Scandinavian Cardiovascular Journal最新文献

{"title":"Beyond anatomic predictors: unaddressed variables in pacemaker risk after TAVI.","authors":"Hakan Suygun","doi":"10.1080/14017431.2025.2566058","DOIUrl":"10.1080/14017431.2025.2566058","url":null,"abstract":"","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":" ","pages":"2566058"},"PeriodicalIF":1.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145131830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autopsy results and factors associated with sudden cardiac death in young individuals with congenital heart disease - a nationwide study.","authors":"Emma Galos, Christina Christersson, Tomasz Baron, Bodil Svennblad, Aase Wisten, Eva-Lena Stattin","doi":"10.1080/14017431.2025.2480131","DOIUrl":"10.1080/14017431.2025.2480131","url":null,"abstract":"<p><strong>Objectives: </strong>Sudden cardiac death (SCD) is a leading cause of mortality among individuals with congenital heart disease (CHD), and risk stratification remains challenging. This study aimed to describe the underlying structural cardiac abnormalities in a national cohort of SCD victims with CHD, their socioeconomic status, and interactions with the healthcare system before death.</p><p><strong>Methods: </strong>The Swedish study of Sudden Cardiac Death in the Young, 2000-2010, included SCD victims under 36 years, along with population-based controls and their parents. Of 903 SCD victims, 39 with autopsy-defined CHD were included in this study, together with 195 controls. Information on socioeconomic variables and healthcare contacts was gathered from Swedish national registers.</p><p><strong>Results: </strong>The median age for SCD was 24 years, and 64% were male. The CHD was undiagnosed before death in 31% of the cases, of whom 8 had coronary anomalies. Moderate to complex CHD was observed in 41%. Structural abnormalities of the ventricles were prevalent, with left ventricular hypertrophy present in 56% and fibrosis in 64%. The cases had a higher frequency of hospital admissions within 6 months before SCD compared to controls (OR 14.1,95% CI 3.80-52.44), <i>p</i> < 0.001. No socioeconomic differences were observed.</p><p><strong>Conclusions: </strong>This study identified a broad spectrum of underlying anatomical defects, with ventricular structural abnormalities being a common autopsy finding. The majority of cases had moderate to severe lesions. An increased frequency of healthcare contacts prior to death was noted, which may be a variable needing more attention as a predictor for a higher risk of SCD.</p>","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":" ","pages":"2480131"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of COVID-19 on cardiovascular function and exercise tolerance in healthy middle-age and older individuals.","authors":"Sophie L Russell, Nduka C Okwose, Mushidur Rahman, Ben J Lee, Gordon McGregor, Stuart M Raleigh, Hardip Sandhu, Laura C Roden, Prithwish Banerjee, Djordje G Jakovljevic","doi":"10.1080/14017431.2025.2468339","DOIUrl":"10.1080/14017431.2025.2468339","url":null,"abstract":"<p><strong>Aims: </strong>Coronavirus disease (COVID-19) can affect cardiovascular function in health and disease. The present study assessed the effect of prior COVID-19 infection on cardiovascular phenotype at rest and in response to exercise in middle age and older individuals.</p><p><strong>Methods: </strong>This case-control, single-centre study recruited 124 participants: 84 with a history of COVID-19 (59.9 ± 7.41 years, 54.8% female) and 40 participants without history of COVID-19 infection (62.8 ± 7.14 years, 62.5% female). All participants underwent non-invasive assessment of arterial function using pulse wave velocity (PWV), augmentation index (Alx) and hemodynamic function (i.e. cardiac index (CI), stroke volume index (SVI), heart rate (HR), mean arterial blood pressure (MAP)) at rest. Cardiopulmonary exercise stress testing with simultaneous gas exchange and hemodynamic (bioreactance) measurements was also performed.