian Cardiovascular Journal Pub Date : 2025-12-01 Epub Date: 2025-09-01 DOI: 10.1080/14017431.2025.2554681

Holger H Sigusch, Zuzana Hudcovská, Anna Aleevskaia, Ralf Surber

{"title":"Left atrial appendage occlusion: real world observational data on in-hospital results, clinical outcome and hemoglobin level.","authors":"Holger H Sigusch, Zuzana Hudcovská, Anna Aleevskaia, Ralf Surber","doi":"10.1080/14017431.2025.2554681","DOIUrl":"10.1080/14017431.2025.2554681","url":null,"abstract":"Background: Interventional left atrial appendage occlusion (LAAO) was developed as a treatment option for patients who cannot receive traditional anticoagulation therapies. To date, randomized study data on this treatment are still limited, so registries and other non-randomized studies may help define the role of LAAO in clinical practice.Design: We performed LAAO consecutively on 599 patients. All patients had non-valvular atrial fibrillation and a guideline-based indication for anticoagulation with either a history of a clinically relevant bleeding episode under anticoagulation (post-bleeding patients, PBP) or a high bleeding risk (HBR) based on a joint clinical decision. Data on the patients' index hospital stay were completely recorded; follow-up transesophageal echocardiography (TEE) was performed on approximately 50% of these patients. Clinical and laboratory follow-up data were available for 509 and 458 of these patients, respectively.Results: Device implantation was successful in 98.8% of cases. There were 7 (1.2%) device dislocations and 6 (1.0%) periprocedural deaths. Of these, 5 deaths were procedure-related, and 4 were due to either accession site bleeding complications or device dislocation. In 96.3% of cases, follow-up TEE showed good results after device implantation. Compared to baseline values, hemoglobin concentration in the PBP group increased significantly by 5.0 g/l during the follow-up interval, while it decreased significantly by 5.0 g/l in the HBR group. During the follow-up period, renal function deteriorated significantly in the total cohort.Conclusion: LAAO was associated with a significant increase in hemoglobin concentration in patients with a history of clinically relevant bleeding episodes.","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":"59 1","pages":"2554681"},"PeriodicalIF":1.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144967108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0