</p><p><strong>Results: </strong>There were no differences between COVID-19 and non-COVID-19 groups in PWV (COVID-19: 7.52 ± 1.66 m/s, non-COVID-19: 7.32 ± 1.79 m/s, <i>p</i> = 0.440); Alx (COVID-19: 29.2 ± 9.12%, non-COVID-19: 29.2 ± 8.44%, <i>p</i> = 0.980); CI (COVID-19: 2.85 ± 0.39 L/min/m², non-COVID-19: 2.79 ± 0.37 L/min/m², <i>p</i> = 0.407); SVI (COVID-19: 46.5 ± 7.54 mL/m², non-COVID-19: 47.0 ± 7.59 mL/m², <i>p</i> = 0.776), HR (COVID-19: 62.3 ± 10.6 beats/min, Non-COVID-19: 60.2 ± 8.52 beats/min, <i>p</i> = 0.263), or MAP (COVID-19: 98.1 ± 11.2 mmHg, non-COVID-19: 96.6 ± 9.46 mmHg, <i>p</i> = 0.464). COVID-19 participants however demonstrated lower O₂ consumption at anaerobic threshold (15.5 ± 4.25 vs 16.8 ± 4.51 mL/kg/m², <i>p</i> = 0.034), peak cardiac index (10.4 ± 2.3 vs 11.3 ± 2.5 L/min/m², <i>p</i> = 0.040) and peak stroke volume index (82.1 ± 25.3 vs 98.6 ± 37.6 mL/m², <i>p</i> = 0.028).</p><p><strong>Conclusion: </strong>Healthy middle-age and older individuals with history COVID-19 infection demonstrate reduced exercise tolerance and cardiac function response to exercise.</p>","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":" ","pages":"2468339"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The ESCAPER study-exploring protective mechanisms against cardiovascular disease in subjects at high risk: rationale, study protocol, and first results.","authors":"Ola Ekström, Håkan Arheden, Anders Christensson, Gunnar Engström, Erik Hedström, Cecilia Kennbäck, Agne Laucyte-Cibulskiene, Simon Lundgren, Valeriya Lyssenko, Magnus Löndahl, Martin Magnusson, Peter M Nilsson, Anders Gottsäter","doi":"10.1080/14017431.2025.2513865","DOIUrl":"10.1080/14017431.2025.2513865","url":null,"abstract":"<p><p><i>Introduction.</i> The ESCAPER project explores cardiovascular resilience in individuals who, despite a high-risk factor burden-longstanding Type 1 Diabetes (T1D), obesity, or kidney failure-avoid or delay macrovascular complications. This suggests underlying protective mechanisms. Initiated in September 2022, this exploratory study aims to uncover and define these mechanisms, potentially leading to novel therapeutic targets in preventive medicine. <i>Research design and methods.</i> Participants from the Skåne region, Southern Sweden, are divided into three subgroups: (1) T1D patients (>30 years duration) without macrovascular complications or macroalbuminuria, (2) obese individuals with normal cardiac function and no cardiovascular medications, and (3) kidney failure patients awaiting transplantation with no arterial calcification, alongside respective controls. Comprehensive phenotyping includes 24-h blood pressure, ECG monitoring, vascular ultrasound, cardiac MRI, and ergospirometry (in a subgroup), along with laboratory investigations, including biomarker and omics analyses. Arterial biopsies are collected from kidney failure patients. The study leverages Swedish national medical registries for detailed follow-up of healthcare utilization, diagnoses, and prescriptions, enabling longitudinal outcome assessments. <i>Results.</i> Initial findings from 90 T1D patients and 31 obese individuals indicate well-managed cardiovascular risk factors. The T1D subgroup shows a mean BMI of 25.6 kg/m² and HbA1c of 52 mmol/mol, while the obesity subgroup presents a BMI of 32.9 kg/m² with normal glucose levels. <i>Conclusions.</i> ESCAPER has the potential to advance understanding of cardiovascular resilience and refine prevention strategies. Its comprehensive methodology and registry-based follow-up provide robust insights into protective mechanisms and long-term outcomes.</p>","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":" ","pages":"2513865"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes following repair of acute type A aortic dissection in patients with cerebral malperfusion.","authors":"Jacob Ede, Karl Teurneau-Hermansson, Birgitta Ramgren, Marion Moseby-Knappe, Mårten Larsson, Johan Sjögren, Per Wierup, Shahab Nozohoor, Igor Zindovic","doi":"10.1080/14017431.2025.2514742","DOIUrl":"10.1080/14017431.2025.2514742","url":null,"abstract":"<p><strong>Objectives: </strong>Patients with acute type A aortic dissection (ATAAD) presenting with cerebral malperfusion have significantly poorer postoperative outcomes, making the decision whether to perform acute surgery difficult. The aim of this study was to investigate types of neurological symptoms and radiological findings and their association with permanent neurological injury and mortality following ATAAD repair.</p><p><strong>Methods: </strong>This was a single-center, retrospective, observational study. A total of 629 patients underwent ATAAD surgery between January 1998 and December 2023 at Skåne University Hospital, Lund, Sweden. Of these, 93 (14.7%) presented with cerebral malperfusion and constituted the study population. The primary endpoints were clinical neurological injury and 30-day mortality.</p><p><strong>Results: </strong>Overall 30-day mortality was 25.0%. Fifty-two patients (57.1%) had persisting neurological deficit. Patients with postoperative neurological deficit had significantly higher 30-day mortality than patients without postoperative neurological deficit (37.3% vs 5.1%, <i>p</i> > 0.001<b>)</b>. Common carotid artery dissection and carotid artery occlusion were significantly more frequent in patients who developed postoperative neurological injury. Preoperative hemiparesis/hemiplegia was associated with a significant increase of persisting neurological deficits, and unconsciousness was associated with a significant increase in 30-day mortality or persisting neurological deficits. After repair, 52.2% of patients showed an improvement in their clinical neurological status.</p><p><strong>Conclusion: </strong>In ATAAD patients who present with cerebral malperfusion, the risk of permanent neurological deficit and 30-day mortality is high, but a significant proportion of patients survive and more than half demonstrate an improved neurological state postoperatively.</p>","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":" ","pages":"2514742"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144209404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Percutaneous coronary intervention in nonagenarians.","authors":"Matti Riihiniemi, Jarkko Piuhola, Matti Niemelä, Fausto Biancari, Juhani Junttila","doi":"10.1080/14017431.2025.2514880","DOIUrl":"10.1080/14017431.2025.2514880","url":null,"abstract":"<p><strong>Background: </strong>Due to aging population, nonagenarians are increasingly undergoing percutaneous coronary intervention (PCI). However, the safety and efficacy of PCI in this elderly population remains somewhat unknown.</p><p><strong>Methods: </strong>A retrospective study was conducted to investigate the characteristics and outcomes of consecutive nonagenarians who underwent PCI at the Oulu University Hospital between 2012 and 2022. Patients (<i>n</i> = 107; mean age 91.2 ± 1.4 years; 58.9% women) were stratified into three groups based on their presentation: ST-elevation myocardial infarction (STEMI), non-ST-elevation acute coronary syndrome (NSTEACS) or stable coronary artery disease (CAD). One-year mortality was the primary outcome of this analysis. Secondary outcomes were in-hospital major bleeding and 1-year rates of myocardial infarction, stroke and repeat revascularisation.</p><p><strong>Results: </strong>Majority had acute coronary syndrome, with STEMI in 35 (32.7%) and NSTEACS in 51 (47.7%) patients, while in 21 (19.6%) patients' indication was stable CAD. Early mortality was mainly related to STEMI (in-hospital mortality: STEMI 22.9% vs. NSTEACS 5.9% vs. stable CAD 0.0%, <i>p</i> = 0.011; 30-day mortality: 34.3% vs. 13.7% vs. 4.8%, respectively, <i>p</i> = 0.011). Rate of major in-hospital bleeding was 3.7%. There was no significant difference in 1-year mortality between groups (40.0% vs. 27.5% vs. 19.0%, respectively, <i>p</i> = 0.227). One-year rates for myocardial infarction, stroke and repeat revascularisation were 7.5%, 1.9% and 3.7%, respectively.</p><p><strong>Conclusions: </strong>Excess mortality in nonagenarians undergoing PCI is mainly related to STEMI where it is driven by early adverse events. Mortality in this study can be seen as acceptable in comparison to that in general population, supporting the use of PCI in selected nonagenarians.</p>","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":" ","pages":"2514880"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144209405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementation of alcohol screening and brief interventions in cardiology: a cross-sectional study of practice in Sweden.","authors":"Paul Welfordsson, Anna-Karin Danielsson, Caroline Björck, Bartosz Grzymala-Lubanski, Kristina Hambraeus, Ida Haugen Löfman, Frieder Braunschweig, Matthias Lidin, Sara Wallhed Finn","doi":"10.1080/14017431.2025.2533825","DOIUrl":"10.1080/14017431.2025.2533825","url":null,"abstract":"<p><p><i>Aims</i>. To investigate rates of alcohol screening and brief interventions (SBI) in cardiology, and to examine associations between patient characteristics and the implementation of screening and brief interventions (BIs). <i>Methods</i>. Cross-sectional survey of cardiology patients (aged ≥18 years) in three towns/cities in Sweden (Falun, Gävle, Stockholm). Self-reported study outcomes included: (a) being screened for alcohol use and (b) receiving a BI. Covariates included sociodemographic characteristics and clinical factors. We examined associations between covariates and study outcomes using logistic regression models. <i>Results</i>. From a total of 1051 participants (median age = 73 years, 66% men), 54% were screened for alcohol use, mostly by doctors (48%) and nurses (40%). Odds ratios (ORs) for being screened were lower among participants aged ≥80 years (OR = 0.57, 95% confidence intervals (CI) = 0.41-0.79), relative to those aged 65-79 years, and higher among participants with overweight (OR = 1.84, 95%CI = 1.38-2.44). Of those screened, 12% received BIs. Odds ratios for receiving BIs were higher among: men (OR = 3.04, 95%CI = 1.41-6.56), current smokers (OR = 10.88, 95%CI = 3.86-30.69), and participants with hazardous drinking (OR = 5.66, 95%CI = 2.59-12.36). <i>Conclusions</i>. Just over half cardiology patients were screened for alcohol use. Almost two-thirds of those identified with hazardous drinking did not receive BIs. Screening and BI practices varied according to individual participant characteristics, and there was a shortfall in screening among the elderly. Findings indicate inconsistent implementation of European cardiology guidelines, which recommend universal screening, and highlight a need for improved implementation strategies.</p>","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":" ","pages":"2533825"},"PeriodicalIF":1.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144643271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep duration and quality, physical activity and cardiometabolic multimorbidity: findings from the English Longitudinal study of Ageing.","authors":"Setor K Kunutsor, Jari A Laukkanen","doi":"10.1080/14017431.2025.2550279","DOIUrl":"https://doi.org/10.1080/14017431.2025.2550279","url":null,"abstract":"<p><p><i>Objectives:</i> We aimed to assess the prospective associations of sleep duration and quality with the risk of cardiometabolic multimorbidity (CMM) and the interplay with physical activity. <i>Design:</i> Sleep duration and quality and physical activity were self-reported using standardized questionnaires. Cardiometabolic multimorbidity was defined as the presence of at least two multiple long-term conditions (hypertension, diabetes, coronary heart disease, stroke, and other cardiovascular diseases) at follow-up. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated using logistic regression models adjusted for cardiometabolic risk factors including physical activity. <i>Results:</i> We included 3,428 participants [mean (SD) age 63 (9) years, 44.8% male] free of hypertension, coronary heart disease, diabetes, and stroke at baseline. At 15 years follow-up, 206 participants developed CMM. There was an approximate U-shaped trend between sleep duration and CMM risk. Compared to sleep duration of 7-8 hrs/day, the multivariable OR (95% CI) for CMM was 1.39 (1.03-1.90) for sleep duration ≤6 hrs/day and 1.05 (0.55-2.00) for sleep duration ≥9 hrs/day. The odds of CMM appeared to decrease with each additional hour of sleep among participants with short sleep duration (≤6 hrs/day), although this association did not reach statistical significance (OR, 0.78, 95% CI: 0.59-1.02). Sleep quality or physical activity was not associated with CMM. <i>Conclusions:</i> Short sleep duration is associated with an increased CMM risk independent of physical activity. The observed trend suggests that increasing sleep duration among short sleepers may help mitigate CMM risk.</p>","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":"59 1","pages":"2550279"},"PeriodicalIF":1.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144967049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linear growth pattern can be used to predict ascending aortic aneurysm growth.","authors":"Iida-Mari Viitala, Tuomas Selander, Marja Hedman, Johanna Turtiainen","doi":"10.1080/14017431.2024.2430001","DOIUrl":"10.1080/14017431.2024.2430001","url":null,"abstract":"<p><p><i>Objectives.</i> Current guidelines recommend that surveillance imaging should be performed at least every third year for patients with ascending thoracic aortic aneurysm (ATAA) even though such aneurysms' growth rate is mostly minimal. The purpose of this study was to clarify the pattern of the growth of ATAAs in a real-life patient population to adjust the optimal timing of aortic surveillance for each patient. <i>Methods.</i> This study includes patients (<i>n</i> = 209) who had been followed due to ATAA in the central hospital of North Karelia in Eastern Finland between years 2007 and 2023. Aortic imaging was performed using either computed tomography (CT) or transthoracic echocardiography (TTE). In the CT images, the aortic dimensions were measured according to guidelines in four levels of the ascending aorta. TTE measurements were collected from medical records. Measurements were used to explore the pattern of the ATAA growth. <i>Results.</i> During the mean surveillance time 5.0 ± 3.5 years, the median growth rate of ATAAs was 0.37 mm/year. One fifth (21.5%) of the aneurysms showed no expansion during the follow-up. Despite the minimal growth rate during surveillance, some patients ended up exceeding the cut-off for preventive surgery. Among the patients, who showed expansion during the follow-up, the linear model seemed to best describe the growth of ATAA. <i>Conclusions.</i> The majority of the patients had a very low ATAA growth rate. Based on this study, the growth of ATAAs could be described using a linear model, which could, in turn, be used to predict the growth of an aneurysm.</p>","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":"58 1","pages":"2430001"},"PeriodicalIF":1.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142668974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical value of BRE-AS1 in myocardial infarction and its role in myocardial infarction-induced cardiac muscle cell apoptosis.","authors":"Zhen Gao, Hezhong Zhu, Jieqiong Chen, Wei Liu, Jiangtao Huo, Chaoyong He, Jiajuan Chen","doi":"10.1080/14017431.2024.2347290","DOIUrl":"10.1080/14017431.2024.2347290","url":null,"abstract":"<p><p><i>Objectives.</i> The aim of this study was to investigate the expression of long non-coding RNA (lncRNA) brain and reproductive organ-expressed protein (BRE) antisense RNA 1 (BRE-AS1) in patients with acute myocardial infarction (AMI) and its effect on ischemia/reperfusion (I/R)-induced oxidative stress and apoptosis of cardiomyocytes. <i>Methods.</i> Serum BRE-AS1 levels in patients with AMI was detected using quantitative real-time polymerase chain reaction (qRT-PCR). The diagnostic and prognostic values of BRE-AS1 were evaluated. H9c2 cells were treated with hypoxia/reoxygenation to establish an <i>in vitro</i> myocardial infarction cell model. The levels of inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and IL-6 were detected by enzyme-linked immunosorbent assay (ELISA). Levels of lactate dehydrogenase (LDH), malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) were determined by commercial kits. Cell counting kit-8 (CCK-8) and flow cytometry were used to evaluate the cell viability and cell apoptosis. <i>Results.</i> The expression of BRE-AS1 in serum of patients with AMI is upregulated, which shows the clinical diagnostic value for AMI. In the I/R injury cell model, the knockout of BRE-AS1 can significantly alleviate the increase in TNF-α, IL-1β, and IL-6 levels, inhibit the production of LDH and MDA, increase the activities of SOD and GSH-Px, promote the cell viability and suppress cell apoptosis. <i>Conclusions.</i> Abnormally elevated BRE-AS1 has a high diagnostic value for AMI as well as a prognostic value for major adverse cardiovascular events (MACEs). The elevation of BRE-AS1 promoted oxidative stress injury and cell apoptosis <i>in vitro</i>.</p>","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":"58 1","pages":"2347290"},"PeriodicalIF":1.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140909198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}